Page last updated: 2024-11-03

risperidone and Neuroblastoma

risperidone has been researched along with Neuroblastoma in 4 studies

Risperidone: A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.
risperidone : A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.

Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Research Excerpts

ExcerptRelevanceReference
" In this study, the effects of risperidone on the insulin-induced protein kinase B (PKB) phosphorylation and leptin-stimulated signal transducer and activator of transcription 3 (STAT3) phosphorylation were investigated in the human SH-SY5Y neuroblastoma cell line."7.80SOCS3 and SOCS6 are required for the risperidone-mediated inhibition of insulin and leptin signaling in neuroblastoma cells. ( Hur, GM; Kim, JL; Kong, G; Li, Y; Park, J; Piao, L; Shin, S; Shrestha, R; Tran, Q, 2014)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (50.00)18.2507
2000's0 (0.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Piao, L1
Park, J2
Li, Y1
Shin, S2
Kong, G1
Shrestha, R1
Tran, Q1
Hur, GM1
Kim, JL1
Gassó, P1
Mas, S1
Molina, O1
Bernardo, M1
Lafuente, A1
Parellada, E1
Griffon, N1
Pilon, C1
Sautel, F1
Schwartz, JC1
Sokoloff, P1
Volonté, M1
Monferini, E1
Cerutti, M1
Fodritto, F1
Borsini, F1

Other Studies

4 other studies available for risperidone and Neuroblastoma

ArticleYear
SOCS3 and SOCS6 are required for the risperidone-mediated inhibition of insulin and leptin signaling in neuroblastoma cells.
    International journal of molecular medicine, 2014, Volume: 33, Issue:5

    Topics: Cell Line, Tumor; Humans; Insulin; Leptin; Neuroblastoma; Phosphorylation; Risperidone; Signal Trans

2014
Neurotoxic/neuroprotective activity of haloperidol, risperidone and paliperidone in neuroblastoma cells.
    Progress in neuro-psychopharmacology & biological psychiatry, 2012, Jan-10, Volume: 36, Issue:1

    Topics: Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Haloperidol; Huma

2012
Antipsychotics with inverse agonist activity at the dopamine D3 receptor.
    Journal of neural transmission (Vienna, Austria : 1996), 1996, Volume: 103, Issue:10

    Topics: Animals; Antipsychotic Agents; Calcium; CHO Cells; Clozapine; Colforsin; Cricetinae; Cyclic AMP; DNA

1996
BIMG 80, a novel potential antipsychotic drug: evidence for multireceptor actions and preferential release of dopamine in prefrontal cortex.
    Journal of neurochemistry, 1997, Volume: 69, Issue:1

    Topics: Animals; Antipsychotic Agents; Benzodiazepines; CHO Cells; Clozapine; Corpus Striatum; COS Cells; Cr

1997