ro 31-8220 has been researched along with Disease Models, Animal in 7 studies
Ro 31-8220: a protein kinase C inhibitor
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We demonstrate that ruboxistaurin administration to a pig model of myocardial infarction-induced heart failure was protective." | 7.77 | Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury. ( Correll, RN; Hajjar, RJ; Houser, SR; Ishikawa, K; Kawase, Y; Ladage, D; Molkentin, JD; Tilemann, L, 2011) |
| "We demonstrate that ruboxistaurin administration to a pig model of myocardial infarction-induced heart failure was protective." | 3.77 | Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury. ( Correll, RN; Hajjar, RJ; Houser, SR; Ishikawa, K; Kawase, Y; Ladage, D; Molkentin, JD; Tilemann, L, 2011) |
| "These data indicate that the formation of O2- by the endothelial gp91phox-containing NADPH oxidase accounts for the reduced NO bioavailability in the 2K1C model and contributes to the development of renovascular hypertension and endothelial dysfunction." | 1.32 | gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension. ( Brandes, RP; Busse, R; Geiger, H; Jung, O; Pedrazzini, T; Schreiber, JG, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shim, KH | 1 |
| Kim, SH | 1 |
| Hur, J | 1 |
| Kim, DH | 1 |
| Demirev, AV | 1 |
| Yoon, SY | 1 |
| Ketley, A | 1 |
| Chen, CZ | 1 |
| Li, X | 1 |
| Arya, S | 1 |
| Robinson, TE | 1 |
| Granados-Riveron, J | 1 |
| Udosen, I | 1 |
| Morris, GE | 1 |
| Holt, I | 1 |
| Furling, D | 1 |
| Chaouch, S | 1 |
| Haworth, B | 1 |
| Southall, N | 1 |
| Shinn, P | 1 |
| Zheng, W | 1 |
| Austin, CP | 1 |
| Hayes, CJ | 1 |
| Brook, JD | 1 |
| Cazarolli, LH | 1 |
| Folador, P | 1 |
| Moresco, HH | 1 |
| Brighente, IM | 1 |
| Pizzolatti, MG | 1 |
| Silva, FR | 1 |
| Bal, MS | 1 |
| Paulis, L | 1 |
| Zicha, J | 1 |
| Kunes, J | 1 |
| Ladage, D | 1 |
| Tilemann, L | 1 |
| Ishikawa, K | 1 |
| Correll, RN | 1 |
| Kawase, Y | 1 |
| Houser, SR | 1 |
| Molkentin, JD | 1 |
| Hajjar, RJ | 1 |
| Jung, O | 1 |
| Schreiber, JG | 1 |
| Geiger, H | 1 |
| Pedrazzini, T | 1 |
| Busse, R | 1 |
| Brandes, RP | 1 |
| Hirst, SJ | 1 |
| Webb, BL | 1 |
| Giembycz, MA | 1 |
| Barnes, PJ | 1 |
| Twort, CH | 1 |
7 other studies available for ro 31-8220 and Disease Models, Animal
| Article | Year |
|---|---|
Small-molecule drug screening identifies drug Ro 31-8220 that reduces toxic phosphorylated tau in Drosophila melanogaster.
Topics: Animals; Disease Models, Animal; Drosophila melanogaster; Drug Evaluation, Preclinical; Frontotempor | 2019 |
High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines.
Topics: Alternative Splicing; Animals; CELF1 Protein; Cell Nucleus; Cells, Cultured; Chromomycin A3; Disease | 2014 |
Mechanism of action of the stimulatory effect of apigenin-6-C-(2''-O-alpha-l-rhamnopyranosyl)-beta-L-fucopyranoside on 14C-glucose uptake.
Topics: Alloxan; Androstadienes; Animals; Biological Transport; Blood Glucose; Carbon Radioisotopes; Colchic | 2009 |
Effect of protein kinase C and protein kinase A inhibitors on contraction of isolated femoral arteries of SHR and Wistar rats.
Topics: Animals; Calcium; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Femoral Artery; Hype | 2009 |
Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury.
Topics: Animals; Cardiac Output; Coronary Occlusion; Disease Models, Animal; Dose-Response Relationship, Dru | 2011 |
gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcholine; Angiotensin II; Animals; Anti | 2004 |
Inhibition of fetal calf serum-stimulated proliferation of rabbit cultured tracheal smooth muscle cells by selective inhibitors of protein kinase C and protein tyrosine kinase.
Topics: Animals; Asthma; Cell Division; Cells, Cultured; Cinnamates; Culture Media; Disease Models, Animal; | 1995 |