ritanserin has been researched along with Depression in 10 studies
Ritanserin: A selective and potent serotonin-2 antagonist that is effective in the treatment of a variety of syndromes related to anxiety and depression. The drug also improves the subjective quality of sleep and decreases portal pressure.
ritanserin : A thiazolopyrimidine that is 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one which is substituted at position 7 by a methyl group and at position 6 by a 2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl group. A potent and long-acting seratonin (5-hydroxytryptamine, 5-HT) antagonist of the subtype 5-HT2 (Ki = 0.39 nM), it is used in the treatment of a variety of disorders including anxiety, depression and schizophrenia. It has little sedative action.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ritanserin was highly effective in reducing Pain Total Index and analgesic consumption in chronic headache, and its activity was similar to that observed during amitriptyline treatment." | 6.67 | A new 5-HT2 antagonist (ritanserin) in the treatment of chronic headache with depression. A double-blind study vs amitriptyline. ( Blandini, F; Cerutti, G; Facchinetti, F; Granella, F; Manzoni, GC; Nappi, G; Ruiz, L; Sandrini, G, 1990) |
| "The effect of inositol as an antidepressant was previously demonstrated in both animal models of depression-like behavior and in clinical trials." | 3.71 | The antidepressant activity of inositol in the forced swim test involves 5-HT(2) receptors. ( Belmaker, RH; Bourin, M; Clenet, F; Einat, H; Shaldubina, A, 2001) |
| "Methysergide was found to decrease significantly the PRL response to TRH, while ritanserin had no effect." | 2.68 | Effects of methysergide and ritanserin on the prolactin and thyrotropin responses to TRH in depressed patients. ( Markianos, M; Papadimitriou, GN; Papakostas, YG; Stefanis, CN; Zervas, IM, 1995) |
| " Ritanserin discontinuation following chronic dosing in healthy volunteers does not appear to be associated with withdrawal symptoms." | 2.67 | Absence of withdrawal effects of ritanserin following chronic dosing in healthy volunteers. ( Ashton, CH; Emanuel, MB; Hammond, GL; Kamali, F; Rawlins, MD; Stansfield, SC, 1992) |
| "Ritanserin was highly effective in reducing Pain Total Index and analgesic consumption in chronic headache, and its activity was similar to that observed during amitriptyline treatment." | 2.67 | A new 5-HT2 antagonist (ritanserin) in the treatment of chronic headache with depression. A double-blind study vs amitriptyline. ( Blandini, F; Cerutti, G; Facchinetti, F; Granella, F; Manzoni, GC; Nappi, G; Ruiz, L; Sandrini, G, 1990) |
| "Both paroxetine and pargyline were effective in reducing the immobility time of stressed OVX mice in the FST." | 1.38 | Effects of diphenyl diselenide on depressive-like behavior in ovariectomized mice submitted to subchronic stress: involvement of the serotonergic system. ( Bazanella Sampaio, T; Mozzaquatro Gai, B; Nogueira, CW; Pinton, S; Trevisan da Rocha, J; Zeni, G, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (60.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stachowicz, K | 1 |
| Kłodzińska, A | 1 |
| Palucha-Poniewiera, A | 1 |
| Schann, S | 1 |
| Neuville, P | 1 |
| Pilc, A | 1 |
| Yamada, N | 1 |
| Araki, H | 1 |
| Yoshimura, H | 1 |
| Trevisan da Rocha, J | 1 |
| Mozzaquatro Gai, B | 1 |
| Pinton, S | 1 |
| Bazanella Sampaio, T | 1 |
| Nogueira, CW | 1 |
| Zeni, G | 1 |
| Papakostas, YG | 1 |
| Markianos, M | 1 |
| Papadimitriou, GN | 1 |
| Zervas, IM | 1 |
| Stefanis, CN | 1 |
| Bailey, P | 1 |
| Duval, F | 1 |
| Macher, JP | 1 |
| Einat, H | 1 |
| Clenet, F | 1 |
| Shaldubina, A | 1 |
| Belmaker, RH | 1 |
| Bourin, M | 1 |
| Kamali, F | 1 |
| Stansfield, SC | 1 |
| Ashton, CH | 1 |
| Hammond, GL | 1 |
| Emanuel, MB | 1 |
| Rawlins, MD | 1 |
| Anderson, I | 1 |
| Cowen, P | 1 |
| Strauss, WH | 1 |
| Klieser, E | 1 |
| Nappi, G | 1 |
| Sandrini, G | 1 |
| Granella, F | 1 |
| Ruiz, L | 1 |
| Cerutti, G | 1 |
| Facchinetti, F | 1 |
| Blandini, F | 1 |
| Manzoni, GC | 1 |
3 trials available for ritanserin and Depression
| Article | Year |
|---|---|
Effects of methysergide and ritanserin on the prolactin and thyrotropin responses to TRH in depressed patients.
Topics: Aged; Depression; Female; Humans; Methysergide; Middle Aged; Prolactin; Ritanserin; Thyrotropin; Thy | 1995 |
Absence of withdrawal effects of ritanserin following chronic dosing in healthy volunteers.
Topics: Adolescent; Adult; Anxiety; Depression; Double-Blind Method; Female; Humans; Male; Ritanserin; Singl | 1992 |
A new 5-HT2 antagonist (ritanserin) in the treatment of chronic headache with depression. A double-blind study vs amitriptyline.
Topics: Adult; Amitriptyline; Chronic Disease; Depression; Double-Blind Method; Female; Headache; Humans; Ma | 1990 |
7 other studies available for ritanserin and Depression
| Article | Year |
|---|---|
The group III mGlu receptor agonist ACPT-I exerts anxiolytic-like but not antidepressant-like effects, mediated by the serotonergic and GABA-ergic systems.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Cyclopentanes; Depression; Flumazenil; | 2009 |
Identification of antidepressant-like ingredients in ginseng root (Panax ginseng C.A. Meyer) using a menopausal depressive-like state in female mice: participation of 5-HT2A receptors.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Dose-Response Relationship, Drug | 2011 |
Effects of diphenyl diselenide on depressive-like behavior in ovariectomized mice submitted to subchronic stress: involvement of the serotonergic system.
Topics: Animals; Antidepressive Agents; Benzene Derivatives; Cerebral Cortex; Depression; Disease Models, An | 2012 |
Treating negative symptoms.
Topics: Antipsychotic Agents; Depression; Drug Therapy, Combination; Humans; Psychiatric Status Rating Scale | 1994 |
The antidepressant activity of inositol in the forced swim test involves 5-HT(2) receptors.
Topics: Animals; Antidepressive Agents; Benzylamines; Depression; Disease Models, Animal; Drug Interactions; | 2001 |
Neuroendocrine responses to L-tryptophan as an index of brain serotonin function: effect of weight loss.
Topics: Adult; Biological Transport, Active; Brain Chemistry; Clomipramine; Depression; Diet, Reducing; Fema | 1991 |
Psychotropic effects of ritanserin, a selective S2 antagonist: an open study.
Topics: Adult; Depression; Electrocardiography; Female; Humans; Male; Psychiatric Status Rating Scales; Psyc | 1991 |