ro 15-4513 has been researched along with Disease Models, Animal in 13 studies
Ro 15-4513: a partial inverse agonist of benzodiazepine receptors
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prenatal exposure to valproic acid (VPA) enhances the risk for later development of autism spectrum disorders (ASD)." | 3.85 | Increased GABAA receptor binding in amygdala after prenatal administration of valproic acid to rats. ( Bertelsen, F; Drasbek, KR; Folloni, D; Landau, AM; Møller, A; Scheel-Krüger, J, 2017) |
| "The neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one (allopregnanolone) was administered systemically to rats which were tested in the Geller-Seifter conflict paradigm, an established animal model of anxiety." | 3.69 | The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABA(A) receptors. ( Akwa, Y; Britton, KT; Brot, MD; Koob, GF; Purdy, RH, 1997) |
| "The evolution of hepatic encephalopathy in this model was sufficiently slow to readily permit the staging of the syndrome." | 1.28 | Reversal of the behavioral and electrophysiological abnormalities of an animal model of hepatic encephalopathy by benzodiazepine receptor ligands. ( Basile, AS; Gammal, SH; Geller, D; Jones, EA; Skolnick, P, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (46.15) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Horder, J | 1 |
| Andersson, M | 1 |
| Mendez, MA | 1 |
| Singh, N | 1 |
| Tangen, Ä | 1 |
| Lundberg, J | 1 |
| Gee, A | 1 |
| Halldin, C | 1 |
| Veronese, M | 1 |
| Bölte, S | 1 |
| Farde, L | 1 |
| Sementa, T | 1 |
| Cash, D | 1 |
| Higgins, K | 1 |
| Spain, D | 1 |
| Turkheimer, F | 1 |
| Mick, I | 1 |
| Selvaraj, S | 1 |
| Nutt, DJ | 1 |
| Lingford-Hughes, A | 1 |
| Howes, OD | 1 |
| Murphy, DG | 1 |
| Borg, J | 1 |
| Bertelsen, F | 1 |
| Møller, A | 1 |
| Folloni, D | 1 |
| Drasbek, KR | 1 |
| Scheel-Krüger, J | 1 |
| Landau, AM | 1 |
| Melón, LC | 1 |
| Boehm, SL | 1 |
| Contó, MB | 1 |
| Hipólide, DC | 1 |
| de Carvalho, JG | 1 |
| Venditti, MA | 1 |
| Kuzmin, A | 1 |
| Liljequist, S | 1 |
| Meis, J | 1 |
| Chefer, V | 1 |
| Shippenberg, T | 1 |
| Bakalkin, G | 1 |
| Jones, EA | 2 |
| Basile, AS | 3 |
| Yurdaydin, C | 2 |
| Skolnich, P | 1 |
| Gu, ZQ | 1 |
| Nowak, G | 1 |
| Fromm, C | 1 |
| Holt, AG | 1 |
| Wu, WJ | 2 |
| Pruett, SB | 2 |
| Brot, MD | 1 |
| Akwa, Y | 1 |
| Purdy, RH | 1 |
| Koob, GF | 1 |
| Britton, KT | 1 |
| Collier, SD | 1 |
| Zhao, L | 1 |
| Yamashima, T | 1 |
| Wang, XD | 1 |
| Tonchev, AB | 1 |
| Yamashita, J | 1 |
| Kakiuchi, T | 1 |
| Nishiyama, S | 1 |
| Kuhara, S | 1 |
| Takahashi, K | 1 |
| Tsukada, H | 1 |
| Gammal, SH | 1 |
| Geller, D | 1 |
| Skolnick, P | 1 |
1 review available for ro 15-4513 and Disease Models, Animal
| Article | Year |
|---|---|
Do benzodiazepine ligands contribute to hepatic encephalopathy?
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Disease Models, Animal; Flumazenil; GABA-A Rece | 1993 |
12 other studies available for ro 15-4513 and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
GABA
Topics: Adult; Animals; Autism Spectrum Disorder; Azides; Behavior; Benzodiazepines; Carbon Radioisotopes; C | 2018 |
Increased GABAA receptor binding in amygdala after prenatal administration of valproic acid to rats.
Topics: Amygdala; Animals; Autism Spectrum Disorder; Autoradiography; Azides; Benzodiazepines; Carbon Radioi | 2017 |
GABAA receptors in the posterior, but not anterior, ventral tegmental area mediate Ro15-4513-induced attenuation of binge-like ethanol consumption in C57BL/6J female mice.
Topics: Alcohol Drinking; Analysis of Variance; Animals; Azides; Benzodiazepines; Disease Models, Animal; Dr | 2011 |
Rats with different thresholds for DMCM-induced clonic convulsions differ in the sleep-time of diazepam and [(3)H]-Ro 15-4513 binding.
Topics: Animals; Anticonvulsants; Autoradiography; Azides; Benzodiazepines; Carbolines; Convulsants; Diazepa | 2012 |
Repeated moderate-dose ethanol bouts impair cognitive function in Wistar rats.
Topics: Alcohol Drinking; Analysis of Variance; Animals; Azides; Benzodiazepines; Central Nervous System Dep | 2012 |
Benzodiazepine receptor ligands are elevated in an animal model of hepatic encephalopathy: relationship between brain concentration and severity of encephalopathy.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Brain; Disease Models, Animal; GABA-A Receptor | 1993 |
Suppression of splenic natural killer cell activity in a mouse model for binge drinking. II. Role of the neuroendocrine system.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alcoholism; Animals; Azides; Benzodiazepi | 1996 |
The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABA(A) receptors.
Topics: Affinity Labels; Animals; Anti-Anxiety Agents; Anxiety; Azides; Behavior, Animal; Benzodiazepines; B | 1997 |
Ethanol-induced activation of the hypothalamic-pituitary-adrenal axis in a mouse model for binge drinking: role of Ro15-4513-sensitive gamma aminobutyric acid receptors, tolerance, and relevance to humans.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Corticosterone; Disease Models, Animal; Dose-Resp | 1998 |
PET imaging of ischemic neuronal death in the hippocampus of living monkeys.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Brain Ischemia; Carbon Radioisotopes; Cell Death; | 2002 |
Reversal of the behavioral and electrophysiological abnormalities of an animal model of hepatic encephalopathy by benzodiazepine receptor ligands.
Topics: Animals; Azides; Benzodiazepines; Disease Models, Animal; Electrophysiology; Evoked Potentials, Visu | 1990 |