Page last updated: 2024-11-03

risperidone and Stroke

risperidone has been researched along with Stroke in 29 studies

Risperidone: A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.
risperidone : A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.

Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)

Research Excerpts

ExcerptRelevanceReference
"Post-hoc analysis by the pharmaceutical company Eli Lilly of 5 randomised clinical trials concerning the efficacy ofolanzapine in patients with dementia, has shown that patients taking olanzapine have a risk of experiencing a cerebrovascular accident which is 3 times higher than patients taking placebo."8.82[Increased risk of stroke during the use of olanzapine or risperidone in patients with dementia]. ( Jansen, PA; van Marum, RJ, 2005)
" Strong concerns have been raised about whether the risk of ischemic stroke differs between risperidone and haloperidol."7.81A comparison of risperidone and haloperidol for the risk of ischemic stroke in the elderly: a propensity score-matched cohort analysis. ( Choi, NK; Lee, J; Lee, SH; Park, BJ; Park, MJ; Shin, JY, 2015)
"We conducted a case-crossover study to evaluate the comparative risk of ischemic stroke associated with the use of risperidone, quetiapine and olanzapine in geriatric patients using the Korean Health Insurance Review and Assessment Service database."7.79Risk of ischemic stroke with the use of risperidone, quetiapine and olanzapine in elderly patients: a population-based, case-crossover study. ( Choi, NK; Jung, SY; Kwon, JS; Lee, J; Park, BJ; Shin, JY, 2013)
"Experiment 1: Wistar-Kyoto (WKY) rats, spontaneously hypertensive rats (SHRs) and stroke-prone SHRs (SHR-SPs) were treated with risperidone (0."7.78Risperidone enhances the vulnerability to stroke in hypertensive rats. ( Godfraind, T; Liu, C; Song, SW; Su, BL; Su, DF; Sun, Y; Yang, C, 2012)
"Following changes in the safety information on the use of risperidone and olanzapine in elderly patients with dementia, data from prescription-event monitoring (PEM) studies of risperidone, quetiapine and olanzapine were examined."7.73Comparison of incidence rates of cerebrovascular accidents and transient ischaemic attacks in observational cohort studies of patients prescribed risperidone, quetiapine or olanzapine in general practice in England including patients with dementia. ( Harris, S; Layton, D; Shakir, SA; Wilton, LV, 2005)
"Post hoc analyses of pooled results from 11 randomised controlled trials of risperidone and olanzapine in elderly dementia subjects revealed an increased incidence of cerebrovascular adverse events compared with placebo."4.82Do atypical antipsychotics cause stroke? ( Herrmann, N; Lanctôt, KL, 2005)
"Post-hoc analysis by the pharmaceutical company Eli Lilly of 5 randomised clinical trials concerning the efficacy ofolanzapine in patients with dementia, has shown that patients taking olanzapine have a risk of experiencing a cerebrovascular accident which is 3 times higher than patients taking placebo."4.82[Increased risk of stroke during the use of olanzapine or risperidone in patients with dementia]. ( Jansen, PA; van Marum, RJ, 2005)
" Strong concerns have been raised about whether the risk of ischemic stroke differs between risperidone and haloperidol."3.81A comparison of risperidone and haloperidol for the risk of ischemic stroke in the elderly: a propensity score-matched cohort analysis. ( Choi, NK; Lee, J; Lee, SH; Park, BJ; Park, MJ; Shin, JY, 2015)
"We conducted a case-crossover study to evaluate the comparative risk of ischemic stroke associated with the use of risperidone, quetiapine and olanzapine in geriatric patients using the Korean Health Insurance Review and Assessment Service database."3.79Risk of ischemic stroke with the use of risperidone, quetiapine and olanzapine in elderly patients: a population-based, case-crossover study. ( Choi, NK; Jung, SY; Kwon, JS; Lee, J; Park, BJ; Shin, JY, 2013)
"Experiment 1: Wistar-Kyoto (WKY) rats, spontaneously hypertensive rats (SHRs) and stroke-prone SHRs (SHR-SPs) were treated with risperidone (0."3.78Risperidone enhances the vulnerability to stroke in hypertensive rats. ( Godfraind, T; Liu, C; Song, SW; Su, BL; Su, DF; Sun, Y; Yang, C, 2012)
"Following changes in the safety information on the use of risperidone and olanzapine in elderly patients with dementia, data from prescription-event monitoring (PEM) studies of risperidone, quetiapine and olanzapine were examined."3.73Comparison of incidence rates of cerebrovascular accidents and transient ischaemic attacks in observational cohort studies of patients prescribed risperidone, quetiapine or olanzapine in general practice in England including patients with dementia. ( Harris, S; Layton, D; Shakir, SA; Wilton, LV, 2005)
"Olanzapine and risperidone use were not associated with a statistically significant increased risk of stroke compared with typical antipsychotic use."3.72Atypical antipsychotics and risk of cerebrovascular accidents. ( Herrmann, N; Lanctôt, KL; Mamdani, M, 2004)
"The Medication Use and Alzheimer's Disease (MEDALZ) cohort included 70,718 community-dwelling people with AD in Finland during 2005-2011."1.72Antipsychotic Use and Risk of Stroke Among Community-Dwelling People With Alzheimer's Disease. ( Bell, JS; Hartikainen, S; Koponen, M; Lavikainen, P; Rajamaki, B; Taipale, H; Tanskanen, A; Tolppanen, AM, 2022)
"Psychiatric illnesses following cerebrovascular accidents has been a popular area of research in recent times."1.39Poststroke psychosis in an 8-year-old child with moyamoya disease. ( Gnanavel, S, 2013)
"The proportions of cerebrovascular accidents were 3."1.33Second-generation antipsychotics and risk of cerebrovascular accidents in the elderly. ( Barbui, C; Fortino, I; Percudani, M; Petrovich, L; Tansella, M, 2005)
" Clinicians should attempt to treat patients with the lowest effective dosage of medication for the briefest therapeutic period to minimize the risks of adverse reactions."1.31Metoclopramide-induced supersensitivity psychosis. ( Lu, ML; Pan, JJ; Shen, WW; Su, KP; Teng, HW, 2002)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's19 (65.52)29.6817
2010's8 (27.59)24.3611
2020's2 (6.90)2.80

