Page last updated: 2024-11-03

risperidone and Dementia

risperidone has been researched along with Dementia in 183 studies

Risperidone: A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.
risperidone : A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.

Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.

Research Excerpts

ExcerptRelevanceReference
"To examine the effects of galantamine and risperidone on neuropsychiatric symptoms in dementia (NPSD) and global function."9.19Galantamine versus risperidone treatment of neuropsychiatric symptoms in patients with probable dementia: an open randomized trial. ( Eriksdotter, M; Freund-Levi, Y; Jedenius, E; Lärksäter, M; Tysen-Bäckström, AC; Wahlund, LO, 2014)
"To examine the effects of galantamine and risperidone on agitation in patients with dementia."9.19Galantamine versus risperidone for agitation in people with dementia: a randomized, twelve-week, single-center study. ( Aarsland, D; Auestad, B; Bloniecki, V; Freund-Levi, Y; Lärksäter, M; Tysen Bäckström, AC, 2014)
"When comparing treatment effects on individual symptoms frequently occurring in patients with dementia, risperidone significantly improved symptoms of agitation, wandering, diurnal rhythm disturbance and anxieties, among other symptoms, compared with haloperidol."9.12Comparative efficacy of risperidone versus haloperidol on behavioural and psychological symptoms of dementia. ( Choi, SK; Greenspan, AJ; Suh, GH, 2006)
"In this study we directly compared the efficacy and tolerability of the atypical antipsychotics quetiapine and risperidone in elderly patients with dementia and symptoms of disturbed perception, thought content, mood or behaviour (behavioural and psychological symptoms of dementia-BPSD)."9.12Quetiapine versus risperidone in elderly patients with behavioural and psychological symptoms of dementia: efficacy, safety and cognitive function. ( Haushofer, M; Pfolz, H; Rainer, M; Struhal, C; Wick, W, 2007)
"To compare citalopram and risperidone for the treatment of psychotic symptoms and agitation associated with dementia, with a priori hypotheses that risperidone would be more efficacious for psychosis and citalopram for agitation."9.12A double-blind comparison of citalopram and risperidone for the treatment of behavioral and psychotic symptoms associated with dementia. ( Blakesley, RE; Houck, PR; Huber, KA; Mazumdar, S; Mulsant, BH; Pollock, BG; Rosen, J, 2007)
"Large randomized controlled trials have shown that risperidone reduces the frequency and severity of behavioral and psychological symptoms of dementia (BPSD) in patients with dementia."9.11Efficacy of risperidone for treating patients with behavioral and psychological symptoms of dementia. ( Wancata, J, 2004)
"To compare risperidone treatment with placebo for the burden to nursing staff of older nursing-home residents with dementia."9.11The effect of risperidone on nursing burden associated with caring for patients with dementia. ( Brodaty, H; Ciesla, G; Frank, L; Kleinman, L; Rupnow, MF, 2004)
"To examine the effect of risperidone on specific behavioral and psychological symptoms of dementia (BPSD)."9.11Behavioral and psychological symptoms in patients with dementia as a target for pharmacotherapy with risperidone. ( Brodaty, H; Davidson, M; De Deyn, PP; Greenspan, A; Katz, IR; Rabinowitz, J, 2004)
"Eighty-six patients with probable Alzheimer's disease, vascular dementia, or mixed-etiology dementia (DSM-IV criteria) were randomly assigned to treatment with olanzapine or risperidone."9.11Correlates of anticholinergic activity in patients with dementia and psychosis treated with risperidone or olanzapine. ( Bastean, JN; Bossie, CA; Gharabawi, GM; Greenspan, AJ; Mao, L; Martinez, RA; Mulsant, BH; Pollock, BG; Tune, LE, 2004)
" Dementia patients with behavioral and psychological symptoms received risperidone for 3 months."9.11Open-label, observational study of the effects of risperidone on the behavioral and psychological symptoms of dementia and caregiver stress in the community setting. ( Antonio Burón, J; Arriola, E; Gallego, R; Ignacio Diago, J, 2005)
"Risperidone significantly improves behavioral and psychological symptoms of dementia (BPSD), including aggression, agitation and psychosis, as shown by randomized, placebo-controlled trials."9.11Effects of risperidone on behavioral and psychological symptoms associated with dementia in clinical practice. ( Kurz, A; Schmitt, A; Schwalen S, S, 2005)
"In a double-blind parallel study allowing dose titration over 14 days, 39 agitated persons with DSM-IV dementia who were residing in long-term care facilities were administered olanzapine (N = 20) or risperidone (N = 19) as acute treatment."9.10A double-blind comparison of olanzapine versus risperidone in the acute treatment of dementia-related behavioral disturbances in extended care facilities. ( Fontaine, CS; Hynan, LS; Koch, K; Martin-Cook, K; Svetlik, D; Weiner, MF, 2003)
"To compare the effects of risperidone and olanzapine on cognition in elderly patients with dementia and psychosis, and to compare the side effects of these drugs."9.10Comparison of risperidone with olanzapine in elderly patients with dementia and psychosis. ( Arndt, S; Ekstam-Smith, K; Ellingrod, VL; Kutscher, E; Schultz, SK; Turvey, C, 2002)
"65 patients suffering from AD, 10 from vascular dementia, and 15 from both were randomized to open label rivastigmine and risperidone, alone or in combination, for 20 weeks."9.10A pilot, randomized, open-label trial assessing safety and pharmakokinetic parameters of co-administration of rivastigmine with risperidone in dementia patients with behavioral disturbances. ( Anand, R; Cicin-Sain, A; Hartman, R; Korczyn, AD; Rotmensch, HH; Weiser, M, 2002)
"We report the findings from the first large, double-blind, placebo-controlled study conducted to evaluate the efficacy and safety of risperidone in the treatment of psychotic and behavioral symptoms in institutionalized elderly patients with dementia."9.09Comparison of risperidone and placebo for psychosis and behavioral disturbances associated with dementia: a randomized, double-blind trial. Risperidone Study Group. ( Brecher, M; Clyde, C; Jeste, DV; Katz, IR; Mintzer, JE; Napolitano, J, 1999)
"The authors studied the incidence of tardive dyskinesia in elderly institutionalized patients with dementia being treated with risperidone."9.09Low incidence of persistent tardive dyskinesia in elderly patients with dementia treated with risperidone. ( Jeste, DV; Kane, JM; Martinez, RA; Napolitano, J; Okamoto, A, 2000)
"Risperidone was used to treat 11 elderly hospitalized patients between 61 and 79 years of age who manifested signs of psychoses related to schizophrenia, schizoaffective disorder, bipolar disorder, or senile dementia."9.08Efficacy of risperidone treatment for psychoses associated with schizophrenia, schizoaffective disorder, bipolar disorder, or senile dementia in 11 geriatric patients: a case series. ( Abaza, A; Araujo, L; Brenner, R; Madhusoodanan, S, 1995)
"The efficacy and safety of risperidone, haloperidol, and thioridazine for treating dementia-associated behavioral disturbances were evaluated in a retrospective study of 186 patients aged 65 years or older with DSM-III-R or DSM-IV diagnoses of Alzheimer's dementia, senile dementia NOS, or organic brain syndrome."9.08Clinical experience with risperidone, haloperidol, and thioridazine for dementia-associated behavioral disturbances. ( Frenchman, IB; Prince, T, 1997)
"The authors describe a series of 22 patients with dementia and behavioral disturbances, including agitation, aggression, delusions, and hallucinations, who were treated with risperidone."9.08Risperidone for the treatment of behavioral disturbances in dementia: a case series. ( Campbell, B; Flynn, M; Herrmann, N; Rabheru, K; Rivard, MF; Ward, C, 1998)
"Data from all double-blind randomised controlled trials of risperidone in dementia patients (risperidone n = 1009, placebo n = 712) were included."8.93Baseline characteristics and treatment-emergent risk factors associated with cerebrovascular event and death with risperidone in dementia patients. ( Berlin, JA; Coppola, D; Costafreda, SG; Hough, D; Howard, R; Karcher, K, 2016)
"This study is a meta-analysis of patients with psychosis of AD from four large placebo-controlled clinical trials of risperidone in dementia."8.84The efficacy and safety of risperidone in the treatment of psychosis of Alzheimer's disease and mixed dementia: a meta-analysis of 4 placebo-controlled clinical trials. ( Brodaty, H; de Deyn, PP; Greenspan, A; Katz, I; Mintzer, J; Zhu, Y, 2007)
"Post-hoc analysis by the pharmaceutical company Eli Lilly of 5 randomised clinical trials concerning the efficacy ofolanzapine in patients with dementia, has shown that patients taking olanzapine have a risk of experiencing a cerebrovascular accident which is 3 times higher than patients taking placebo."8.82[Increased risk of stroke during the use of olanzapine or risperidone in patients with dementia]. ( Jansen, PA; van Marum, RJ, 2005)
"Risperidone offers physicians the unique combination of extensive, published clinical experience and a good safety profile for treating patients with dementia who have symptoms of aggression, agitation, and psychosis."8.81Risperidone for the treatment of behavioral and psychological symptoms of dementia. ( Tune, LE, 2001)
"Currently available research on the use of risperidone to manage agitation in patients with dementia is discussed."8.80Risperidone for control of agitation in dementia patients. ( Falsetti, AE, 2000)
"The efficacy of risperidone has been demonstrated in the treatment of the behavioural and psychological symptoms associated with dementia in the elderly."8.80Risperidone: a review of its use in the management of the behavioural and psychological symptoms of dementia. ( Bhana, N; Spencer, CM, 2000)
"The aim of this study was to compare the efficacy and side-effect profile of the typical antipsychotic haloperidol with that of the atypical antipsychotics risperidone, olanzapine, and aripiprazole in the management of delirium."7.81Haloperidol, risperidone, olanzapine and aripiprazole in the management of delirium: A comparison of efficacy, safety, and side effects. ( Boettger, S; Breitbart, W; Jenewein, J, 2015)
"This study was intended to compare the consistency of risperidone exposure in patients who have dementia and behavioral disturbances treated in a psychiatric hospital versus a community care setting."7.73Population pharmacokinetics as a method to detect variable risperidone exposure in patients suffering from dementia with behavioral disturbances. ( Bies, RR; Huber, KA; Kirshner, MA; Mulsant, BH; Pollock, BG; Rosen, J; Wilson, NL, 2005)
"Following changes in the safety information on the use of risperidone and olanzapine in elderly patients with dementia, data from prescription-event monitoring (PEM) studies of risperidone, quetiapine and olanzapine were examined."7.73Comparison of incidence rates of cerebrovascular accidents and transient ischaemic attacks in observational cohort studies of patients prescribed risperidone, quetiapine or olanzapine in general practice in England including patients with dementia. ( Harris, S; Layton, D; Shakir, SA; Wilton, LV, 2005)
"In March 2004, the UK Committee of Safety of Medicines (CSM) informed clinicians that risperidone and olanzapine should not be used to treat behavioural and psychological symptoms of dementia (BPSD) because of increased risk of strokes with both drugs and increased risk of mortality with olanzapine."7.73Can risperidone and olanzapine in elderly patients with dementia and other mental disorders be discontinued? ( Shah, A, 2006)
" Three nursing-home residents who suffered from multiple somatic disorders and dementia, two men aged 78 and 76 years respectively and a woman aged 72 years, developed neuroleptic malignant syndrome following the use of risperidone."7.72[Neuroleptic malignant syndrome in users of risperidone]. ( de Jonghe-Rouleau, AP; Gerritsen, AA; Stienstra-Liem, LH, 2004)
" We conducted an 8-week, rater-blinded, randomized trial, administering flexibly dosed risperidone, yokukansan, or fluvoxamine."6.78Efficacy and tolerability of risperidone, yokukansan, and fluvoxamine for the treatment of behavioral and psychological symptoms of dementia: a blinded, randomized trial. ( Kurita, M; Nishino, S; Numata, Y; Okubo, Y; Sato, T; Takeyoshi, K; Tateno, A; Teranishi, M, 2013)
"The treatment with risperidone was well tolerated."6.72[Changeover to risperidone after treatment with conventional low potency neuroleptics in dementia patients. An observation study during usage]. ( Schmitt, AB; Schreiner, A; Stoppe, G, 2006)
"Dementia is associated with progressive cognitive impairment and behavioral and psychological symptoms."6.71Evaluation of risperidone in the treatment of behavioral and psychological symptoms and sleep disturbances associated with dementia. ( Diago, JI; Durán, JC; Gallego, R; Greenspan, A; Martinez, G, 2005)
"Despite the scarcity of high-quality evidence, risperidone is probably the best pharmacological option to consider for alleviating NPS in people with dementia in short-term treatment when considering the risk-benefit profile of drugs."5.41Pharmacological treatment of neuropsychiatric symptoms of dementia: a network meta-analysis. ( Cai, WJ; Chen, KL; Chen, SD; Dong, Q; Feng, L; Giovane, CD; Huang, SY; Huang, YY; Kuo, K; Li, CB; Liu, CY; Shen, XN; Suckling, J; Teng, T; Wang, RZ; Yu, JT; Zhang, C; Zhao, QH; Zhou, XY, 2023)
