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risperidone and Sexual Dysfunctions, Psychological

risperidone has been researched along with Sexual Dysfunctions, Psychological in 17 studies

Risperidone: A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.
risperidone : A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.

Sexual Dysfunctions, Psychological: Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked distress and interpersonal difficulty. (APA, DSM-IV, 1994)

Research Excerpts

ExcerptRelevanceReference
" Thus, we compared ziprasidone and risperidone in patients with acute exacerbation of schizophrenia or schizoaffective disorder."9.11Efficacy and tolerability of ziprasidone versus risperidone in patients with acute exacerbation of schizophrenia or schizoaffective disorder: an 8-week, double-blind, multicenter trial. ( Addington, DE; Benattia, I; Dineen, M; Pantelis, C; Romano, SJ, 2004)
"This study was conducted to prospectively examine the effect of switching from risperidone to olanzapine on female schizophrenia patients who experienced menstrual disturbances, galactorrhea, and/or sexual dysfunction."9.10Effects of olanzapine on prolactin levels of female patients with schizophrenia treated with risperidone. ( Bahk, WM; Chae, JH; Dickson, RA; Jun, TY; Kim, DJ; Kim, KS; Pae, CU, 2002)
"This study evaluated 169 patients with schizophrenia who were receiving risperidone monotherapy."7.81Factors associated with self-rated sexual function in Korean patients with schizophrenia receiving risperidone monotherapy. ( Bae, KY; Kang, HJ; Kim, JM; Kim, SW; Kim, SY; Lee, JY; Lee, YH; Shin, IS; Yoon, JS, 2015)
"This open-label study included patients with schizophrenia or a related psychotic illness who were randomized to quetiapine (200-1200 mg/d) or risperidone (1-6 mg/d) for 6 weeks."5.11A randomized open-label study of the impact of quetiapine versus risperidone on sexual functioning. ( Bous, H; Bruggeman, R; Castelein, S; Kluiter, H; Knegtering, R; van den Bosch, RJ; Van Der Linde, J, 2004)
" Thus, we compared ziprasidone and risperidone in patients with acute exacerbation of schizophrenia or schizoaffective disorder."5.11Efficacy and tolerability of ziprasidone versus risperidone in patients with acute exacerbation of schizophrenia or schizoaffective disorder: an 8-week, double-blind, multicenter trial. ( Addington, DE; Benattia, I; Dineen, M; Pantelis, C; Romano, SJ, 2004)
"This study was conducted to prospectively examine the effect of switching from risperidone to olanzapine on female schizophrenia patients who experienced menstrual disturbances, galactorrhea, and/or sexual dysfunction."5.10Effects of olanzapine on prolactin levels of female patients with schizophrenia treated with risperidone. ( Bahk, WM; Chae, JH; Dickson, RA; Jun, TY; Kim, DJ; Kim, KS; Pae, CU, 2002)
" The newer atypical agents have a lower risk of EPS, but are associated in varying degrees with sedation, cardiovascular effects, anticholinergic effects, weight gain, sexual dysfunction, hepatic effects, lowered seizure threshold (primarily clozapine), and agranulocytosis (clozapine only)."4.80Adverse effects of the atypical antipsychotics. Collaborative Working Group on Clinical Trial Evaluations. ( , 1998)
"This study evaluated 169 patients with schizophrenia who were receiving risperidone monotherapy."3.81Factors associated with self-rated sexual function in Korean patients with schizophrenia receiving risperidone monotherapy. ( Bae, KY; Kang, HJ; Kim, JM; Kim, SW; Kim, SY; Lee, JY; Lee, YH; Shin, IS; Yoon, JS, 2015)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (11.76)18.2507
2000's9 (52.94)29.6817
2010's6 (35.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Davidson, CK1
Johnson, T1
Jansen, K1
Lee, JY1
Kim, SW1
Lee, YH1
Kang, HJ1
Kim, SY1
Bae, KY1
Kim, JM1
Shin, IS1
Yoon, JS1
Nunes, LV1
Dieckmann, LH1
Lacaz, FS1
Bressan, RA1
Mari, Jde J1
Cao, Y1
Zhu, Z1
Wang, R1
Wang, S1
Zhao, J1
de Boer, MK1
Wiersma, D1
Bous, J1
Sytema, S1
van der Moolen, AE1
Wilffert, B1
Hamamura, T1
Knegtering, H1
Iagubov, MI1
Shtark, LN1
Jeong, HG1
Lee, MS1
Lee, HY1
Ko, YH1
Han, C1
Joe, SH1
Brunelleschi, S1
Zeppegno, P1
Risso, F1
Cattaneo, CI1
Torre, E1
Fortier, P1
Mottard, JP1
Trudel, G1
Even, S1
Knegtering, R1
Castelein, S1
Bous, H1
Van Der Linde, J1
Bruggeman, R1
Kluiter, H1
van den Bosch, RJ1
Addington, DE1
Pantelis, C1
Dineen, M1
Benattia, I1
Romano, SJ1
Ahl, J1
Kinon, BJ1
Liu-Seifert, H1
Lam, MH1
Fong, SY1
Wing, YK1
Byerly, MJ1
Nakonezny, PA1
Rush, AJ1
Dickson, RA2
Glazer, WM1
Kim, KS1
Pae, CU1
Chae, JH1
Bahk, WM1
Jun, TY1
Kim, DJ1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An Open-label Study to Determine the Effect of Switching to Aripiprazole Once Monthly for Subjects With Schizophrenia Experiencing Worsening Sexual Dysfunction With Invega Sustenna or Risperdal Consta[NCT02472652]Phase 42 participants (Actual)Interventional2015-06-30Terminated (stopped due to Lack of adequate enrollment)
A Survey of Sexual Function in Schizophrenic Patients[NCT01835522]0 participants (Actual)Observational2009-07-31Withdrawn
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Arizona Sexual Experiences Scale (ASEX) Score

