ro 31-8220 has been researched along with Breast Neoplasms in 8 studies
Ro 31-8220: a protein kinase C inhibitor
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "ErbB2 overexpression drives oncogenesis in 20-30% cases of breast cancer." | 1.40 | A kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells. ( Ahmad, G; Bailey, TA; Band, H; Band, V; Bielecki, TA; George, M; Kelly, DL; Luan, H; Mohapatra, B; Natarajan, A; Raja, SM; Tom, E, 2014) |
| "Sphingosine kinases (SK) catalyze the phosphorylation of proapoptotic sphingosine to the prosurvival factor sphingosine 1-phosphate (S1P), thereby promoting oncogenic processes." | 1.38 | Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis. ( Fabbro, D; Huwiler, A; Kotelevets, N; Zangemeister-Wittke, U, 2012) |
| "Staurosporine was the most potent and the bisindolylmaleimides RO 31 8220 and GF 109203X the least potent cytostatic agents." | 1.29 | Comparison of staurosporine and four analogues: their effects on growth, rhodamine 123 retention and binding to P-glycoprotein in multidrug-resistant MCF-7/Adr cells. ( Budworth, J; Davies, R; Ferry, DR; Gant, TW; Gescher, A; Malkhandi, J, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhong, Y | 1 |
| Xue, M | 1 |
| Zhao, X | 1 |
| Yuan, J | 1 |
| Liu, X | 1 |
| Huang, J | 1 |
| Zhao, Z | 1 |
| Li, H | 1 |
| Xu, Y | 1 |
| Bailey, TA | 1 |
| Luan, H | 1 |
| Tom, E | 1 |
| Bielecki, TA | 1 |
| Mohapatra, B | 1 |
| Ahmad, G | 1 |
| George, M | 1 |
| Kelly, DL | 1 |
| Natarajan, A | 1 |
| Raja, SM | 1 |
| Band, V | 1 |
| Band, H | 1 |
| Kotelevets, N | 1 |
| Fabbro, D | 1 |
| Huwiler, A | 1 |
| Zangemeister-Wittke, U | 1 |
| Budworth, J | 2 |
| Gescher, A | 2 |
| Davies, R | 1 |
| Malkhandi, J | 1 |
| Gant, TW | 1 |
| Ferry, DR | 1 |
| Mao, M | 1 |
| Fang, X | 1 |
| Lu, Y | 1 |
| Lapushin, R | 1 |
| Bast, RC | 1 |
| Mills, GB | 1 |
| Marino, M | 1 |
| Distefano, E | 1 |
| Caporali, S | 1 |
| Ceracchi, G | 1 |
| Pallottini, V | 1 |
| Trentalance, A | 1 |
| Yao, J | 1 |
| Xiong, S | 1 |
| Klos, K | 1 |
| Nguyen, N | 1 |
| Grijalva, R | 1 |
| Li, P | 1 |
| Yu, D | 1 |
8 other studies available for ro 31-8220 and Breast Neoplasms
| Article | Year |
|---|---|
Substituted indolin-2-ones as p90 ribosomal S6 protein kinase 2 (RSK2) inhibitors: Molecular docking simulation and structure-activity relationship analysis.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Indol | 2013 |
A kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells.
Topics: Antineoplastic Agents; Benzoquinones; Breast Neoplasms; Carbazoles; Carcinogenesis; Cell Line, Tumor | 2014 |
Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis.
Topics: Apoptosis; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Proliferation; Chromatography, Liqu | 2012 |
Differential inhibition of cytosolic and membrane-derived protein kinase C activity by staurosporine and other kinase inhibitors.
Topics: Alkaloids; Breast Neoplasms; Cell Membrane; Cytosol; Humans; Immunoblotting; Indoles; Naphthalenes; | 1995 |
Comparison of staurosporine and four analogues: their effects on growth, rhodamine 123 retention and binding to P-glycoprotein in multidrug-resistant MCF-7/Adr cells.
Topics: Alkaloids; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Ne | 1996 |
Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells.
Topics: Breast Neoplasms; Enzyme Activation; Epidermal Growth Factor; Humans; Indoles; Lysophospholipids; Ph | 2000 |
beta-estradiol stimulation of DNA synthesis requires different PKC isoforms in HepG2 and MCF7 cells.
Topics: Androstadienes; Breast Neoplasms; Carcinoma, Hepatocellular; Cell Division; Cell Membrane; DNA Repli | 2001 |
Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells.
Topics: Breast Neoplasms; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulati | 2001 |