Authors

AuthorsStudies
Koponen, M1
Rajamaki, B1
Lavikainen, P1
Bell, JS1
Taipale, H1
Tanskanen, A1
Hartikainen, S1
Tolppanen, AM1
Spiegel, DR2
Harsch, C1
Pattison, A1
Thusius, N1
Romanowicz, M1
Mlynek, K1
Sola, C1
Shin, JY2
Choi, NK2
Jung, SY1
Lee, J2
Kwon, JS1
Park, BJ2
Gnanavel, S1
Yan, BC1
Park, JH2
Ahn, JH1
Kim, IH1
Park, OK1
Lee, JC1
Yoo, KY1
Choi, JH1
Lee, CH1
Hwang, IK1
Her, S1
Kim, JS1
Shin, HC1
Cho, JH1
Kim, YM1
Kwon, SH1
Won, MH1
Cadacio, K1
Kiamanesh, M1
Park, MJ1
Lee, SH1
Wallach, JD1
Sullivan, PG1
Trepanowski, JF1
Steyerberg, EW1
Ioannidis, JP1
Song, SW1
Sun, Y1
Su, BL1
Liu, C1
Yang, C1
Godfraind, T1
Su, DF1
Lu, ML1
Pan, JJ1
Teng, HW1
Su, KP1
Shen, WW1
Wooltorton, E1
Mahmoud, R1
Greenspan, A1
Mowat, D1
Fowlie, D1
MacEwan, T1
Herrmann, N2
Mamdani, M1
Lanctôt, KL2
Tariot, PN1
van Marum, RJ1
Jansen, PA1
Hafkamp, GJ1
van der Mast, RC1
Zhao, CS1
Puurunen, K1
Sivenius, J1
Jolkkonen, J1
Schallert, T1
Shah, A1
Suh, GH1
Percudani, M1
Barbui, C1
Fortino, I1
Tansella, M1
Petrovich, L1
Layton, D1
Harris, S1
Wilton, LV1
Shakir, SA1
Snowdon, J1
Wang, PS1
Schneeweiss, S1
Setoguchi, S1
Patrick, A1
Avorn, J1
Mogun, H1
Choudhry, NK1
Brookhart, MA1
Dervaux, A1
Levasseur, M1
Selbaek, G1
Engedal, K1

Reviews

3 reviews available for risperidone and Stroke

ArticleYear
Sex based subgroup differences in randomized controlled trials: empirical evidence from Cochrane meta-analyses.
    BMJ (Clinical research ed.), 2016, Nov-24, Volume: 355

