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risperidone and Schizotypal Personality Disorder

risperidone has been researched along with Schizotypal Personality Disorder in 13 studies

Risperidone: A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.
risperidone : A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.

Schizotypal Personality Disorder: A personality disorder in which there are oddities of thought (magical thinking, paranoid ideation, suspiciousness), perception (illusions, depersonalization), speech (digressive, vague, overelaborate), and behavior (inappropriate affect in social interactions, frequently social isolation) that are not severe enough to characterize schizophrenia.

Research Excerpts

ExcerptRelevanceReference
"These results suggest that OCD patients with and without comorbid chronic tic disorders or schizotypal personality disorder may respond to the addition of low-dose risperidone to ongoing SRI therapy."9.09A double-blind, placebo-controlled study of risperidone addition in serotonin reuptake inhibitor-refractory obsessive-compulsive disorder. ( Epperson, CN; McDougle, CJ; Pelton, GH; Price, LH; Wasylink, S, 2000)
"These results suggest that OCD patients with and without comorbid chronic tic disorders or schizotypal personality disorder may respond to the addition of low-dose risperidone to ongoing SRI therapy."5.09A double-blind, placebo-controlled study of risperidone addition in serotonin reuptake inhibitor-refractory obsessive-compulsive disorder. ( Epperson, CN; McDougle, CJ; Pelton, GH; Price, LH; Wasylink, S, 2000)
"•We assessed self-monitoring in schizotypal personality disorder (SPD) using ERPs."2.82Neurophysiological evidence of impaired self-monitoring in schizotypal personality disorder and its reversal by dopaminergic antagonism. ( Antonijoan, RM; Corripio, I; Grasa, E; Mañanas, MÀ; Münte, TF; Pérez, V; Rabella, M; Riba, J; Romero, S, 2016)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (53.85)29.6817
2010's6 (46.15)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Schmechtig, A2
Lees, J2
Grayson, L2
Craig, KJ2
Dadhiwala, R2
Dawson, GR2
Deakin, JF2
Dourish, CT2
Koychev, I2
McMullen, K2
Migo, EM1
Perry, C2
Wilkinson, L2
Morris, R1
Williams, SC1
Ettinger, U2
Rabella, M1
Grasa, E1
Corripio, I1
Romero, S1
Mañanas, MÀ1
Antonijoan, RM1
Münte, TF1
Pérez, V1
Riba, J1
Takahashi, T1
Wood, SJ1
Yung, AR1
Soulsby, B1
McGorry, PD1
Suzuki, M1
Kawasaki, Y1
Phillips, LJ2
Velakoulis, D1
Pantelis, C1
Gaebel, W1
Riesbeck, M1
Wölwer, W1
Klimke, A1
Eickhoff, M1
von Wilmsdorff, M1
Lemke, M1
Heuser, I1
Maier, W1
Huff, W1
Schmitt, A1
Sauer, H1
Riedel, M1
Klingberg, S1
Köpcke, W1
Ohmann, C1
Möller, HJ1
Edwards, J1
McMurray, N1
Francey, S1
Walters, J1
Williams, S1
Barkus, E1
Stone, WS1
Hsi, X1
Giuliano, AJ1
Tan, L1
Zhu, S1
Li, L1
Seidman, LJ1
Tsuang, MT1
Weiner, I1
Schiller, D1
Gaisler-Salomon, I1
Koenigsberg, HW1
Reynolds, D1
Goodman, M1
New, AS1
Mitropoulou, V1
Trestman, RL1
Silverman, J1
Siever, LJ1
Rybakowski, JK2
Drózdz, W2
Borkowska, A2
Crespo-Facorro, B1
Pelayo-Terán, JM1
Pérez-Iglesias, R1
Ramírez-Bonilla, M1
Martínez-García, O1
Pardo-García, G1
Vázquez-Barquero, JL1
McDougle, CJ1
Epperson, CN1
Pelton, GH1
Wasylink, S1
Price, LH1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Maintenance Treatment vs. Stepwise Drug Discontinuation After One Year of Maintenance Treatment in First-Episode Schizophrenia[NCT00159120]Phase 471 participants (Anticipated)Interventional2001-11-30Completed
Risk of Breakthrough Symptoms On Antipsychotic Maintenance Medication When Remitted Patients Are Treated With Long-Acting Injectable Medications[NCT05473741]180 participants (Anticipated)Observational2023-01-09Recruiting
Risperidone in the Treatment of Psychotic-like and Deficit Symptoms of Schizotypal Personality Disorder[NCT00158028]25 participants (Actual)Interventional1995-11-30Completed
A D1 Agonist For Working Memory Enhancement In The Schizophrenia Spectrum[NCT02507206]Phase 2120 participants (Actual)Interventional2013-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

10 trials available for risperidone and Schizotypal Personality Disorder

ArticleYear
Effects of risperidone, amisulpride and nicotine on eye movement control and their modulation by schizotypy.
    Psychopharmacology, 2013, Volume: 227, Issue:2

    Topics: Adolescent; Adult; Amisulpride; Antipsychotic Agents; Double-Blind Method; Female; Humans; Male; Nic

2013
Neurophysiological evidence of impaired self-monitoring in schizotypal personality disorder and its reversal by dopaminergic antagonism.
    NeuroImage. Clinical, 2016, Volume: 11

    Topics: Adult; Brain Mapping; Contingent Negative Variation; Cross-Over Studies; Dopamine Antagonists; Doubl

2016
Progressive gray matter reduction of the superior temporal gyrus during transition to psychosis.
    Archives of general psychiatry, 2009, Volume: 66, Issue:4

