Page last updated: 2024-11-03

risperidone and Hyperactivity, Motor

risperidone has been researched along with Hyperactivity, Motor in 19 studies

Risperidone: A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.
risperidone : A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.

Research Excerpts

ExcerptRelevanceReference
"Ninety-two patients with early stage schizophrenia treated with risperidone entered this 16-week, double blind, randomized, placebo-controlled clinical trial."9.19Minocycline supplementation for treatment of negative symptoms in early-phase schizophrenia: a double blind, randomized, controlled trial. ( Guo, X; Liu, F; Ou, J; Ruan, Y; Wu, R; Xie, L; Xu, X; Yang, J; Yang, L; Yang, S; Zeng, Y; Zhang, B; Zhang, L; Zhao, J; Zheng, Y, 2014)
"Several clinical reports have suggested that the mirtazapine-induced augmentation of risperidone activity may effectively improve the positive, negative and some cognitive symptoms of schizophrenia."7.78Effect of co-treatment with mirtazapine and risperidone in animal models of the positive symptoms of schizophrenia in mice. ( Rogóż, Z, 2012)
"Ninety-two patients with early stage schizophrenia treated with risperidone entered this 16-week, double blind, randomized, placebo-controlled clinical trial."5.19Minocycline supplementation for treatment of negative symptoms in early-phase schizophrenia: a double blind, randomized, controlled trial. ( Guo, X; Liu, F; Ou, J; Ruan, Y; Wu, R; Xie, L; Xu, X; Yang, J; Yang, L; Yang, S; Zeng, Y; Zhang, B; Zhang, L; Zhao, J; Zheng, Y, 2014)
"Several clinical reports have suggested that the mirtazapine-induced augmentation of risperidone activity may effectively improve the positive, negative and some cognitive symptoms of schizophrenia."3.78Effect of co-treatment with mirtazapine and risperidone in animal models of the positive symptoms of schizophrenia in mice. ( Rogóż, Z, 2012)
"Risperidone is an antipsychotic drug approved for use in children, but little is known about the long-term effects of early-life risperidone treatment."1.39Adult rats treated with risperidone during development are hyperactive. ( Bardgett, ME; Colemire, KR; Franks-Henry, JM; Griffith, MS; Juneau, KR; Marczinski, CA; Stevens, RM, 2013)
" Pharmacokinetic study showed that PDs were quickly metabolized to paliperidone to take effect in the treatment of schizophrenia in rats after i."1.36Studies on the acute toxicity, pharmacokinetics and pharmacodynamics of paliperidone derivatives--comparison to paliperidone and risperidone in mice and rats. ( Li, Y; Meng, Q; Su, Z; Sui, C; Sun, F; Teng, L; Yuan, L; Zhang, C, 2010)
" While typical antipsychotics are often switched to atypical agents when adverse effects become limiting, there is little preclinical information to support this strategy, both in terms of efficacy and side effects."1.32Combined treatment of quetiapine with haloperidol in animal models of antipsychotic effect and extrapyramidal side effects: comparison with risperidone and chlorpromazine. ( Matsuoka, N; Mutoh, S; Shirakawa, K; Tada, M, 2004)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.26)18.2507
2000's6 (31.58)29.6817
2010's12 (63.16)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rogóż, Z1
Bardgett, ME3
Franks-Henry, JM1
Colemire, KR1
Juneau, KR1
Stevens, RM2
Marczinski, CA1
Griffith, MS2
Gao, J2
Li, M2
Qiao, J1
Shu, Q1
Zhang, Q1
Hu, G1
Liu, F1
Guo, X1
Wu, R1
Ou, J1
Zheng, Y1
Zhang, B1
Xie, L1
Zhang, L1
Yang, L1
Yang, S1
Yang, J1
Ruan, Y1
Zeng, Y1
Xu, X1
Zhao, J1
Connolly, JG1
Toomey, TJ1
Schneeweiss, MC1
Gannon, MA1
van der Staay, FJ1
Pouzet, B1
Mahieu, M1
Nordquist, RE1
Schuurman, T1
Marchese, G1
Casu, G1
Casti, P1
Spada, GP1
Pani, L1
Hidaka, N1
Suemaru, K1
Araki, H1
Sun, F1
Su, Z1
Sui, C1
Zhang, C1
Yuan, L1
Meng, Q1
Teng, L1
Li, Y1
Celikyurt, IK1
Kayir, H1
Ulak, G1
Erden, FB1
Ulusoy, GK1
Uzbay, TI1
Budisteanu, M1
Papuc, SM1
Tutulan-Cunita, A1
Budisteanu, B1
Arghir, A1
Kovacs, N1
Balas, I1
Janszky, J1
Simon, M1
Fekete, S1
Komoly, S1
Tada, M1
Shirakawa, K1
Matsuoka, N1
Mutoh, S1
Hartfield, AW1
Moore, NA1
Clifton, PG1
Baum, KT1
O'Connell, SM1
Lee, NM1
Hon, JC1
Demb, HB1
Stalman, SL1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Double-Blind,Randomized Study of Minocycline for the Treatment of Negative and Cognitive Symptoms in Schizophrenia[NCT01493622]Phase 478 participants (Actual)Interventional2010-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for risperidone and Hyperactivity, Motor

ArticleYear
Minocycline supplementation for treatment of negative symptoms in early-phase schizophrenia: a double blind, randomized, controlled trial.
    Schizophrenia research, 2014, Volume: 153, Issue:1-3

    Topics: Adult; Analysis of Variance; Antipsychotic Agents; Cognition Disorders; Double-Blind Method; Female;