"Domperidone is a dopamine D₂ receptor antagonist that does not usually cross the blood-brain barrier."5.37Domperidone-induced tardive dyskinesia and withdrawal psychosis in an elderly woman with dementia. ( Bocti, C; Hottin, P; Landry, J; Roy-Desruisseaux, J; Tessier, D; Trudel, JF, 2011)
"Risperidone was well tolerated overall and nursing staff viewed it as helpful in 38 of 100 patients, moderately helpful in 26, slightly helpful in 17, and not helpful in 19."5.30Risperidone for dementia-related disturbed behavior in nursing home residents: a clinical experience. ( Goldberg, J; Goldberg, RJ, 1997)
"Overall results demonstrate that, compared with placebo, quetiapine is not associated with improvement in psychosis in patients with dementia, while olanzapine and aripiprazole have non-significant small numerical improvements."5.22Comparative Outcomes of Commonly Used Off-Label Atypical Antipsychotics in the Treatment of Dementia-Related Psychosis: A Network Meta-analysis. ( Abler, VC; Demos, GN; Mahadik, BS; Rajagopalan, K; Rashid, N; Yunusa, I, 2022)
"To examine the effects of galantamine and risperidone on neuropsychiatric symptoms in dementia (NPSD) and global function."5.19Galantamine versus risperidone treatment of neuropsychiatric symptoms in patients with probable dementia: an open randomized trial. ( Eriksdotter, M; Freund-Levi, Y; Jedenius, E; Lärksäter, M; Tysen-Bäckström, AC; Wahlund, LO, 2014)
"To examine the effects of galantamine and risperidone on agitation in patients with dementia."5.19Galantamine versus risperidone for agitation in people with dementia: a randomized, twelve-week, single-center study. ( Aarsland, D; Auestad, B; Bloniecki, V; Freund-Levi, Y; Lärksäter, M; Tysen Bäckström, AC, 2014)
"When comparing treatment effects on individual symptoms frequently occurring in patients with dementia, risperidone significantly improved symptoms of agitation, wandering, diurnal rhythm disturbance and anxieties, among other symptoms, compared with haloperidol."5.12Comparative efficacy of risperidone versus haloperidol on behavioural and psychological symptoms of dementia. ( Choi, SK; Greenspan, AJ; Suh, GH, 2006)
"In this study we directly compared the efficacy and tolerability of the atypical antipsychotics quetiapine and risperidone in elderly patients with dementia and symptoms of disturbed perception, thought content, mood or behaviour (behavioural and psychological symptoms of dementia-BPSD)."5.12Quetiapine versus risperidone in elderly patients with behavioural and psychological symptoms of dementia: efficacy, safety and cognitive function. ( Haushofer, M; Pfolz, H; Rainer, M; Struhal, C; Wick, W, 2007)
"To compare citalopram and risperidone for the treatment of psychotic symptoms and agitation associated with dementia, with a priori hypotheses that risperidone would be more efficacious for psychosis and citalopram for agitation."5.12A double-blind comparison of citalopram and risperidone for the treatment of behavioral and psychotic symptoms associated with dementia. ( Blakesley, RE; Houck, PR; Huber, KA; Mazumdar, S; Mulsant, BH; Pollock, BG; Rosen, J, 2007)
"Large randomized controlled trials have shown that risperidone reduces the frequency and severity of behavioral and psychological symptoms of dementia (BPSD) in patients with dementia."5.11Efficacy of risperidone for treating patients with behavioral and psychological symptoms of dementia. ( Wancata, J, 2004)
"To compare risperidone treatment with placebo for the burden to nursing staff of older nursing-home residents with dementia."5.11The effect of risperidone on nursing burden associated with caring for patients with dementia. ( Brodaty, H; Ciesla, G; Frank, L; Kleinman, L; Rupnow, MF, 2004)
"To examine the effect of risperidone on specific behavioral and psychological symptoms of dementia (BPSD)."5.11Behavioral and psychological symptoms in patients with dementia as a target for pharmacotherapy with risperidone. ( Brodaty, H; Davidson, M; De Deyn, PP; Greenspan, A; Katz, IR; Rabinowitz, J, 2004)
"Eighty-six patients with probable Alzheimer's disease, vascular dementia, or mixed-etiology dementia (DSM-IV criteria) were randomly assigned to treatment with olanzapine or risperidone."5.11Correlates of anticholinergic activity in patients with dementia and psychosis treated with risperidone or olanzapine. ( Bastean, JN; Bossie, CA; Gharabawi, GM; Greenspan, AJ; Mao, L; Martinez, RA; Mulsant, BH; Pollock, BG; Tune, LE, 2004)
" Dementia patients with behavioral and psychological symptoms received risperidone for 3 months."5.11Open-label, observational study of the effects of risperidone on the behavioral and psychological symptoms of dementia and caregiver stress in the community setting. ( Antonio Burón, J; Arriola, E; Gallego, R; Ignacio Diago, J, 2005)
"Risperidone significantly improves behavioral and psychological symptoms of dementia (BPSD), including aggression, agitation and psychosis, as shown by randomized, placebo-controlled trials."5.11Effects of risperidone on behavioral and psychological symptoms associated with dementia in clinical practice. ( Kurz, A; Schmitt, A; Schwalen S, S, 2005)
"In a double-blind parallel study allowing dose titration over 14 days, 39 agitated persons with DSM-IV dementia who were residing in long-term care facilities were administered olanzapine (N = 20) or risperidone (N = 19) as acute treatment."5.10A double-blind comparison of olanzapine versus risperidone in the acute treatment of dementia-related behavioral disturbances in extended care facilities. ( Fontaine, CS; Hynan, LS; Koch, K; Martin-Cook, K; Svetlik, D; Weiner, MF, 2003)
"To compare the effects of risperidone and olanzapine on cognition in elderly patients with dementia and psychosis, and to compare the side effects of these drugs."5.10Comparison of risperidone with olanzapine in elderly patients with dementia and psychosis. ( Arndt, S; Ekstam-Smith, K; Ellingrod, VL; Kutscher, E; Schultz, SK; Turvey, C, 2002)
"65 patients suffering from AD, 10 from vascular dementia, and 15 from both were randomized to open label rivastigmine and risperidone, alone or in combination, for 20 weeks."5.10A pilot, randomized, open-label trial assessing safety and pharmakokinetic parameters of co-administration of rivastigmine with risperidone in dementia patients with behavioral disturbances. ( Anand, R; Cicin-Sain, A; Hartman, R; Korczyn, AD; Rotmensch, HH; Weiser, M, 2002)
"We report the findings from the first large, double-blind, placebo-controlled study conducted to evaluate the efficacy and safety of risperidone in the treatment of psychotic and behavioral symptoms in institutionalized elderly patients with dementia."5.09Comparison of risperidone and placebo for psychosis and behavioral disturbances associated with dementia: a randomized, double-blind trial. Risperidone Study Group. ( Brecher, M; Clyde, C; Jeste, DV; Katz, IR; Mintzer, JE; Napolitano, J, 1999)
"The authors studied the incidence of tardive dyskinesia in elderly institutionalized patients with dementia being treated with risperidone."5.09Low incidence of persistent tardive dyskinesia in elderly patients with dementia treated with risperidone. ( Jeste, DV; Kane, JM; Martinez, RA; Napolitano, J; Okamoto, A, 2000)
"Risperidone was used to treat 11 elderly hospitalized patients between 61 and 79 years of age who manifested signs of psychoses related to schizophrenia, schizoaffective disorder, bipolar disorder, or senile dementia."5.08Efficacy of risperidone treatment for psychoses associated with schizophrenia, schizoaffective disorder, bipolar disorder, or senile dementia in 11 geriatric patients: a case series. ( Abaza, A; Araujo, L; Brenner, R; Madhusoodanan, S, 1995)
"This pilot study investigated effectiveness and tolerability of risperidone for the treatment of psychosis and agitation in 9 inpatients with Parkinson's disease and dementia."5.08The use of risperidone for psychosis and agitation in demented patients with Parkinson's disease. ( Bakey, AA; Kunik, ME; Molinari, VA; Orengo, CA; Workman, RH, 1997)
"The efficacy and safety of risperidone, haloperidol, and thioridazine for treating dementia-associated behavioral disturbances were evaluated in a retrospective study of 186 patients aged 65 years or older with DSM-III-R or DSM-IV diagnoses of Alzheimer's dementia, senile dementia NOS, or organic brain syndrome."5.08Clinical experience with risperidone, haloperidol, and thioridazine for dementia-associated behavioral disturbances. ( Frenchman, IB; Prince, T, 1997)
"The authors describe a series of 22 patients with dementia and behavioral disturbances, including agitation, aggression, delusions, and hallucinations, who were treated with risperidone."5.08Risperidone for the treatment of behavioral disturbances in dementia: a case series. ( Campbell, B; Flynn, M; Herrmann, N; Rabheru, K; Rivard, MF; Ward, C, 1998)
"Risperidone, serotonin reuptake inhibitors as a class and dextromethorphan/quinidine demonstrated evidence of efficacy for agitation in dementia, although findings for dextromethorphan/quinidine were based on a single RCT."4.98Pharmacological treatments for alleviating agitation in dementia: a systematic review and network meta-analysis. ( Bell, JS; Chaiyakunapruk, N; Hilmer, SN; Kongpakwattana, K; Sawangjit, R; Tawankanjanachot, I, 2018)
"Data from all double-blind randomised controlled trials of risperidone in dementia patients (risperidone n = 1009, placebo n = 712) were included."4.93Baseline characteristics and treatment-emergent risk factors associated with cerebrovascular event and death with risperidone in dementia patients. ( Berlin, JA; Coppola, D; Costafreda, SG; Hough, D; Howard, R; Karcher, K, 2016)
"Randomized, controlled trials of antidepressants (selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, trazodone, and other antidepressants), compared to either placebo or comparator medications (typical or atypical antipsychotics, anticonvulsants, benzodiazepines, cholinesterase inhibitors, memantine or other medications) for treatment of agitation or psychosis in older adults with dementia."4.87Antidepressants for agitation and psychosis in dementia. ( Adunuri, N; Gill, SS; Gruneir, A; Herrmann, N; Rochon, P; Seitz, DP, 2011)
"This study is a meta-analysis of patients with psychosis of AD from four large placebo-controlled clinical trials of risperidone in dementia."4.84The efficacy and safety of risperidone in the treatment of psychosis of Alzheimer's disease and mixed dementia: a meta-analysis of 4 placebo-controlled clinical trials. ( Brodaty, H; de Deyn, PP; Greenspan, A; Katz, I; Mintzer, J; Zhu, Y, 2007)
"Post hoc analyses of pooled results from 11 randomised controlled trials of risperidone and olanzapine in elderly dementia subjects revealed an increased incidence of cerebrovascular adverse events compared with placebo."4.82Do atypical antipsychotics cause stroke? ( Herrmann, N; Lanctôt, KL, 2005)
"Post-hoc analysis by the pharmaceutical company Eli Lilly of 5 randomised clinical trials concerning the efficacy ofolanzapine in patients with dementia, has shown that patients taking olanzapine have a risk of experiencing a cerebrovascular accident which is 3 times higher than patients taking placebo."4.82[Increased risk of stroke during the use of olanzapine or risperidone in patients with dementia]. ( Jansen, PA; van Marum, RJ, 2005)
"To compare the efficacy and safety of risperidone and olanzapine in the treatment of psychotic symptoms and behavioural disturbances in institutionalised patients with dementia and other psychiatric disorders."4.82Atypical antipsychotics for nursing home patients: a retrospective chart review. ( Frenchman, IB, 2005)
"There is a now a substantial body of evidence that suggests the new antipsychotic agent, risperidone, may be safe and effective for treating psychotic, affective or behavioural symptoms associated with various disorders other than schizophrenia, schizophreniform disorder or schizo-affective disorder."4.81Does risperidone have a place in the treatment of nonschizophrenic patients? ( Schweitzer, I, 2001)
"Relevant data relating to the dosage of risperidone identified through an online (MEDLINE) search using the keywords risperidone, schizophrenia, schizoaffective disorder dementia, bipolar disorder, and dose were supplemented by a review of international and U."4.81Optimal dosing with risperidone: updated recommendations. ( Williams, R, 2001)
"Advances in the assessment of the behavioral and psychological symptoms of dementia (BPSD) have been employed in large-scale clinical trials of new antipsychotic medications such as risperidone."4.81Scales to assess efficacy and safety of pharmacologic agents in the treatment of behavioral and psychological symptoms of dementia. ( De Deyn, PP; Wirshing, WC, 2001)
"Risperidone offers physicians the unique combination of extensive, published clinical experience and a good safety profile for treating patients with dementia who have symptoms of aggression, agitation, and psychosis."4.81Risperidone for the treatment of behavioral and psychological symptoms of dementia. ( Tune, LE, 2001)
"Currently available research on the use of risperidone to manage agitation in patients with dementia is discussed."4.80Risperidone for control of agitation in dementia patients. ( Falsetti, AE, 2000)
