risperidone has been researched along with Chemical and Drug Induced Liver Injury in 25 studies
Risperidone: A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.
risperidone : A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with risperidone was immediately discontinued." | 1.40 | Liver enzyme abnormalities during antipsychotic treatment: a case report of risperidone-associated hepatotoxicity. ( Berecz, R; Doña, A; Dorado, P; LLerena, A; López-Torres, E; Peñas-LLedó, EM; Süveges, A, 2014) |
| "Risperidone have been reported to commonly lead to asymptomatic elevation of liver enzymes in adult population, and recently in children and adolescents." | 1.37 | Risperidone rechallenge for marked liver function test abnormalities in an autistic child. ( Copur, M; Erdogan, A, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| " The aim of the present study was to analyse whether or not the chronic administration of risperidone has a toxic effect on rat livers." | 1.35 | Chronically administered risperidone did not change the number of hepatocytes in rats: a stereological and histopathological study. ( Albayrak, M; Cadirci, E; Halici, Z; Kaplan, S; Keles, ON; Suleyman, H; Unal, B; Unal, D, 2008) |
| "Risperidone is an atypical neuroleptic drug widely used due to the lower incidence and severity of hepatic adverse effects in comparison to phenothiazines." | 1.33 | Acute cholestatic hepatitis probably associated with risperidone. ( Bosacoma Ros, N; Climent Grana, E; Hernández Prats, C; Llinares Tello, F; Navarro Polo, JN; Ordovás Baines, JP; Pérez Martínez, E, 2005) |
| "The purpose of this case study is to document hepatic adverse effects associated with long-term risperidone use in pediatric populations." | 1.30 | Case study: risperidone-induced hepatotoxicity in pediatric patients. ( Briguglia, C; Grothe, D; Herion, D; Jacobsen, LK; Kumra, S, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (20.00) | 18.2507 |
| 2000's | 5 (20.00) | 29.6817 |
| 2010's | 15 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Kenna, JG | 1 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Azirak, S | 1 |
| Bilgic, S | 1 |
| Tastemir Korkmaz, D | 1 |
| Guvenc, AN | 1 |
| Kocaman, N | 1 |
| Ozer, MK | 1 |
| López-Torres, E | 1 |
| Süveges, A | 1 |
| Peñas-LLedó, EM | 1 |
| Doña, A | 1 |
| Dorado, P | 1 |
| LLerena, A | 1 |
| Berecz, R | 1 |
| Saglam, O | 1 |
| Bahsi, R | 1 |
| Akkoca, Y | 1 |
| Filik, L | 1 |
| Eftekhari, A | 1 |
| Ahmadian, E | 1 |
| Azarmi, Y | 1 |
| Parvizpur, A | 1 |
| Hamishehkar, H | 1 |
| Eghbal, MA | 1 |
| Paulzen, M | 1 |
| Orfanos, S | 1 |
| Gründer, G | 1 |
| Manceaux, P | 1 |
| Constant, E | 1 |
| Zdanowicz, N | 1 |
| Jacques, D | 1 |
| Reynaert, C | 1 |
| Copur, M | 1 |
| Erdogan, A | 1 |
| Esposito, D | 1 |
| Brocvielle, H | 1 |
| Becquemont, L | 1 |
| Hardy, P | 1 |
| Chouinard, G | 1 |
| Corruble, E | 1 |
| Llinares Tello, F | 1 |
| Hernández Prats, C | 1 |
| Bosacoma Ros, N | 1 |
| Pérez Martínez, E | 1 |
| Climent Grana, E | 1 |
| Navarro Polo, JN | 1 |
| Ordovás Baines, JP | 1 |
| Halici, Z | 1 |
| Keles, ON | 1 |
| Unal, D | 1 |
| Albayrak, M | 1 |
| Suleyman, H | 1 |
| Cadirci, E | 1 |
| Unal, B | 1 |
| Kaplan, S | 1 |
| Fuller, MA | 1 |
| Simon, MR | 1 |
| Freedman, L | 1 |
| Kumra, S | 1 |
| Herion, D | 1 |
| Jacobsen, LK | 1 |
| Briguglia, C | 1 |
| Grothe, D | 1 |
| Geller, WK | 1 |
| Zuiderwijk, PB | 1 |
| Landau, J | 1 |
| Martin, A | 1 |
| Benazzi, F | 1 |
| Krebs, S | 1 |
| Dormann, H | 1 |
| Muth-Selbach, U | 1 |
| Hahn, EG | 1 |
| Brune, K | 1 |
| Schneider, HT | 1 |
| Cordeiro, Q | 1 |
| Elkis, H | 1 |
2 reviews available for risperidone and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Management of marked liver enzyme increase during olanzapine treatment: a case report and review of the literature.
