Page last updated: 2024-11-03

risperidone and Serotonin Syndrome

risperidone has been researched along with Serotonin Syndrome in 16 studies

Risperidone: A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.
risperidone : A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.

Serotonin Syndrome: An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.

Research Excerpts

ExcerptRelevanceReference
" The first reported case of quetiapine and citalopram-associated serotonin syndrome is discussed with reference to a Medline, Embase, and PsycINFO literature search."7.73Quetiapine and citalopram: aetiological significances in serotonin syndrome. ( Marlowe, K; Schirgel, D, 2006)
"To report 2 cases of serotonin syndrome associated with combined therapy of risperidone and selective serotonin-reuptake inhibitors (SSRIs) in elderly patients."7.72Combination risperidone and SSRI-induced serotonin syndrome. ( Karki, SD; Masood, GR, 2003)
"BACKGROUND Serotonin syndrome is a condition characterized predominantly by neuromuscular symptoms and altered thermoregulation in response to serotonergic overtone."5.48Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose. ( Lin, CM; Little, K; Reynolds, PM, 2018)
"Pretreatment with risperidone (0."5.32Memantine, an NMDA antagonist, prevents the development of hyperthermia in an animal model for serotonin syndrome. ( Kato, S; Nisijima, K; Shioda, K; Takano, K; Yoshino, T, 2004)
" The Naranjo probability scale indicated probable causality for NMS due to quetiapine, haloperidol, and risperidone in this patient, whereas the Naranjo scale assigned only possible causality for serotonin syndrome developing with serotonergic agents."3.77Neuroleptic malignant syndrome versus serotonin syndrome: the search for a diagnostic tool. ( Ariano, RE; Sokoro, AA; Zivot, J, 2011)
" The first reported case of quetiapine and citalopram-associated serotonin syndrome is discussed with reference to a Medline, Embase, and PsycINFO literature search."3.73Quetiapine and citalopram: aetiological significances in serotonin syndrome. ( Marlowe, K; Schirgel, D, 2006)
"Serotonin syndrome and neuroleptic malignant syndrome are two drug toxidromes that have often overlapping and confusing clinical pictures."2.50Serotonin syndrome versus neuroleptic malignant syndrome: a challenging clinical quandary. ( Ambaliya, A; Dosi, R; Joshi, H; Patell, R, 2014)
"BACKGROUND Serotonin syndrome is a condition characterized predominantly by neuromuscular symptoms and altered thermoregulation in response to serotonergic overtone."1.48Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose. ( Lin, CM; Little, K; Reynolds, PM, 2018)
"Serotonin syndrome is an iatrogenic disorder that results from serotonergic overactivity."1.36A perfect storm in the emergency department. ( Wijdicks, EF; Yee, AH, 2010)
"Pretreatment with risperidone (0."1.32Memantine, an NMDA antagonist, prevents the development of hyperthermia in an animal model for serotonin syndrome. ( Kato, S; Nisijima, K; Shioda, K; Takano, K; Yoshino, T, 2004)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (56.25)29.6817
2010's6 (37.50)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Prakash, S1
Lodha, D1
Rawat, KS1
Little, K1
Lin, CM1
Reynolds, PM1
Dosi, R1
Ambaliya, A1
Joshi, H1
Patell, R1
Yee, AH1
Wijdicks, EF1
Zand, L1
Hoffman, SJ1
Nyman, MA1
Sokoro, AA1
Zivot, J1
Ariano, RE1
Shioda, K2
Nisijima, K3
Kasai, M1
Yoshino, T3
Kato, S2
Karki, SD1
Masood, GR1
Isbister, GK1
Takano, K1
Marlowe, K1
Schirgel, D1
Güzelcan, Y1
Kleinpenning, AS1
Kohen, I1
Gordon, ML1
Manu, P1
Hamilton, S1
Malone, K1
Ishiguro, T1
Gillman, PK1

Reviews

1 review available for risperidone and Serotonin Syndrome

ArticleYear
Serotonin syndrome versus neuroleptic malignant syndrome: a challenging clinical quandary.
    BMJ case reports, 2014, Jun-23, Volume: 2014

    Topics: Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Clonazepam; Diagnosis, Differential; GABA M

2014

Other Studies

15 other studies available for risperidone and Serotonin Syndrome

ArticleYear
Coexistence of serotonin syndrome and neuroleptic malignant syndrome: does it exist?
    BMJ case reports, 2021, Aug-16, Volume: 14, Issue:8