    Topics: Benzodiazepines; Bias; Carotid Stenosis; Endarterectomy, Carotid; Female; Humans; Hyperprolactinemia

2016
Do atypical antipsychotics cause stroke?
    CNS drugs, 2005, Volume: 19, Issue:2

    Topics: Antipsychotic Agents; Behavioral Symptoms; Benzodiazepines; Dementia; Humans; MEDLINE; Olanzapine; R

2005
[Increased risk of stroke during the use of olanzapine or risperidone in patients with dementia].
    Nederlands tijdschrift voor geneeskunde, 2005, Jan-22, Volume: 149, Issue:4

    Topics: Antipsychotic Agents; Benzodiazepines; Dementia; Humans; Olanzapine; Randomized Controlled Trials as

2005

Other Studies

26 other studies available for risperidone and Stroke

ArticleYear
Antipsychotic Use and Risk of Stroke Among Community-Dwelling People With Alzheimer's Disease.
    Journal of the American Medical Directors Association, 2022, Volume: 23, Issue:6

    Topics: Alzheimer Disease; Antipsychotic Agents; Cohort Studies; Humans; Independent Living; Quetiapine Fuma

2022
A Case of Peduncular Hallucinosis Due to Right Pontine and Cerebral Peduncle Cerebrovascular Accident Treated Successfully With Risperidone: Insights Into an Uncommon Cause of Visual Hallucinations.
    The primary care companion for CNS disorders, 2020, Oct-15, Volume: 22, Issue:5

    Topics: Cerebral Peduncle; Hallucinations; Humans; Risperidone; Stroke

2020
Prolonged Psychosis Associated with Left Insular Stroke: Talking to God in the Walls.
    Psychosomatics, 2018, Volume: 59, Issue:6

    Topics: Aged; Antimanic Agents; Antipsychotic Agents; Cerebral Cortex; Electroencephalography; Hallucination

2018
Risk of ischemic stroke with the use of risperidone, quetiapine and olanzapine in elderly patients: a population-based, case-crossover study.
    Journal of psychopharmacology (Oxford, England), 2013, Volume: 27, Issue:7

    Topics: Age Factors; Aged; Antipsychotic Agents; Benzodiazepines; Confidence Intervals; Cross-Over Studies;

2013
Poststroke psychosis in an 8-year-old child with moyamoya disease.
    BMJ case reports, 2013, Dec-10, Volume: 2013

    Topics: Antipsychotic Agents; Child; Humans; Male; Moyamoya Disease; Psychotic Disorders; Risperidone; Strok

2013
Neuroprotection of posttreatment with risperidone, an atypical antipsychotic drug, in rat and gerbil models of ischemic stroke and the maintenance of antioxidants in a gerbil model of ischemic stroke.
    Journal of neuroscience research, 2014, Volume: 92, Issue:6

    Topics: Animals; Antioxidants; Blotting, Western; Brain Ischemia; Disease Models, Animal; Gerbillinae; Immun

2014
A probable case of reduplicative paramnesia status-post right fronto-temporal cerebrovascular accident, treated successfully with risperidone.
    The Journal of neuropsychiatry and clinical neurosciences, 2014,Winter, Volume: 26, Issue:1

    Topics: Aged; Antipsychotic Agents; Frontal Lobe; Humans; Male; Memory Disorders; Psychiatric Status Rating

2014
A comparison of risperidone and haloperidol for the risk of ischemic stroke in the elderly: a propensity score-matched cohort analysis.
    Journal of psychopharmacology (Oxford, England), 2015, Volume: 29, Issue:8

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Brain Ischemia; Cohort Studies; Female; Haloperidol;

2015
Risperidone enhances the vulnerability to stroke in hypertensive rats.
    CNS neuroscience & therapeutics, 2012, Volume: 18, Issue:4

    Topics: Animals; Apoptosis; Cells, Cultured; Hypertension; Neurons; Rats; Rats, Inbred SHR; Rats, Inbred WKY

2012
Metoclopramide-induced supersensitivity psychosis.
    The Annals of pharmacotherapy, 2002, Volume: 36, Issue:9

    Topics: Aged; Antiemetics; Antipsychotic Agents; Diabetes Mellitus, Type 2; Drug Hypersensitivity; Hallucina

2002
Risperidone (Risperdal): increased rate of cerebrovascular events in dementia trials.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2002, Nov-26, Volume: 167, Issue:11

