ritonavir and Hyperthyroidism

ritonavir has been researched along with Hyperthyroidism* in 1 studies

Other Studies

1 other study(ies) available for ritonavir and Hyperthyroidism

Article	Year
Early neuropsychological adverse events after switching from PI/r to dolutegravir could be related to hyperthyroidism in patients under levothyroxine. Antiviral therapy, 2017, Volume: 22, Issue:3 We report two patients who had taken levothyroxine at the same dose for several years and who had stable thyroid stimulating hormone (TSH) levels, and who developed clinical and biological hyperthyroidism following switch from ritonavir-boosted protease inhibitors (PIs) to dolutegravir-based HAART. Levothyroxine is metabolized by deiodination and glucuronidation and the induction of glucuronidation by ritonavir leads to an increased elimination of levothyroxine and a necessity of higher daily doses. Patients who switch from ritonavir-boosted PIs to antiretroviral drugs-based HAART with minimal drug-interaction such as dolutegravir, may require an adjustment in their dose of levothyroxine in order to prevent hyperthyroidism due to impaired elimination of levothyroxine without ritonavir. Topics: Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Interactions; Drug Substitution; Female; Heterocyclic Compounds, 3-Ring; HIV Infections; HIV Protease Inhibitors; Humans; Hyperthyroidism; Male; Neuropsychological Tests; Oxazines; Piperazines; Pyridones; Ritonavir; Thyroxine	2017

Article

Year

Early neuropsychological adverse events after switching from PI/r to dolutegravir could be related to hyperthyroidism in patients under levothyroxine.

Antiviral therapy, 2017, Volume: 22, Issue:3

We report two patients who had taken levothyroxine at the same dose for several years and who had stable thyroid stimulating hormone (TSH) levels, and who developed clinical and biological hyperthyroidism following switch from ritonavir-boosted protease inhibitors (PIs) to dolutegravir-based HAART. Levothyroxine is metabolized by deiodination and glucuronidation and the induction of glucuronidation by ritonavir leads to an increased elimination of levothyroxine and a necessity of higher daily doses. Patients who switch from ritonavir-boosted PIs to antiretroviral drugs-based HAART with minimal drug-interaction such as dolutegravir, may require an adjustment in their dose of levothyroxine in order to prevent hyperthyroidism due to impaired elimination of levothyroxine without ritonavir.

Topics: Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Interactions; Drug Substitution; Female; Heterocyclic Compounds, 3-Ring; HIV Infections; HIV Protease Inhibitors; Humans; Hyperthyroidism; Male; Neuropsychological Tests; Oxazines; Piperazines; Pyridones; Ritonavir; Thyroxine

2017