ristocetin and Alcoholism

Platelet hemostasis was studied in 23 patients with chronic alcoholism (CA) stage II at rest and under muscular exercise. At rest, the patients had elevated spontaneous aggregation of platelets and more active start of adrenaline and ristomycin aggregation. Exercise stimulated spontaneous platelet aggregation, enhances adrenaline and ristomycin aggregation. According to adrenalin test 32% of the examinees had platelet dysfunction. According to ristomycin aggregation, vascular endothelium was impaired in 95.7%of the patients. Thus, it is evident that CA stage II patients develop disorder of platelet hemostasis and vascular endothelium. Such patients are at high risk of thrombogenesis.

Topics: Adult; Alcoholism; Anti-Bacterial Agents; Chronic Disease; Epinephrine; Exercise; Exercise Test; Hemostasis; Humans; Male; Platelet Aggregation; Rest; Ristocetin; Severity of Illness Index; Vasoconstrictor Agents