ro 15-4513 has been researched along with Alcoholism in 18 studies
Ro 15-4513: a partial inverse agonist of benzodiazepine receptors
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| " CIE is validated as a model for human alcohol withdrawal syndrome (AWS) by demonstrating increased level of anxiety; diazepam improved performance in the test." | 3.72 | Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABAA receptors. ( Cagetti, E; Liang, J; Olsen, RW; Spigelman, I, 2003) |
| "Like acetaldehyde, alcohol has been widely considered a nonspecific drug, despite rather persuasive evidence implicating inhibitory GABA(A) receptors (GABA(A)Rs) in acute alcohol actions, for example, a GABA(A)R ligand, the imidazobenzodiazepine Ro15-4513 antagonizes many low-to-moderate dose alcohol actions in mammals." | 2.44 | Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development? ( Olsen, RW; Wallner, M, 2008) |
| "Intermittent chronic administration of ethanol to rats has been shown previously to produce a hyperexcitable, kindling-like state, accompanied by reduced inhibitory synaptic transmission in the hippocampus and changes in gamma-aminobutyric acid type A (GABAA) receptors." | 1.31 | Altered gabaa receptor subunit and splice variant expression in rats treated with chronic intermittent ethanol. ( Fanselow, M; Olsen, RW; Park, MK; Petrie, J; Sapp, DW; Tyndale, RF, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (16.67) | 18.7374 |
| 1990's | 8 (44.44) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 3 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lingford-Hughes, A | 2 |
| Myers, J | 2 |
| Watson, B | 1 |
| Reid, AG | 2 |
| Kalk, N | 1 |
| Feeney, A | 2 |
| Hammers, A | 2 |
| Riaño-Barros, DA | 1 |
| McGinnity, CJ | 1 |
| Taylor, LG | 2 |
| Rosso, L | 2 |
| Brooks, DJ | 2 |
| Turkheimer, F | 2 |
| Nutt, DJ | 2 |
| Grasby, P | 1 |
| Kontturi, LS | 1 |
| Aalto, AJ | 1 |
| Wallner, M | 2 |
| Uusi-Oukari, M | 3 |
| Cagetti, E | 2 |
| Liang, J | 2 |
| Spigelman, I | 2 |
| Olsen, RW | 4 |
| Mhatre, MC | 2 |
| Ticku, MK | 5 |
| Wu, WJ | 1 |
| Pruett, SB | 1 |
| Morrow, AL | 1 |
| Devaud, LL | 1 |
| Bucci, D | 1 |
| Smith, FD | 1 |
| Mehta, AK | 1 |
| Mäkelä, R | 1 |
| Oja, SS | 1 |
| Alho, H | 1 |
| Anghelescu, I | 1 |
| Klawe, C | 1 |
| Lüddens, H | 1 |
| Korpi, ER | 2 |
| Petrie, J | 1 |
| Sapp, DW | 1 |
| Tyndale, RF | 1 |
| Park, MK | 1 |
| Fanselow, M | 1 |
| Wegelius, K | 1 |
| Casanova, M | 1 |
| Zito, M | 1 |
| Kleinman, JE | 1 |
| Mhatre, M | 1 |
| McBride, WJ | 1 |
| Murphy, JM | 1 |
| Lumeng, L | 1 |
| Li, TK | 1 |
| Gallant, DM | 1 |
3 reviews available for ro 15-4513 and Alcoholism
| Article | Year |
|---|---|
Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development?
Topics: Acetaldehyde; Alcoholism; Animals; Azides; Behavior, Addictive; Benzodiazepines; Binding, Competitiv | 2008 |
Alcohol: effects on GABAA receptor function and gene expression.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Cerebellum; Cerebral Cortex; Ethanol; Gene Expression; | 1993 |
Alcohol and GABA-benzodiazepine receptor function.
