ristocetin and Myeloproliferative-Disorders

Topics: Adenosine Diphosphate; Adenosine Triphosphate; Anemia, Megaloblastic; Anti-Inflammatory Agents; Blood Coagulation Disorders; Blood Coagulation Tests; Blood Platelet Disorders; Blood Platelets; Carbenicillin; Collagen; Epinephrine; Hemorrhage; Humans; Isoantibodies; Leukemia; Myeloproliferative Disorders; Platelet Aggregation; Postoperative Complications; Purpura, Thrombocytopenic; Ristocetin; Stress, Psychological; Uremia; von Willebrand Diseases

A group of patients with myeloproliferative disorders was studies with respect to platelet aggregation responses, release of beta-thromboglobulin and incorporated 5-hydroxy-tryptamine, and synthesis of thromboxane b 2. In all patients the resting plasma beta-thrombo-globulin was elevated. Aggregation responses were frequently impaired to adrenaline, arachidonic acid, A23187 and the prostaglandin endoperoxide analogue, U44069. Both 5-hydroxy-tryptamine and beta-thromboglobulin release were greater with patients' platelets than with those of controls in response to adrenaline, ADP and U44069. The patients' platelets produced more thromboxane B2 than did controls, irrespective of the agonist used, yet those aggregating agents which are thought to act by generating thromboxane A2 were relatively ineffective in causing aggregation. This might reflect resistance to thromboxane A2 action in these patients, which is met by increased thromboxane formation.

Topics: Adenosine Diphosphate; Adult; Aged; Arachidonic Acid; Arachidonic Acids; beta-Thromboglobulin; Blood Platelets; Calcimycin; Collagen; Epinephrine; Female; Humans; Male; Middle Aged; Myeloproliferative Disorders; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Ristocetin; Serotonin; Thromboxane B2; Thromboxanes

The authors report a case of chronic eosinophilic leukemia. Ristocetin did not aggregate patient's platelets in the absence of bleeding disorder. A possible relationship between arterial thrombosis observed in patients with eosinophilic leukemia and platelet abnormality is evoked.

Topics: Arteries; Blood Platelet Disorders; Cytoplasmic Granules; Diagnosis, Differential; Eosinophils; Hematopoiesis; Heparin Antagonists; Humans; Male; Middle Aged; Myeloproliferative Disorders; Platelet Adhesiveness; Platelet Aggregation; Ristocetin; Thrombosis; von Willebrand Diseases