Page last updated: 2024-11-03

risperidone and Attention Deficit and Disruptive Behavior Disorders

risperidone has been researched along with Attention Deficit and Disruptive Behavior Disorders in 72 studies

Risperidone: A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.
risperidone : A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.

Attention Deficit and Disruptive Behavior Disorders: Includes two similar disorders: oppositional defiant disorder and CONDUCT DISORDERS. Symptoms occurring in children with these disorders include: defiance of authority figures, angry outbursts, and other antisocial behaviors.

Research Excerpts

ExcerptRelevanceReference
"Although the nonrandomized, nonblind design limits the conclusions of our exploratory study, our findings suggest that when ADHD is comorbid with ODD and aggression MPH and risperidone are both effective on aggressive behavior, but only stimulants are effective on ADHD symptoms."9.24A Naturalistic Comparison of Methylphenidate and Risperidone Monotherapy in Drug-Naive Youth With Attention-Deficit/Hyperactivity Disorder Comorbid With Oppositional Defiant Disorder and Aggression. ( Manfredi, A; Masi, G; Milone, A; Muratori, P; Nieri, G; Pfanner, C, 2017)
"A total of 168 children with severe aggression, disruptive behavior disorder, and attention-deficit/hyperactivity disorder (ADHD) were enrolled in a 9-week trial of basic treatment (n=84, stimulant+parent training+placebo) versus augmented treatment (n=84, stimulant+parent training+risperidone)."9.20Comorbid symptomatology moderates response to risperidone, stimulant, and parent training in children with severe aggression, disruptive behavior disorder, and attention-deficit/hyperactivity disorder. ( Aman, MG; Arnold, LE; Bangalore, SS; Brown, NV; Buchan-Page, KA; Bukstein, O; Farmer, CA; Findling, RL; Gadow, KD; Kolko, DG; McNamara, N; Molina, BS; Rice, RR; Rundberg-Rivera, EV, 2015)
"In the four-site Treatment of Severe Childhood Aggression (TOSCA) study, addition of risperidone to stimulant and parent training moderately improved parent-rated disruptive behavior disorder (DBD) symptoms."9.20Comorbid anxiety and social avoidance in treatment of severe childhood aggression: response to adding risperidone to stimulant and parent training; mediation of disruptive symptom response. ( Aman, MG; Arnold, LE; Bangalore, S; Brown, NV; Buchan-Page, K; Bukstein, O; Farmer, CA; Findling, RL; Gadow, KD; Hurt, EA; Li, X; McNamara, NK; Molina, BS; Rice, R; Rundberg-Rivera, EV, 2015)
"TOSCA was a randomized clinical trial of psychostimulant plus parent training plus placebo (basic treatment) versus psychostimulant plus parent training plus risperidone (augmented treatment) for children with severe physical aggression, disruptive behavior disorder, and attention-deficit/hyperactivity disorder."9.20Participant satisfaction in a study of stimulant, parent training, and risperidone in children with severe physical aggression. ( Aman, MG; Arnold, LE; Austin, A; Buchan-Page, KA; Bukstein, OG; Farmer, CA; Findling, RL; Gadow, KD; Kipp, H; Kolko, DJ; McNamara, NK; Michel, C; Molina, BB; Rice, RR; Rundberg-Rivera, EV; Schneider, J; Townsend, LD, 2015)
"We report on an open-label, naturalistic study using risperidone to treat disruptive behaviors and self-injury in children with Down syndrome, severe intellectual disability, and comorbid autism spectrum disorders (DS+ASDs)."9.13Risperidone use in children with Down syndrome, severe intellectual disability, and comorbid autistic spectrum disorders: a naturalistic study. ( Capone, GT; Goyal, P; Grados, M; Kammann, H; Smith, B, 2008)
"The present study aimed to analyse the effect of risperidone on a priori defined core aggression items."9.11Risperidone reduces aggression in boys with a disruptive behaviour disorder and below average intelligence quotient: analysis of two placebo-controlled randomized trials. ( Aman, MG; Armenteros, JL; Binder, CE; Hew, H; Kusumakar, V; LeBlanc, JC; Wang, JS, 2005)
