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ritanserin and Pyrexia

ritanserin has been researched along with Pyrexia in 9 studies

Ritanserin: A selective and potent serotonin-2 antagonist that is effective in the treatment of a variety of syndromes related to anxiety and depression. The drug also improves the subjective quality of sleep and decreases portal pressure.
ritanserin : A thiazolopyrimidine that is 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one which is substituted at position 7 by a methyl group and at position 6 by a 2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl group. A potent and long-acting seratonin (5-hydroxytryptamine, 5-HT) antagonist of the subtype 5-HT2 (Ki = 0.39 nM), it is used in the treatment of a variety of disorders including anxiety, depression and schizophrenia. It has little sedative action.

Research Excerpts

ExcerptRelevanceReference
"As part of our characterization of the developmental consequences of prenatal cocaine exposure, cocaine was injected into eggs containing viable chicken embryos on embryonic day (E) 18 and the fever response to the endotoxin lipopolysaccharide (LPS) and a delayed-type hypersensitivity response to phytohemagglutinin (PHA) were assessed postnatally."3.71Embryonic "binge" cocaine exposure alters neural-immune and neural-endocrine interactions in young chickens: involvement of serotonin(2) receptors. ( Schrott, LM; Sparber, SB, 2001)
" LPS administration induces a syndrome collectively known as sickness behavior, manifest as altered thermoregulatory processes leading to fever, and increased serum concentrations of neuroendocrine hormones, including corticosterone."3.70Late embryonic ritanserin exposure fails to alter normal responses to immune system stimulation in young chicks. ( Bodensteiner, KE; Schrott, LM; Sparber, SB; Sweeney, WA, 1999)
"Pretreatment with propranolol (10 mg/kg), a 5-HT(1A) receptor antagonist as well as a beta-blocker, and dantrolene (20 mg/kg), a peripheral muscle relaxant, did not prevent the death of the animals, even though these two drugs suppressed the increase in rectal temperature to some extent."1.31Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome. ( Katoh, S; Nisijima, K; Yoshino, T; Yui, K, 2001)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (22.22)18.2507
2000's5 (55.56)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wierońska, JM2
Stachowicz, K2
Pałucha-Poniewiera, A2
Acher, F1
Brański, P2
Pilc, A2
Schrott, LM2
Sweeney, WA1
Bodensteiner, KE1
Sparber, SB2
Raghavendra, V1
Kulkarni, SK1
Nisijima, K1
Yoshino, T1
Yui, K1
Katoh, S1
Yamada, J1
Sugimoto, Y1
Ohkura, M1
Inoue, K1
Mechan, AO1
Esteban, B1
O'Shea, E1
Elliott, JM1
Colado, MI1
Green, AR1
Lecci, A1
Borsini, F1
Mancinelli, A1
D'Aranno, V1
Stasi, MA1
Volterra, G1
Meli, A1

Other Studies

9 other studies available for ritanserin and Pyrexia

ArticleYear
Metabotropic glutamate receptor 4 novel agonist LSP1-2111 with anxiolytic, but not antidepressant-like activity, mediated by serotonergic and GABAergic systems.
    Neuropharmacology, 2010, Volume: 59, Issue:7-8

    Topics: Aminobutyrates; Animals; Anti-Anxiety Agents; Antidepressive Agents; Diazepam; Fever; Flumazenil; GA

2010
On the mechanism of anti-hyperthermic effects of LY379268 and LY487379, group II mGlu receptors activators, in the stress-induced hyperthermia in singly housed mice.
    Neuropharmacology, 2012, Volume: 62, Issue:1

    Topics: Amino Acids; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Disease Models,

2012
Late embryonic ritanserin exposure fails to alter normal responses to immune system stimulation in young chicks.
    Pharmacology, biochemistry, and behavior, 1999, Volume: 64, Issue:1

    Topics: Adjuvants, Immunologic; Animals; Antipsychotic Agents; Chick Embryo; Chickens; Corticosterone; Fever

1999
Melatonin reversal of DOI-induced hypophagia in rats; possible mechanism by suppressing 5-HT(2A) receptor-mediated activation of HPA axis.
    Brain research, 2000, Mar-31, Volume: 860, Issue:1-2

    Topics: Adrenal Glands; Amphetamines; Animals; Anorexia; Ascorbic Acid; Exploratory Behavior; Feeding Behavi

2000
Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome.
    Brain research, 2001, Jan-26, Volume: 890, Issue:1

    Topics: 5-Hydroxytryptophan; Animals; Anterior Hypothalamic Nucleus; Antidepressive Agents; Body Temperature

2001
Embryonic "binge" cocaine exposure alters neural-immune and neural-endocrine interactions in young chickens: involvement of serotonin(2) receptors.
    Brain research. Developmental brain research, 2001, Sep-23, Volume: 130, Issue:1

    Topics: Animals; Basophils; Chick Embryo; Chickens; Cocaine; Corticosterone; Dopamine Uptake Inhibitors; Fev

2001
Effects of the 5-HT2 receptor antagonist, ritanserin on hyperthermia and depletion of 5-HT in frontal cortex induced by a 5-HT releasing drug, p-chloroamphetamine (PCA) in mice.
    Biological & pharmaceutical bulletin, 2001, Volume: 24, Issue:10

    Topics: Animals; Body Temperature; Fever; Male; Mice; p-Chloroamphetamine; Prefrontal Cortex; Receptors, Ser

2001
The pharmacology of the acute hyperthermic response that follows administration of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') to rats.
    British journal of pharmacology, 2002, Volume: 135, Issue:1

    Topics: 3,4-Methylenedioxyamphetamine; Acute Disease; Animals; Benzazepines; Body Temperature; Corpus Striat

2002
Effect of serotoninergic drugs on stress-induced hyperthermia (SIH) in mice.
    Journal of neural transmission. General section, 1990, Volume: 82, Issue:3

    Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Body

1990