ro 31-8220 has been researched along with Heart Failure in 1 studies
Ro 31-8220: a protein kinase C inhibitor
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We demonstrate that ruboxistaurin administration to a pig model of myocardial infarction-induced heart failure was protective." | 7.77 | Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury. ( Correll, RN; Hajjar, RJ; Houser, SR; Ishikawa, K; Kawase, Y; Ladage, D; Molkentin, JD; Tilemann, L, 2011) |
| "We demonstrate that ruboxistaurin administration to a pig model of myocardial infarction-induced heart failure was protective." | 3.77 | Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury. ( Correll, RN; Hajjar, RJ; Houser, SR; Ishikawa, K; Kawase, Y; Ladage, D; Molkentin, JD; Tilemann, L, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ladage, D | 1 |
| Tilemann, L | 1 |
| Ishikawa, K | 1 |
| Correll, RN | 1 |
| Kawase, Y | 1 |
| Houser, SR | 1 |
| Molkentin, JD | 1 |
| Hajjar, RJ | 1 |
1 other study available for ro 31-8220 and Heart Failure
| Article | Year |
|---|---|
Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury.
Topics: Animals; Cardiac Output; Coronary Occlusion; Disease Models, Animal; Dose-Response Relationship, Dru | 2011 |