ritanserin has been researched along with Blood Pressure, High in 11 studies
Ritanserin: A selective and potent serotonin-2 antagonist that is effective in the treatment of a variety of syndromes related to anxiety and depression. The drug also improves the subjective quality of sleep and decreases portal pressure.
ritanserin : A thiazolopyrimidine that is 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one which is substituted at position 7 by a methyl group and at position 6 by a 2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl group. A potent and long-acting seratonin (5-hydroxytryptamine, 5-HT) antagonist of the subtype 5-HT2 (Ki = 0.39 nM), it is used in the treatment of a variety of disorders including anxiety, depression and schizophrenia. It has little sedative action.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have studied the acute effects of the serotonergic type-2 (5-HT2) antagonists ketanserin and ritanserin given as single oral doses to patients with essential hypertension." | 9.06 | Does acute serotonergic type-2 antagonism reduce blood pressure? Comparative effects of single doses of ritanserin and ketanserin in essential hypertension. ( Ball, SG; Hosie, J; Robertson, JI; Stott, DJ, 1987) |
| "We have given the selective 5 HT2 antagonist ritanserin in a dose of 10 mg twice daily for 4 weeks in a double-blind, randomized, placebo-controlled, parallel group study of 18 patients with untreated essential hypertension." | 9.06 | The effects of the 5 HT2 antagonist ritanserin on blood pressure and serotonin-induced platelet aggregation in patients with untreated essential hypertension. ( Ball, SG; Hosie, J; Lowe, GD; Saniabadi, AR; Stott, DJ, 1988) |
| "We have studied the acute effects of the serotonergic type-2 (5-HT2) antagonists ketanserin and ritanserin given as single oral doses to patients with essential hypertension." | 5.06 | Does acute serotonergic type-2 antagonism reduce blood pressure? Comparative effects of single doses of ritanserin and ketanserin in essential hypertension. ( Ball, SG; Hosie, J; Robertson, JI; Stott, DJ, 1987) |
| "In patients with essential hypertension, ketanserin (40 mg once or twice daily) reduces the blood pressure in mono- and combination therapy." | 5.06 | Experience with ketanserin and ritanserin in hypertensive patients. ( Hedner, T; Persson, B, 1988) |
| "We have given the selective 5 HT2 antagonist ritanserin in a dose of 10 mg twice daily for 4 weeks in a double-blind, randomized, placebo-controlled, parallel group study of 18 patients with untreated essential hypertension." | 5.06 | The effects of the 5 HT2 antagonist ritanserin on blood pressure and serotonin-induced platelet aggregation in patients with untreated essential hypertension. ( Ball, SG; Hosie, J; Lowe, GD; Saniabadi, AR; Stott, DJ, 1988) |
| " Whereas the blood pressure reduction to acute administration of ketanserin was directly related to its ability to shift the dose-response curve of phenylephrine (alpha 1-adrenergic blockade), the same relationship was not apparent following chronic treatment with ketanserin." | 1.27 | Antihypertensive effects of ketanserin and ritanserin in the spontaneously hypertensive rat. ( Gradin, K; Hedner, T; Persson, B; Pettersson, A, 1988) |
| "Ketanserin is a new antihypertensive agent with affinity to serotonin (5-HT)2 receptors and at higher concentrations also to alpha 1-adrenoceptors." | 1.27 | Antihypertensive mechanism of action of ketanserin and some ketanserin analogues in the spontaneously hypertensive rat. ( Gradin, K; Hedner, T; Persson, B; Pettersson, A, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (90.91) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barrett, RJ | 1 |
| Wright, KF | 1 |
| Allen, AD | 1 |
| Taylor, DR | 1 |
| Hosie, J | 2 |
| Stott, DJ | 2 |
| Robertson, JI | 1 |
| Ball, SG | 2 |
| Persson, B | 5 |
| Gradin, K | 3 |
| Pettersson, A | 4 |
| Hedner, T | 5 |
| Chau, NP | 1 |
| Pithois-Merli, I | 1 |
| Levenson, J | 1 |
| Simon, AC | 1 |
| Nelson, M | 1 |
| Coghlan, JP | 1 |
| Denton, DA | 1 |
| Tresham, JJ | 1 |
| Whitworth, JA | 1 |
| Scoggins, BA | 1 |
| Saniabadi, AR | 1 |
| Lowe, GD | 1 |
| Smits, J | 1 |
| van Dorsten, F | 1 |
| Struyker Boudier, H | 1 |
5 trials available for ritanserin and Blood Pressure, High
| Article | Year |
|---|---|
Does acute serotonergic type-2 antagonism reduce blood pressure? Comparative effects of single doses of ritanserin and ketanserin in essential hypertension.
Topics: Adult; Affect; Aged; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Ketanserin; Male; Mid | 1987 |
Experience with ketanserin and ritanserin in hypertensive patients.
Topics: Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Huma | 1988 |
Comparative haemodynamic effects of ketanserin and ritanserin in the proximal and distal upper limb circulations of hypertensive patients.
Topics: Arm; Blood Pressure; Brachial Artery; Double-Blind Method; Hand; Humans; Hypertension; Ketanserin; M | 1989 |
Chronic 5-HT2-receptor blockade by ritanserin does not reduce blood pressure in patients with essential hypertension.
Topics: Aged; Clinical Trials as Topic; Double-Blind Method; Female; Histamine H2 Antagonists; Humans; Hyper | 1987 |
The effects of the 5 HT2 antagonist ritanserin on blood pressure and serotonin-induced platelet aggregation in patients with untreated essential hypertension.
Topics: Aged; Blood Pressure; Double-Blind Method; Electrocardiography; Female; Forearm; Heart Rate; Humans; | 1988 |
6 other studies available for ritanserin and Blood Pressure, High
| Article | Year |
|---|---|
Cardiovascular and renal actions of AHR-16303B, an antagonist of 5-HT2 receptors and calcium channels, in hypertensive and normotensive rats.
Topics: Administration, Oral; Animals; Blood Pressure; Calcium Channel Blockers; Cardiovascular System; Dose | 1991 |
Antihypertensive effects of ketanserin and ritanserin in the spontaneously hypertensive rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Heart Rate; Hypertension; Ketanserin; Male; Phenyl | 1988 |
Chronic 5-HT2 receptor blockade with ritanserin does not reduce blood pressure in the spontaneously hypertensive rat.
Topics: Animals; Blood Pressure; Decerebrate State; Dose-Response Relationship, Drug; Electric Stimulation; | 1985 |
Antihypertensive mechanism of action of ketanserin and some ketanserin analogues in the spontaneously hypertensive rat.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Electric Stimulation; Hypertension; Ketan | 1985 |
Ritanserin and serotonergic mechanisms in blood pressure and fluid regulation in sheep.
Topics: Animals; Blood Pressure; Cardiac Output; Heart Rate; Hypertension; Ketanserin; Phenylephrine; Piperi | 1987 |
Interference of ketanserin with baroreflex control of the circulation in the conscious spontaneously hypertensive rat.
Topics: Animals; Blood Pressure; Heart Rate; Hypertension; Ketanserin; Male; Piperidines; Prazosin; Pressore | 1988 |