ro-28-1675 and Disease-Models--Animal

ro-28-1675 has been researched along with Disease-Models--Animal* in 1 studies

Other Studies

1 other study(ies) available for ro-28-1675 and Disease-Models--Animal

Article	Year
Design, synthesis and SAR of novel glucokinase activators. Bioorganic & medicinal chemistry letters, 2013, Apr-01, Volume: 23, Issue:7 Guided by co-crystal structures of compounds 15, 22 and 30, an SBDD approach led to the discovery of the 6-methyl pyridone series as a novel class of GKAs that potently activate GK in enzyme and cell assays. Anti-diabetic OGTT efficacy was demonstrated with 54 in a mouse model of type 2 diabetes. Topics: Animals; Crystallography, X-Ray; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug Design; Enzyme Activation; Enzyme Activators; Glucokinase; Glucose Tolerance Test; Hypoglycemic Agents; Mice; Mice, Inbred C57BL; Mice, Obese; Models, Molecular; Molecular Structure; Pyridones; Structure-Activity Relationship	2013

Article

Year

Design, synthesis and SAR of novel glucokinase activators.

Bioorganic & medicinal chemistry letters, 2013, Apr-01, Volume: 23, Issue:7

Guided by co-crystal structures of compounds 15, 22 and 30, an SBDD approach led to the discovery of the 6-methyl pyridone series as a novel class of GKAs that potently activate GK in enzyme and cell assays. Anti-diabetic OGTT efficacy was demonstrated with 54 in a mouse model of type 2 diabetes.

Topics: Animals; Crystallography, X-Ray; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug Design; Enzyme Activation; Enzyme Activators; Glucokinase; Glucose Tolerance Test; Hypoglycemic Agents; Mice; Mice, Inbred C57BL; Mice, Obese; Models, Molecular; Molecular Structure; Pyridones; Structure-Activity Relationship

2013