"We randomly assigned 38 adolescents (33 boys; 10 subjects with slightly subaverage IQ, 14 with borderline IQ, and 14 with mild mental retardation), who were hospitalized for treatment of psychiatric disorders associated with severe aggression, to receive risperidone or placebo."9.09A randomized controlled trial of risperidone in the treatment of aggression in hospitalized adolescents with subaverage cognitive abilities. ( Buitelaar, JK; Cohen-Kettenis, P; Melman, CT; van der Gaag, RJ, 2001)
"MEDLINE and EMBASE databases were used to identify controlled studies of risperidone in the treatment of disruptive behavior disorders and pervasive developmental disorders in pediatric patients, acute agitation or aggression in adults, and psychological and behavioral symptoms of dementia in the elderly."8.83Risperidone in the management of agitation and aggression associated with psychiatric disorders. ( Buitelaar, J; De Deyn, PP, 2006)
"The Panel considered recent studies of the efficacy and tolerability of risperidone and other atypical antipsychotics in adults and children with mental retardation and developmental disabilities."8.82Treatment of behavior disorders in mental retardation: report on transitioning to atypical antipsychotics, with an emphasis on risperidone. ( Aman, MG; Gharabawi, GM, 2004)
"Hyperprolactinemia is a common side effect in young males treated over the long term with risperidone."7.78Risk of hyperprolactinemia and sexual side effects in males 10-20 years old diagnosed with autism spectrum disorders or disruptive behavior disorder and treated with risperidone. ( Boot, AM; Buitelaar, JK; Roke, Y; Tenback, D; van Harten, PN, 2012)
"Co-morbid diagnoses, such as disruptive behavior disorders (DBDs) and high levels of aggression, are extremely common among youth with pediatric bipolar disorder (PBD) and may interfere with treatment response; however, they have rarely been examined as predictors of response to pharmacotherapy."6.76Co-morbid disruptive behavior disorder and aggression predict functional outcomes and differential response to risperidone versus divalproex in pharmacotherapy for pediatric bipolar disorder. ( Celio, CI; Henry, D; Pavuluri, MN; Weinstein, SM; West, AE, 2011)
"Although the nonrandomized, nonblind design limits the conclusions of our exploratory study, our findings suggest that when ADHD is comorbid with ODD and aggression MPH and risperidone are both effective on aggressive behavior, but only stimulants are effective on ADHD symptoms."5.24A Naturalistic Comparison of Methylphenidate and Risperidone Monotherapy in Drug-Naive Youth With Attention-Deficit/Hyperactivity Disorder Comorbid With Oppositional Defiant Disorder and Aggression. ( Manfredi, A; Masi, G; Milone, A; Muratori, P; Nieri, G; Pfanner, C, 2017)
"The Treatment of Severe Childhood Aggression (TOSCA) project examined augmentation of stimulant treatment and parent training (PT) with risperidone for severe physical aggression."5.24Clinical Implications From the Treatment of Severe Childhood Aggression (TOSCA) Study: A Re-Analysis and Integration of Findings. ( Aman, MG; Arnold, LE; Barterian, JA; Brown, NV; Bukstein, OG; Farmer, CA; Findling, RL; Kolko, DJ; Molina, BSG; Townsend, L; Williams, C, 2017)
"The objective of this study was to evaluate 52-week clinical outcomes of children with co-occurring attention-deficit/hyperactivity disorder (ADHD), disruptive behavior disorder, and serious physical aggression who participated in a prospective, longitudinal study that began with a controlled, 9-week clinical trial comparing the relative efficacy of parent training + stimulant medication + placebo (Basic; n = 84) versus parent training + stimulant + risperidone (Augmented; n = 84)."5.22Severely Aggressive Children Receiving Stimulant Medication Versus Stimulant and Risperidone: 12-Month Follow-Up of the TOSCA Trial. ( Aman, MG; Arnold, LE; Brown, NV; Buchan-Page, KA; Bukstein, OG; Butter, E; Farmer, CA; Findling, RL; Gadow, KD; Kolko, DJ; Molina, BS; Rice, RR; Schneider, J, 2016)
