Page last updated: 2024-11-03

ritanserin and Leukoencephalopathy, Progressive Multifocal

ritanserin has been researched along with Leukoencephalopathy, Progressive Multifocal in 3 studies

Ritanserin: A selective and potent serotonin-2 antagonist that is effective in the treatment of a variety of syndromes related to anxiety and depression. The drug also improves the subjective quality of sleep and decreases portal pressure.
ritanserin : A thiazolopyrimidine that is 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one which is substituted at position 7 by a methyl group and at position 6 by a 2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl group. A potent and long-acting seratonin (5-hydroxytryptamine, 5-HT) antagonist of the subtype 5-HT2 (Ki = 0.39 nM), it is used in the treatment of a variety of disorders including anxiety, depression and schizophrenia. It has little sedative action.

Leukoencephalopathy, Progressive Multifocal: An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
O'Hara, BA2
Gee, GV1
Atwood, WJ2
Haley, SA1
Loignon, M1
Toma, E1
Schaumburg, C1
Lane, TE1

Reviews

1 review available for ritanserin and Leukoencephalopathy, Progressive Multifocal

ArticleYear
Treatment options for progressive multifocal leukoencephalopathy in HIV-infected persons: current status and future directions.
    Expert review of anti-infective therapy, 2016, Volume: 14, Issue:2

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Antiviral Agents; Cidofovir; Coinfection; Cy

2016

Other Studies

2 other studies available for ritanserin and Leukoencephalopathy, Progressive Multifocal

ArticleYear
Susceptibility of Primary Human Choroid Plexus Epithelial Cells and Meningeal Cells to Infection by JC Virus.
    Journal of virology, 2018, 04-15, Volume: 92, Issue:8

    Topics: Cell Line; Choroid Plexus; Epithelial Cells; Humans; JC Virus; Leukoencephalopathy, Progressive Mult

2018
Human embryonic stem cell-derived oligodendrocyte progenitor cells express the serotonin receptor and are susceptible to JC virus infection.
    Journal of virology, 2008, Volume: 82, Issue:17

    Topics: Antibodies, Monoclonal; Antigens; Biomarkers; Cell Line; Embryonic Stem Cells; Fetus; Humans; JC Vir

2008