Page last updated: 2024-11-03

risperidone and Hypertension

risperidone has been researched along with Hypertension in 7 studies

Risperidone: A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.
risperidone : A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.

Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Research Excerpts

ExcerptRelevanceReference
"Experiment 1: Wistar-Kyoto (WKY) rats, spontaneously hypertensive rats (SHRs) and stroke-prone SHRs (SHR-SPs) were treated with risperidone (0."7.78Risperidone enhances the vulnerability to stroke in hypertensive rats. ( Godfraind, T; Liu, C; Song, SW; Su, BL; Su, DF; Sun, Y; Yang, C, 2012)
"Risperidone has a relatively low risk of causing obesity and diabetes mellitus and is a first-line treatment for schizophrenia."7.74Glucose and lipid metabolism of long-term risperidone monotherapy in patients with schizophrenia. ( Hosoda, H; Inoue, T; Itoh, K; Izumi, T; Kangawa, K; Koyama, T; Kusumi, I; Murashita, M; Nakagawa, S; Tanaka, T, 2007)
"Our data show a potential pharmacokinetic interaction, most likely via CYP3A4 between amlodipine and RIS, reflected in significantly different C/Ds for RIS, 9-OH-RIS and AM."5.43Pharmacokinetic considerations in the treatment of hypertension in risperidone-medicated patients - thinking of clinically relevant CYP2D6 interactions. ( Gründer, G; Haen, E; Lammertz, SE; Paulzen, M; Schoretsanitis, G; Schruers, KR; Stegmann, B; Walther, S, 2016)
"Posterior reversible cerebral edema syndrome is a generally reversible neurologic condition that is diagnosed based on distinctive clinical and radiologic findings."5.40Arterial hypertension and posterior reversible cerebral edema syndrome induced by risperidone. ( Agostoni, C; Bianchetti, MG; Fossali, EF; Mauri, MC; Mazzoni, MB; Milani, GP; Triulzi, F, 2014)
"Experiment 1: Wistar-Kyoto (WKY) rats, spontaneously hypertensive rats (SHRs) and stroke-prone SHRs (SHR-SPs) were treated with risperidone (0."3.78Risperidone enhances the vulnerability to stroke in hypertensive rats. ( Godfraind, T; Liu, C; Song, SW; Su, BL; Su, DF; Sun, Y; Yang, C, 2012)
"Risperidone has a relatively low risk of causing obesity and diabetes mellitus and is a first-line treatment for schizophrenia."3.74Glucose and lipid metabolism of long-term risperidone monotherapy in patients with schizophrenia. ( Hosoda, H; Inoue, T; Itoh, K; Izumi, T; Kangawa, K; Koyama, T; Kusumi, I; Murashita, M; Nakagawa, S; Tanaka, T, 2007)
"Our data show a potential pharmacokinetic interaction, most likely via CYP3A4 between amlodipine and RIS, reflected in significantly different C/Ds for RIS, 9-OH-RIS and AM."1.43Pharmacokinetic considerations in the treatment of hypertension in risperidone-medicated patients - thinking of clinically relevant CYP2D6 interactions. ( Gründer, G; Haen, E; Lammertz, SE; Paulzen, M; Schoretsanitis, G; Schruers, KR; Stegmann, B; Walther, S, 2016)
"Data for 60,162 subjects with type 1 diabetes up to the age of 25 years registered in the nationwide German/Austrian Diabetes Survey were included in the analysis."1.42Comparison of glycemic and metabolic control in youth with type 1 diabetes with and without antipsychotic medication: analysis from the nationwide German/Austrian Diabetes Survey (DPV). ( Bartus, B; Bollow, E; Galler, A; Haberland, H; Holl, RW; Meusers, M; Näke, A; Schober, E, 2015)
"Posterior reversible cerebral edema syndrome is a generally reversible neurologic condition that is diagnosed based on distinctive clinical and radiologic findings."1.40Arterial hypertension and posterior reversible cerebral edema syndrome induced by risperidone. ( Agostoni, C; Bianchetti, MG; Fossali, EF; Mauri, MC; Mazzoni, MB; Milani, GP; Triulzi, F, 2014)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (28.57)29.6817
2010's5 (71.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Milani, GP1
Bianchetti, MG1
Mazzoni, MB1
Triulzi, F1
Mauri, MC1
Agostoni, C1
Fossali, EF1
Godman, B1
Petzold, M1
Bennett, K1
Bennie, M1
Bucsics, A1
Finlayson, AE1
Martin, A1
Persson, M1
Piessnegger, J1
Raschi, E1
Simoens, S1
Zara, C1
Barbui, C1
Galler, A1
Bollow, E1
Meusers, M1
Bartus, B1
Näke, A1
Haberland, H1
Schober, E1
Holl, RW1
Paulzen, M1
Haen, E1
Gründer, G1
Lammertz, SE1
Stegmann, B1
Schruers, KR1
Walther, S1
Schoretsanitis, G1
Clark, D1
Skrobot, OA1
Adebiyi, I1
Susce, MT1
de Leon, J1
Blakemore, AF1
Arranz, MJ1
Song, SW1
Sun, Y1
Su, BL1
Liu, C1
Yang, C1
Godfraind, T1
Su, DF1
Murashita, M1
Inoue, T1
Kusumi, I1
Nakagawa, S1
Itoh, K1
Tanaka, T1
Izumi, T1
Hosoda, H1
Kangawa, K1
Koyama, T1

