risperidone has been researched along with Electrocardiogram QT Prolonged in 29 studies
Risperidone: A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.
risperidone : A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Results of these analyses suggest that olanzapine, as therapeutically administered to patients with schizophrenia and related psychoses, does not contribute to QTc prolongation resulting in potentially fatal ventricular arrhythmias." | 9.09 | Analysis of the QTc interval during olanzapine treatment of patients with schizophrenia and related psychosis. ( Beasley, CM; Berg, PH; Czekalla, J; Dellva, MA; Grundy, S, 2001) |
| "We examined sex differences in the effect of olanzapine (OLZ), risperidone (RIS), aripiprazole (ARP), or quetiapine (QTP) on mean corrected QT (QTc) intervals among 222 patients with schizophrenia." | 5.17 | Sex differences in the effect of four second-generation antipsychotics on QTc interval in patients with schizophrenia. ( Fukui, N; Ono, S; Saito, M; Someya, T; Sugai, T; Suzuki, Y; Tsuneyama, N; Watanabe, J, 2013) |
| " Sixty-six patients with a diagnosis of schizophrenia that were treated with risperidone or olanzapine and 40 healthy volunteers were enrolled." | 5.16 | Increased risk of antipsychotic-related QT prolongation during nighttime: a 24-hour holter electrocardiogram recording study. ( Fukui, N; Ono, S; Someya, T; Sugai, T; Suzuki, Y; Tsuneyama, N; Watanabe, J, 2012) |
| "Results of these analyses suggest that olanzapine, as therapeutically administered to patients with schizophrenia and related psychoses, does not contribute to QTc prolongation resulting in potentially fatal ventricular arrhythmias." | 5.09 | Analysis of the QTc interval during olanzapine treatment of patients with schizophrenia and related psychosis. ( Beasley, CM; Berg, PH; Czekalla, J; Dellva, MA; Grundy, S, 2001) |
| "Risperidone is an antipsychotic medication suspected of causing QT prolongation and several cases are reported in this regard." | 2.77 | Risperidone and corrected QT-interval prolongation in surface electrocardiogram. ( Abbasnejhad, M; Ahmadi, NM; Akbarzadeh, F; Ranjbar, F, 2012) |
| "The present study evaluated associations between risperidone metabolism and QT interval in 61 psychiatric patients who had been receiving risperidone for ≥4 weeks at an average dosage of 4." | 2.77 | QT prolongation of the antipsychotic risperidone is predominantly related to its 9-hydroxy metabolite paliperidone. ( Fukui, N; Inoue, Y; Ono, S; Saito, M; Someya, T; Sugai, T; Suzuki, Y; Tsuneyama, N; Watanabe, J, 2012) |
| "Risperidone is an atypical antipsychotic drug with combined dopamine-2/serotonin-2 (D(2)/5-HT(2)) antagonist activity that has been effective in reducing cocaine use in some animal studies." | 2.73 | A randomized, double-blind, placebo-controlled trial of long-acting risperidone in cocaine-dependent men. ( Angarita, GA; Culhane, MA; Evins, AE; Huang, KL; Lee, SH; Loebl, T; Logvinenko, T; Nino, J; Pachas, GN, 2008) |
| "Risperidone has been shown to inhibit the delayed rectifier leading to lengthening of cardiac repolarization." | 1.32 | QTc interval, CYP2D6 and CYP2C9 genotypes and risperidone plasma concentrations. ( Berecz, R; de la Rubia, A; Dorado, P; Llerena, A, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 17 (58.62) | 29.6817 |
