risperidone has been researched along with Long QT Syndrome in 29 studies
Risperidone: A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.
risperidone : A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Results of these analyses suggest that olanzapine, as therapeutically administered to patients with schizophrenia and related psychoses, does not contribute to QTc prolongation resulting in potentially fatal ventricular arrhythmias." | 9.09 | Analysis of the QTc interval during olanzapine treatment of patients with schizophrenia and related psychosis. ( Beasley, CM; Berg, PH; Czekalla, J; Dellva, MA; Grundy, S, 2001) |
| "We examined sex differences in the effect of olanzapine (OLZ), risperidone (RIS), aripiprazole (ARP), or quetiapine (QTP) on mean corrected QT (QTc) intervals among 222 patients with schizophrenia." | 5.17 | Sex differences in the effect of four second-generation antipsychotics on QTc interval in patients with schizophrenia. ( Fukui, N; Ono, S; Saito, M; Someya, T; Sugai, T; Suzuki, Y; Tsuneyama, N; Watanabe, J, 2013) |
| " Sixty-six patients with a diagnosis of schizophrenia that were treated with risperidone or olanzapine and 40 healthy volunteers were enrolled." | 5.16 | Increased risk of antipsychotic-related QT prolongation during nighttime: a 24-hour holter electrocardiogram recording study. ( Fukui, N; Ono, S; Someya, T; Sugai, T; Suzuki, Y; Tsuneyama, N; Watanabe, J, 2012) |
| "Results of these analyses suggest that olanzapine, as therapeutically administered to patients with schizophrenia and related psychoses, does not contribute to QTc prolongation resulting in potentially fatal ventricular arrhythmias." | 5.09 | Analysis of the QTc interval during olanzapine treatment of patients with schizophrenia and related psychosis. ( Beasley, CM; Berg, PH; Czekalla, J; Dellva, MA; Grundy, S, 2001) |
| "Risperidone is an antipsychotic medication suspected of causing QT prolongation and several cases are reported in this regard." | 2.77 | Risperidone and corrected QT-interval prolongation in surface electrocardiogram. ( Abbasnejhad, M; Ahmadi, NM; Akbarzadeh, F; Ranjbar, F, 2012) |
| "The present study evaluated associations between risperidone metabolism and QT interval in 61 psychiatric patients who had been receiving risperidone for ≥4 weeks at an average dosage of 4." | 2.77 | QT prolongation of the antipsychotic risperidone is predominantly related to its 9-hydroxy metabolite paliperidone. ( Fukui, N; Inoue, Y; Ono, S; Saito, M; Someya, T; Sugai, T; Suzuki, Y; Tsuneyama, N; Watanabe, J, 2012) |
| "Risperidone is an atypical antipsychotic drug with combined dopamine-2/serotonin-2 (D(2)/5-HT(2)) antagonist activity that has been effective in reducing cocaine use in some animal studies." | 2.73 | A randomized, double-blind, placebo-controlled trial of long-acting risperidone in cocaine-dependent men. ( Angarita, GA; Culhane, MA; Evins, AE; Huang, KL; Lee, SH; Loebl, T; Logvinenko, T; Nino, J; Pachas, GN, 2008) |
| "Risperidone has been shown to inhibit the delayed rectifier leading to lengthening of cardiac repolarization." | 1.32 | QTc interval, CYP2D6 and CYP2C9 genotypes and risperidone plasma concentrations. ( Berecz, R; de la Rubia, A; Dorado, P; Llerena, A, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 17 (58.62) | 29.6817 |