"The efficacy of risperidone has been demonstrated in the treatment of the behavioural and psychological symptoms associated with dementia in the elderly."4.80Risperidone: a review of its use in the management of the behavioural and psychological symptoms of dementia. ( Bhana, N; Spencer, CM, 2000)
"We used Pharmaceutical Benefits Scheme dispensing claims to identify patients who initiated donepezil, rivastigmine, galantamine or memantine between 1 January 2013 and 30 June 2017 (after a period of ≥180 days with no dispensing of these medicines) and remained on therapy for ≥180 days (n = 4393), and dispensed anticholinergic medicines in the 180 days before and after initiating dementia medicines."3.91Anticholinergic medicines use among older adults before and after initiating dementia medicines. ( Buckley, N; Le Couteur, DG; Litchfield, M; McLachlan, AJ; Narayan, SW; Pearson, SA; Zoega, H, 2019)
"The aim of this study was to compare the efficacy and side-effect profile of the typical antipsychotic haloperidol with that of the atypical antipsychotics risperidone, olanzapine, and aripiprazole in the management of delirium."3.81Haloperidol, risperidone, olanzapine and aripiprazole in the management of delirium: A comparison of efficacy, safety, and side effects. ( Boettger, S; Breitbart, W; Jenewein, J, 2015)
"Second-generation antipsychotic (SGA) monotherapy was the most common type of therapy in both those with dementia and with schizophrenia, and quetiapine and risperidone were the most commonly prescribed drugs for these conditions, respectively."3.81Antipsychotic polypharmacy among elderly patients with schizophrenia and dementia during hospitalization at a Taiwanese psychiatric hospital. ( Chang, YS; Lai, CY; Wu, YH, 2015)
" Department of Veterans Affairs (fiscal years 1999-2008) for dementia patients age 65 and older who began outpatient treatment with an antipsychotic (risperidone, olanzapine, quetiapine, or haloperidol) or valproic acid and its derivatives (as a nonantipsychotic comparison)."3.78Risk of mortality among individual antipsychotics in patients with dementia. ( Blow, FC; Chiang, C; Cunningham, F; Kales, HC; Kim, HM; Schneider, LS; Seyfried, LS; Valenstein, M; Zivin, K, 2012)
"We compared the incidence of parkinsonism after new treatment with risperidone, olanzapine, or quetiapine in patients with dementia and examined the effects of dose and sex on the risk of parkinsonism."3.78Atypical antipsychotic use and parkinsonism in dementia: effects of drug, dose, and sex. ( Anderson, GM; Fischer, HD; Herrmann, N; Marras, C; Rochon, PA; Wang, X, 2012)
"Patients with a diagnosis of dementia and in treatment with AA (risperidone, olanzapine, and quetiapine) were selected from three main Alzheimer Evaluation Centers (Geriatrics, Neurology, Internal Medicine) of the University Hospital in Ferrara, in the period 05/2003-04/2006."3.76Profile of atypical-antipsychotics use in patients affected by dementia in the University Hospital of Ferrara. ( Bianchi, S; Chiabrando, G; Montanaro, N; Poluzzi, E; Scanavacca, P, 2010)
"This study was intended to compare the consistency of risperidone exposure in patients who have dementia and behavioral disturbances treated in a psychiatric hospital versus a community care setting."3.73Population pharmacokinetics as a method to detect variable risperidone exposure in patients suffering from dementia with behavioral disturbances. ( Bies, RR; Huber, KA; Kirshner, MA; Mulsant, BH; Pollock, BG; Rosen, J; Wilson, NL, 2005)
"Following changes in the safety information on the use of risperidone and olanzapine in elderly patients with dementia, data from prescription-event monitoring (PEM) studies of risperidone, quetiapine and olanzapine were examined."3.73Comparison of incidence rates of cerebrovascular accidents and transient ischaemic attacks in observational cohort studies of patients prescribed risperidone, quetiapine or olanzapine in general practice in England including patients with dementia. ( Harris, S; Layton, D; Shakir, SA; Wilton, LV, 2005)
"In March 2004, the UK Committee of Safety of Medicines (CSM) informed clinicians that risperidone and olanzapine should not be used to treat behavioural and psychological symptoms of dementia (BPSD) because of increased risk of strokes with both drugs and increased risk of mortality with olanzapine."3.73Can risperidone and olanzapine in elderly patients with dementia and other mental disorders be discontinued? ( Shah, A, 2006)
"Olanzapine and risperidone use were not associated with a statistically significant increased risk of stroke compared with typical antipsychotic use."3.72Atypical antipsychotics and risk of cerebrovascular accidents. ( Herrmann, N; Lanctôt, KL; Mamdani, M, 2004)
" Three nursing-home residents who suffered from multiple somatic disorders and dementia, two men aged 78 and 76 years respectively and a woman aged 72 years, developed neuroleptic malignant syndrome following the use of risperidone."3.72[Neuroleptic malignant syndrome in users of risperidone]. ( de Jonghe-Rouleau, AP; Gerritsen, AA; Stienstra-Liem, LH, 2004)
"Risperidone was also found to be more efficacious than placebo (SMD -0."2.82Pharmacological treatments for psychotic symptoms in dementia: A systematic review with pairwise and network meta-analysis. ( Chen, KL; Chen, SD; Dong, Q; Dou, KX; Huang, YY; Shen, XN; Tan, L; Teng, T; Wang, J; Wang, RZ; Yu, JT; Zhang, RQ; Zhao, QH; Zhong, XL; Zhou, XY, 2022)
" We conducted an 8-week, rater-blinded, randomized trial, administering flexibly dosed risperidone, yokukansan, or fluvoxamine."2.78Efficacy and tolerability of risperidone, yokukansan, and fluvoxamine for the treatment of behavioral and psychological symptoms of dementia: a blinded, randomized trial. ( Kurita, M; Nishino, S; Numata, Y; Okubo, Y; Sato, T; Takeyoshi, K; Tateno, A; Teranishi, M, 2013)
"In this systematic literature review (SLR), we qualitatively synthesized evidence on the comparative efficacy (based on neuropsychiatric inventory), tolerability (weight gain), and safety (cerebrovascular adverse events [CVAE], cardiovascular events, mortality, somnolence, extrapyramidal symptoms [EPS]) of AAPs used to treat DRP."2.72Comparative Efficacy, Safety, Tolerability, and Effectiveness of Antipsychotics in The Treatment of Dementia-Related Psychosis (DRP): A Systematic Literature Review. ( Abler, V; Rajagopalan, K; Rashid, N; Yunusa, I, 2021)
" Dosing strategies, discontinuation considerations, and side effects are discussed."2.72The Psychopharmacology Algorithm Project at the Harvard South Shore Program: An update on management of behavioral and psychological symptoms in dementia. ( Chen, A; Cloutier, A; Copeli, F; Metzger, E; Osser, DN, 2021)
"The treatment with risperidone was well tolerated."2.72[Changeover to risperidone after treatment with conventional low potency neuroleptics in dementia patients. An observation study during usage]. ( Schmitt, AB; Schreiner, A; Stoppe, G, 2006)
"Dementia is associated with progressive cognitive impairment and behavioral and psychological symptoms."2.71Evaluation of risperidone in the treatment of behavioral and psychological symptoms and sleep disturbances associated with dementia. ( Diago, JI; Durán, JC; Gallego, R; Greenspan, A; Martinez, G, 2005)
"Aripiprazole has the most consistent evidence of symptom improvement; however, this improvement is small."2.53Behavioral Disorders in Dementia: Appropriate Nondrug Interventions and Antipsychotic Use. ( Cocker, KE; Reese, TR; Thiel, DJ, 2016)
" It is well-tolerated and rather safe for elderly patients."2.48[Efficasy and safety of the use of risperidone (rispoluxe) in demented patients with psychotic and behavioural disorders]. ( Bocharov, AV; Kondakova, VE; Tuleninov, ES, 2012)
"Hallucinations and psychosis are common in patients with Parkinson's disease (PD), with reported prevalences of up to 48% and 80%, respectively."2.46Management of hallucinations and psychosis in Parkinson's disease. ( Eng, ML; Welty, TE, 2010)
"In 2 pivotal trials comparing risperidone with placebo, the risk of adverse events was similar in both treatment groups when risperidone was given at the optimal clinical dose (1 mg/day)."2.41Long-term safety of risperidone. ( Davidson, M, 2001)
" Dosing requirements for elderly patients tend to be much lower than those for younger adults."2.40Conventional vs. newer antipsychotics in elderly patients. ( Harris, MJ; Jeste, DV; Lacro, J; Lohr, JB; Rockwell, E, 1999)
"Significant consequences of untreated psychosis in patients with dementia have led clinicians to seek improved therapeutic options."2.40Pharmacologic management of psychosis in dementia. ( Schneider, LS, 1999)
"Degenerative dementia is characterized by progressive cognitive decline and neuropsychiatric symptoms."1.72Neuropsychiatric Symptoms in Dementia: Considering a Clinical Role for Electroencephalography. ( Aarsland, D; Andersson, T; Berglund, A; Cummings, J; Freund-Levi, Y; Holmgren, S, 2022)
" Atypical antipsychotic dosages were standardized using a defined daily dose, and the cumulative dosage was calculated."1.62Atypical Antipsychotics Augmentation in Patients with Depressive Disorder and Risk of Subsequent Dementia: A Nationwide Population-Based Cohort Study. ( Ha, TH; Kim, DK; Kim, H; Kim, J; Kim, K; Lee, EM; Lee, H; Lewis, M; Myung, W; Won, HH, 2021)
"There were 291 residents treated with anti-dementia medicines, 129 (44%) of whom received antipsychotics concomitantly with an anti-dementia medicine."1.43The use of antipsychotics among people treated with medications for dementia in residential aged care facilities. ( Gadzhanova, S; Pont, LG; Roughead, EE; Shin, HY; Ward, MB, 2016)
"Risperidone was analysed separately, in accordance with its limited licence for use in older adults with dementia, granted in October 2008."1.42Second-generation antipsychotic drug use in hospital inpatients with dementia: the impact of a safety warning on rates of prescribing. ( Coleman, JJ; McIlroy, G; Thomas, SK, 2015)
" Although our study suggests the prescription dosage and duration of antipsychotic treatment decreased significantly after FDA warning in 2005, the duration of treatment was still long."1.42Dosage and duration of antipsychotic treatment in demented outpatients with agitation or psychosis. ( Chiang, HL; Hwang, TJ; Hwu, HG; Lin, YT; Shan, JC; Sheu, YH, 2015)
" As a group, the atypical antipsychotics (olanzapine, quetiapine, and risperidone) showed a dose-response increase in mortality risk, with 3."1.42Antipsychotics, other psychotropics, and the risk of death in patients with dementia: number needed to harm. ( Chiang, C; Kales, HC; Kavanagh, J; Kim, HM; Maust, DT; Schneider, LS; Seyfried, LS, 2015)
"Haloperidol was associated with higher mortality risk (HR 30 days = 1."1.40Short- and long-term mortality risk associated with the use of antipsychotics among 26,940 dementia outpatients: a population-based study. ( Aarsland, D; Ballard, C; Engdahl, B; Langballe, EM; Nordeng, H; Selbæk, G, 2014)
" There was a dose-response relation for all drugs except quetiapine."1.38Differential risk of death in older residents in nursing homes prescribed specific antipsychotic drugs: population based cohort study. ( Avorn, J; Crystal, S; Gerhard, T; Huybrechts, KF; Levin, R; Lucas, JA; Olfson, M; Schneeweiss, S, 2012)
"Domperidone is a dopamine D₂ receptor antagonist that does not usually cross the blood-brain barrier."1.37Domperidone-induced tardive dyskinesia and withdrawal psychosis in an elderly woman with dementia. ( Bocti, C; Hottin, P; Landry, J; Roy-Desruisseaux, J; Tessier, D; Trudel, JF, 2011)
" Further investigations are warranted to identify patient characteristics and antipsychotic dosage regimens that are not associated with a greater risk of mortality in elderly patients with dementia."1.36Are all commonly prescribed antipsychotics associated with greater mortality in elderly male veterans with dementia? ( Dysken, MW; Lederle, FA; Rector, TS; Rossom, RC, 2010)
"Risperidone and promazine were the most frequently prescribed antipsychotic; 40."1.35Use and misuse of antipsychotic drugs in patients with dementia in Alzheimer special care units. ( Lucca, U; Matucci, M; Nobili, A; Pasina, L; Riva, E; Tarantola, M; Tettamanti, M; Trevisan, S, 2009)
" Most people did not have any adverse effects; 5 patients (15."1.34Behavioral and psychological symptoms of dementia (BPSD) in elderly demented subjects: is the long lasting use of atypical antipsychotic drugs useful and safe? ( Angelini, A; Bendini, C; Neri, M; Neviani, F, 2007)
"Risperidone was the most frequently prescribed antipsychotic (n = 136, 44."1.33Psychotropic drug use in older people with mental illness with particular reference to antipsychotics: a systematic study of tolerability and use in different diagnostic groups. ( Curran, S; Musa, S; Turner, D; Wattis, J, 2005)
"With risperidone treatment, the vocalizations diminished to less than 20% of baseline ratings."1.30The use of risperidone in severely demented patients with persistent vocalizations. ( Honer, WG; Kopala, LC, 1997)
"Risperidone was well tolerated overall and nursing staff viewed it as helpful in 38 of 100 patients, moderately helpful in 26, slightly helpful in 17, and not helpful in 19."1.30Risperidone for dementia-related disturbed behavior in nursing home residents: a clinical experience. ( Goldberg, J; Goldberg, RJ, 1997)
"Risperidone was an effective and safe treatment in three cases of delusions of infestation."1.30Risperidone in the treatment of delusions of infestation. ( Bailey, LG; Canterbury, AL; De León, OA; Furmaga, KM, 1997)