    Topics: Adolescent; Adult; Antipsychotic Agents; Atrophy; Bipolar Disorder; Cognitive Behavioral Therapy; Co

2009
Relapse prevention in first-episode schizophrenia--maintenance vs intermittent drug treatment with prodrome-based early intervention: results of a randomized controlled trial within the German Research Network on Schizophrenia.
    The Journal of clinical psychiatry, 2011, Volume: 72, Issue:2

    Topics: Acute Disease; Adult; Antipsychotic Agents; Cognitive Behavioral Therapy; Combined Modality Therapy;

2011
Relapse prevention in first-episode schizophrenia--maintenance vs intermittent drug treatment with prodrome-based early intervention: results of a randomized controlled trial within the German Research Network on Schizophrenia.
    The Journal of clinical psychiatry, 2011, Volume: 72, Issue:2

    Topics: Acute Disease; Adult; Antipsychotic Agents; Cognitive Behavioral Therapy; Combined Modality Therapy;

2011
Relapse prevention in first-episode schizophrenia--maintenance vs intermittent drug treatment with prodrome-based early intervention: results of a randomized controlled trial within the German Research Network on Schizophrenia.
    The Journal of clinical psychiatry, 2011, Volume: 72, Issue:2

    Topics: Acute Disease; Adult; Antipsychotic Agents; Cognitive Behavioral Therapy; Combined Modality Therapy;

2011
Relapse prevention in first-episode schizophrenia--maintenance vs intermittent drug treatment with prodrome-based early intervention: results of a randomized controlled trial within the German Research Network on Schizophrenia.
    The Journal of clinical psychiatry, 2011, Volume: 72, Issue:2

    Topics: Acute Disease; Adult; Antipsychotic Agents; Cognitive Behavioral Therapy; Combined Modality Therapy;

2011
Comparison of experiences of stress and coping between young people at risk of psychosis and a non-clinical cohort.
    Behavioural and cognitive psychotherapy, 2012, Volume: 40, Issue:1

    Topics: Adaptation, Psychological; Adolescent; Adult; Antimanic Agents; Antipsychotic Agents; Cognitive Beha

2012
A validation of cognitive biomarkers for the early identification of cognitive enhancing agents in schizotypy: a three-center double-blind placebo-controlled study.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2012, Volume: 22, Issue:7

    Topics: Adult; Amisulpride; Analysis of Variance; Biomarkers; Cognition Disorders; Double-Blind Method; Fema

2012
Are neurocognitive, clinical and social dysfunctions in schizotaxia reversible pharmacologically?: Results from the Changsha study.
    Asian journal of psychiatry, 2012, Volume: 5, Issue:1

    Topics: Adolescent; Adult; Antipsychotic Agents; China; Cluster Analysis; Cognitive Dysfunction; Double-Blin

2012
Risperidone in the treatment of schizotypal personality disorder.
    The Journal of clinical psychiatry, 2003, Volume: 64, Issue:6

    Topics: Adolescent; Adult; Antipsychotic Agents; Comorbidity; Double-Blind Method; Drug Administration Sched

2003
Risperidone in the treatment of schizotypal personality disorder.
    The Journal of clinical psychiatry, 2003, Volume: 64, Issue:6

    Topics: Adolescent; Adult; Antipsychotic Agents; Comorbidity; Double-Blind Method; Drug Administration Sched

2003
Risperidone in the treatment of schizotypal personality disorder.
    The Journal of clinical psychiatry, 2003, Volume: 64, Issue:6

    Topics: Adolescent; Adult; Antipsychotic Agents; Comorbidity; Double-Blind Method; Drug Administration Sched

2003
Risperidone in the treatment of schizotypal personality disorder.
    The Journal of clinical psychiatry, 2003, Volume: 64, Issue:6

    Topics: Adolescent; Adult; Antipsychotic Agents; Comorbidity; Double-Blind Method; Drug Administration Sched

2003
Predictors of acute treatment response in patients with a first episode of non-affective psychosis: sociodemographics, premorbid and clinical variables.
    Journal of psychiatric research, 2007, Volume: 41, Issue:8

    Topics: Acute Disease; Adolescent; Adult; Age Factors; Antipsychotic Agents; Benzodiazepines; Comorbidity; F

2007
A double-blind, placebo-controlled study of risperidone addition in serotonin reuptake inhibitor-refractory obsessive-compulsive disorder.
    Archives of general psychiatry, 2000, Volume: 57, Issue:8

    Topics: Adult; Antipsychotic Agents; Comorbidity; Dopamine Antagonists; Double-Blind Method; Drug Administra

2000

Other Studies

3 other studies available for risperidone and Schizotypal Personality Disorder

ArticleYear
Disruption and potentiation of latent inhibition by risperidone: the latent inhibition model of atypical antipsychotic action.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:3

    Topics: Animals; Antipsychotic Agents; Conditioning, Psychological; Inhibition, Psychological; Male; Rats; R

2003
Low dose risperidone in the treatment of schizophrenia-like symptoms in high-risk subjects.
    Journal of clinical psychopharmacology, 2003, Volume: 23, Issue:6

    Topics: Adolescent; Adult; Antipsychotic Agents; Dose-Response Relationship, Drug; Female; Humans; Male; Ris

2003
Long-term administration of the low-dose risperidone in schizotaxia subjects.
    Human psychopharmacology, 2007, Volume: 22, Issue:6

    Topics: Adolescent; Adult; Antipsychotic Agents; Cognition Disorders; Drug Administration Schedule; Eye Move

2007