ro 15-4513 has been researched along with Seizures in 21 studies
Ro 15-4513: a partial inverse agonist of benzodiazepine receptors
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Differences in the seizure scores further subdivided the two groups." | 1.30 | Protection against cocaine and combined cocaine-ethanol toxicities in mice by imidazobenzodiazepine Ro 15-4513. ( Hayase, T; Yamamoto, K; Yamamoto, Y, 1997) |
| "Flumazenil did not produce any significant pharmacological effect." | 1.28 | In vivo bidirectional modulatory effect of benzodiazepine receptor ligands on GABAergic transmission evaluated by positron emission tomography in non-human primates. ( Bottlaender, M; Brouillet, E; Chavoix, C; Dodd, RH; Fournier, D; Hantraye, P; Khalili-Varasteh, M; Mazière, M, 1991) |
| "Using a model of seizure activity electrically elicited from the inferior colliculus, ethanol exerted a dose-related attenuation of seizure activity." | 1.28 | Mechanistic and functional divergence between thyrotropin-releasing hormone and RO 15-4513 interactions with ethanol. ( Breese, GR; McCown, TJ, 1989) |
| "Pentylenetetrazol (PTZ)-induced convulsion were studied in control, chronic ethanol-maintained, and ethanol-withdrawal rats." | 1.28 | Chronic ethanol treatment alters the behavioral effects of Ro 15-4513, a partially negative ligand for benzodiazepine binding sites. ( Mehta, AK; Ticku, MK, 1989) |
| " Dose-response and time course studies of Ro 15-4513 against gamma-aminobutyric acid (GABA) antagonists were performed." | 1.27 | Interactions of the imidazodiazepine Ro 15-4513 with chemical convulsants. ( Lister, RG; Nutt, DJ, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (52.38) | 18.7374 |
| 1990's | 9 (42.86) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (4.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Contó, MB | 1 |
| Hipólide, DC | 1 |
| de Carvalho, JG | 1 |
| Venditti, MA | 1 |
| Clark, M | 1 |
| Massenburg, GS | 1 |
| Weiss, SR | 1 |
| Post, RM | 1 |
| Morrow, AL | 1 |
| Devaud, LL | 1 |
| Bucci, D | 1 |
| Smith, FD | 1 |
| Hayase, T | 1 |
| Yamamoto, Y | 1 |
| Yamamoto, K | 1 |
| Mhatre, MC | 1 |
| Gonzalez, LP | 1 |
| Ticku, MK | 4 |
| Mhatre, M | 2 |
| Mehta, AK | 3 |
| Dar, MS | 1 |
| Brouillet, E | 1 |
| Chavoix, C | 1 |
| Bottlaender, M | 1 |
| Khalili-Varasteh, M | 1 |
| Hantraye, P | 1 |
| Fournier, D | 1 |
| Dodd, RH | 1 |
| Mazière, M | 1 |
| Corda, MG | 2 |
| Orlandi, M | 1 |
| Lecca, D | 1 |
| Carboni, G | 1 |
| Frau, V | 1 |
| Giorgi, O | 2 |
| Lowson, S | 1 |
| Gent, JP | 1 |
| Goodchild, CS | 1 |
| McCown, TJ | 1 |
| Breese, GR | 1 |
| Becker, HC | 1 |
| Anton, RF | 1 |
| Lister, RG | 3 |
| Durcan, MJ | 1 |
| Nutt, DJ | 3 |
| Linnoila, M | 1 |
| Kulkarni, SK | 1 |
| Longoni, B | 1 |
| Biggio, G | 1 |
| Belzung, C | 1 |
| Misslin, R | 1 |
| Vogel, E | 1 |
| Miczek, KA | 1 |
| Weerts, EM | 1 |
21 other studies available for ro 15-4513 and Seizures
| Article | Year |
|---|---|
Rats with different thresholds for DMCM-induced clonic convulsions differ in the sleep-time of diazepam and [(3)H]-Ro 15-4513 binding.
Topics: Animals; Anticonvulsants; Autoradiography; Azides; Benzodiazepines; Carbolines; Convulsants; Diazepa | 2012 |
Analysis of the hippocampal GABAA receptor system in kindled rats by autoradiographic and in situ hybridization techniques: contingent tolerance to carbamazepine.
Topics: Affinity Labels; Amygdala; Animals; Autoradiography; Azides; Benzodiazepines; Bridged Bicyclo Compou | 1994 |
GABAA and NMDA receptor subunit mRNA expression in ethanol dependent rats.