Research

Studies (183)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's25 (13.66)18.2507
2000's106 (57.92)29.6817
2010's43 (23.50)24.3611
2020's9 (4.92)2.80

Authors

AuthorsStudies
Kołaczkowski, M1
Marcinkowska, M1
Bucki, A1
Pawłowski, M1
Mitka, K1
Jaśkowska, J1
Kowalski, P1
Kazek, G1
Siwek, A1
Wasik, A1
Wesołowska, A1
Mierzejewski, P1
Bienkowski, P1
Yunusa, I2
Rashid, N2
Abler, V1
Rajagopalan, K2
Huang, YY2
Teng, T2
Shen, XN2
Chen, SD2
Wang, RZ2
Zhang, RQ1
Dou, KX1
Zhong, XL1
Wang, J1
Chen, KL2
Zhao, QH2
Tan, L1
Dong, Q2
Zhou, XY2
Yu, JT2
Demos, GN1
Mahadik, BS1
Abler, VC1
Holmgren, S1
Andersson, T1
Berglund, A1
Aarsland, D6
Cummings, J1
Freund-Levi, Y4
Rogowska, M2
Thornton, M2
Creese, B2
Velayudhan, L2
Ballard, C6
Tsamakis, K2
Stewart, R2
Mueller, C2
Seifert, J1
Maier, HB1
Toto, S1
Dabbert, D1
Giovane, CD1
Suckling, J1
Huang, SY1
Kuo, K1
Cai, WJ1
Feng, L1
Zhang, C1
Liu, CY1
Li, CB1
Chen, A1
Copeli, F1
Metzger, E1
Cloutier, A1
Osser, DN1
Kim, J1
Ha, TH1
Kim, K1
Lee, EM1
Kim, H1
Kim, DK1
Won, HH1
Lewis, M1
Lee, H1
Myung, W1
Nerius, M1
Johnell, K1
Garcia-Ptacek, S1
Eriksdotter, M3
Haenisch, B1
Doblhammer, G1
Kongpakwattana, K1
Sawangjit, R1
Tawankanjanachot, I1
Bell, JS1
Hilmer, SN1
Chaiyakunapruk, N1
Xue, XJ1
He, RL1
Li, WX1
Xin, JW1
Ye, QY1
Chen, XC1
Pan, XD1
Narayan, SW1
Pearson, SA1
Litchfield, M1
Le Couteur, DG1
Buckley, N1
McLachlan, AJ1
Zoega, H1
Vasilyeva, I1
Biscontri, RG1
Enns, MW1
Metge, CJ1
Alessi-Severini, S1
Gurwitz, D1
Morag, A1
Oved, K1
Teranishi, M1
Kurita, M1
Nishino, S1
Takeyoshi, K1
Numata, Y1
Sato, T1
Tateno, A1
Okubo, Y1
Langballe, EM1
Engdahl, B1
Nordeng, H1
Selbæk, G1
Jedenius, E2
Tysen-Bäckström, AC2
Lärksäter, M3
Wahlund, LO2
McIlroy, G1
Thomas, SK1
Coleman, JJ1
Bloniecki, V1
Auestad, B1
Tysen Bäckström, AC1
Bogaisky, M1
Boettger, S1
Jenewein, J1
Breitbart, W1
Corbett, A1
Burns, A2
Phizackerley, D1
Wu, YH1
Lai, CY1
Chang, YS1
Marston, L1
Nazareth, I1
Petersen, I1
Walters, K1
Osborn, DP1
Reifler, BV1
Blazer, D1
Lin, YT1
Hwang, TJ1
Shan, JC1
Chiang, HL1
Sheu, YH1
Hwu, HG1
Kim, HM3
Chiang, C3
Weintraub, D1
Schneider, LS4
Kales, H1
Maust, DT1
Seyfried, LS2
Kavanagh, J1
Kales, HC2
Shin, HY1
Gadzhanova, S1
Roughead, EE1
Ward, MB1
Pont, LG1
Howard, R2
Costafreda, SG1
Karcher, K1
Coppola, D1
Berlin, JA1
Hough, D1
Sultana, J1
Fontana, A1
Giorgianni, F1
Pasqua, A1
Cricelli, C1
Spina, E1
Gambassi, G1
Ivanovic, J1
Ferrajolo, C1
Molokhia, M1
Sharp, S1
Sturkenboom, M1
Trifirò, G1
Reese, TR1
Thiel, DJ1
Cocker, KE1
Lapeyre-Mestre, M1
Forlenza, OV1
Cretaz, E1
Diniz, BS1
Kálmán, J1
Kálmán, S1
Pákáski, M1
Kalapatapu, RK1
Schimming, C1
Landreville, P1
Leblanc, V1
Chan, MC1
Chong, CS1
Wu, AY1
Wong, KC1
Dunn, EL1
Tang, OW1
Chan, WF1
Sanfélix-Gimeno, G1
Cervera-Casino, P1
Peiró, S1
López-Valcarcel, BG1
Blázquez, A1
Barbera, T1
Dombrovski, AY1
Mulsant, BH5
Ferrell, RE1
Lotrich, FE1
Rosen, JI1
Wallace, M1
Houck, PR3
Mazumdar, S3
Pollock, BG5
Duggal, H1
Singh, I1
Chiabrando, G1
Bianchi, S1
Poluzzi, E1
Montanaro, N1
Scanavacca, P1
Rossom, RC1
Rector, TS1
Lederle, FA1
Dysken, MW1
Eng, ML1
Welty, TE1
Seitz, DP1
Adunuri, N1
Gill, SS1
Gruneir, A1
Herrmann, N5
Rochon, P1
Nobili, A1
Pasina, L1
Trevisan, S1
Riva, E1
Lucca, U1
Tettamanti, M1
Matucci, M1
Tarantola, M1
Roy-Desruisseaux, J1
Landry, J1
Bocti, C1
Tessier, D1
Hottin, P1
Trudel, JF1
Zivin, K1
Valenstein, M1
Cunningham, F1
Blow, FC1
Huybrechts, KF1
Gerhard, T1
Crystal, S1
Olfson, M1
Avorn, J2
Levin, R1
Lucas, JA1
Schneeweiss, S2
Meguro, K1
Meguro, M1
Akanuma, K1
Bocharov, AV1
Kondakova, VE1
Tuleninov, ES1
Marras, C1
Anderson, GM1
Fischer, HD1
Wang, X1
Rochon, PA1
Ismail, Z1
Emeremni, CA1
Rosen, J3
Rajji, TK1
Bullock, R1
Saharan, A1
Wooltorton, E1
McIntyre, RS1
Motsinger, CD1
Perron, GA1
Lacy, TJ1
Fontaine, CS1
Hynan, LS1
Koch, K1
Martin-Cook, K1
Svetlik, D1
Weiner, MF1
Kurz, A2
Delius-Stute, H1
Rettig, K1
Schwalen, S1
Mahmoud, R2
Greenspan, A5
Saxe, T1
Watanabe, H1
Tominaga, K1
Ogino, A1
Sekino, K1
Aoba, A1
Grossman, F1
Okamoto, A2
Turkoz, I1
Gharabawi, G1
Mowat, D1
Fowlie, D1
MacEwan, T1
Mamdani, M1
Lanctôt, KL2
Wancata, J2
Tariot, PN3
Profenno, LA1
Ismail, MS1
Ballard, CG2
Margallo-Lana, ML1
Frank, L1
Kleinman, L1
Ciesla, G1
Rupnow, MF1
Brodaty, H5
Rabinowitz, J2
Katz, IR4
De Deyn, PP7
Davidson, M3
Gerritsen, AA1
de Jonghe-Rouleau, AP1
Stienstra-Liem, LH1
Tran, KT1
Golden, P1
Goldman, P1
Lark, T1
Jacob, NJ1
Englert, I1
Gharabawi, GM1
Bossie, CA1
Mao, L1
Martinez, RA2
Tune, LE2
Greenspan, AJ3
Bastean, JN1
Warner, J1
Butler, R1
Arya, P1
van Waarde, JA1
Kuiper, J1
Verwey, B1
Kroon, JG1
Bonte-Mineur, F1
Geerlings, CJ1
Rietveld, AP1
Vorel, SK1
Bos, F1
Vorel-Havelkova, E1
Brombacher, PJ1
van Marum, RJ1
Jansen, PA1
Cruz Jentoft, AJ1
Gil Gregorio, P1
Altimir Losada, S1
van Bemmel, T1
Westendorp, RG1
Frenchman, IB2
Hafkamp, GJ1
van der Mast, RC1
Zhao, CS1
Puurunen, K1
Sivenius, J1
Jolkkonen, J1
Schallert, T1
Kuehn, BM1
Cream, J1
Shah, A2
Suh, GH3
Formiga, F1
Fort, I1
Pérez-Castejón, JM1
Ruiz, D1
Duaso, E1
Riu, S1
Arriola, E1
Ignacio Diago, J1
Antonio Burón, J1
Gallego, R2
Asghar Ali, AA1
Espinoza, R1
Kavirajan, H1
Read, S1
Raju, J1
Sikdar, S1
Krishna, T1
Curran, S1
Turner, D1
Musa, S1
Wattis, J1
Bies, RR1
Huber, KA2
Wilson, NL1
Kirshner, MA1
Layton, D1
Harris, S1
Wilton, LV1
Shakir, SA1
Schwalen S, S1
Schmitt, A1
Durán, JC1
Diago, JI1
Martinez, G1
Finkel, S1
Kozma, C1
Long, S1
Baser, O1
Engelhart, L1
Katz, I2
Cohen-Mansfield, J1
Stoppe, G1
Schreiner, A1
Schmitt, AB1
Friedman, JH1
Al Chekakie, MO1
Ketz, JM1
Whinney, CM1
Snowdon, J1
Ames, D1
Day, S1
Choi, SK2
Zuidema, SU1
van Iersel, MB1
Koopmans, RT1
Verhey, FR1
Olde Rikkert, MG1
Lolk, A1
Gulmann, NC1
Haupt, M1
Cruz-Jentoft, A1
Jeste, D1
Nonino, F1
De Girolamo, G1
Gamberini, L1
Goldoni, CA1
Jackson, GA1
Angelini, A1
Bendini, C1
Neviani, F1
Neri, M1
Kudo, T1
Mintzer, J1
Zhu, Y1
Rainer, M1
Haushofer, M1
Pfolz, H1
Struhal, C1
Wick, W1
Yury, CA1
Fisher, JE1
Daiello, LA1
Blakesley, RE1
Wang, PS1
Setoguchi, S1
Patrick, A1
Mogun, H1
Choudhry, NK1
Brookhart, MA1
Czarnecki, K1
Kumar, N1
Josephs, KA1
Jano, E1
Johnson, M1
Chen, H1
Aparasu, RR1
Ruths, S1
Straand, J1
Nygaard, HA1
Selbaek, G1
Engedal, K1
Singh, D1
Forlano, R1
Athey, R1
Williams, S1
Bullmore, E1
Brammer, M1
Mellers, J1
Woodruff, P1
David, A1
Allen, RL1
Walker, Z1
D'Ath, PJ1
Katona, CL1
Jeanblanc, W1
Davis, YB1
McKeith, IG1
Harrison, RW1
Madhusoodanan, S1
Brenner, R1
Araujo, L1
Abaza, A1
Wijeratne, C1
Webster, P1
Maany, I1
Kopala, LC1
Honer, WG1
Brecher, M2
Goldberg, RJ1
Goldberg, J1
Finkel, SI1
Workman, RH1
Orengo, CA1
Bakey, AA1
Molinari, VA1
Kunik, ME1
Prince, T1
De León, OA1
Furmaga, KM1
Canterbury, AL1
Bailey, LG1
Geizer, M1
Ancill, RJ1
Rivard, MF1
Flynn, M1
Ward, C1
Rabheru, K2
Campbell, B1
Jeste, DV3
Rockwell, E1
Harris, MJ1
Lohr, JB1
Lacro, J1
Beers, MH1
Mintzer, JE1
Clyde, C1
Napolitano, J2
Meares, S1
Draper, B1
Chengappa, KN1
Sheth, S1
Brar, JS1
Parepally, H1
Marcus, S1
Gopalani, A1
Palmer, A1
Baker, RW1
Schooler, NR1
Rasmussen, A1
Bocksberger, JP1
Dautzenberg, PL1
Eriksson, S1
Lawlor, BA1
Reynolds, PL1
Strayer, SM1
Windhaber, J1
Urbanits, S1
Grisold, W1
Reznik, I1
Paleacu, D1
Masand, PS1
Falsetti, AE1
Kane, JM1
Bhana, N1
Spencer, CM1
Zaudig, M1
Schweitzer, I1
Biswas, A1
Mittal, P1
Chaturvedi, S1
Prasad, A1
Williams, R1
Chaplin, RH1
Wirshing, WC2
Laks, J1
Engelhardt, E1
Marinho, V1
Rozenthal, M1
Souza, FC1
Bacaltchuk, J1
Stoppe, A1
Ferreira, RC1
Bottino, C1
Scalco, M1
Buckley, PF1
Ellingrod, VL1
Schultz, SK1
Ekstam-Smith, K1
Kutscher, E1
Turvey, C1
Arndt, S1
Stryjer, R1
Bar, F1
Strous, RD1
Baruch, Y1
Rabey, JM1
Weiser, M1
Rotmensch, HH1
Korczyn, AD1
Hartman, R1
Cicin-Sain, A1
Anand, R1
Kruglov, LS1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Feru-guard (Ferulic Acid and Angelica Archangelica Extract) for Behavioral Symptoms in Dementia[NCT03451760]Phase 270 participants (Anticipated)Interventional2018-09-30Not yet recruiting
A Pragmatic Randomized-controlled Trial of a Multi-pronged Electronic Health Record-based Clinical Decision Support Tool to Reduce Low-value Antipsychotic Prescriptions Among Older Adults With Alzheimer's and Related Dementias[NCT04851691]117 participants (Anticipated)Interventional2021-08-03Enrolling by invitation
Treatment of Psychosis and Agitation in Alzheimer's Disease[NCT02129348]Phase 277 participants (Actual)Interventional2014-06-30Completed
Post Marketing Study of Escitalopram Versus Risperidone for the Treatment of Behavioral and Psychological Symptoms Amongst Alzheimer's Disease Patients[NCT01119638]Phase 440 participants (Actual)Interventional2008-04-30Completed
A Randomized, Double-Blind, Placebo-Controlled Study of Risperidone for Treatment of Behavioral Disturbances in Subjects With Dementia[NCT00253123]Phase 3626 participants (Actual)InterventionalCompleted
Risperidone in the Treatment of Behavioral Disturbances in Demented Patients: an International, Multicenter, Placebo-controlled, Double-blind, Parallel-group Trial Using Haloperidol as Internal Reference[NCT00249145]Phase 3349 participants (Actual)Interventional1995-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Basic Activities of Daily Living (BADL)

Basic Activities of Daily Living with items for 6 functions: bathing, dressing, toileting, transferring, continence, and feeding. Each item is scored as unimpaired=1, impaired=0. Total score is the measure used, range 0-6; higher scores indicate better functioning. (NCT02129348)
Timeframe: Assessed at Week 0, Week2, Week 4, Week 6, Week 8, Week 10, Week 12

Interventionscore on a scale (Least Squares Mean)
Lithium Treatment Group0.3
Placebo Group0.1

Change in Neuropsychiatric Inventory (NPI) Agitation/Aggression Domain Score

Neuropsychiatric Inventory (NPI) Agitation/Aggression Domain is the measure used that combines symptoms of agitation and aggression. Frequency X Severity rating score, range 0-12. Higher score indicates more agitation and aggressive behavior. (NCT02129348)
Timeframe: Assessed at screening, Week 0, Week 2, Week 4, Week 6, Week 8, Week 10, Week 12

Interventionscore on a scale (Least Squares Mean)
Lithium Treatment Group3.2
Placebo Group2.5

Clinical Global Impression (CGI) Behavior Change

Clinical Global Impression (CGI) Behavior Change score is the measure used to assess change in overall behavior; scoring range 1-7 with higher scores indicating worsening over time and lower scores indicating improvement over time. Scores ranging from 1-3 indicate improvement. Only patients that demonstrated improvement at week 12 were reported; scores for earlier weeks were only used to assess progress throughout the study. (NCT02129348)
Timeframe: Week 12

InterventionParticipants (Count of Participants)
Lithium Treatment Group12
Placebo Group8