Topics: Alcoholism; Animals; Azides; Behavior; Benzodiazepines; Chlorides; Ethanol; Humans; Ion Channels; Re | 1990 |
15 other studies available for ro 15-4513 and Alcoholism
| Article | Year |
|---|---|
Using [(11)C]Ro15 4513 PET to characterise GABA-benzodiazepine receptors in opiate addiction: Similarities and differences with alcoholism.
Topics: Adult; Affinity Labels; Alcoholism; Azides; Benzodiazepines; Brain; Carbon Radioisotopes; Hippocampu | 2016 |
A [11C]Ro15 4513 PET study suggests that alcohol dependence in man is associated with reduced α5 benzodiazepine receptors in limbic regions.
Topics: Adult; Alcoholism; Azides; Benzodiazepines; Carbon Radioisotopes; Case-Control Studies; Ethanol; Hum | 2012 |
The cerebellar GABAAR α6-R100Q polymorphism alters ligand binding in outbred Sprague-Dawley rats in a similar manner as in selectively bred AT and ANT rats.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Binding Sites; Cerebellum; Drug Tolerance; Ethanol; Ge | 2011 |
Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABAA receptors.
Topics: Affinity Labels; Alcoholism; Allosteric Regulation; Anesthetics; Animals; Anxiety; Azides; Benzodiaz | 2003 |
Altered pharmacology of synaptic and extrasynaptic GABAA receptors on CA1 hippocampal neurons is consistent with subunit changes in a model of alcohol withdrawal and dependence.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Diazepam; Drug Interactions; Ethanol; GABA Agonists; H | 2004 |
Suppression of splenic natural killer cell activity in a mouse model for binge drinking. II. Role of the neuroendocrine system.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alcoholism; Animals; Azides; Benzodiazepi | 1996 |
GABAA and NMDA receptor subunit mRNA expression in ethanol dependent rats.
Topics: Alcoholism; Animals; Azides; Base Sequence; Benzodiazepines; Cerebellum; Cerebral Cortex; Dizocilpin | 1994 |
Prevalence of the GABAA receptor assemblies containing alpha1-subunit in the rat cerebellum and cerebral cortex as determined by immunoprecipitation: lack of modulation by chronic ethanol administration.
Topics: Affinity Labels; Alcoholism; Animals; Azides; Benzodiazepines; Brain Chemistry; Central Nervous Syst | 1999 |
Furosemide action on cerebellar GABA(A) receptors in alcohol-sensitive ANT rats.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Bicuculline; Bridged Bicyclo Compounds, Heterocyclic; | 1999 |
Altered gabaa receptor subunit and splice variant expression in rats treated with chronic intermittent ethanol.
Topics: Alcoholism; Alternative Splicing; Animals; Azides; Benzodiazepines; Cerebellum; Cerebral Cortex; Eth | 2001 |
Cerebellar and frontal cortical benzodiazepine receptors in human alcoholics and chronically alcohol-drinking rats.
Topics: Adult; Alcohol Drinking; Alcoholism; Animals; Azides; Benzodiazepines; Brain; Cerebellum; Diazepam; | 1992 |
Chronic ethanol administration alters gamma-aminobutyric acidA receptor gene expression.
Topics: Affinity Labels; Alcoholism; Animals; Azides; Base Sequence; Benzodiazepines; Binding Sites; Cerebel | 1992 |
Chronic ethanol treatment selectively increases the binding of inverse agonists for benzodiazepine binding sites in cultured spinal cord neurons.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Cells, Cultured; Female; Flumazenil; Flunitrazepam; Ma | 1989 |
Effects of Ro 15-4513, fluoxetine and desipramine on the intake of ethanol, water and food by the alcohol-preferring (P) and -nonpreferring (NP) lines of rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Azides; Benzodiazepines; Desipramine; Drinking Behavior; Feed | 1988 |
A specific antagonist of ethanol: clinical implications.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Ethanol; Rats | 1987 |