risperidone has been researched along with Torsade de Pointes in 13 studies
Risperidone: A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.
risperidone : A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Sixty-six patients with a diagnosis of schizophrenia that were treated with risperidone or olanzapine and 40 healthy volunteers were enrolled." | 5.16 | Increased risk of antipsychotic-related QT prolongation during nighttime: a 24-hour holter electrocardiogram recording study. ( Fukui, N; Ono, S; Someya, T; Sugai, T; Suzuki, Y; Tsuneyama, N; Watanabe, J, 2012) |
| "Five new antipsychotic drugs introduced in the United States in the last decade offer physicians the ability to treat patients with schizophrenia and bipolar mania without the adverse effects of the first-generation antipsychotics." | 2.42 | The promise of atypical antipsychotics: fewer side effects mean enhanced compliance and improved functioning. ( Citrome, L; Volavka, J, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 9 (69.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mirams, GR | 1 |
| Cui, Y | 1 |
| Sher, A | 1 |
| Fink, M | 1 |
| Cooper, J | 1 |
| Heath, BM | 1 |
| McMahon, NC | 1 |
| Gavaghan, DJ | 1 |
| Noble, D | 1 |
| Wiśniowska, B | 1 |
| Mendyk, A | 1 |
| Fijorek, K | 1 |
| Glinka, A | 1 |
| Polak, S | 1 |
| Kramer, J | 1 |
| Obejero-Paz, CA | 1 |
| Myatt, G | 1 |
| Kuryshev, YA | 1 |
| Bruening-Wright, A | 1 |
| Verducci, JS | 1 |
| Brown, AM | 1 |
| Vieweg, WV | 1 |
| Hasnain, M | 1 |
| Hancox, JC | 1 |
| Baranchuk, A | 1 |
| Digby, GC | 1 |
| Kogut, C | 1 |
| Crouse, EL | 1 |
| Koneru, JN | 1 |
| Deshmukh, A | 1 |
| Pandurangi, AK | 1 |
| Willcox, ME | 1 |
| Kudenchuk, PJ | 1 |
| Prutkin, JM | 1 |
| Hagiwara, M | 1 |
| Kambayashi, R | 1 |
| Aimoto, M | 1 |
| Nagasawa, Y | 1 |
| Takahara, A | 1 |
| Frommeyer, G | 1 |
| von der Ahe, H | 1 |
| Brücher, B | 1 |
| Dechering, DG | 1 |
| Lange, PS | 1 |
| Reinke, F | 1 |
| Wasmer, K | 1 |
| Köbe, J | 1 |
| Pott, C | 1 |
| Mönnig, G | 1 |
| Eckardt, L | 1 |
| Watanabe, J | 1 |
| Suzuki, Y | 1 |
| Fukui, N | 1 |
| Ono, S | 1 |
| Sugai, T | 1 |
| Tsuneyama, N | 1 |
| Someya, T | 1 |
| Said, TH | 1 |
| Wilson, LD | 1 |
| Jeyaraj, D | 1 |
| Fossa, AA | 1 |
| Rosenbaum, DS | 1 |
| Citrome, L | 1 |
| Volavka, J | 1 |
| Raviña, T | 2 |
| Gutierrez, J | 2 |
| Raviña, P | 2 |
| Blaschke, D | 1 |
| Parwani, AS | 1 |
| Huemer, M | 1 |
| Rolf, S | 1 |
| Boldt, LH | 1 |
| Dietz, R | 1 |
| Haverkamp, W | 1 |
2 reviews available for risperidone and Torsade de Pointes
| Article | Year |
|---|---|
Risperidone, QTc interval prolongation, and torsade de pointes: a systematic review of case reports.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Child; Dose-Response Relationship, Drug; Female; Huma | 2013 |
The promise of atypical antipsychotics: fewer side effects mean enhanced compliance and improved functioning.
Topics: Antipsychotic Agents; Aripiprazole; Benzodiazepines; Clozapine; Diabetes Mellitus, Type 2; Dibenzoth | 2004 |
1 trial available for risperidone and Torsade de Pointes
| Article | Year |
|---|---|
Increased risk of antipsychotic-related QT prolongation during nighttime: a 24-hour holter electrocardiogram recording study.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Circadian Rhythm; Death, Sudden, Cardiac; Electrocardi | 2012 |
10 other studies available for risperidone and Torsade de Pointes
| Article | Year |
|---|---|
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; | 2011 |
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computationa | 2012 |
MICE models: superior to the HERG model in predicting Torsade de Pointes.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp T | 2013 |
Very abnormal T waves in a 37-year-old man.
Topics: Adult; Antipsychotic Agents; Defibrillators, Implantable; Electrocardiography; Humans; Male; Risperi | 2016 |
In vivo analysis of torsadogenic potential of an antipsychotic drug paliperidone using the acute atrioventricular block rabbit as a proarrhythmia model.
Topics: Action Potentials; Animals; Antipsychotic Agents; Atrioventricular Block; Dose-Response Relationship | 2016 |
Severe proarrhythmic potential of risperidone compared to quetiapine in an experimental whole-heart model of proarrhythmia.
Topics: Action Potentials; Animals; Antipsychotic Agents; Atrioventricular Block; Bradycardia; Cardiac Pacin | 2016 |
Transmural dispersion of repolarization as a preclinical marker of drug-induced proarrhythmia.
Topics: Action Potentials; Animals; Bepridil; Dogs; Dose-Response Relationship, Drug; Electrocardiography; E | 2012 |
Acquired long QT syndrome: long-term electrocardiographic (Holter) recording of torsades de pointes ending in asystole: II.
Topics: Aged; Electrocardiography, Ambulatory; Female; Heart Arrest; Humans; Long QT Syndrome; Risperidone; | 2007 |
Acquired long QT syndrome: risperidone-facilitated triggered activity and Torsades de Pointes during complete AV block. I.
Topics: Aged, 80 and over; Antipsychotic Agents; Electrocardiography; Fatal Outcome; Female; Heart Block; Hu | 2007 |
Torsade de pointes during combined treatment with risperidone and citalopram.
Topics: Aged; Antipsychotic Agents; Citalopram; Drug Therapy, Combination; Electrocardiography, Ambulatory; | 2007 |