Clinical Responder Defined as a 30% Decrease in NPI Core Score (Sum Score of NPI Domains of Agitation/Aggression, Delusions and Hallucinations) Together With a Clinical Global Impression (CGI) Behavior Change Score of 1 or 2

The patient is classified as a responder (score=1) if both criteria are met or as a non-responder (score=0) if both criteria are not met. The first criterion to determine responder status, NPI core score, has a scoring range 0-36; each of the three component scores for symptoms of agitation/aggression, delusions and hallucinations has a scoring range 0-12. For each symptom and the total score, higher score indicates more symptoms. The second criterion to determine responder status, Clinical Global Impression (CGI), is used to assess change in overall behavior; scoring range 1-7 with higher scores indicating worsening over time and lower scores indicating improvement over time. Only patients who met both criteria, assessed as change compared to baseline, were counted as responders; all other patients were non-responders. Patients that demonstrated improvement at week 12 were reported; scores for earlier weeks were only used to assess progress throughout the study. (NCT02129348)
Timeframe: Week 12

InterventionParticipants (Count of Participants)
Lithium Treatment Group12
Placebo Group7

Folstein Mini-Mental Status Exam

30 item questionnaire used to assess degree of cognitive impairment. Orientation, registration, attention/calculation, recall, language, repetitions and commands are assessed. Total score is the measure used; range 0-30, higher scores indicate better global cognitive function. (NCT02129348)
Timeframe: Assessed at Screening, Week 12

Interventionscore on a scale (Least Squares Mean)
Lithium Treatment Group0.9
Placebo Group0.9

Severe Impairment Battery

Neuropsychological test used to assess a patient's cognitive ability. The patient is asked to complete small tasks such as drawing shapes and printing their name. They are also asked to remember certain names and objects, such as a cup and a spoon, and the evaluator's first name. Total score is the measure used; range 0-100, higher scores indicate better cognition. (NCT02129348)
Timeframe: Assessed at Week 0, Week 12

Interventionscore on a scale (Least Squares Mean)
Lithium Treatment Group2.1
Placebo Group-0.0

Simpson-Angus Scale

Simpson Angus Scale for Extrapyramidal Sign requires in-person examination to assess gait, arm dropping, shoulder shaking, elbow rigidity, wrist rigidity, leg pendulousness, head dropping, glabella tap, tremor, and salivation. Total score is the measure used, range 0-40; higher scores indicate increased severity of signs. (NCT02129348)
Timeframe: Assessed at Week 0, Week 2, Week 4, Week 6, Week 8, Week 10, Week 12

Interventionscore on a scale (Least Squares Mean)
Lithium Treatment Group-0.0
Placebo Group0.0

Treatment Emergent Signs and Symptoms

Treatment Emergent Symptom Scale that covers 26 somatic symptoms, each rated as present (score=1) or absent (score=0). Total score is the measure used with scoring range 0-26; higher scores indicate more somatic symptoms. (NCT02129348)
Timeframe: Assessed at Week 0, Week 2, Week 4, Week 6, Week 8, Week 10, Week 12

Interventionscore on a scale (Least Squares Mean)
Lithium Treatment Group0.6
Placebo Group0.7

Young Mania Rating Scale

Young Mania Rating Scale total score is the measure used to assess symptoms that occur in mania; each item is a symptom that is rated for severity. Scoring range 0-60; higher scores indicate more severe symptoms. (NCT02129348)
Timeframe: Assessed at Week 0, Week 2, Week 4, Week 6, Week 8, Week 10, Week 12

Interventionscore on a scale (Least Squares Mean)
Lithium Treatment Group3.1
Placebo Group1.1

Zarit Caregiver Burden Interview

Zarit Caregiver Burden Interview with the caregiver asked to rank 22 items on a scale with responses for each item from 'never' (score 0) to 'nearly always' (score 4). Total score is the measure used; range 0-88 with higher scores indicating greater caregiver burden. (NCT02129348)
Timeframe: Assessed at Week 0, Week 4, Week 8, Week 10, Week 12

Interventionscore on a scale (Least Squares Mean)
Lithium Treatment Group2.8
Placebo Group-0.4

Reviews

48 reviews available for risperidone and Dementia

ArticleYear
Comparative Efficacy, Safety, Tolerability, and Effectiveness of Antipsychotics in The Treatment of Dementia-Related Psychosis (DRP): A Systematic Literature Review.
    The journal of prevention of Alzheimer's disease, 2021, Volume: 8, Issue:4

    Topics: Antipsychotic Agents; Aripiprazole; Dementia; Humans; Olanzapine; Psychotic Disorders; Risperidone

2021
Pharmacological treatments for psychotic symptoms in dementia: A systematic review with pairwise and network meta-analysis.
    Ageing research reviews, 2022, Volume: 75

    Topics: Aripiprazole; Dementia; Donepezil; Humans; Memantine; Network Meta-Analysis; Risperidone; United Sta

2022
Comparative Outcomes of Commonly Used Off-Label Atypical Antipsychotics in the Treatment of Dementia-Related Psychosis: A Network Meta-analysis.
    Advances in therapy, 2022, Volume: 39, Issue:5

    Topics: Antipsychotic Agents; Aripiprazole; Benzodiazepines; Dementia; Humans; Network Meta-Analysis; Off-La

2022
Implications of Adverse Outcomes Associated with Antipsychotics in Older Patients with Dementia: A 2011-2022 Update.
    Drugs & aging, 2023, Volume: 40, Issue:1

    Topics: Aged; Antipsychotic Agents; Benzodiazepines; Dementia; Humans; Olanzapine; Psychotic Disorders; Quet

2023
Implications of Adverse Outcomes Associated with Antipsychotics in Older Patients with Dementia: A 2011-2022 Update.
    Drugs & aging, 2023, Volume: 40, Issue:1

    Topics: Aged; Antipsychotic Agents; Benzodiazepines; Dementia; Humans; Olanzapine; Psychotic Disorders; Quet

2023
Implications of Adverse Outcomes Associated with Antipsychotics in Older Patients with Dementia: A 2011-2022 Update.
    Drugs & aging, 2023, Volume: 40, Issue:1

    Topics: Aged; Antipsychotic Agents; Benzodiazepines; Dementia; Humans; Olanzapine; Psychotic Disorders; Quet

2023
Implications of Adverse Outcomes Associated with Antipsychotics in Older Patients with Dementia: A 2011-2022 Update.
    Drugs & aging, 2023, Volume: 40, Issue:1

    Topics: Aged; Antipsychotic Agents; Benzodiazepines; Dementia; Humans; Olanzapine; Psychotic Disorders; Quet

2023
Pharmacological treatment of neuropsychiatric symptoms of dementia: a network meta-analysis.
    Age and ageing, 2023, 06-01, Volume: 52, Issue:6

    Topics: Aged; Databases, Factual; Dementia; Galantamine; Humans; Network Meta-Analysis; Randomized Controlle

2023
The Psychopharmacology Algorithm Project at the Harvard South Shore Program: An update on management of behavioral and psychological symptoms in dementia.
    Psychiatry research, 2021, Volume: 295

    Topics: Academic Medical Centers; Aged; Algorithms; Antidepressive Agents; Antipsychotic Agents; Aripiprazol

2021
Pharmacological treatments for alleviating agitation in dementia: a systematic review and network meta-analysis.
    British journal of clinical pharmacology, 2018, Volume: 84, Issue:7

    Topics: Antipsychotic Agents; Dementia; Dextromethorphan; Drug Combinations; Humans; Network Meta-Analysis;

2018
[Safety of atypical antipsychotics in the treatment of behavioral and psychological symptoms in dementia: a meta-analysis].
    Zhonghua yi xue za zhi, 2018, Jul-03, Volume: 98, Issue:25

    Topics: Antipsychotic Agents; Dementia; Europe; Humans; Risperidone; Schizophrenia

2018
Baseline characteristics and treatment-emergent risk factors associated with cerebrovascular event and death with risperidone in dementia patients.
    The British journal of psychiatry : the journal of mental science, 2016, Volume: 209, Issue:5

    Topics: Antipsychotic Agents; Cerebrovascular Disorders; Dementia; Humans; Risperidone

2016
Behavioral Disorders in Dementia: Appropriate Nondrug Interventions and Antipsychotic Use.
    American family physician, 2016, Aug-15, Volume: 94, Issue:4

    Topics: Antipsychotic Agents; Aripiprazole; Arrhythmias, Cardiac; Basal Ganglia Diseases; Behavior Therapy;

2016
A Review of Adverse Outcomes Associated with Psychoactive Drug Use in Nursing Home Residents with Dementia.
    Drugs & aging, 2016, Volume: 33, Issue:12

    Topics: Aged; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Dementia; Humans; Nursing Homes;

2016
[The use of antipsychotics in patients with dementia].
    Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2008, Volume: 30, Issue:3

    Topics: Antipsychotic Agents; Aripiprazole; Benzodiazepines; Cerebrovascular Disorders; Dementia; Dementia,

2008
[Recognition and treatment of behavioral and psychological symptoms of dementias: lessons from the CATIE-AD study].
    Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2008, Volume: 10, Issue:4

    Topics: Affect; Aggression; Antipsychotic Agents; Brain; Caregivers; Conduct Disorder; Dementia; Diagnosis,

2008
Management of hallucinations and psychosis in Parkinson's disease.
    The American journal of geriatric pharmacotherapy, 2010, Volume: 8, Issue:4

    Topics: Aged; Antipsychotic Agents; Brief Psychiatric Rating Scale; Clozapine; Comorbidity; Delusions; Demen

2010
Antidepressants for agitation and psychosis in dementia.
    The Cochrane database of systematic reviews, 2011, Feb-16, Issue:2

    Topics: Adult; Antidepressive Agents; Citalopram; Dementia; Humans; Psychomotor Agitation; Psychotic Disorde

2011
[Efficasy and safety of the use of risperidone (rispoluxe) in demented patients with psychotic and behavioural disorders].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2012, Volume: 112, Issue:6

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Cognition; Dementia; Female; Humans; Male; Mental Dis

2012
Atypical antipsychotics: experience and use in the elderly.
    International journal of clinical practice, 2002, Volume: 56, Issue:7

    Topics: Aged; Aged, 80 and over; Akathisia, Drug-Induced; Antipsychotic Agents; Benzodiazepines; Clozapine;

2002
[Dementia induced by antipsychotic drugs].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl

    Topics: Antipsychotic Agents; Butyrophenones; Clozapine; Dementia; Diagnostic and Statistical Manual of Ment

2004
Efficacy of atypical antipsychotics in elderly patients with dementia.
    The Journal of clinical psychiatry, 2004, Volume: 65 Suppl 11

    Topics: Aged; Antipsychotic Agents; Aripiprazole; Basal Ganglia Diseases; Benzodiazepines; Brief Psychiatric

2004
The relationship between antipsychotic treatment and quality of life for patients with dementia living in residential and nursing home care facilities.
    The Journal of clinical psychiatry, 2004, Volume: 65 Suppl 11

    Topics: Aged; Antipsychotic Agents; Choice Behavior; Controlled Clinical Trials as Topic; Dementia; Dibenzot

2004
Optimizing atypical antipsychotic treatment strategies in the elderly.
    Journal of the American Geriatrics Society, 2004, Volume: 52, Issue:12 Suppl

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Clozapine; Controlled

2004
Dementia.
    Clinical evidence, 2004, Issue:11

    Topics: Alzheimer Disease; Antipsychotic Agents; Benzodiazepines; Cognition; Dementia; Donepezil; Galantamin

2004
Do atypical antipsychotics cause stroke?
    CNS drugs, 2005, Volume: 19, Issue:2

    Topics: Antipsychotic Agents; Behavioral Symptoms; Benzodiazepines; Dementia; Humans; MEDLINE; Olanzapine; R

2005
[Increased risk of stroke during the use of olanzapine or risperidone in patients with dementia].
    Nederlands tijdschrift voor geneeskunde, 2005, Jan-22, Volume: 149, Issue:4

    Topics: Antipsychotic Agents; Benzodiazepines; Dementia; Humans; Olanzapine; Randomized Controlled Trials as

2005
Atypical antipsychotics for nursing home patients: a retrospective chart review.
    Drugs & aging, 2005, Volume: 22, Issue:3

    Topics: Aged; Antipsychotic Agents; Benzodiazepines; Dementia; Homes for the Aged; Humans; Medical Records;

2005
[Efficacy and adverse reactions of antipsychotics for neuropsychiatric symptoms in dementia: a systematic review].
    Nederlands tijdschrift voor geneeskunde, 2006, Jul-15, Volume: 150, Issue:28

    Topics: Aggression; Antipsychotic Agents; Benzodiazepines; Dementia; Haloperidol; Humans; Olanzapine; Psycho

2006
[Psychopharmacological treatment of behavioral and psychological symptoms in dementia].
    Ugeskrift for laeger, 2006, Oct-02, Volume: 168, Issue:40

    Topics: Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines;

2006
Risperidone for the treatment of neuropsychiatric features in dementia.
    Drugs & aging, 2006, Volume: 23, Issue:11

    Topics: Accidental Falls; Aged; Aged, 80 and over; Antipsychotic Agents; Cerebrovascular Disorders; Cognitio

2006
Mortality in elderly dementia patients treated with risperidone.
    Journal of clinical psychopharmacology, 2006, Volume: 26, Issue:6

    Topics: Age Distribution; Age Factors; Aged; Aged, 80 and over; Aging; Antipsychotic Agents; Clinical Trials

2006
[Application of neuroleptics for dementia].
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 2007, Volume: 44, Issue:1

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Behavioral Symptoms; Benzodiazepines; Dementia; Diben

2007
The efficacy and safety of risperidone in the treatment of psychosis of Alzheimer's disease and mixed dementia: a meta-analysis of 4 placebo-controlled clinical trials.
    International journal of geriatric psychiatry, 2007, Volume: 22, Issue:5

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antipsychotic Agents; Dementia; Double-Blind Method; Fem

2007
Meta-analysis of the effectiveness of atypical antipsychotics for the treatment of behavioural problems in persons with dementia.
    Psychotherapy and psychosomatics, 2007, Volume: 76, Issue:4