| 2010's | 11 (37.93) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Kongsamut, S | 1 |
| Kang, J | 1 |
| Chen, XL | 1 |
| Roehr, J | 1 |
| Rampe, D | 1 |
| Cavalli, A | 1 |
| Poluzzi, E | 1 |
| De Ponti, F | 1 |
| Recanatini, M | 1 |
| Arditti, R | 1 |
| Mongin, Y | 1 |
| Drancourt, N | 1 |
| Hotier, S | 1 |
| Laguerre, A | 1 |
| Hamdani, N | 1 |
| Suzuki, Y | 3 |
| Sugai, T | 3 |
| Fukui, N | 3 |
| Watanabe, J | 3 |
| Ono, S | 3 |
| Tsuneyama, N | 3 |
| Saito, M | 2 |
| Someya, T | 3 |
| Vieweg, WV | 1 |
| Hasnain, M | 1 |
| Hancox, JC | 1 |
| Baranchuk, A | 1 |
| Digby, GC | 1 |
| Kogut, C | 1 |
| Crouse, EL | 1 |
| Koneru, JN | 1 |
| Deshmukh, A | 1 |
| Pandurangi, AK | 1 |
| Ranjbar, F | 1 |
| Akbarzadeh, F | 1 |
| Ahmadi, NM | 1 |
| Abbasnejhad, M | 1 |
| Mizuki, Y | 1 |
| Takaki, M | 1 |
| Alda, JA | 1 |
| Muñoz-Samons, D | 1 |
| Tor, J | 1 |
| Merchán-Naranjo, J | 2 |
| Tapia-Casellas, C | 1 |
| Baeza, I | 1 |
| Calvo-Escalona, R | 1 |
| Castro-Fornieles, J | 1 |
| Martínez-Cantarero, C | 1 |
| Andrés-Nestares, P | 1 |
| Fernández-Avilés, F | 1 |
| Arango, C | 2 |
| Brahmbhatt, K | 1 |
| Whitgob, E | 1 |
| Önen, Ö | 1 |
| Kutlu, A | 1 |
| Erkuran, HÖ | 1 |
| Zink, M | 1 |
| Kuwilsky, A | 1 |
| Krumm, B | 1 |
| Dressing, H | 1 |
| de Castro, MJ | 1 |
| Fraguas, D | 1 |
| Laita, P | 1 |
| Moreno, D | 1 |
| Parellada, M | 1 |
| Pascual, D | 1 |
| Alvarez, M | 1 |
| Rapado, M | 1 |
| Giráldez, M | 1 |
| Leiva, M | 1 |
| Inoue, Y | 1 |
| Said, TH | 1 |
| Wilson, LD | 1 |
| Jeyaraj, D | 1 |
| Fossa, AA | 1 |
| Rosenbaum, DS | 1 |
| Lazarczyk, MJ | 1 |
| Bhuiyan, ZA | 1 |
| Perrin, N | 1 |
| Giannakopoulos, P | 1 |
| Timell, AM | 1 |
| Harrigan, EP | 1 |
| Miceli, JJ | 1 |
| Anziano, R | 1 |
| Watsky, E | 1 |
| Reeves, KR | 1 |
| Cutler, NR | 1 |
| Sramek, J | 1 |
| Shiovitz, T | 1 |
| Middle, M | 1 |
| Llerena, A | 1 |
| Berecz, R | 1 |
| Dorado, P | 1 |
| de la Rubia, A | 1 |
| Raviña, T | 2 |
| Gutierrez, J | 2 |
| Raviña, P | 2 |
| Huang, CL | 1 |
| Su, KP | 1 |
| Hsu, HB | 1 |
| Pariante, CM | 1 |
| Katagai, H | 1 |
| Yasui-Furukori, N | 1 |
| Kikuchi, A | 1 |
| Kaneko, S | 1 |
| Blaschke, D | 1 |
| Parwani, AS | 1 |
| Huemer, M | 1 |
| Rolf, S | 1 |
| Boldt, LH | 1 |
| Dietz, R | 1 |
| Haverkamp, W | 1 |
| Loebl, T | 1 |
| Angarita, GA | 1 |
| Pachas, GN | 1 |
| Huang, KL | 1 |
| Lee, SH | 1 |
| Nino, J | 1 |
| Logvinenko, T | 1 |
| Culhane, MA | 1 |
| Evins, AE | 1 |
| Czekalla, J | 1 |
| Beasley, CM | 1 |
| Dellva, MA | 1 |
| Berg, PH | 1 |
| Grundy, S | 1 |
| Beelen, AP | 1 |
| Yeo, KT | 1 |
| Lewis, LD | 1 |
| Wilton, LV | 1 |
| Heeley, EL | 1 |
| Pickering, RM | 1 |
| Shakir, SA | 1 |
| Taylor, DM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-Blind, Placebo-Controlled Study of the Effects of Risperdal Consta on Brain Reward Circuitry, Craving and Cocaine Use in Active Cocaine Dependence[NCT00385801] | Phase 2 | 31 participants (Actual) | Interventional | 2005-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The University of Minnesota Cocaine Craving Scale was performed to assess cocaine craving. The scale contains 1 continuous scale for intensity and 2 categorical scales for frequency and duration of craving episodes. The continuous scale for craving intensity ranges from 0 (no craving at all in the past week) to 10 (a great deal of craving in the past week) (NCT00385801)
