Page last updated: 2024-11-03

risperidone and Lesch-Nyhan Syndrome

risperidone has been researched along with Lesch-Nyhan Syndrome in 3 studies

Risperidone: A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.
risperidone : A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.

Lesch-Nyhan Syndrome: An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (66.67)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Allen, SM2
Rice, SN1
Freeman, JN1
Davis, WM1
Saito, Y1
Yamashita, S1
Kaneko, K1
Kimura, S1
Osawa, M1

Other Studies

3 other studies available for risperidone and Lesch-Nyhan Syndrome

ArticleYear
Risperidone antagonism of self-mutilation in a Lesch-Nyhan patient.
    Progress in neuro-psychopharmacology & biological psychiatry, 1996, Volume: 20, Issue:5

    Topics: Adult; Dopamine Antagonists; Humans; Lesch-Nyhan Syndrome; Male; Risperidone; Self Mutilation

1996
Evaluation of risperidone in the neonatal 6-hydroxydopamine model of Lesch-Nyhan syndrome.
    Pharmacology, biochemistry, and behavior, 1998, Volume: 59, Issue:2

    Topics: Animals; Animals, Newborn; Behavior, Animal; Benzazepines; Disease Models, Animal; Dopamine Agents;

1998
[The effect of risperidone on the self-mutilation of Lesch-Nyhan syndrome].
    No to hattatsu = Brain and development, 2001, Volume: 33, Issue:3

    Topics: Child; Dopamine Antagonists; Humans; Lesch-Nyhan Syndrome; Male; Risperidone; Self Mutilation

2001