ritanserin has been researched along with Narcolepsy in 3 studies
Ritanserin: A selective and potent serotonin-2 antagonist that is effective in the treatment of a variety of syndromes related to anxiety and depression. The drug also improves the subjective quality of sleep and decreases portal pressure.
ritanserin : A thiazolopyrimidine that is 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one which is substituted at position 7 by a methyl group and at position 6 by a 2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl group. A potent and long-acting seratonin (5-hydroxytryptamine, 5-HT) antagonist of the subtype 5-HT2 (Ki = 0.39 nM), it is used in the treatment of a variety of disorders including anxiety, depression and schizophrenia. It has little sedative action.
Narcolepsy: A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with automatic behaviors and AMNESIA. CATAPLEXY; SLEEP PARALYSIS, and hypnagogic HALLUCINATIONS frequently accompany narcolepsy. The pathophysiology of this disorder includes sleep-onset rapid eye movement (REM) sleep, which normally follows stage III or IV sleep. (From Neurology 1998 Feb;50(2 Suppl 1):S2-S7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A recent study in narcolepsy patients has shown that ritanserin, a 5HT2-antagonist, reduced wake after sleep onset times and subjective sleepiness during daytime." | 9.10 | Ritanserin improves sleep quality in narcolepsy. ( Mayer, G, 2003) |
| "In a double-blind placebo-controlled trial, ritanserin (a 5-HT2 receptor blocker) 5 mg/day or placebo was added to the usual medication in 28 patients with narcolepsy during 4 wk." | 9.07 | Ritanserin, a 5-HT2 receptor blocker, as add-on treatment in narcolepsy. ( Arends, J; Declerck, AC; Kamphuisen, HA; Lammers, GJ; Schouwink, G; Troost, J, 1991) |
| "A recent study in narcolepsy patients has shown that ritanserin, a 5HT2-antagonist, reduced wake after sleep onset times and subjective sleepiness during daytime." | 5.10 | Ritanserin improves sleep quality in narcolepsy. ( Mayer, G, 2003) |
| "In a double-blind placebo-controlled trial, ritanserin (a 5-HT2 receptor blocker) 5 mg/day or placebo was added to the usual medication in 28 patients with narcolepsy during 4 wk." | 5.07 | Ritanserin, a 5-HT2 receptor blocker, as add-on treatment in narcolepsy. ( Arends, J; Declerck, AC; Kamphuisen, HA; Lammers, GJ; Schouwink, G; Troost, J, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mayer, G | 1 |
| Lammers, GJ | 1 |
| Arends, J | 1 |
| Declerck, AC | 1 |
| Kamphuisen, HA | 1 |
| Schouwink, G | 1 |
| Troost, J | 1 |
| Mitler, MM | 1 |
| Hajdukovic, R | 1 |
3 trials available for ritanserin and Narcolepsy
| Article | Year |
|---|---|
Ritanserin improves sleep quality in narcolepsy.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Hum | 2003 |
Ritanserin, a 5-HT2 receptor blocker, as add-on treatment in narcolepsy.
Topics: Adolescent; Adult; Animals; Circadian Rhythm; Double-Blind Method; Histamine H2 Antagonists; Humans; | 1991 |
Relative efficacy of drugs for the treatment of sleepiness in narcolepsy.
Topics: Adult; Arousal; Benzhydryl Compounds; Central Nervous System Stimulants; Codeine; Dextroamphetamine; | 1991 |