2014

Other Studies

18 other studies available for risperidone and Hyperactivity, Motor

ArticleYear
Effect of co-treatment with mirtazapine and risperidone in animal models of the positive symptoms of schizophrenia in mice.
    Pharmacological reports : PR, 2012, Volume: 64, Issue:6

    Topics: Amphetamines; Animals; Antipsychotic Agents; Behavior, Animal; Dextroamphetamine; Disease Models, An

2012
Adult rats treated with risperidone during development are hyperactive.
    Experimental and clinical psychopharmacology, 2013, Volume: 21, Issue:3

    Topics: Animals; Antipsychotic Agents; Female; Hyperkinesis; Learning; Male; Rats; Rats, Long-Evans; Risperi

2013
Time-dependence of risperidone and asenapine sensitization and associated D2 receptor mechanism.
    Behavioural brain research, 2013, Nov-15, Volume: 257

    Topics: Analysis of Variance; Animals; Antipsychotic Agents; Avoidance Learning; Dibenzocycloheptenes; Dopam

2013
Long-lasting sensitization induced by repeated risperidone treatment in adolescent Sprague-Dawley rats: a possible D2 receptor mediated phenomenon?
    Psychopharmacology, 2014, Volume: 231, Issue:8

    Topics: Aging; Animals; Antipsychotic Agents; Avoidance Learning; Conditioning, Psychological; Dopamine Agon

2014
Metabolic monitoring for youths initiating use of second-generation antipsychotics, 2003-2011.
    Psychiatric services (Washington, D.C.), 2015, Volume: 66, Issue:6

    Topics: Adolescent; Affective Disorders, Psychotic; Antipsychotic Agents; Anxiety Disorders; Aripiprazole; B

2015
Delayed yet persistent effects of daily risperidone on activity in developing rats.
    Behavioural pharmacology, 2016, Volume: 27, Issue:5

    Topics: Age Factors; Animals; Antipsychotic Agents; Dose-Response Relationship, Drug; Drug Administration Sc

2016
The d-amphetamine-treated Göttingen miniature pig: an animal model for assessing behavioral effects of antipsychotics.
    Psychopharmacology, 2009, Volume: 206, Issue:4

    Topics: Animals; Antipsychotic Agents; Dextroamphetamine; Disease Models, Animal; Dose-Response Relationship

2009
Evaluation of amphetamine-induced hyperlocomotion and catalepsy following long-acting risperidone administration in rats.
    European journal of pharmacology, 2009, Oct-12, Volume: 620, Issue:1-3

    Topics: Amphetamine; Animals; Antipsychotic Agents; Behavior, Animal; Catalepsy; Chemistry, Pharmaceutical;

2009
Serotonin-dopamine antagonism ameliorates impairments of spontaneous alternation and locomotor hyperactivity induced by repeated electroconvulsive seizures in rats.
    Epilepsy research, 2010, Volume: 90, Issue:3

    Topics: Analysis of Variance; Animals; Behavior, Animal; Dopamine Antagonists; Electroshock; Haloperidol; Hy

2010
Studies on the acute toxicity, pharmacokinetics and pharmacodynamics of paliperidone derivatives--comparison to paliperidone and risperidone in mice and rats.
    Basic & clinical pharmacology & toxicology, 2010, Volume: 107, Issue:2

    Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Dizocilpine Maleate; Electrocardiography; Exc

2010
Effects of risperidone, quetiapine and ziprasidone on ethanol withdrawal syndrome in rats.
    Progress in neuro-psychopharmacology & biological psychiatry, 2011, Mar-30, Volume: 35, Issue:2

    Topics: Alcoholism; Animals; Antipsychotic Agents; Behavior, Animal; Body Weight; Central Nervous System Dep

2011
Novel clinical finding in MECP2 duplication syndrome.
    European child & adolescent psychiatry, 2011, Volume: 20, Issue:7

    Topics: Child; Child Development; Chromosomes, Human, X; Cognitive Behavioral Therapy; Early Intervention, E

2011
Status dystonicus in tardive dystonia successfully treated by bilateral deep brain stimulation.
    Clinical neurology and neurosurgery, 2011, Volume: 113, Issue:9

    Topics: Adolescent; Antipsychotic Agents; Clonazepam; Deep Brain Stimulation; Disability Evaluation; Electro

2011
Combined treatment of quetiapine with haloperidol in animal models of antipsychotic effect and extrapyramidal side effects: comparison with risperidone and chlorpromazine.
    Psychopharmacology, 2004, Volume: 176, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Oral; Animals; Antipsychotic Agents; Basal G

2004
Effects of atypical antipsychotic drugs on intralipid intake and cocaine-induced hyperactivity in rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:9

    Topics: Animals; Antipsychotic Agents; Cocaine; Dibenzothiazepines; Dopamine Antagonists; Dopamine Uptake In

2006
Effects of risperidone on locomotor activity and spatial memory in rats with hippocampal damage.
    Neuropharmacology, 2006, Volume: 51, Issue:7-8

    Topics: Animals; Drug Evaluation, Preclinical; Hippocampus; Hyperkinesis; Injections; Locomotion; Male; Memo

2006
Risperidone in young children with pervasive developmental disorders and other developmental disabilities.
    Journal of child and adolescent psychopharmacology, 1996,Spring, Volume: 6, Issue:1

    Topics: Aggression; Autistic Disorder; Child; Child Development Disorders, Pervasive; Child, Preschool; Huma

1996
Prevention of relapse in schizophrenia.
    The New England journal of medicine, 2002, May-02, Volume: 346, Issue:18

    Topics: Antipsychotic Agents; Haloperidol; Humans; Hyperkinesis; Psychomotor Agitation; Risperidone; Schizop

2002