| 2010's | 11 (37.93) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Kongsamut, S | 1 |
| Kang, J | 1 |
| Chen, XL | 1 |
| Roehr, J | 1 |
| Rampe, D | 1 |
| Cavalli, A | 1 |
| Poluzzi, E | 1 |
| De Ponti, F | 1 |
| Recanatini, M | 1 |
| Arditti, R | 1 |
| Mongin, Y | 1 |
| Drancourt, N | 1 |
| Hotier, S | 1 |
| Laguerre, A | 1 |
| Hamdani, N | 1 |
| Suzuki, Y | 3 |
| Sugai, T | 3 |
| Fukui, N | 3 |
| Watanabe, J | 3 |
| Ono, S | 3 |
| Tsuneyama, N | 3 |
| Saito, M | 2 |
| Someya, T | 3 |
| Vieweg, WV | 1 |
| Hasnain, M | 1 |
| Hancox, JC | 1 |
| Baranchuk, A | 1 |
| Digby, GC | 1 |
| Kogut, C | 1 |
| Crouse, EL | 1 |
| Koneru, JN | 1 |
| Deshmukh, A | 1 |
| Pandurangi, AK | 1 |
| Ranjbar, F | 1 |
| Akbarzadeh, F | 1 |
| Ahmadi, NM | 1 |
| Abbasnejhad, M | 1 |
| Mizuki, Y | 1 |
| Takaki, M | 1 |
| Alda, JA | 1 |
| Muñoz-Samons, D | 1 |
| Tor, J | 1 |
| Merchán-Naranjo, J | 2 |
| Tapia-Casellas, C | 1 |
| Baeza, I | 1 |
| Calvo-Escalona, R | 1 |
| Castro-Fornieles, J | 1 |
| Martínez-Cantarero, C | 1 |
| Andrés-Nestares, P | 1 |
| Fernández-Avilés, F | 1 |
| Arango, C | 2 |
| Brahmbhatt, K | 1 |
| Whitgob, E | 1 |
| Önen, Ö | 1 |
| Kutlu, A | 1 |
| Erkuran, HÖ | 1 |
| Zink, M | 1 |
| Kuwilsky, A | 1 |
| Krumm, B | 1 |
| Dressing, H | 1 |
| de Castro, MJ | 1 |
| Fraguas, D | 1 |
| Laita, P | 1 |
| Moreno, D | 1 |
| Parellada, M | 1 |
| Pascual, D | 1 |
| Alvarez, M | 1 |
| Rapado, M | 1 |
| Giráldez, M | 1 |
| Leiva, M | 1 |
| Inoue, Y | 1 |
| Said, TH | 1 |
| Wilson, LD | 1 |
| Jeyaraj, D | 1 |
| Fossa, AA | 1 |
| Rosenbaum, DS | 1 |
| Lazarczyk, MJ | 1 |
| Bhuiyan, ZA | 1 |
| Perrin, N | 1 |
| Giannakopoulos, P | 1 |
| Timell, AM | 1 |
| Harrigan, EP | 1 |
| Miceli, JJ | 1 |
| Anziano, R | 1 |
| Watsky, E | 1 |
| Reeves, KR | 1 |
| Cutler, NR | 1 |
| Sramek, J | 1 |
| Shiovitz, T | 1 |
| Middle, M | 1 |
| Llerena, A | 1 |
| Berecz, R | 1 |
| Dorado, P | 1 |
| de la Rubia, A | 1 |
| Raviña, T | 2 |
| Gutierrez, J | 2 |
| Raviña, P | 2 |
| Huang, CL | 1 |
| Su, KP | 1 |
| Hsu, HB | 1 |
| Pariante, CM | 1 |
| Katagai, H | 1 |
| Yasui-Furukori, N | 1 |
| Kikuchi, A | 1 |
| Kaneko, S | 1 |
| Blaschke, D | 1 |
| Parwani, AS | 1 |
| Huemer, M | 1 |
| Rolf, S | 1 |
| Boldt, LH | 1 |
| Dietz, R | 1 |
| Haverkamp, W | 1 |
| Loebl, T | 1 |
| Angarita, GA | 1 |
| Pachas, GN | 1 |
| Huang, KL | 1 |
| Lee, SH | 1 |
| Nino, J | 1 |
| Logvinenko, T | 1 |
| Culhane, MA | 1 |
| Evins, AE | 1 |
| Czekalla, J | 1 |
| Beasley, CM | 1 |
| Dellva, MA | 1 |
| Berg, PH | 1 |
| Grundy, S | 1 |
| Beelen, AP | 1 |
| Yeo, KT | 1 |
| Lewis, LD | 1 |
| Wilton, LV | 1 |
| Heeley, EL | 1 |
| Pickering, RM | 1 |
| Shakir, SA | 1 |
| Taylor, DM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-Blind, Placebo-Controlled Study of the Effects of Risperdal Consta on Brain Reward Circuitry, Craving and Cocaine Use in Active Cocaine Dependence[NCT00385801] | Phase 2 | 31 participants (Actual) | Interventional | 2005-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The University of Minnesota Cocaine Craving Scale was performed to assess cocaine craving. The scale contains 1 continuous scale for intensity and 2 categorical scales for frequency and duration of craving episodes. The continuous scale for craving intensity ranges from 0 (no craving at all in the past week) to 10 (a great deal of craving in the past week) (NCT00385801)