Topics: Alcoholism; Animals; Azides; Base Sequence; Benzodiazepines; Cerebellum; Cerebral Cortex; Dizocilpin | 1994 |
Protection against cocaine and combined cocaine-ethanol toxicities in mice by imidazobenzodiazepine Ro 15-4513.
Topics: Animals; Azides; Benzodiazepines; Brain Chemistry; Central Nervous System Depressants; Cocaine; Drug | 1997 |
Increased Ro15-4513-induced seizures following multiple ethanol withdrawals.
Topics: Animals; Azides; Benzodiazepines; Body Weight; Convulsants; Drug Synergism; Ethanol; GABA Agonists; | 1999 |
Modulation of GABAergic transmission by ethanol.
Topics: Animals; Anticonvulsants; Azides; Benzodiazepines; Brain Chemistry; Ethanol; Female; Flumazenil; GAB | 1992 |
Selective antagonism of acute ethanol-induced motor disturbances by centrally administered Ro 15-4513 in mice.
Topics: Animals; Azides; Benzodiazepines; Dose-Response Relationship, Drug; Electrodes, Implanted; Ethanol; | 1992 |
In vivo bidirectional modulatory effect of benzodiazepine receptor ligands on GABAergic transmission evaluated by positron emission tomography in non-human primates.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Carbolines; Cerebral Cort | 1991 |
Pentylenetetrazol-induced kindling in rats: effect of GABA function inhibitors.
Topics: Animals; Azides; Benzodiazepines; Carbolines; GABA Antagonists; Isoniazid; Kindling, Neurologic; Mal | 1991 |
Convulsive thresholds in mice during the recovery phase from anaesthesia induced by propofol, thiopentone, methohexitone and etomidate.
Topics: Anesthesia, Intravenous; Animals; Anticonvulsants; Azides; Behavior, Animal; Benzodiazepines; Etomid | 1991 |
Mechanistic and functional divergence between thyrotropin-releasing hormone and RO 15-4513 interactions with ethanol.
Topics: Animals; Arousal; Azides; Benzodiazepines; Dose-Response Relationship, Drug; Ethanol; Inferior Colli | 1989 |
The benzodiazepine receptor inverse agonist RO15-4513 exacerbates, but does not precipitate, ethanol withdrawal in mice.
Topics: Acoustic Stimulation; Affinity Labels; Animals; Azides; Benzodiazepines; Ethanol; Male; Mice; Mice, | 1989 |
Chronic ethanol treatment alters the behavioral effects of Ro 15-4513, a partially negative ligand for benzodiazepine binding sites.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Convulsants; Drug Interactions; Ethanol; Male; Pentyle | 1989 |
Attenuation of ethanol intoxication by alpha-2 adrenoceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Alcoholic Intoxication; Animals; Azides; Behavior, Animal; Benzodiazep | 1989 |
RO15-4513 but not FG-7142 reverses anticonvulsant effects of ethanol against bicuculline- and picrotoxin-induced convulsions in rats.
Topics: Affinity Labels; Animals; Appetite Depressants; Azides; Benzodiazepines; Bicuculline; Carbolines; Et | 1989 |
Decreased sensitivity to diazepam induced by chronic administration of FG 7142.
Topics: Animals; Anticonvulsants; Azides; Benzodiazepines; Brain; Brain Chemistry; Carbolines; Convulsants; | 1988 |
Chronic ethanol administration increases the binding of the benzodiazepine inverse agonist and alcohol antagonist [3H]RO15-4513 in rat brain.
Topics: Acoustic Stimulation; Animals; Azides; Benzodiazepines; Body Temperature; Brain Chemistry; Diazepam; | 1988 |
Antagonizing the anticonvulsant effect of ethanol using drugs acting at the benzodiazepine/GABA receptor complex.
Topics: Animals; Anticonvulsants; Azides; Benzodiazepines; Benzodiazepinones; Carbolines; Convulsants; Dose- | 1988 |
Does RO 15-4513 reverse the anxiolytic effects of ethanol by its intrinsic properties?
Topics: Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Choice Behavior; Convulsants; Ethanol; Male; | 1988 |
Interactions of the imidazodiazepine Ro 15-4513 with chemical convulsants.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Bicuculline; Carbolines; Convulsants; Drug Inte | 1988 |
Seizures in drug-treated animals.
Topics: Animals; Azides; Benzodiazepines; Male; Rats; Rats, Inbred Strains; Saimiri; Seizures | 1987 |