ro 15-4513 has been researched along with Hepatic Encephalopathy in 8 studies
Ro 15-4513: a partial inverse agonist of benzodiazepine receptors
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effects of Ro 14-7437, of the partial inverse agonist Ro 15-4513, and the inverse agonist DMCM in rats with hepatic encephalopathy grade II/III were tested." | 7.68 | Hepatic encephalopathy in rats with thioacetamide-induced acute liver failure is not mediated by endogenous benzodiazepines. ( Ferenci, P; Herneth, A; Püspök, A; Steindl, P, 1993) |
| " The effects of Ro 14-7437, of the partial inverse agonist Ro 15-4513, and the inverse agonist DMCM in rats with hepatic encephalopathy grade II/III were tested." | 3.68 | Hepatic encephalopathy in rats with thioacetamide-induced acute liver failure is not mediated by endogenous benzodiazepines. ( Ferenci, P; Herneth, A; Püspök, A; Steindl, P, 1993) |
| "Two benzodiazepine-receptor partial inverse agonists (Ro 15-4513, Ro 15-3505) and one benzodiazepine-receptor antagonist (flumazenil) were administered to rats with hepatic encephalopathy due to acute liver ischemia." | 3.68 | The effects of benzodiazepine-receptor antagonists and partial inverse agonists on acute hepatic encephalopathy in the rat. ( Bosman, DK; Chamuleau, RA; de Haan, JG; Maas, MA; van den Buijs, CA, 1991) |
| "Hepatic encephalopathy is ameliorated by drugs acting on the central GABAA-benzodiazepine receptor complex." | 1.28 | Beneficial effect of pharmacological modulation of the GABAA-benzodiazepine receptor on hepatic encephalopathy in the rat: comparison with uremic encephalopathy. ( Druml, W; Ferenci, P; Püspök, A; Steindl, P, 1991) |
| "The evolution of hepatic encephalopathy in this model was sufficiently slow to readily permit the staging of the syndrome." | 1.28 | Reversal of the behavioral and electrophysiological abnormalities of an animal model of hepatic encephalopathy by benzodiazepine receptor ligands. ( Basile, AS; Gammal, SH; Geller, D; Jones, EA; Skolnick, P, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (87.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahboucha, S | 1 |
| Coyne, L | 1 |
| Hirakawa, R | 1 |
| Butterworth, RF | 1 |
| Halliwell, RF | 1 |
| Jones, EA | 3 |
| Basile, AS | 3 |
| Yurdaydin, C | 2 |
| Skolnich, P | 1 |
| Püspök, A | 2 |
| Herneth, A | 1 |
| Steindl, P | 2 |
| Ferenci, P | 2 |
| Gu, ZQ | 1 |
| Nowak, G | 1 |
| Fromm, C | 1 |
| Holt, AG | 1 |
| Bosman, DK | 1 |
| van den Buijs, CA | 1 |
| de Haan, JG | 1 |
| Maas, MA | 1 |
| Chamuleau, RA | 1 |
| Druml, W | 1 |
| Gammal, SH | 1 |
| Geller, D | 1 |
| Skolnick, P | 1 |
1 review available for ro 15-4513 and Hepatic Encephalopathy
| Article | Year |
|---|---|
Do benzodiazepine ligands contribute to hepatic encephalopathy?
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Disease Models, Animal; Flumazenil; GABA-A Rece | 1993 |
7 other studies available for ro 15-4513 and Hepatic Encephalopathy
| Article | Year |
|---|---|
An interaction between benzodiazepines and neuroactive steroids at GABA A receptors in cultured hippocampal neurons.
Topics: Affinity Labels; Allosteric Regulation; Animals; Azides; Benzodiazepines; Cells, Cultured; Chloride | 2006 |
Hepatic encephalopathy in rats with thioacetamide-induced acute liver failure is not mediated by endogenous benzodiazepines.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Convulsants; Flunitrazepam; Hepatic Encephalopathy; Li | 1993 |
Benzodiazepine receptor ligands are elevated in an animal model of hepatic encephalopathy: relationship between brain concentration and severity of encephalopathy.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Brain; Disease Models, Animal; GABA-A Receptor | 1993 |
The effects of benzodiazepine-receptor antagonists and partial inverse agonists on acute hepatic encephalopathy in the rat.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Electroencephalography; Evoked Potentials, Visu | 1991 |
Benzodiazepine receptor ligands and hepatic encephalopathy: further unfolding of the GABA story.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Brain; Central Nervous System; Flumazenil; gamm | 1991 |
Beneficial effect of pharmacological modulation of the GABAA-benzodiazepine receptor on hepatic encephalopathy in the rat: comparison with uremic encephalopathy.
Topics: Animals; Azides; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Coma; Flumazenil; Hepatic Enc | 1991 |
Reversal of the behavioral and electrophysiological abnormalities of an animal model of hepatic encephalopathy by benzodiazepine receptor ligands.
Topics: Animals; Azides; Benzodiazepines; Disease Models, Animal; Electrophysiology; Evoked Potentials, Visu | 1990 |