Timeframe: 12 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | NA |
| Risperidone | NA |
After randomization, participants provided urine samples every week for the first 3 weeks and then every 2 weeks for 8 weeks, up to 7 samples per participant. The average visits with cocaine negative urine samples per participant are reported below (NCT00385801)
Timeframe: 12 weeks
| Intervention | visit with negative UBE (Mean) |
|---|---|
| Placebo | 1.81 |
| Risperidone Consta | 0.87 |
2 reviews available for risperidone and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Risperidone, QTc interval prolongation, and torsade de pointes: a systematic review of case reports.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Child; Dose-Response Relationship, Drug; Female; Huma | 2013 |
Diagnosis and Management of Delirium in Critically Ill Infants: Case Report and Review.
Topics: Abnormalities, Multiple; Antipsychotic Agents; Critical Illness; Delirium; Humans; Infant; Long QT S | 2016 |
10 trials available for risperidone and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Sex differences in the effect of four second-generation antipsychotics on QTc interval in patients with schizophrenia.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Dibenzothiazepines; El | 2013 |
Risperidone and corrected QT-interval prolongation in surface electrocardiogram.
Topics: Adult; Antipsychotic Agents; Cohort Studies; Female; Humans; Iran; Long QT Syndrome; Male; Middle Ag | 2012 |
Absence of Change in Corrected QT Interval in Children and Adolescents Receiving Antipsychotic Treatment: A 12 Month Study.
Topics: Adolescent; Antipsychotic Agents; Benzodiazepines; Biomarkers, Pharmacological; Child; Child, Presch | 2016 |
Efficacy and tolerability of ziprasidone versus risperidone as augmentation in patients partially responsive to clozapine: a randomised controlled clinical trial.
Topics: Adolescent; Adult; Antipsychotic Agents; Clozapine; Drug Therapy, Combination; Female; Humans; Long | 2009 |
QT prolongation of the antipsychotic risperidone is predominantly related to its 9-hydroxy metabolite paliperidone.
Topics: Adult; Age Factors; Antipsychotic Agents; Dose-Response Relationship, Drug; Electrocardiography; Fem | 2012 |
Increased risk of antipsychotic-related QT prolongation during nighttime: a 24-hour holter electrocardiogram recording study.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Circadian Rhythm; Death, Sudden, Cardiac; Electrocardi | 2012 |
A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition.
Topics: Adolescent; Adult; Antipsychotic Agents; Aryl Hydrocarbon Hydroxylases; Benzodiazepines; Biotransfor | 2004 |
A pilot observational crossover study of QTc interval changes associated with switching between olanzapine and risperidone.
Topics: Adult; Benzodiazepines; Cross-Over Studies; Electrocardiography; Female; Humans; Long QT Syndrome; M | 2007 |
A randomized, double-blind, placebo-controlled trial of long-acting risperidone in cocaine-dependent men.