    Topics: Antipsychotic Agents; Benzodiazepines; Controlled Clinical Trials as Topic; Dementia; Dibenzothiazep

2007
Treatment strategies for agitation and psychosis in dementia.
    The Journal of clinical psychiatry, 1996, Volume: 57 Suppl 14

    Topics: Aged; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Clozapine;

1996
Managing the behavioral and psychological signs and symptoms of dementia.
    International clinical psychopharmacology, 1997, Volume: 12 Suppl 4

    Topics: Aged; Antipsychotic Agents; Benzodiazepines; Clinical Trials as Topic; Clozapine; Dementia; Humans;

1997
Treatment of special populations with the atypical antipsychotics. Collaborative Working Group on Clinical Trial Evaluations.
    The Journal of clinical psychiatry, 1998, Volume: 59 Suppl 12

    Topics: Adult; Age Factors; Aged; Algorithms; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Clini

1998
Conventional vs. newer antipsychotics in elderly patients.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 1999,Winter, Volume: 7, Issue:1

    Topics: Adult; Aged; Antipsychotic Agents; Benzodiazepines; Clozapine; Dementia; Dibenzothiazepines; Dose-Re

1999
Pharmacologic management of psychosis in dementia.
    The Journal of clinical psychiatry, 1999, Volume: 60 Suppl 8

    Topics: Aged; Antipsychotic Agents; Clozapine; Comorbidity; Delusions; Dementia; Hallucinations; Humans; Psy

1999
Control of aggression and agitation in patients with dementia: efficacy and safety of risperidone.
    International journal of geriatric psychiatry, 2000, Volume: 15 Suppl 1

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Canada; Dementia; Dose-Response Relationship, Drug; D

2000
Risperidone for control of agitation in dementia patients.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2000, May-01, Volume: 57, Issue:9

    Topics: Aged; Clinical Trials as Topic; Dementia; Female; Humans; Risperidone

2000
Risperidone: a review of its use in the management of the behavioural and psychological symptoms of dementia.
    Drugs & aging, 2000, Volume: 16, Issue:6

    Topics: Age Factors; Aggression; Animals; Antipsychotic Agents; Clinical Trials as Topic; Dementia; Dopamine

2000
A risk-benefit assessment of risperidone for the treatment of behavioural and psychological symptoms in dementia.
    Drug safety, 2000, Volume: 23, Issue:3

    Topics: Aged; Aging; Agranulocytosis; Antipsychotic Agents; Basal Ganglia Diseases; Dementia; Humans; Risk A

2000
Does risperidone have a place in the treatment of nonschizophrenic patients?
    International clinical psychopharmacology, 2001, Volume: 16, Issue:1

    Topics: Bipolar Disorder; Clinical Trials as Topic; Dementia; Humans; Mental Disorders; Obsessive-Compulsive

2001
Optimal dosing with risperidone: updated recommendations.
    The Journal of clinical psychiatry, 2001, Volume: 62, Issue:4

    Topics: Adolescent; Adult; Age Factors; Aged; Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Top

2001
Movement disorders associated with neuroleptic treatment.
    The Journal of clinical psychiatry, 2001, Volume: 62 Suppl 21

    Topics: Age Factors; Aged; Akathisia, Drug-Induced; Antipsychotic Agents; Basal Ganglia Diseases; Dementia;

2001
Scales to assess efficacy and safety of pharmacologic agents in the treatment of behavioral and psychological symptoms of dementia.
    The Journal of clinical psychiatry, 2001, Volume: 62 Suppl 21

    Topics: Aged; Alzheimer Disease; Antipsychotic Agents; Basal Ganglia Diseases; Clinical Trials as Topic; Con

2001
Long-term safety of risperidone.
    The Journal of clinical psychiatry, 2001, Volume: 62 Suppl 21

    Topics: Aged; Antipsychotic Agents; Basal Ganglia Diseases; Cholinesterase Inhibitors; Clinical Trials as To

2001
Risperidone for the treatment of behavioral and psychological symptoms of dementia.
    The Journal of clinical psychiatry, 2001, Volume: 62 Suppl 21

    Topics: Aged; Aggression; Antipsychotic Agents; Basal Ganglia Diseases; Clinical Trials as Topic; Cognition

2001
Broad therapeutic uses of atypical antipsychotic medications.
    Biological psychiatry, 2001, Dec-01, Volume: 50, Issue:11

    Topics: Antipsychotic Agents; Basal Ganglia Diseases; Benzodiazepines; Child; Child Development Disorders, P

2001

Trials

29 trials available for risperidone and Dementia

ArticleYear
Efficacy and tolerability of risperidone, yokukansan, and fluvoxamine for the treatment of behavioral and psychological symptoms of dementia: a blinded, randomized trial.
    Journal of clinical psychopharmacology, 2013, Volume: 33, Issue:5

    Topics: Activities of Daily Living; Aged; Aged, 80 and over; Basal Ganglia Diseases; Central Nervous System

2013
Galantamine versus risperidone treatment of neuropsychiatric symptoms in patients with probable dementia: an open randomized trial.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2014, Volume: 22, Issue:4

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Cholinesterase Inhibitors; Dementia; Female; Galantam

2014
Galantamine versus risperidone for agitation in people with dementia: a randomized, twelve-week, single-center study.
    Dementia and geriatric cognitive disorders, 2014, Volume: 38, Issue:3-4

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antipsychotic Agents; Dementia; Dementia, Vascular; Fema

2014
Serotonin transporter triallelic genotype and response to citalopram and risperidone in dementia with behavioral symptoms.
    International clinical psychopharmacology, 2010, Volume: 25, Issue:1

    Topics: Aged; Aged, 80 and over; Alleles; Antipsychotic Agents; Behavioral Symptoms; Citalopram; Dementia; F

2010
A comparison of the E-BEHAVE-AD, NBRS, and NPI in quantifying clinical improvement in the treatment of agitation and psychosis associated with dementia.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2013, Volume: 21, Issue:1

    Topics: Aged, 80 and over; Citalopram; Dementia; Double-Blind Method; Female; Humans; Male; Psychiatric Stat

2013
A double-blind comparison of olanzapine versus risperidone in the acute treatment of dementia-related behavioral disturbances in extended care facilities.
    The Journal of clinical psychiatry, 2003, Volume: 64, Issue:6

    Topics: Aged; Antipsychotic Agents; Benzodiazepines; Dementia; Double-Blind Method; Drug Administration Sche

2003
Efficacy of risperidone for treating patients with behavioral and psychological symptoms of dementia.
    International psychogeriatrics, 2004, Volume: 16, Issue:1

    Topics: Aged; Antipsychotic Agents; Dementia; Humans; Mental Disorders; Middle Aged; Prospective Studies; Ri

2004
The effect of risperidone on nursing burden associated with caring for patients with dementia.
    Journal of the American Geriatrics Society, 2004, Volume: 52, Issue:9

    Topics: Administration, Oral; Aged; Aged, 80 and over; Analysis of Variance; Antipsychotic Agents; Attitude

2004
Behavioral and psychological symptoms in patients with dementia as a target for pharmacotherapy with risperidone.
    The Journal of clinical psychiatry, 2004, Volume: 65, Issue:10

    Topics: Aged; Aggression; Alzheimer Disease; Antipsychotic Agents; Dementia; Dementia, Vascular; Female; Hum

2004
Correlates of anticholinergic activity in patients with dementia and psychosis treated with risperidone or olanzapine.
    The Journal of clinical psychiatry, 2004, Volume: 65, Issue:12

    Topics: Antipsychotic Agents; Basal Ganglia Diseases; Benzodiazepines; Cognition Disorders; Delusions; Demen

2004
Open-label, observational study of the effects of risperidone on the behavioral and psychological symptoms of dementia and caregiver stress in the community setting.
    The American journal of geriatric pharmacotherapy, 2005, Volume: 3, Issue:1

    Topics: Aged; Antipsychotic Agents; Basal Ganglia Diseases; Behavior; Caregivers; Community Health Services;

2005
Effects of risperidone on behavioral and psychological symptoms associated with dementia in clinical practice.
    International psychogeriatrics, 2005, Volume: 17, Issue:4

    Topics: Aged; Aggression; Antipsychotic Agents; Basal Ganglia Diseases; Delusions; Dementia; Female; Humans;

2005
Evaluation of risperidone in the treatment of behavioral and psychological symptoms and sleep disturbances associated with dementia.
    International psychogeriatrics, 2005, Volume: 17, Issue:4

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Basal Ganglia Diseases; Dementia; Female; Humans; Mal

2005
[Changeover to risperidone after treatment with conventional low potency neuroleptics in dementia patients. An observation study during usage].
    Deutsche medizinische Wochenschrift (1946), 2006, Mar-03, Volume: 131, Issue:9

    Topics: Aged; Aggression; Antipsychotic Agents; Behavior; Dementia; Dose-Response Relationship, Drug; Female

2006
Comparative efficacy of risperidone versus haloperidol on behavioural and psychological symptoms of dementia.
    International journal of geriatric psychiatry, 2006, Volume: 21, Issue:7

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Anxiety Disorders; Cross-Over Studies; Dementia; Doub

2006
Quetiapine versus risperidone in elderly patients with behavioural and psychological symptoms of dementia: efficacy, safety and cognitive function.
    European psychiatry : the journal of the Association of European Psychiatrists, 2007, Volume: 22, Issue:6

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Dementia; Dibenzothiazepines; Female; Humans; Male; M

2007
A double-blind comparison of citalopram and risperidone for the treatment of behavioral and psychotic symptoms associated with dementia.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2007, Volume: 15, Issue:11

    Topics: Aged, 80 and over; Antipsychotic Agents; Citalopram; Dementia; Double-Blind Method; Female; Hospital

2007
Stopping antipsychotic drug therapy in demented nursing home patients: a randomized, placebo-controlled study--the Bergen District Nursing Home Study (BEDNURS).
    International journal of geriatric psychiatry, 2008, Volume: 23, Issue:9

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Benzodiazepines; Dementia; Double-Blind Method; Femal

2008
Efficacy of risperidone treatment for psychoses associated with schizophrenia, schizoaffective disorder, bipolar disorder, or senile dementia in 11 geriatric patients: a case series.
    The Journal of clinical psychiatry, 1995, Volume: 56, Issue:11

    Topics: Aged; Bipolar Disorder; Chronic Disease; Comorbidity; Dementia; Female; Hospitalization; Humans; Hyp

1995
Nursing home research from industry's perspective.
    International psychogeriatrics, 1996, Volume: 8 Suppl 3

    Topics: Aged; Alzheimer Disease; Antipsychotic Agents; Dementia; Dose-Response Relationship, Drug; Ethics, M

1996
The use of risperidone for psychosis and agitation in demented patients with Parkinson's disease.
    The Journal of neuropsychiatry and clinical neurosciences, 1997,Fall, Volume: 9, Issue:4

    Topics: Aged; Antipsychotic Agents; Dementia; Female; Humans; Male; Parkinson Disease; Pilot Projects; Psych

1997
Clinical experience with risperidone, haloperidol, and thioridazine for dementia-associated behavioral disturbances.
    International psychogeriatrics, 1997, Volume: 9, Issue:4

    Topics: Aged; Antipsychotic Agents; Chi-Square Distribution; Dementia; Haloperidol; Humans; Retrospective St

1997
Risperidone for the treatment of behavioral disturbances in dementia: a case series.
    The Journal of neuropsychiatry and clinical neurosciences, 1998,Spring, Volume: 10, Issue:2

    Topics: Aged; Aged, 80 and over; Aggression; Antipsychotic Agents; Behavioral Symptoms; Delusions; Dementia;

1998
Comparison of risperidone and placebo for psychosis and behavioral disturbances associated with dementia: a randomized, double-blind trial. Risperidone Study Group.
    The Journal of clinical psychiatry, 1999, Volume: 60, Issue:2

    Topics: Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Antipsychotic Agents; Basal Ganglia Diseases

1999
A randomized trial of risperidone, placebo, and haloperidol for behavioral symptoms of dementia.
    Neurology, 1999, Sep-22, Volume: 53, Issue:5

    Topics: Aged; Aged, 80 and over; Behavior; Dementia; Double-Blind Method; Female; Haloperidol; Humans; Male;

1999
Low incidence of persistent tardive dyskinesia in elderly patients with dementia treated with risperidone.
    The American journal of psychiatry, 2000, Volume: 157, Issue:7

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antipsychotic Agents; Dementia; Dementia, Vascular; Dose

2000
Efficacy and safety of risperidone oral solution in agitation associated with dementia in the elderly.
    Arquivos de neuro-psiquiatria, 2001, Volume: 59, Issue:4

    Topics: Administration, Oral; Aged; Alzheimer Disease; Antipsychotic Agents; Basal Ganglia Diseases; Dementi

2001
Comparison of risperidone with olanzapine in elderly patients with dementia and psychosis.
    Pharmacotherapy, 2002, Volume: 22, Issue:1

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Benzodiazepines; Cognition; Dementia; Female; Humans;

2002
A pilot, randomized, open-label trial assessing safety and pharmakokinetic parameters of co-administration of rivastigmine with risperidone in dementia patients with behavioral disturbances.
    International journal of geriatric psychiatry, 2002, Volume: 17, Issue:4

    Topics: Aged; Analysis of Variance; Antipsychotic Agents; Carbamates; Cholinesterase Inhibitors; Dementia; D

2002

Other Studies

106 other studies available for risperidone and Dementia

ArticleYear
Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.
    Journal of medicinal chemistry, 2014, Jun-12, Volume: 57, Issue:11

    Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Avoidance Learning; Benzoxazoles; Catalepsy; C

2014
Neuropsychiatric Symptoms in Dementia: Considering a Clinical Role for Electroencephalography.
    The Journal of neuropsychiatry and clinical neurosciences, 2022,Summer, Volume: 34, Issue:3

    Topics: Alzheimer Disease; Dementia; Electroencephalography; Galantamine; Humans; Neuropsychological Tests;

2022
[Clinical use of psychotropic drugs: A look at antipsychotic drugs].
    Deutsche medizinische Wochenschrift (1946), 2023, Volume: 148, Issue:9