    Topics: Aged; Dementia; Dopamine Antagonists; Humans; Ischemic Attack, Transient; Randomized Controlled Tria

2002
Risperidone and stroke.
    Prescrire international, 2003, Volume: 12, Issue:64

    Topics: Antipsychotic Agents; Canada; Double-Blind Method; Humans; Randomized Controlled Trials as Topic; Ri

2003
Early Alzheimer's disease.
    The New England journal of medicine, 2004, Jan-01, Volume: 350, Issue:1

    Topics: Antipsychotic Agents; Dementia; Humans; Risperidone; Stroke

2004
CSM warning on atypical psychotics and stroke may be detrimental for dementia.
    BMJ (Clinical research ed.), 2004, May-22, Volume: 328, Issue:7450

    Topics: Antipsychotic Agents; Benzodiazepines; Dementia; Humans; Olanzapine; Risk Factors; Risperidone; Stro

2004
Atypical antipsychotics and risk of cerebrovascular accidents.
    The American journal of psychiatry, 2004, Volume: 161, Issue:6

    Topics: Aged; Antipsychotic Agents; Benzodiazepines; Cohort Studies; Comorbidity; Dementia; Female; Geriatri

2004
Clinical effectiveness of atypical antipsychotics in dementia.
    The Journal of clinical psychiatry, 2004, Volume: 65 Suppl 11

    Topics: Adverse Drug Reaction Reporting Systems; Aged; Antipsychotic Agents; Basal Ganglia Diseases; Benzodi

2004
[Increased risk of stroke during the use of olanzapine or risperidone in patients with dementia].
    Nederlands tijdschrift voor geneeskunde, 2005, Mar-26, Volume: 149, Issue:13

    Topics: Antipsychotic Agents; Benzodiazepines; Dementia; Humans; Olanzapine; Risk Factors; Risperidone; Stro

2005
[Increased risk of stroke during the use of olanzapine or risperidone in patients with dementia].
    Nederlands tijdschrift voor geneeskunde, 2005, Mar-26, Volume: 149, Issue:13

    Topics: Antipsychotic Agents; Benzodiazepines; Dementia; Humans; Olanzapine; Risk Factors; Risperidone; Stro

2005
Psychotropic medication and stroke outcome.
    The American journal of psychiatry, 2005, Volume: 162, Issue:5

    Topics: Age Factors; Aged; Animals; Behavior, Animal; Dementia; Humans; Male; Outcome Assessment, Health Car

2005
A case for judicious use of risperidone and olanzapine in behavioral and psychological symptoms of dementia (BPSD). Favour.
    International psychogeriatrics, 2005, Volume: 17, Issue:1

    Topics: Aged; Antipsychotic Agents; Benzodiazepines; Dementia; Geriatric Psychiatry; Humans; Ischemic Attack

2005
Second-generation antipsychotics and risk of cerebrovascular accidents in the elderly.
    Journal of clinical psychopharmacology, 2005, Volume: 25, Issue:5

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Benzodiazepines; Female; Haloperidol; Humans; Male; O

2005
Comparison of incidence rates of cerebrovascular accidents and transient ischaemic attacks in observational cohort studies of patients prescribed risperidone, quetiapine or olanzapine in general practice in England including patients with dementia.
    Journal of psychopharmacology (Oxford, England), 2005, Volume: 19, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Benzodiazepines; Cohort Studies; D

2005
Psychosis of Alzheimer disease.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2006, Volume: 14, Issue:3

    Topics: Aged; Alzheimer Disease; Antipsychotic Agents; Benzodiazepines; Cause of Death; Controlled Clinical

2006
Ventricular arrhythmias and cerebrovascular events in the elderly using conventional and atypical antipsychotic medications.
    Journal of clinical psychopharmacology, 2007, Volume: 27, Issue:6

    Topics: Administration, Oral; Aged; Antipsychotic Agents; Aripiprazole; Arrhythmias, Cardiac; Benzodiazepine

2007
Risperidone and valproate for mania following stroke.
    The Journal of neuropsychiatry and clinical neurosciences, 2008,Spring, Volume: 20, Issue:2

    Topics: Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Humans; Male; Middle Aged; Risperidone; Str

2008
[Atypical antipsychotics in elderly patients with dementia].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2008, May-01, Volume: 128, Issue:9

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Benzodiazepines; Dementia; Haloperidol; Humans; Metho

2008