Timeframe: 12 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | NA |
| Risperidone | NA |
After randomization, participants provided urine samples every week for the first 3 weeks and then every 2 weeks for 8 weeks, up to 7 samples per participant. The average visits with cocaine negative urine samples per participant are reported below (NCT00385801)
Timeframe: 12 weeks
| Intervention | visit with negative UBE (Mean) |
|---|---|
| Placebo | 1.81 |
| Risperidone Consta | 0.87 |
2 reviews available for risperidone and Long QT Syndrome
| Article | Year |
|---|---|
Risperidone, QTc interval prolongation, and torsade de pointes: a systematic review of case reports.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Child; Dose-Response Relationship, Drug; Female; Huma | 2013 |
Diagnosis and Management of Delirium in Critically Ill Infants: Case Report and Review.
Topics: Abnormalities, Multiple; Antipsychotic Agents; Critical Illness; Delirium; Humans; Infant; Long QT S | 2016 |
10 trials available for risperidone and Long QT Syndrome
| Article | Year |
|---|---|
Sex differences in the effect of four second-generation antipsychotics on QTc interval in patients with schizophrenia.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Dibenzothiazepines; El | 2013 |
Risperidone and corrected QT-interval prolongation in surface electrocardiogram.
Topics: Adult; Antipsychotic Agents; Cohort Studies; Female; Humans; Iran; Long QT Syndrome; Male; Middle Ag | 2012 |
Absence of Change in Corrected QT Interval in Children and Adolescents Receiving Antipsychotic Treatment: A 12 Month Study.
Topics: Adolescent; Antipsychotic Agents; Benzodiazepines; Biomarkers, Pharmacological; Child; Child, Presch | 2016 |
Efficacy and tolerability of ziprasidone versus risperidone as augmentation in patients partially responsive to clozapine: a randomised controlled clinical trial.
Topics: Adolescent; Adult; Antipsychotic Agents; Clozapine; Drug Therapy, Combination; Female; Humans; Long | 2009 |
QT prolongation of the antipsychotic risperidone is predominantly related to its 9-hydroxy metabolite paliperidone.
Topics: Adult; Age Factors; Antipsychotic Agents; Dose-Response Relationship, Drug; Electrocardiography; Fem | 2012 |
Increased risk of antipsychotic-related QT prolongation during nighttime: a 24-hour holter electrocardiogram recording study.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Circadian Rhythm; Death, Sudden, Cardiac; Electrocardi | 2012 |
A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition.
Topics: Adolescent; Adult; Antipsychotic Agents; Aryl Hydrocarbon Hydroxylases; Benzodiazepines; Biotransfor | 2004 |
A pilot observational crossover study of QTc interval changes associated with switching between olanzapine and risperidone.
Topics: Adult; Benzodiazepines; Cross-Over Studies; Electrocardiography; Female; Humans; Long QT Syndrome; M | 2007 |
A randomized, double-blind, placebo-controlled trial of long-acting risperidone in cocaine-dependent men.