    Topics: Aged; Antipsychotic Agents; Dementia; Drug-Related Side Effects and Adverse Reactions; Humans; Psych

2023
Atypical Antipsychotics Augmentation in Patients with Depressive Disorder and Risk of Subsequent Dementia: A Nationwide Population-Based Cohort Study.
    Journal of Alzheimer's disease : JAD, 2021, Volume: 80, Issue:1

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Cohort Studies; Dementia; Depressive Disorder; Female

2021
The Impact of Antipsychotic Drugs on Long-term Care, Nursing Home Admission, and Death in Dementia Patients.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2018, 09-11, Volume: 73, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Butyrophenones; Cohort Studies; Dementia; Female; Ger

2018
Anticholinergic medicines use among older adults before and after initiating dementia medicines.
    British journal of clinical pharmacology, 2019, Volume: 85, Issue:9

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Australia; Cholinergic Antagonists; Cholinesterase In

2019
Movement disorders in elderly users of risperidone and first generation antipsychotic agents: a Canadian population-based study.
    PloS one, 2013, Volume: 8, Issue:5

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Benzodiazepines; Canada; Dementia; Dibenzothiazepines

2013
A biological basis for the sex bias of antipsychotic drugs adverse events.
    Journal of the American Geriatrics Society, 2013, Volume: 61, Issue:8

    Topics: Aged; Antipsychotic Agents; Cell Line; Cell Proliferation; Dementia; Dose-Response Relationship, Dru

2013
Short- and long-term mortality risk associated with the use of antipsychotics among 26,940 dementia outpatients: a population-based study.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2014, Volume: 22, Issue:4

    Topics: Aged; Aged, 80 and over; Ambulatory Care; Antipsychotic Agents; Cohort Studies; Dementia; Female; Ha

2014
Second-generation antipsychotic drug use in hospital inpatients with dementia: the impact of a safety warning on rates of prescribing.
    Journal of public health (Oxford, England), 2015, Volume: 37, Issue:2

    Topics: Antipsychotic Agents; Dementia; England; Female; Humans; Inpatients; Male; Practice Patterns, Physic

2015
Response to Bogaiksy's letter to the editor.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2014, Volume: 22, Issue:9

    Topics: Antipsychotic Agents; Cholinesterase Inhibitors; Dementia; Female; Galantamine; Humans; Irritable Mo

2014
Galantamine versus risperidone treatment of neuropsychiatric symptoms in patients with probable dementia: an open randomized trial.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2014, Volume: 22, Issue:9

    Topics: Antipsychotic Agents; Cholinesterase Inhibitors; Dementia; Female; Galantamine; Humans; Irritable Mo

2014
Haloperidol, risperidone, olanzapine and aripiprazole in the management of delirium: A comparison of efficacy, safety, and side effects.
    Palliative & supportive care, 2015, Volume: 13, Issue:4

    Topics: Aged; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Delirium; Dementia; Female; Haloperidol;

2015
Don't use antipsychotics routinely to treat agitation and aggression in people with dementia.
    BMJ (Clinical research ed.), 2014, Nov-03, Volume: 349

    Topics: Aggression; Antipsychotic Agents; Dementia; Drug Substitution; Humans; Interpersonal Relations; Long

2014
Licensed indication for risperidone in dementia.
    BMJ (Clinical research ed.), 2014, Dec-10, Volume: 349

    Topics: Aggression; Antipsychotic Agents; Dementia; Humans; Psychomotor Agitation; Risperidone

2014
Antipsychotic polypharmacy among elderly patients with schizophrenia and dementia during hospitalization at a Taiwanese psychiatric hospital.
    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2015, Volume: 15, Issue:1

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Dementia; Drug Therapy, Combination; Female; Hospital

2015
Prescribing of antipsychotics in UK primary care: a cohort study.
    BMJ open, 2014, Dec-18, Volume: 4, Issue:12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Bipolar Disorder; Child; Cohort St

2014
An unsubstantiated conclusion.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2015, Volume: 23, Issue:2

    Topics: Antipsychotic Agents; Cholinesterase Inhibitors; Dementia; Female; Galantamine; Humans; Irritable Mo

2015
Dosage and duration of antipsychotic treatment in demented outpatients with agitation or psychosis.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2015, Volume: 114, Issue:2

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Dementia; Female; Humans; Male; Middle Aged; Outpatie

2015
Treatment changes among older patients with dementia treated with antipsychotics.
    International journal of geriatric psychiatry, 2015, Volume: 30, Issue:12

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Benzodiazepines; Dementia; Follow-Up Studies; Humans;

2015
Antipsychotics, other psychotropics, and the risk of death in patients with dementia: number needed to harm.
    JAMA psychiatry, 2015, Volume: 72, Issue:5

    Topics: Aged; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Case-Control Studies; Dementia;

2015
The use of antipsychotics among people treated with medications for dementia in residential aged care facilities.
    International psychogeriatrics, 2016, Volume: 28, Issue:6

    Topics: Aged; Antipsychotic Agents; Assisted Living Facilities; Australia; Cross-Sectional Studies; Dementia

2016
The Effect of Safety Warnings on Antipsychotic Drug Prescribing in Elderly Persons with Dementia in the United Kingdom and Italy: A Population-Based Study.
    CNS drugs, 2016, Volume: 30, Issue:11

    Topics: Aged; Antipsychotic Agents; Benzodiazepines; Databases, Factual; Dementia; Drug Prescriptions; Femal

2016
Update on neuropsychiatric symptoms of dementia: antipsychotic use.
    Geriatrics, 2009, Volume: 64, Issue:5

    Topics: Aged; Aggression; Antipsychotic Agents; Aripiprazole; Dementia; Geriatric Psychiatry; Humans; Pipera

2009
Older adult's acceptability ratings of treatments for verbal agitation in persons with dementia.
    American journal of Alzheimer's disease and other dementias, 2010, Volume: 25, Issue:2

    Topics: Aged; Aged, 80 and over; Aggression; Aging; Behavior Therapy; Dementia; Female; Humans; Male; Neurop

2010
Antipsychotics and risk of cerebrovascular events in treatment of behavioural and psychological symptoms of dementia in Hong Kong: a hospital-based, retrospective, cohort study.
    International journal of geriatric psychiatry, 2010, Volume: 25, Issue:4

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Cerebrovascular Disorders; Dementia; Female; Hong Kon

2010
Effectiveness of safety warnings in atypical antipsychotic drugs: an interrupted time-series analysis in Spain.
    Drug safety, 2009, Volume: 32, Issue:11

    Topics: Aged; Antipsychotic Agents; Benzodiazepines; Dementia; Dose-Response Relationship, Drug; Drug and Na

2009
Risperidone and dementia-related aggression: new indication. A last resort, no better than haloperidol.
    Prescrire international, 2009, Volume: 18, Issue:104

    Topics: Aged; Aggression; Alzheimer Disease; Antipsychotic Agents; Dementia; Drug Approval; Europe; France;

2009
Delusional parasitosis as a presenting feature of dementia.
    The Journal of neuropsychiatry and clinical neurosciences, 2010,Winter, Volume: 22, Issue:1

    Topics: Aged; Animals; Antipsychotic Agents; Atrophy; Brain; Delusions; Dementia; Diagnosis, Differential; F

2010
Profile of atypical-antipsychotics use in patients affected by dementia in the University Hospital of Ferrara.
    European journal of clinical pharmacology, 2010, Volume: 66, Issue:7

    Topics: Antipsychotic Agents; Behavioral Symptoms; Benzodiazepines; Cholinesterase Inhibitors; Dementia; Dib

2010
Are all commonly prescribed antipsychotics associated with greater mortality in elderly male veterans with dementia?
    Journal of the American Geriatrics Society, 2010, Volume: 58, Issue:6

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Benzodiazepines; Cohort Studies; Comorbidity; Dementi

2010
Use and misuse of antipsychotic drugs in patients with dementia in Alzheimer special care units.
    International clinical psychopharmacology, 2009, Volume: 24, Issue:2

    Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Antidepressive Agents; Antip

2009
Domperidone-induced tardive dyskinesia and withdrawal psychosis in an elderly woman with dementia.
    The Annals of pharmacotherapy, 2011, Volume: 45, Issue:9

    Topics: Aged; Blood-Brain Barrier; Dementia; Domperidone; Dopamine Antagonists; Dopamine D2 Receptor Antagon

2011
Risk of mortality among individual antipsychotics in patients with dementia.
    The American journal of psychiatry, 2012, Volume: 169, Issue:1

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Benzodiazepines; Dementia; Dibenzothiazepines; Female

2012
Differential risk of death in older residents in nursing homes prescribed specific antipsychotic drugs: population based cohort study.
    BMJ (Clinical research ed.), 2012, Feb-23, Volume: 344

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Cause of Death; Comorbidity; Dementia; Dibenzothiazep

2012
Recurrent delusional ideas due to left caudate head infarction, without dementia.
    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2012, Volume: 12, Issue:1

    Topics: Aged; Antipsychotic Agents; Brain; Cerebral Infarction; Cerebrovascular Circulation; Delusions; Deme

2012
Atypical antipsychotic use and parkinsonism in dementia: effects of drug, dose, and sex.
    The American journal of geriatric pharmacotherapy, 2012, Volume: 10, Issue:6

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Benzodiazepines; Cohort Studies; Dementia; Dibenzothi

2012
Risperidone (Risperdal): increased rate of cerebrovascular events in dementia trials.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2002, Nov-26, Volume: 167, Issue:11

    Topics: Aged; Dementia; Dopamine Antagonists; Humans; Ischemic Attack, Transient; Randomized Controlled Tria

2002
Antipsychotic drugs and diabetes.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2003, Mar-18, Volume: 168, Issue:6

    Topics: Antipsychotic Agents; Causality; Dementia; Diabetes Mellitus; Humans; Obesity; Risperidone; Weight G

2003
Use of atypical antipsychotic drugs in patients with dementia.
    American family physician, 2003, Jun-01, Volume: 67, Issue:11

    Topics: Aged; Antipsychotic Agents; Benzodiazepines; Clozapine; Comorbidity; Dementia; Dibenzothiazepines; H

2003
[Treatment of behavioral disorders in dementia with risperidone in psychogeriatric outpatients].
    MMW Fortschritte der Medizin, 2003, Oct-16, Volume: 145, Issue:42

    Topics: Antipsychotic Agents; Clinical Trials as Topic; Dementia; Follow-Up Studies; Humans; Mental Disorder

2003
Early Alzheimer's disease.
    The New England journal of medicine, 2004, Jan-01, Volume: 350, Issue:1

    Topics: Antipsychotic Agents; Dementia; Humans; Risperidone; Stroke

2004
Risperidone questioned as dementia first-line treatment.
    Geriatrics, 2004, Volume: 59, Issue:2

    Topics: Aged; Antipsychotic Agents; Dementia; Humans; Psychotic Disorders; Risperidone

2004
Risperidone in the treatment of elderly patients with psychosis of Alzheimer's disease and related dementias.
    Journal of the American Geriatrics Society, 2004, Volume: 52, Issue:5

    Topics: Aged; Alzheimer Disease; Antipsychotic Agents; Dementia; Double-Blind Method; Humans; Middle Aged; P

2004
CSM warning on atypical psychotics and stroke may be detrimental for dementia.
    BMJ (Clinical research ed.), 2004, May-22, Volume: 328, Issue:7450

    Topics: Antipsychotic Agents; Benzodiazepines; Dementia; Humans; Olanzapine; Risk Factors; Risperidone; Stro

2004
Atypical antipsychotics and risk of cerebrovascular accidents.
    The American journal of psychiatry, 2004, Volume: 161, Issue:6

    Topics: Aged; Antipsychotic Agents; Benzodiazepines; Cohort Studies; Comorbidity; Dementia; Female; Geriatri

2004
Clinical effectiveness of atypical antipsychotics in dementia.
    The Journal of clinical psychiatry, 2004, Volume: 65 Suppl 11

    Topics: Adverse Drug Reaction Reporting Systems; Aged; Antipsychotic Agents; Basal Ganglia Diseases; Benzodi

2004
[Neuroleptic malignant syndrome in users of risperidone].
    Nederlands tijdschrift voor geneeskunde, 2004, Sep-11, Volume: 148, Issue:37

    Topics: Aged; Antipsychotic Agents; Dementia; Fatal Outcome; Female; Fever; Humans; Male; Neuroleptic Malign

2004
Bradycardia at low doses of risperidone.
    The American journal of psychiatry, 2004, Volume: 161, Issue:12

    Topics: Age Factors; Aged; Aged, 80 and over; Antipsychotic Agents; Bradycardia; Dementia; Geriatric Psychia

2004
[Diphenhydramin-overdose: anticholinergic symptoms, EEG-findings in the course and drug treatment of a gerontopsychiatric patient].
    Psychiatrische Praxis, 2004, Volume: 31 Suppl 1

    Topics: Aged; Brain; Cholinergic Antagonists; Dementia; Depressive Disorder; Diphenhydramine; Drug Therapy,

2004
[Neuroleptic malignant syndrome in users of risperidone].
    Nederlands tijdschrift voor geneeskunde, 2005, Jan-15, Volume: 149, Issue:3

    Topics: Antipsychotic Agents; Dementia; Diagnosis, Differential; Humans; Neuroleptic Malignant Syndrome; Ris

2005
[Neuroleptic malignant syndrome in users of risperidone].
    Nederlands tijdschrift voor geneeskunde, 2005, Jan-15, Volume: 149, Issue:3

    Topics: Antipsychotic Agents; Dementia; Dose-Response Relationship, Drug; Humans; Neuroleptic Malignant Synd

2005
[Neuroleptic malignant syndrome in users of risperidone].
    Nederlands tijdschrift voor geneeskunde, 2005, Jan-15, Volume: 149, Issue:3

    Topics: Adult; Antipsychotic Agents; Dementia; Diagnosis, Differential; Humans; Male; Neuroleptic Malignant

2005
[Neuroleptic malignant syndrome in users of risperidone].
    Nederlands tijdschrift voor geneeskunde, 2005, Jan-15, Volume: 149, Issue:3

    Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Dementia; Humans; Neuroleptic Malignant Syndrome; Ris

2005
Cerebrovascular events after treatment of dementia patients with risperidone.
    International psychogeriatrics, 2004, Volume: 16, Issue:4

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Dementia; Female; Humans; Ischemic Attack, Transient;

2004
[The recent controversy on the use of neuroleptics in the elderly with dementia].
    Revista clinica espanola, 2005, Volume: 205, Issue:2

    Topics: Aged; Antipsychotic Agents; Dementia; Humans; Risperidone

2005
[Neuroleptic malignant syndrome in users of risperidone].
    Nederlands tijdschrift voor geneeskunde, 2005, Mar-12, Volume: 149, Issue:11

    Topics: Antipsychotic Agents; Dementia; Diagnosis, Differential; Humans; Neuroleptic Malignant Syndrome; Ris

2005
[Increased risk of stroke during the use of olanzapine or risperidone in patients with dementia].
    Nederlands tijdschrift voor geneeskunde, 2005, Mar-26, Volume: 149, Issue:13

    Topics: Antipsychotic Agents; Benzodiazepines; Dementia; Humans; Olanzapine; Risk Factors; Risperidone; Stro

2005
[Increased risk of stroke during the use of olanzapine or risperidone in patients with dementia].
    Nederlands tijdschrift voor geneeskunde, 2005, Mar-26, Volume: 149, Issue:13

    Topics: Antipsychotic Agents; Benzodiazepines; Dementia; Humans; Olanzapine; Risk Factors; Risperidone; Stro

2005
Psychotropic medication and stroke outcome.
    The American journal of psychiatry, 2005, Volume: 162, Issue:5

    Topics: Age Factors; Aged; Animals; Behavior, Animal; Dementia; Humans; Male; Outcome Assessment, Health Car

2005
FDA warns antipsychotic drugs may be risky for elderly.
    JAMA, 2005, May-25, Volume: 293, Issue:20

    Topics: Aged; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Clozapine; Dementia; Dibenzothiazepines;

2005
Drugs used to relieve behavioral symptoms in people with dementia or an unacceptable chemical cosh? Argument.
    International psychogeriatrics, 2005, Volume: 17, Issue:1

    Topics: Accidental Falls; Aged; Antipsychotic Agents; Benzodiazepines; Cerebrovascular Disorders; Cognition;

2005
A case for judicious use of risperidone and olanzapine in behavioral and psychological symptoms of dementia (BPSD). Favour.
    International psychogeriatrics, 2005, Volume: 17, Issue:1

    Topics: Aged; Antipsychotic Agents; Benzodiazepines; Dementia; Geriatric Psychiatry; Humans; Ischemic Attack

2005
Association between risperidone treatment and cerebrovascular adverse events in elderly patients with dementia.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:8

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Cerebrovascular Disorders; Dementia; Female; Humans;

2005
The effect of risperidone on nursing burden associated with caring for patients with dementia.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:7

    Topics: Aged; Antipsychotic Agents; Dementia; Humans; Psychomotor Agitation; Risperidone; Workload

2005
What happened to patients with behavioural and psychological symptoms of dementia (BPSD) after the Committee on Safety in Medicines (CSM) guidelines?
    International journal of geriatric psychiatry, 2005, Volume: 20, Issue:9

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Contraindications; Dementia; Drug Administration Sche

2005
Psychotropic drug use in older people with mental illness with particular reference to antipsychotics: a systematic study of tolerability and use in different diagnostic groups.
    International journal of geriatric psychiatry, 2005, Volume: 20, Issue:9

    Topics: Affective Disorders, Psychotic; Aged; Aged, 80 and over; Antidepressive Agents; Antipsychotic Agents

2005
Population pharmacokinetics as a method to detect variable risperidone exposure in patients suffering from dementia with behavioral disturbances.
    The American journal of geriatric pharmacotherapy, 2005, Volume: 3, Issue:2

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Behavioral Symptoms; Clinical Trials as Topic; Dement

2005
Comparison of incidence rates of cerebrovascular accidents and transient ischaemic attacks in observational cohort studies of patients prescribed risperidone, quetiapine or olanzapine in general practice in England including patients with dementia.
    Journal of psychopharmacology (Oxford, England), 2005, Volume: 19, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Benzodiazepines; Cohort Studies; D

2005
Risperidone treatment in elderly patients with dementia: relative risk of cerebrovascular events versus other antipsychotics.
    International psychogeriatrics, 2005, Volume: 17, Issue:4

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Benzodiazepines; Cerebrovascular Disorders; Cohort St

2005
Factor analysis of the Cohen-Mansfield Agitation Inventory in three large samples of nursing home patients with dementia and behavioral disturbance.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2005, Volume: 13, Issue:11

    Topics: Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Antipsychotic Agents; Cross-Sectional Studie

2005
Can risperidone and olanzapine in elderly patients with dementia and other mental disorders be discontinued?
    International journal of geriatric psychiatry, 2006, Volume: 21, Issue:2

    Topics: Administration, Oral; Aged; Aged, 80 and over; Antipsychotic Agents; Benzodiazepines; Cardiovascular

2006
Anticholinergics in dementia and other confounding problems.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2006, Volume: 14, Issue:4

    Topics: Aged; Antipsychotic Agents; Benzodiazepines; Benztropine; Dementia; Drug Resistance; Humans; Muscari

2006
Hypothermia in a patient receiving risperidone and paroxetine.
    Journal of clinical psychopharmacology, 2006, Volume: 26, Issue:3

    Topics: Aged; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Dementia; Female; Humans; Hypo

2006
Duration of risperidone treatment for BPSD.
    International journal of geriatric psychiatry, 2006, Volume: 21, Issue:7

    Topics: Aged; Aggression; Antipsychotic Agents; Dementia; Drug Administration Schedule; Female; Humans; Male

2006
Survival among elderly Italian patients with dementia treated with atypical antipsychotics: observational study.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2006, Volume: 27, Issue:6

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Benzodiazepines; Cohort Studies; Dementia; Female; Hu

2006
Assertion that risperidone is superior to haloperidol for treatment of behavioural and psychological symptoms of dementia.
    International journal of geriatric psychiatry, 2007, Volume: 22, Issue:3

    Topics: Antipsychotic Agents; Dementia; Haloperidol; Humans; Risperidone; Therapeutic Equivalency

2007
Behavioral and psychological symptoms of dementia (BPSD) in elderly demented subjects: is the long lasting use of atypical antipsychotic drugs useful and safe?
    Archives of gerontology and geriatrics, 2007, Volume: 44 Suppl 1

    Topics: Activities of Daily Living; Aged; Antipsychotic Agents; Benzodiazepines; Dementia; Female; Follow-Up

2007
Comparative efficacy of risperidone versus haloperidol on behavioural and psychological symptoms of dementia.
    International journal of geriatric psychiatry, 2007, Volume: 22, Issue:5

    Topics: Aged; Antipsychotic Agents; Dementia; Dose-Response Relationship, Drug; Double-Blind Method; Haloper

2007
Atypical antipsychotics for the treatment of dementia-related behaviors: an update.
    Medicine and health, Rhode Island, 2007, Volume: 90, Issue:6

    Topics: Aged; Alzheimer Disease; Antipsychotic Agents; Behavioral Symptoms; Benzodiazepines; Dementia; Diben

2007
Ventricular arrhythmias and cerebrovascular events in the elderly using conventional and atypical antipsychotic medications.
    Journal of clinical psychopharmacology, 2007, Volume: 27, Issue:6

    Topics: Administration, Oral; Aged; Antipsychotic Agents; Aripiprazole; Arrhythmias, Cardiac; Benzodiazepine

2007
Parkinsonism and tardive antecollis in frontotemporal dementia--increased sensitivity to newer antipsychotics?
    European journal of neurology, 2008, Volume: 15, Issue:2

    Topics: Antipsychotic Agents; Benzodiazepines; Dementia; Dibenzothiazepines; Dystonia; Humans; Male; Middle

2008
Determinants of atypical antipsychotic use among antipsychotic users in community-dwelling elderly, 1996-2004.
    Current medical research and opinion, 2008, Volume: 24, Issue:3

    Topics: Age Factors; Aged; Aged, 80 and over; Antipsychotic Agents; Anxiety; Benzodiazepines; Cross-Sectiona

2008
[Atypical antipsychotics in elderly patients with dementia].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2008, May-01, Volume: 128, Issue:9

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Benzodiazepines; Dementia; Haloperidol; Humans; Metho

2008
Neuroleptic malignant syndrome and catatonia in a patient with dementia.
    The Australian and New Zealand journal of psychiatry, 2008, Volume: 42, Issue:6

    Topics: Aged; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Catatonia; Chlorpromazine; Choline

2008
Cortical response to exogenous visual stimulation during visual hallucinations.
    Lancet (London, England), 1995, Jan-07, Volume: 345, Issue:8941

    Topics: Aged; Antipsychotic Agents; Dementia; Evoked Potentials, Visual; Hallucinations; Humans; Isoxazoles;

1995
Risperidone for psychotic and behavioural symptoms in Lewy body dementia.
    Lancet (London, England), 1995, Jul-15, Volume: 346, Issue:8968

    Topics: Aged; Antipsychotic Agents; Dementia; Female; Humans; Isoxazoles; Male; Piperidines; Risperidone

1995
Risperidone for treating dementia-associated aggression.
    The American journal of psychiatry, 1995, Volume: 152, Issue:8

    Topics: Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Dementia; Dementia, Vascular; Female; Humans

1995
Neuroleptic sensitivity to risperidone in Lewy body dementia.
    Lancet (London, England), 1995, Sep-09, Volume: 346, Issue:8976

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Basal Ganglia Diseases; Dementia; Female; Humans; Iso

1995
Risperidone and bullous pemphigoid.
    The American journal of psychiatry, 1996, Volume: 153, Issue:5

    Topics: Aged; Dementia; Female; Humans; Pemphigoid, Bullous; Risperidone

1996
Adverse interaction of tacrine and haloperidol.
    The American journal of psychiatry, 1996, Volume: 153, Issue:11

    Topics: Aged; Dementia; Drug Interactions; Drug Therapy, Combination; Female; Haloperidol; Humans; Parkinson

1996
The use of risperidone in severely demented patients with persistent vocalizations.
    International journal of geriatric psychiatry, 1997, Volume: 12, Issue:1

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Dementia; Dyskinesia, Drug-Induced; Female; Geriatric

1997
Risperidone for dementia-related disturbed behavior in nursing home residents: a clinical experience.
    International psychogeriatrics, 1997, Volume: 9, Issue:1

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Dementia; Drug Resistance; Female; Geriatric Assessme

1997
Risperidone in the treatment of delusions of infestation.
    International journal of psychiatry in medicine, 1997, Volume: 27, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Delusions; Dementia; Ectoparasitic Infestation

1997
Combination of risperidone and donepezil in Lewy body dementia.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1998, Volume: 43, Issue:4

    Topics: Aged; Antipsychotic Agents; Cholinesterase Inhibitors; Dementia; Donepezil; Drug Therapy, Combinatio

1998
Risperdal advertising in JAGS. Journal of the American Geriatrics Society.
    Journal of the American Geriatrics Society, 1999, Volume: 47, Issue:3

    Topics: Advertising; Aged; Antipsychotic Agents; Dementia; Drug Industry; Humans; Mental Disorders; Patient

1999
Treatment of vocally disruptive behaviour of multifactorial aetiology.
    International journal of geriatric psychiatry, 1999, Volume: 14, Issue:4

    Topics: Aged; Akathisia, Drug-Induced; Behavior Therapy; Dementia; Depression; Female; Homes for the Aged; H

1999
Risperidone use at a state hospital: a clinical audit 2 years after the first wave of risperidone prescriptions.
    The Journal of clinical psychiatry, 1999, Volume: 60, Issue:6

    Topics: Adult; Antiparkinson Agents; Antipsychotic Agents; Bipolar Disorder; Clozapine; Dementia; Drug Admin

1999
Neuroleptics for behavioral symptoms of dementia.
    The Journal of family practice, 2000, Volume: 49, Issue:1

    Topics: Aggression; Antipsychotic Agents; Dementia; Evidence-Based Medicine; Humans; Mental Disorders; Resea

2000
Neurologic side effects in neuroleptic-naïve patients treated with haloperidol or risperidone.
    Neurology, 2000, Apr-11, Volume: 54, Issue:7

    Topics: Aged; Antipsychotic Agents; Basal Ganglia Diseases; Dementia; Dose-Response Relationship, Drug; Halo

2000
Risperidone and cognitive functioning in elderly schizophrenic patients.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2000,Spring, Volume: 8, Issue:2

    Topics: Aged; Antipsychotic Agents; Dementia; Humans; Mental Status Schedule; Neuropsychological Tests; Risp

2000
Side effects of antipsychotics in the elderly.
    The Journal of clinical psychiatry, 2000, Volume: 61 Suppl 8

    Topics: Age Factors; Aged; Antipsychotic Agents; Basal Ganglia Diseases; Clinical Trials as Topic; Clozapine

2000
Risperidone induced cytopenias.
    The Journal of the Association of Physicians of India, 2000, Volume: 48, Issue:11

    Topics: Aged; Agranulocytosis; Dementia; Female; Follow-Up Studies; Humans; India; Risk Assessment; Risperid

2000
Risperidone, tardive dyskinesia, and the elderly.
    The American journal of psychiatry, 2001, Volume: 158, Issue:8

    Topics: Age Factors; Aged; Antipsychotic Agents; Dementia; Dyskinesia, Drug-Induced; Follow-Up Studies; Huma

2001
Donepezil management of schizophrenia with associated dementia.
    Journal of clinical psychopharmacology, 2002, Volume: 22, Issue:2

    Topics: Aged; Antiparkinson Agents; Antipsychotic Agents; Comorbidity; Dementia; Donepezil; Drug Therapy, Co

2002
[Use of rispolept for psychotic symptoms in elderly patients with vascular psychoorganic syndrome].
    Voenno-meditsinskii zhurnal, 2002, Volume: 323, Issue:5

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Dementia; Female; Humans; Male; Middle Aged; Risperid

2002