ro-24-0238 and Inflammation

ro-24-0238 has been researched along with Inflammation* in 1 studies

Other Studies

1 other study(ies) available for ro-24-0238 and Inflammation

Article	Year
Platelet activating factor as a proinflammatory mediator in acetic-induced colitis in the rat. Agents and actions, 1991, Volume: 34, Issue:1-2 Platelet activating factor (PAF) induces neutrophilia and produces a variety of gastrointestinal lesions. The role of PAF as a proinflammatory mediator was examined by measuring the production of PAF and the efficacy of the PAF antagonists WEB 2086 and Ro 24-0238 in acetic acid (HOAc)-induced colitis. PAF levels within the colonic mucosa, as measured by radioimmunoassay, increased from 259 +/- 119 ng/mg in control tissue, to 616 +/- 266 ng/mg in HOAc inflamed tissue. The accumulation of neutrophils within the mucosa was decreased by 53 +/- 10% by pretreatment with 3 mg/kg WEB 2086, and by 43 +/- 11% by 3 mg/kg Ro 24-0238. PAF-induced neutrophilia had no effect on the severity of HOAc-induced colitis, therefore, PAF my be involved in sustaining the chronic inflammation of colitis. Topics: Acetates; Animals; Azepines; Colitis; Inflammation; Platelet Activating Factor; Polyunsaturated Alkamides; Pyridines; Rats; Rats, Inbred Strains; Triazoles	1991

Article

Year

Platelet activating factor as a proinflammatory mediator in acetic-induced colitis in the rat.

Agents and actions, 1991, Volume: 34, Issue:1-2

Platelet activating factor (PAF) induces neutrophilia and produces a variety of gastrointestinal lesions. The role of PAF as a proinflammatory mediator was examined by measuring the production of PAF and the efficacy of the PAF antagonists WEB 2086 and Ro 24-0238 in acetic acid (HOAc)-induced colitis. PAF levels within the colonic mucosa, as measured by radioimmunoassay, increased from 259 +/- 119 ng/mg in control tissue, to 616 +/- 266 ng/mg in HOAc inflamed tissue. The accumulation of neutrophils within the mucosa was decreased by 53 +/- 10% by pretreatment with 3 mg/kg WEB 2086, and by 43 +/- 11% by 3 mg/kg Ro 24-0238. PAF-induced neutrophilia had no effect on the severity of HOAc-induced colitis, therefore, PAF my be involved in sustaining the chronic inflammation of colitis.

Topics: Acetates; Animals; Azepines; Colitis; Inflammation; Platelet Activating Factor; Polyunsaturated Alkamides; Pyridines; Rats; Rats, Inbred Strains; Triazoles

1991