Subjects enrolled in this study will be followed for an average of about 5 months. The ASEX will be done at screening to ensure subjects meet criteria for sexual dysfunction as defined by the scale. In addition subjects must remember at least a 2 point change in the scale since starting Invega Sustenna or Risperdal Consta. Subjects must also score no greater than or equal to 25 on the scale to ensure a baseline of minimal sexual activity. The primary outcome of the study is the change in ASEX score from Baseline to Endpoint. Total scores range from 5 - 30 with the higher scores indicating more sexual dysfunction. (NCT02472652)
Timeframe: Baseline and 12 weeks

Interventionunits on a scale (Number)
Abilify Maintena11

Prolactin Concentrations ng/ml (Normal Range 4.0 - 15.2ng/ml)

Subjects enrolled in this study will be followed for an average of about 5 months. Serum prolactin concentrations will be measured to assess change from Baseline to Endpoint (NCT02472652)
Timeframe: Baseline and Endpoint average of about 5 months

Interventionng/ml (Number)
Baseline5 months
Abilify Maintena49.214.2

Reviews

1 review available for risperidone and Sexual Dysfunctions, Psychological

ArticleYear
Adverse effects of the atypical antipsychotics. Collaborative Working Group on Clinical Trial Evaluations.
    The Journal of clinical psychiatry, 1998, Volume: 59 Suppl 12

    Topics: Agranulocytosis; Antipsychotic Agents; Basal Ganglia Diseases; Benzodiazepines; Central Nervous Syst

1998

Trials

6 trials available for risperidone and Sexual Dysfunctions, Psychological

ArticleYear
A randomized open-label comparison of the impact of aripiprazole versus risperidone on sexual functioning (RAS study).
    Journal of clinical psychopharmacology, 2011, Volume: 31, Issue:4

    Topics: Adult; Aripiprazole; Female; Humans; Male; Middle Aged; Piperazines; Prolactin; Quinolones; Risperid

2011
Risperidone-associated hyperprolactinemia: evaluation in twenty psychiatric outpatients.
    Pharmacological research, 2003, Volume: 48, Issue:4

    Topics: Adult; Amenorrhea; Drug Administration Schedule; Female; Hospitals, Psychiatric; Humans; Hyperprolac

2003
A randomized open-label study of the impact of quetiapine versus risperidone on sexual functioning.
    Journal of clinical psychopharmacology, 2004, Volume: 24, Issue:1