Topics: Age Factors; Antipsychotic Agents; Benzodiazepines; Chemical and Drug Induced Liver Injury; Clozapin | 2011 |
23 other studies available for risperidone and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
The protective effect of resveratrol against risperidone-induced liver damage through an action on FAS gene expression.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; fas Receptor; Female; Liver; Protecti | 2019 |
Liver enzyme abnormalities during antipsychotic treatment: a case report of risperidone-associated hepatotoxicity.
Topics: Adult; Antipsychotic Agents; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2D6; Homozy | 2014 |
Risperidone-induced hepatotoxicity in a patient addicted to synthetic cannabinoid.
Topics: Adult; Antipsychotic Agents; Cannabinoids; Chemical and Drug Induced Liver Injury; Drug Substitution | 2016 |
In vitro/vivo studies towards mechanisms of risperidone-induced oxidative stress and the protective role of coenzyme Q10 and N-acetylcysteine.
Topics: Acetylcysteine; Animals; Antioxidants; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liv | 2016 |
Remission of drug-induced hepatitis after switching from risperidone to paliperidone.
Topics: Adult; Antipsychotic Agents; Biotransformation; Chemical and Drug Induced Liver Injury; Clozapine; D | 2010 |
Risperidone rechallenge for marked liver function test abnormalities in an autistic child.
Topics: Antipsychotic Agents; Autistic Disorder; Chemical and Drug Induced Liver Injury; Child, Preschool; D | 2011 |
Risperidone-induced immunoallergic hepatitis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Humans; Male; Risperidone; Sch | 2005 |
Acute cholestatic hepatitis probably associated with risperidone.
Topics: Acute Disease; Antipsychotic Agents; Chemical and Drug Induced Liver Injury; Humans; Male; Middle Ag | 2005 |
Chronically administered risperidone did not change the number of hepatocytes in rats: a stereological and histopathological study.
Topics: Animals; Antipsychotic Agents; Chemical and Drug Induced Liver Injury; Hepatocytes; Injections, Intr | 2008 |
Risperidone-associated hepatotoxicity.
Topics: Aged; Antipsychotic Agents; Chemical and Drug Induced Liver Injury; Female; Humans; Male; Middle Age | 1996 |
Case study: risperidone-induced hepatotoxicity in pediatric patients.
Topics: Adolescent; Antipsychotic Agents; Chemical and Drug Induced Liver Injury; Child; Female; Humans; Mal | 1997 |
Risperidone-induced hepatotoxicity?
Topics: Adolescent; Antipsychotic Agents; Chemical and Drug Induced Liver Injury; Child; Humans; Liver Funct | 1998 |
Is liver function monitoring warranted during risperidone treatment?
Topics: Adolescent; Antipsychotic Agents; Chemical and Drug Induced Liver Injury; Child; Dose-Response Relat | 1998 |
Risperidone-induced hepatotoxicity.
Topics: Adult; Antipsychotic Agents; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Function | 1998 |
Risperidone-induced cholestatic hepatitis.
Topics: Adult; Antipsychotic Agents; Chemical and Drug Induced Liver Injury; Cholestasis; Humans; Liver; Liv | 2001 |
Pancreatitis and cholestatic hepatitis induced by risperidone.
Topics: Adult; Antipsychotic Agents; Chemical and Drug Induced Liver Injury; Cholestasis; Humans; Male; Panc | 2001 |