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ro 15-4513 and Hepatic Encephalopathy

ro 15-4513 has been researched along with Hepatic Encephalopathy in 8 studies

Ro 15-4513: a partial inverse agonist of benzodiazepine receptors

Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)

Research Excerpts

ExcerptRelevanceReference
" The effects of Ro 14-7437, of the partial inverse agonist Ro 15-4513, and the inverse agonist DMCM in rats with hepatic encephalopathy grade II/III were tested."7.68Hepatic encephalopathy in rats with thioacetamide-induced acute liver failure is not mediated by endogenous benzodiazepines. ( Ferenci, P; Herneth, A; Püspök, A; Steindl, P, 1993)
" The effects of Ro 14-7437, of the partial inverse agonist Ro 15-4513, and the inverse agonist DMCM in rats with hepatic encephalopathy grade II/III were tested."3.68Hepatic encephalopathy in rats with thioacetamide-induced acute liver failure is not mediated by endogenous benzodiazepines. ( Ferenci, P; Herneth, A; Püspök, A; Steindl, P, 1993)
"Two benzodiazepine-receptor partial inverse agonists (Ro 15-4513, Ro 15-3505) and one benzodiazepine-receptor antagonist (flumazenil) were administered to rats with hepatic encephalopathy due to acute liver ischemia."3.68The effects of benzodiazepine-receptor antagonists and partial inverse agonists on acute hepatic encephalopathy in the rat. ( Bosman, DK; Chamuleau, RA; de Haan, JG; Maas, MA; van den Buijs, CA, 1991)
"Hepatic encephalopathy is ameliorated by drugs acting on the central GABAA-benzodiazepine receptor complex."1.28Beneficial effect of pharmacological modulation of the GABAA-benzodiazepine receptor on hepatic encephalopathy in the rat: comparison with uremic encephalopathy. ( Druml, W; Ferenci, P; Püspök, A; Steindl, P, 1991)
"The evolution of hepatic encephalopathy in this model was sufficiently slow to readily permit the staging of the syndrome."1.28Reversal of the behavioral and electrophysiological abnormalities of an animal model of hepatic encephalopathy by benzodiazepine receptor ligands. ( Basile, AS; Gammal, SH; Geller, D; Jones, EA; Skolnick, P, 1990)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (87.50)18.2507
2000's1 (12.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ahboucha, S1
Coyne, L1
Hirakawa, R1
Butterworth, RF1
Halliwell, RF1
Jones, EA3
Basile, AS3
Yurdaydin, C2
Skolnich, P1
Püspök, A2
Herneth, A1
Steindl, P2
Ferenci, P2
Gu, ZQ1
Nowak, G1
Fromm, C1
Holt, AG1
Bosman, DK1
van den Buijs, CA1
de Haan, JG1
Maas, MA1
Chamuleau, RA1
Druml, W1
Gammal, SH1
Geller, D1
Skolnick, P1

Reviews

1 review available for ro 15-4513 and Hepatic Encephalopathy

ArticleYear
Do benzodiazepine ligands contribute to hepatic encephalopathy?
    Advances in experimental medicine and biology, 1993, Volume: 341

    Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Disease Models, Animal; Flumazenil; GABA-A Rece

1993

Other Studies

7 other studies available for ro 15-4513 and Hepatic Encephalopathy

ArticleYear
An interaction between benzodiazepines and neuroactive steroids at GABA A receptors in cultured hippocampal neurons.
    Neurochemistry international, 2006, Volume: 48, Issue:8

    Topics: Affinity Labels; Allosteric Regulation; Animals; Azides; Benzodiazepines; Cells, Cultured; Chloride

2006
Hepatic encephalopathy in rats with thioacetamide-induced acute liver failure is not mediated by endogenous benzodiazepines.
    Gastroenterology, 1993, Volume: 105, Issue:3

    Topics: Animals; Azides; Benzodiazepines; Carbolines; Convulsants; Flunitrazepam; Hepatic Encephalopathy; Li

1993
Benzodiazepine receptor ligands are elevated in an animal model of hepatic encephalopathy: relationship between brain concentration and severity of encephalopathy.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:2

    Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Brain; Disease Models, Animal; GABA-A Receptor

1993
The effects of benzodiazepine-receptor antagonists and partial inverse agonists on acute hepatic encephalopathy in the rat.
    Gastroenterology, 1991, Volume: 101, Issue:3

    Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Electroencephalography; Evoked Potentials, Visu

1991
Benzodiazepine receptor ligands and hepatic encephalopathy: further unfolding of the GABA story.
    Hepatology (Baltimore, Md.), 1991, Volume: 14, Issue:6

    Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Brain; Central Nervous System; Flumazenil; gamm

1991
Beneficial effect of pharmacological modulation of the GABAA-benzodiazepine receptor on hepatic encephalopathy in the rat: comparison with uremic encephalopathy.
    Hepatology (Baltimore, Md.), 1991, Volume: 14, Issue:6

    Topics: Animals; Azides; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Coma; Flumazenil; Hepatic Enc

1991
Reversal of the behavioral and electrophysiological abnormalities of an animal model of hepatic encephalopathy by benzodiazepine receptor ligands.
    Hepatology (Baltimore, Md.), 1990, Volume: 11, Issue:3

    Topics: Animals; Azides; Benzodiazepines; Disease Models, Animal; Electrophysiology; Evoked Potentials, Visu

1990