Other Studies

7 other studies available for risperidone and Hypertension

ArticleYear
Arterial hypertension and posterior reversible cerebral edema syndrome induced by risperidone.
    Pediatrics, 2014, Volume: 133, Issue:3

    Topics: Antipsychotic Agents; Brain Edema; Child; Female; Humans; Hypertension; Risperidone

2014
Can authorities appreciably enhance the prescribing of oral generic risperidone to conserve resources? Findings from across Europe and their implications.
    BMC medicine, 2014, Jun-13, Volume: 12

    Topics: Adult; Antipsychotic Agents; Drug Prescriptions; Drugs, Generic; Europe; Health Resources; Humans; H

2014
Comparison of glycemic and metabolic control in youth with type 1 diabetes with and without antipsychotic medication: analysis from the nationwide German/Austrian Diabetes Survey (DPV).
    Diabetes care, 2015, Volume: 38, Issue:6

    Topics: Adolescent; Adult; Albuminuria; Antipsychotic Agents; Blood Glucose; Body Mass Index; Diabetes Compl

2015
Pharmacokinetic considerations in the treatment of hypertension in risperidone-medicated patients - thinking of clinically relevant CYP2D6 interactions.
    Journal of psychopharmacology (Oxford, England), 2016, Volume: 30, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Antipsychotic Agent

2016
Apolipoprotein-E gene variants associated with cardiovascular risk factors in antipsychotic recipients.
    European psychiatry : the journal of the Association of European Psychiatrists, 2009, Volume: 24, Issue:7

    Topics: Alleles; Antipsychotic Agents; Apolipoproteins E; Body Mass Index; Cardiovascular Diseases; Diabetes

2009
Risperidone enhances the vulnerability to stroke in hypertensive rats.
    CNS neuroscience & therapeutics, 2012, Volume: 18, Issue:4

    Topics: Animals; Apoptosis; Cells, Cultured; Hypertension; Neurons; Rats; Rats, Inbred SHR; Rats, Inbred WKY

2012
Glucose and lipid metabolism of long-term risperidone monotherapy in patients with schizophrenia.
    Psychiatry and clinical neurosciences, 2007, Volume: 61, Issue:1

    Topics: Adiponectin; Adult; Antipsychotic Agents; Body Composition; Body Mass Index; Cholesterol, HDL; Femal

2007