ristocetin and Streptococcal-Infections

The study of antibacterial and chemotherapeutic activity of eremomycin, a novel glycopeptide antibiotic showed that it inhibited the growth of gram positive and acid fast microbes. The antibacterial spectrum of the novel glycopeptide was close to that of ristomycin and vancomycin. However, the in vitro antibacterial activity of eremomycin was 2-10 times higher than that of ristomycin and vancomycin. It also inhibited the growth of oxacillin resistant microbes at concentrations 5.20 times lower than those of vancomycin and ristomycin. By the therapeutic efficacy in albino mice with staphylococcal or streptococcal sepsis eremomycin was 2-4 times as superior as vancomycin and ristomycin and by the chemotherapeutic indices it was more than 10 times as superior.

Topics: Animals; Anti-Bacterial Agents; Bacteria; Glycopeptides; Gram-Positive Bacteria; Mice; Ristocetin; Staphylococcal Infections; Streptococcal Infections; Vancomycin

Topics: Adult; Aged; Bacterial Infections; Cross Infection; Drug Resistance, Microbial; Eczema; Escherichia coli Infections; Female; Glycols; Humans; Klebsiella Infections; Leg Ulcer; Male; Middle Aged; Ointments; Polymyxins; Proteus Infections; Pseudomonas Infections; Ristocetin; Staphylococcal Infections; Streptococcal Infections; Wound Healing

Topics: Adolescent; Adult; Anti-Bacterial Agents; Ascorbic Acid; Child; Cloxacillin; Female; Humans; Kanamycin; Male; Methicillin; Oxacillin; Penicillin G; Penicillin Resistance; Penicillins; Ristocetin; Staphylococcal Infections; Streptococcal Infections; Vancomycin

Topics: Amphotericin B; Anti-Bacterial Agents; Chloramphenicol; Colistin; Drug Resistance; Drug Resistance, Microbial; Endocarditis; Endocarditis, Bacterial; Enterobacter aerogenes; Enterobacteriaceae; Erythromycin; Escherichia coli Infections; Kanamycin; Penicillin G; Penicillins; Proteus Infections; Pseudomonas Infections; Ristocetin; Staphylococcal Infections; Streptococcal Infections; Streptomycin; Tetracycline; Vancomycin