Topics: Adult; Antipsychotic Agents; Cocaine-Related Disorders; Delayed-Action Preparations; Depressive Diso | 2008 |
Analysis of the QTc interval during olanzapine treatment of patients with schizophrenia and related psychosis.
Topics: Acute Disease; Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Antipsychotic Agent | 2001 |
17 other studies available for risperidone and Long QT Syndrome
| Article | Year |
|---|---|
A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Cation Transport Proteins; Cell Line; Clinical Trials as Topic; Crice | 2002 |
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go- | 2002 |
[Hypothermia due to antipsychotic drug: A case report].
Topics: Adult; Antipsychotic Agents; Consciousness Disorders; Drug Substitution; Female; Haloperidol; Humans | 2020 |
Blonanserin ameliorated the tendency toward QTc prolongation associated with risperidone in a patient with schizophrenia.
Topics: Adult; Antipsychotic Agents; Female; Humans; Long QT Syndrome; Piperazines; Piperidines; Risperidone | 2015 |
Treating an Adolescent with Long QT Syndrome for Bipolar Disorder: A Case Presentation.
Topics: Adolescent; Bipolar Disorder; Female; Humans; Long QT Syndrome; Lorazepam; Risperidone; Valproic Aci | 2017 |
QTc changes after 6 months of second-generation antipsychotic treatment in children and adolescents.
Topics: Adolescent; Antipsychotic Agents; Benzodiazepines; Child; Child, Preschool; Dibenzothiazepines; Elec | 2008 |
Transmural dispersion of repolarization as a preclinical marker of drug-induced proarrhythmia.
Topics: Action Potentials; Animals; Bepridil; Dogs; Dose-Response Relationship, Drug; Electrocardiography; E | 2012 |
Selective acquired long QT syndrome (saLQTS) upon risperidone treatment.
Topics: Adult; Antipsychotic Agents; Clozapine; Electrocardiography; Female; Humans; Long QT Syndrome; Potas | 2012 |
Re: Thioridazine: re-evaluating the risk/benefit equation.
Topics: Antipsychotic Agents; Data Collection; Death, Sudden; Electrocardiography; Female; Humans; Long QT S | 2003 |
QTc interval, CYP2D6 and CYP2C9 genotypes and risperidone plasma concentrations.
Topics: Administration, Oral; Adult; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-45 | 2004 |
Acquired long QT syndrome: long-term electrocardiographic (Holter) recording of torsades de pointes ending in asystole: II.
Topics: Aged; Electrocardiography, Ambulatory; Female; Heart Arrest; Humans; Long QT Syndrome; Risperidone; | 2007 |
Acquired long QT syndrome: risperidone-facilitated triggered activity and Torsades de Pointes during complete AV block. I.
Topics: Aged, 80 and over; Antipsychotic Agents; Electrocardiography; Fatal Outcome; Female; Heart Block; Hu | 2007 |
Effective electroconvulsive therapy in a 92-year-old dementia patient with psychotic feature.
Topics: Aged, 80 and over; Antipsychotic Agents; Combined Modality Therapy; Dementia, Multi-Infarct; Electro | 2007 |
Torsade de pointes during combined treatment with risperidone and citalopram.
Topics: Aged; Antipsychotic Agents; Citalopram; Drug Therapy, Combination; Electrocardiography, Ambulatory; | 2007 |
Asymptomatic QTc prolongation associated with quetiapine fumarate overdose in a patient being treated with risperidone.
Topics: Adult; Antipsychotic Agents; Dibenzothiazepines; Female; Follow-Up Studies; Humans; Long QT Syndrome | 2001 |
Comparative study of mortality rates and cardiac dysrhythmias in post-marketing surveillance studies of sertindole and two other atypical antipsychotic drugs, risperidone and olanzapine.
Topics: Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Arrhythmias, Cardiac; Benzodiazepines; Cohort | 2001 |
Prolongation of QTc interval and antipsychotics.
Topics: Antipsychotic Agents; Death, Sudden, Cardiac; Drug Administration Schedule; Drug Labeling; Drug Moni | 2002 |