    Topics: Adolescent; Adult; Dibenzothiazepines; Drug Administration Schedule; Female; Humans; Male; Prolactin

2004
Efficacy and tolerability of ziprasidone versus risperidone in patients with acute exacerbation of schizophrenia or schizoaffective disorder: an 8-week, double-blind, multicenter trial.
    The Journal of clinical psychiatry, 2004, Volume: 65, Issue:12

    Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Double-Blind Method; Female; Follow-Up Studies

2004
Sexual functioning associated with quetiapine switch vs. risperidone continuation in outpatients with schizophrenia or schizoaffective disorder: a randomized double-blind pilot trial.
    Psychiatry research, 2008, May-30, Volume: 159, Issue:1-2

    Topics: Adult; Ambulatory Care; Antipsychotic Agents; Dibenzothiazepines; Double-Blind Method; Female; Human

2008
Effects of olanzapine on prolactin levels of female patients with schizophrenia treated with risperidone.
    The Journal of clinical psychiatry, 2002, Volume: 63, Issue:5

    Topics: Adolescent; Adult; Amenorrhea; Antipsychotic Agents; Basal Ganglia Diseases; Benzodiazepines; Female

2002

Other Studies

10 other studies available for risperidone and Sexual Dysfunctions, Psychological

ArticleYear
Risperidone-induced hypersexuality.
    The British journal of psychiatry : the journal of mental science, 2013, Volume: 203, Issue:3

    Topics: Aged; Antipsychotic Agents; Female; Humans; Male; Middle Aged; Risperidone; Schizophrenia; Sexual Dy

2013
Factors associated with self-rated sexual function in Korean patients with schizophrenia receiving risperidone monotherapy.
    Human psychopharmacology, 2015, Volume: 30, Issue:6

    Topics: Adolescent; Adult; Antipsychotic Agents; Asian People; Cross-Sectional Studies; Female; Humans; Line

2015
[Strategy for the management of antipsychotic-induced sexual dysfunction: a case report description].
    Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2008, Volume: 30, Issue:3

    Topics: Adult; Antipsychotic Agents; Humans; Male; Phosphodiesterase Inhibitors; Risperidone; Sexual Dysfunc

2008
Hypersexuality from resection of left occipital arteriovenous malformation.
    Neurosurgical review, 2010, Volume: 33, Issue:1

    Topics: Adult; Brain; Brain Chemistry; Cerebral Hemorrhage; Cerebrovascular Circulation; Female; Humans; Int

2010
[Sexual disturbances during the treatment with neuroleptics in patients with schizophrenia and schizophrenia spectrum disorders].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2011, Volume: 111, Issue:9 Pt 2

    Topics: Antipsychotic Agents; Benzodiazepines; Dibenzothiazepines; Humans; Male; Olanzapine; Quetiapine Fuma

2011
Changes in sexual function and gonadal axis hormones after switching to aripiprazole in male schizophrenia patients: a prospective pilot study.
    International clinical psychopharmacology, 2012, Volume: 27, Issue:4

    Topics: Adult; Amisulpride; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Estradiol; Follicle Stimula

2012
Study of sexuality-related characteristics in young adults with schizophrenia treated with novel neuroleptics and in a comparison group of young adults.
    Schizophrenia bulletin, 2003, Volume: 29, Issue:3

    Topics: Adolescent; Adult; Affect; Antipsychotic Agents; Benzodiazepines; Female; Humans; Male; Olanzapine;

2003
Sexual dysfunction associated with neuroleptic-induced hyperprolactinemia improves with reduction in prolactin levels.
    Annals of the New York Academy of Sciences, 2004, Volume: 1032

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Ejaculation; Female; Humans; Hyperprolactinemia; Male;

2004
Sexual disinhibition in schizophrenia possibly induced by risperidone and quetiapine.
    Psychiatry and clinical neurosciences, 2007, Volume: 61, Issue:3

    Topics: Adult; Antimanic Agents; Antipsychotic Agents; Clonazepam; Dibenzothiazepines; Female; GABA Modulato

2007
Hyperprolactinemia and male sexual dysfunction.
    The Journal of clinical psychiatry, 1999, Volume: 60, Issue:2

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Humans; Hyperprolactinemia; Male; Olanzapine; Pirenzep

1999