ro 31-8220 has been researched along with Glioma in 5 studies
Ro 31-8220: a protein kinase C inhibitor
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here we show that the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells due to phospholipid hydrolysis by phospholipase D (PLD) is not inhibited by rapamycin or PD98059, specific inhibitors respectively of p70 S6 kinase and MAPKK (MEK) and thus of MAPKAP kinase-1beta but is still completely blocked by Ro31-8220." | 7.69 | Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD. ( Beale, G; Mallon, B; Morreale, A; Rumsby, M; Watson, J, 1997) |
| " Here we show that the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells due to phospholipid hydrolysis by phospholipase D (PLD) is not inhibited by rapamycin or PD98059, specific inhibitors respectively of p70 S6 kinase and MAPKK (MEK) and thus of MAPKAP kinase-1beta but is still completely blocked by Ro31-8220." | 3.69 | Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD. ( Beale, G; Mallon, B; Morreale, A; Rumsby, M; Watson, J, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, CY | 1 |
| Ma, KH | 1 |
| Wang, JK | 1 |
| Tung, YL | 1 |
| Chueh, SH | 1 |
| Mallon, BS | 2 |
| Thompson, HJ | 2 |
| Turner, RA | 1 |
| Holden, CM | 1 |
| Rumsby, MG | 2 |
| Litherland, GJ | 1 |
| Morreale, A | 1 |
| Mallon, B | 1 |
| Beale, G | 1 |
| Watson, J | 1 |
| Rumsby, M | 1 |
| Uehara, T | 1 |
| Baba, I | 1 |
| Nomura, Y | 1 |
5 other studies available for ro 31-8220 and Glioma
| Article | Year |
|---|---|
Inhibition of protein kinase C promotes differentiation of neuroblastoma × glioma NG108-15 hybrid cells.
Topics: Animals; Carbazoles; Cell Count; Cell Differentiation; Cell Line, Tumor; Cell Shape; Enzyme Inhibito | 2011 |
Protein kinase C activation of phospholipase D in C6 glioma cells.
Topics: Alkaloids; Animals; Cell Line; Enzyme Activation; Glioma; Indoles; Phorbol Esters; Phospholipase D; | 1993 |
Staurosporine and its derivative RO31-8220, both inhibitors of protein kinase C, have different effects on C6 glioma cell morphology.
Topics: Alkaloids; Cell Line; Glioma; Indoles; Molecular Weight; Phosphoproteins; Protein Kinase C; Staurosp | 1993 |
Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD.
Topics: Androstadienes; Animals; Choline; Enzyme Inhibitors; Ethanolamine; Flavonoids; Glioma; Indoles; Phos | 1997 |
Induction of cytokine-induced neutrophil chemoattractant in response to various stresses in rat C6 glioma cells.
Topics: Animals; Astrocytes; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; CCAAT-Enhancer-Bin | 1998 |