ro 15-4513 has been researched along with Anxiety in 12 studies
Ro 15-4513: a partial inverse agonist of benzodiazepine receptors
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of low (2 g/kg) and high (4 g/kg) doses of ethanol and their interaction with the imidazobenzodiazepine Ro 15-4513 (a partial inverse agonist of the benzodiazepine receptor) were studied in two different models of anxiety in rats: the "elevated plus-maze" test and the early acquisition of two-way (shuttlebox) avoidance." | 7.69 | Differential interactions between ethanol and Ro 15-4513 on two anxiety tests in rats. ( Escorihuela, RM; Fernández-Teruel, A; Núñez, JF; Prunell, M; Tobeña, A, 1994) |
| " CIE is validated as a model for human alcohol withdrawal syndrome (AWS) by demonstrating increased level of anxiety; diazepam improved performance in the test." | 3.72 | Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABAA receptors. ( Cagetti, E; Liang, J; Olsen, RW; Spigelman, I, 2003) |
| "The effects of low (2 g/kg) and high (4 g/kg) doses of ethanol and their interaction with the imidazobenzodiazepine Ro 15-4513 (a partial inverse agonist of the benzodiazepine receptor) were studied in two different models of anxiety in rats: the "elevated plus-maze" test and the early acquisition of two-way (shuttlebox) avoidance." | 3.69 | Differential interactions between ethanol and Ro 15-4513 on two anxiety tests in rats. ( Escorihuela, RM; Fernández-Teruel, A; Núñez, JF; Prunell, M; Tobeña, A, 1994) |
| "The neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one (allopregnanolone) was administered systemically to rats which were tested in the Geller-Seifter conflict paradigm, an established animal model of anxiety." | 3.69 | The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABA(A) receptors. ( Akwa, Y; Britton, KT; Brot, MD; Koob, GF; Purdy, RH, 1997) |
| "The effects of RO 15-4513, RO 15-3505 and FG 7142 on the anxiolytic properties of ethanol in mice were investigated using the plus-maze test of anxiety." | 3.67 | Interactions of three benzodiazepine receptor inverse agonists with ethanol in a plus-maze test of anxiety. ( Lister, RG, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 7 (58.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jacobsen, EJ | 1 |
| TenBrink, RE | 1 |
| Stelzer, LS | 1 |
| Belonga, KL | 1 |
| Carter, DB | 1 |
| Im, HK | 1 |
| Im, WB | 1 |
| Sethy, VH | 1 |
| Tang, AH | 1 |
| VonVoigtlander, PF | 1 |
| Petke, JD | 1 |
| Cagetti, E | 1 |
| Liang, J | 1 |
| Spigelman, I | 1 |
| Olsen, RW | 1 |
| Sinkkonen, ST | 1 |
| Lüscher, B | 1 |
| Lüddens, H | 1 |
| Korpi, ER | 1 |
| Weerts, EM | 1 |
| Tornatzky, W | 1 |
| Miczek, KA | 1 |
| Prunell, M | 1 |
| Escorihuela, RM | 2 |
| Fernández-Teruel, A | 2 |
| Núñez, JF | 2 |
| Tobeña, A | 2 |
| Pokk, P | 2 |
| Liljequist, S | 1 |
| Zharkovsky, A | 2 |
| Brot, MD | 1 |
| Akwa, Y | 1 |
| Purdy, RH | 1 |
| Koob, GF | 1 |
| Britton, KT | 1 |
| Zapata, A | 1 |
| Boix, F | 1 |
| Salazar, W | 1 |
| Suzdak, PD | 1 |
| Glowa, JR | 1 |
| Crawley, JN | 1 |
| Schwartz, RD | 1 |
| Skolnick, P | 1 |
| Paul, SM | 1 |
| Lister, RG | 1 |
| Harris, CM | 1 |
| Benjamin, D | 1 |
| Lal, H | 1 |
12 other studies available for ro 15-4513 and Anxiety
| Article | Year |
|---|---|
High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the gamma-aminobutyric acid A/benzodiazepine receptor complex.
Topics: Animals; Anxiety; Benzodiazepines; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyc | 1996 |
Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABAA receptors.
Topics: Affinity Labels; Alcoholism; Allosteric Regulation; Anesthetics; Animals; Anxiety; Azides; Benzodiaz | 2003 |
Autoradiographic imaging of altered synaptic alphabetagamma2 and extrasynaptic alphabeta GABAA receptors in a genetic mouse model of anxiety.
Topics: Animals; Anxiety; Autoradiography; Azides; Benzodiazepines; Female; GABA Agonists; Male; Mice; Mice, | 2004 |
"Anxiolytic" and "anxiogenic" benzodiazepines and beta-carbolines: effects on aggressive and social behavior in rats and squirrel monkeys.
Topics: Aggression; Animals; Anti-Anxiety Agents; Anxiety; Azides; Benzodiazepines; Carbolines; Dose-Respons | 1993 |
Differential interactions between ethanol and Ro 15-4513 on two anxiety tests in rats.
Topics: Animals; Anxiety; Avoidance Learning; Azides; Benzodiazepines; Ethanol; Male; Rats; Rats, Sprague-Da | 1994 |
Ro 15-4513 potentiates, instead of antagonizes, ethanol-induced sleep in mice exposed to small platform stress.
Topics: Animals; Anxiety; Azides; Benzodiazepines; Central Nervous System Depressants; Cerebellum; Chlorides | 1996 |
The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABA(A) receptors.
Topics: Affinity Labels; Animals; Anti-Anxiety Agents; Anxiety; Azides; Behavior, Animal; Benzodiazepines; B | 1997 |
The effects of flumazenil, Ro 15-4513 and beta-CCM on the behaviour of control and stressed mice in the plus-maze test.
Topics: Animals; Anxiety; Azides; Behavior, Animal; Benzodiazepines; Carbolines; Dose-Response Relationship, | 1997 |
The early acquisition of two-way (shuttle-box) avoidance as an anxiety-mediated behavior: psychopharmacological validation.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Azides; Benzodiazepines; Carbolines; Male | 1991 |
A selective imidazobenzodiazepine antagonist of ethanol in the rat.
Topics: Animals; Anxiety; Azides; Benzodiazepines; Chlorides; Ethanol; Flumazenil; Male; Pyrazoles; Rats; Ra | 1986 |
Interactions of three benzodiazepine receptor inverse agonists with ethanol in a plus-maze test of anxiety.
Topics: Animals; Anxiety; Azides; Benzodiazepines; Carbolines; Dose-Response Relationship, Drug; Ethanol; Ex | 1988 |
Anxiety-like subjective effect of ethanol antagonist RO 15-4513 demonstrated in pentylenetetrazol discrimination.
Topics: Animals; Anxiety; Azides; Benzodiazepines; Diazepam; Discrimination, Psychological; Male; Pentylenet | 1987 |