Topics: Adult; Antipsychotic Agents; Cocaine-Related Disorders; Delayed-Action Preparations; Depressive Diso | 2008 |
Analysis of the QTc interval during olanzapine treatment of patients with schizophrenia and related psychosis.
Topics: Acute Disease; Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Antipsychotic Agent | 2001 |
17 other studies available for risperidone and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Cation Transport Proteins; Cell Line; Clinical Trials as Topic; Crice | 2002 |
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go- | 2002 |
[Hypothermia due to antipsychotic drug: A case report].
Topics: Adult; Antipsychotic Agents; Consciousness Disorders; Drug Substitution; Female; Haloperidol; Humans | 2020 |
Blonanserin ameliorated the tendency toward QTc prolongation associated with risperidone in a patient with schizophrenia.
Topics: Adult; Antipsychotic Agents; Female; Humans; Long QT Syndrome; Piperazines; Piperidines; Risperidone | 2015 |
Treating an Adolescent with Long QT Syndrome for Bipolar Disorder: A Case Presentation.
Topics: Adolescent; Bipolar Disorder; Female; Humans; Long QT Syndrome; Lorazepam; Risperidone; Valproic Aci | 2017 |
QTc changes after 6 months of second-generation antipsychotic treatment in children and adolescents.
Topics: Adolescent; Antipsychotic Agents; Benzodiazepines; Child; Child, Preschool; Dibenzothiazepines; Elec | 2008 |
Transmural dispersion of repolarization as a preclinical marker of drug-induced proarrhythmia.
Topics: Action Potentials; Animals; Bepridil; Dogs; Dose-Response Relationship, Drug; Electrocardiography; E | 2012 |
Selective acquired long QT syndrome (saLQTS) upon risperidone treatment.
Topics: Adult; Antipsychotic Agents; Clozapine; Electrocardiography; Female; Humans; Long QT Syndrome; Potas | 2012 |
Re: Thioridazine: re-evaluating the risk/benefit equation.
Topics: Antipsychotic Agents; Data Collection; Death, Sudden; Electrocardiography; Female; Humans; Long QT S | 2003 |
QTc interval, CYP2D6 and CYP2C9 genotypes and risperidone plasma concentrations.
Topics: Administration, Oral; Adult; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-45 | 2004 |
Acquired long QT syndrome: long-term electrocardiographic (Holter) recording of torsades de pointes ending in asystole: II.
Topics: Aged; Electrocardiography, Ambulatory; Female; Heart Arrest; Humans; Long QT Syndrome; Risperidone; | 2007 |
Acquired long QT syndrome: risperidone-facilitated triggered activity and Torsades de Pointes during complete AV block. I.
Topics: Aged, 80 and over; Antipsychotic Agents; Electrocardiography; Fatal Outcome; Female; Heart Block; Hu | 2007 |
Effective electroconvulsive therapy in a 92-year-old dementia patient with psychotic feature.
Topics: Aged, 80 and over; Antipsychotic Agents; Combined Modality Therapy; Dementia, Multi-Infarct; Electro | 2007 |
Torsade de pointes during combined treatment with risperidone and citalopram.
Topics: Aged; Antipsychotic Agents; Citalopram; Drug Therapy, Combination; Electrocardiography, Ambulatory; | 2007 |
Asymptomatic QTc prolongation associated with quetiapine fumarate overdose in a patient being treated with risperidone.
Topics: Adult; Antipsychotic Agents; Dibenzothiazepines; Female; Follow-Up Studies; Humans; Long QT Syndrome | 2001 |
Comparative study of mortality rates and cardiac dysrhythmias in post-marketing surveillance studies of sertindole and two other atypical antipsychotic drugs, risperidone and olanzapine.
Topics: Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Arrhythmias, Cardiac; Benzodiazepines; Cohort | 2001 |
Prolongation of QTc interval and antipsychotics.
Topics: Antipsychotic Agents; Death, Sudden, Cardiac; Drug Administration Schedule; Drug Labeling; Drug Moni | 2002 |