rizatriptan and Nausea studies

Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.

Research Excerpts

Excerpt	Relevance	Reference
"To confirm the efficacy of rizatriptan 10 mg orally disintegrating tablet (ODT) for the elimination of migraine-associated nausea."	9.13	Elimination of migraine-associated nausea in patients treated with rizatriptan orally disintegrating tablet (ODT): a randomized, double-blind, placebo-controlled study. ( Freitag, F; Hamid, MA; Hustad, CM; Ramsey, KE; Rodgers, A; Skobieranda, F; Taylor, FR, 2008)
"To compare the effects of oral rizatriptan, sumatriptan, naratriptan, and zolmitriptan on the relief and emergence of nausea during a migraine attack."	7.71	Effect of rizatriptan and other triptans on the nausea symptom of migraine: a post hoc analysis. ( Goadsby, PJ; Jiang, K; Lines, CR; Lipton, RB; Massiou, H; McCarroll, KA; Pascual, J; Vandormael, K, 2001)
"To confirm the efficacy of rizatriptan 10 mg orally disintegrating tablet (ODT) for the elimination of migraine-associated nausea."	5.13	Elimination of migraine-associated nausea in patients treated with rizatriptan orally disintegrating tablet (ODT): a randomized, double-blind, placebo-controlled study. ( Freitag, F; Hamid, MA; Hustad, CM; Ramsey, KE; Rodgers, A; Skobieranda, F; Taylor, FR, 2008)
"To compare the effects of oral rizatriptan, sumatriptan, naratriptan, and zolmitriptan on the relief and emergence of nausea during a migraine attack."	3.71	Effect of rizatriptan and other triptans on the nausea symptom of migraine: a post hoc analysis. ( Goadsby, PJ; Jiang, K; Lines, CR; Lipton, RB; Massiou, H; McCarroll, KA; Pascual, J; Vandormael, K, 2001)
"Trimebutine is an opioid derivative with exclusive action on receptors of the Meissner and Auerbach plexus throughout the digestive tube."	2.72	Rizatriptan vs. rizatriptan plus trimebutine for the acute treatment of migraine: a double-blind, randomized, cross-over, placebo-controlled study. ( Bigal, ME; Filho, PF; Krymchantowski, AV, 2006)
"Rizatriptan is an effective and fast acting drug for the acute treatment of migraine."	2.70	Rizatriptan combined with rofecoxib vs. rizatriptan for the acute treatment of migraine: an open label pilot study. ( Barbosa, JS; Krymchantowski, AV, 2002)

Research

Studies (6)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Participants With Elimination of Nausea at 2 Hours Postdose

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Igarashi, H	1
Krymchantowski, AV	2
Filho, PF	1
Bigal, ME	1
Freitag, F	1
Taylor, FR	1
Hamid, MA	1
Rodgers, A	1
Hustad, CM	1
Ramsey, KE	1
Skobieranda, F	1
Davies, GM	1
Santanello, N	1
Lipton, R	1
Lipton, RB	1
Pascual, J	1
Goadsby, PJ	1
Massiou, H	1
McCarroll, KA	1
Vandormael, K	1
Jiang, K	1
Lines, CR	1
Barbosa, JS	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Elimination of Migraine-Associated Nausea in Migraine Patients Treated With Rizatriptan Orally Disintegrating Tablet (ODT)[NCT00250458]	Phase 3	346 participants (Actual)	Interventional	2006-03-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Participants reporting the absence of nausea at 2 hours post treatment. Absence or presence of nausea was recorded by the participants in an electronic diary. Absence is defined as no nausea at 2 hours post-treatment. (NCT00250458)
Timeframe: At 2 hours after treatment

Participants With Pain Relief at 2 Hours Postdose

Intervention	Participants (Number)
	No Nausea at 2 Hours	Nausea at 2 Hours
Placebo	57	35
Rizatriptan 10 mg	130	55

Participants reporting pain relief defined as a reduction of pain severity from grades 2 or 3 (moderate or severe pain) at baseline to grades 0 or 1 (no headache or mild pain) at 2 hours after treatment. (NCT00250458)
Timeframe: 2 hours after treatment

Article	Year
Rizatriptan vs. rizatriptan plus trimebutine for the acute treatment of migraine: a double-blind, randomized, cross-over, placebo-controlled study. Cephalalgia : an international journal of headache, 2006, Volume: 26, Issue:7 Topics: Acute Disease; Adolescent; Adult; Aged; Drug Combinations; Female; Gastrointestinal Agents; Gastropa	2006
Elimination of migraine-associated nausea in patients treated with rizatriptan orally disintegrating tablet (ODT): a randomized, double-blind, placebo-controlled study. Headache, 2008, Volume: 48, Issue:3 Topics: Administration, Oral; Adult; Double-Blind Method; Female; Humans; Male; Migraine Disorders; Nausea;	2008
Rizatriptan combined with rofecoxib vs. rizatriptan for the acute treatment of migraine: an open label pilot study. Cephalalgia : an international journal of headache, 2002, Volume: 22, Issue:4 Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Drug Therapy,	2002

Article	Year
Determinants of patient satisfaction with migraine therapy. Cephalalgia : an international journal of headache, 2000, Volume: 20, Issue:6 Topics: Adult; Analgesics; Female; Humans; Male; Middle Aged; Migraine Disorders; Nausea; Patient Satisfacti	2000
Effect of rizatriptan and other triptans on the nausea symptom of migraine: a post hoc analysis. Headache, 2001, Volume: 41, Issue:8 Topics: Administration, Oral; Adult; Double-Blind Method; Humans; Indoles; Migraine Disorders; Nausea; Oxazo	2001

rizatriptan and Nausea