    Topics: Adult; Antipsychotic Agents; Haloperidol; Humans; Male; Neuroleptic Malignant Syndrome; Risperidone;

2021
Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose.
    The American journal of case reports, 2018, May-25, Volume: 19

    Topics: Benzodiazepines; Bupropion; Cyproheptadine; Dopamine Uptake Inhibitors; Drug Overdose; Fluoxetine; H

2018
A perfect storm in the emergency department.
    Neurocritical care, 2010, Volume: 12, Issue:2

    Topics: Aged; Alzheimer Disease; Citalopram; Drug Therapy, Combination; Female; Humans; Iatrogenic Disease;

2010
74-year-old woman with new-onset myoclonus.
    Mayo Clinic proceedings, 2010, Volume: 85, Issue:10

    Topics: Aged; Alzheimer Disease; Cyproheptadine; Diagnosis, Differential; Dopamine Antagonists; Dose-Respons

2010
Neuroleptic malignant syndrome versus serotonin syndrome: the search for a diagnostic tool.
    The Annals of pharmacotherapy, 2011, Volume: 45, Issue:9

    Topics: Antipsychotic Agents; Catecholamines; Diagnosis, Differential; Dibenzothiazepines; Dopamine; Female;

2011
Risperidone attenuates the increase of extracellular nitric oxide and glutamate levels in serotonin syndrome animal models.
    Neuroscience letters, 2012, Oct-18, Volume: 528, Issue:1

    Topics: 5-Hydroxytryptophan; Animals; Brain; Clorgyline; Disease Models, Animal; Fluoxetine; Glutamic Acid;

2012
Combination risperidone and SSRI-induced serotonin syndrome.
    The Annals of pharmacotherapy, 2003, Volume: 37, Issue:3

    Topics: Aged; Aged, 80 and over; Drug Interactions; Fatal Outcome; Female; Humans; Male; Risperidone; Select

2003
Comment: combination risperidone and SSRI-induced serotonin syndrome.
    The Annals of pharmacotherapy, 2003, Volume: 37, Issue:10

    Topics: Drug Therapy, Combination; Humans; Risperidone; Selective Serotonin Reuptake Inhibitors; Serotonin S

2003
Memantine, an NMDA antagonist, prevents the development of hyperthermia in an animal model for serotonin syndrome.
    Pharmacopsychiatry, 2004, Volume: 37, Issue:2

    Topics: 5-Hydroxytryptophan; Animals; Body Temperature; Clorgyline; Disease Models, Animal; Dizocilpine Male

2004
Quetiapine and citalopram: aetiological significances in serotonin syndrome.
    The New Zealand medical journal, 2006, Jul-07, Volume: 119, Issue:1237

    Topics: Adult; Alprazolam; Anti-Anxiety Agents; Antipsychotic Agents; Bipolar Disorder; Citalopram; Dibenzot

2006
[Life-threatening serotonin syndrome following a single dose of a serotonin reuptake inhibitor during maintenance therapy with a monoamine oxidase inhibitor].
    Nederlands tijdschrift voor geneeskunde, 2006, Aug-05, Volume: 150, Issue:31

    Topics: Antidepressive Agents; Drug Interactions; Humans; Monoamine Oxidase Inhibitors; Risperidone; Selecti

2006
Serotonin syndrome in elderly patients treated for psychotic depression with atypical antipsychotics and antidepressants: two case reports.
    CNS spectrums, 2007, Volume: 12, Issue:8

    Topics: Affective Disorders, Psychotic; Aged; Antidepressive Agents; Antipsychotic Agents; Dibenzothiazepine

2007
Serotonin syndrome during treatment with paroxetine and risperidone.
    Journal of clinical psychopharmacology, 2000, Volume: 20, Issue:1

    Topics: Affective Disorders, Psychotic; Humans; Male; Middle Aged; Paroxetine; Risperidone; Selective Seroto

2000
Risperidone counteracts lethality in an animal model of the serotonin syndrome.
    Psychopharmacology, 2000, Volume: 150, Issue:1

    Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Body Temperature; Clorgyline; Disease Models, A

2000
Comments on "Serotonin syndrome during treatment with paroxetine and risperidone".
    Journal of clinical psychopharmacology, 2001, Volume: 21, Issue:3

    Topics: Humans; Paroxetine; Risperidone; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Ser

2001