"TOSCA was a randomized clinical trial of psychostimulant plus parent training plus placebo (basic treatment) versus psychostimulant plus parent training plus risperidone (augmented treatment) for children with severe physical aggression, disruptive behavior disorder, and attention-deficit/hyperactivity disorder."5.20Participant satisfaction in a study of stimulant, parent training, and risperidone in children with severe physical aggression. ( Aman, MG; Arnold, LE; Austin, A; Buchan-Page, KA; Bukstein, OG; Farmer, CA; Findling, RL; Gadow, KD; Kipp, H; Kolko, DJ; McNamara, NK; Michel, C; Molina, BB; Rice, RR; Rundberg-Rivera, EV; Schneider, J; Townsend, LD, 2015)
"A total of 168 children with severe aggression, disruptive behavior disorder, and attention-deficit/hyperactivity disorder (ADHD) were enrolled in a 9-week trial of basic treatment (n=84, stimulant+parent training+placebo) versus augmented treatment (n=84, stimulant+parent training+risperidone)."5.20Comorbid symptomatology moderates response to risperidone, stimulant, and parent training in children with severe aggression, disruptive behavior disorder, and attention-deficit/hyperactivity disorder. ( Aman, MG; Arnold, LE; Bangalore, SS; Brown, NV; Buchan-Page, KA; Bukstein, O; Farmer, CA; Findling, RL; Gadow, KD; Kolko, DG; McNamara, N; Molina, BS; Rice, RR; Rundberg-Rivera, EV, 2015)
"In the four-site Treatment of Severe Childhood Aggression (TOSCA) study, addition of risperidone to stimulant and parent training moderately improved parent-rated disruptive behavior disorder (DBD) symptoms."5.20Comorbid anxiety and social avoidance in treatment of severe childhood aggression: response to adding risperidone to stimulant and parent training; mediation of disruptive symptom response. ( Aman, MG; Arnold, LE; Bangalore, S; Brown, NV; Buchan-Page, K; Bukstein, O; Farmer, CA; Findling, RL; Gadow, KD; Hurt, EA; Li, X; McNamara, NK; Molina, BS; Rice, R; Rundberg-Rivera, EV, 2015)
"We report on an open-label, naturalistic study using risperidone to treat disruptive behaviors and self-injury in children with Down syndrome, severe intellectual disability, and comorbid autism spectrum disorders (DS+ASDs)."5.13Risperidone use in children with Down syndrome, severe intellectual disability, and comorbid autistic spectrum disorders: a naturalistic study. ( Capone, GT; Goyal, P; Grados, M; Kammann, H; Smith, B, 2008)
"The results of this post hoc analysis of affective symptoms of DBDs using data from a previously published randomized, double-blind clinical comparison of risperidone and placebo in the treatment of children with DBDs and subaverage intelligence suggest that risperidone was effective in treating the factors of explosive irritability; agitated, expansive, grandiose; and depression."5.12Risperidone for the treatment of affective symptoms in children with disruptive behavior disorder: a post hoc analysis of data from a 6-week, multicenter, randomized, double-blind, parallel-arm study. ( Biederman, J; Faraone, SV; Mick, E; Pandina, G; Spencer, T; Wozniak, J, 2006)
"The present study aimed to analyse the effect of risperidone on a priori defined core aggression items."5.11Risperidone reduces aggression in boys with a disruptive behaviour disorder and below average intelligence quotient: analysis of two placebo-controlled randomized trials. ( Aman, MG; Armenteros, JL; Binder, CE; Hew, H; Kusumakar, V; LeBlanc, JC; Wang, JS, 2005)
"The atypical antipsychotic medication risperidone was evaluated using a double-blind, placebo-controlled design in the treatment of destructive behavior in two individuals with autism."5.10Use of functional analysis methodology in the evaluation of medication effects. ( Crosland, KA; Hellings, JA; Lindauer, SE; Schroeder, SR; Valdovinos, MG; Zarcone, JR; Zarcone, TJ, 2003)
"To determine whether risperidone is effective in reducing symptoms of disruptive behaviors (such as aggression, impulsivity, defiance of authority figures, and property destruction) associated with conduct disorder, oppositional defiant disorder, and disruptive behavior disorder-not otherwise specified in children with subaverage IQs."5.10Effects of risperidone on conduct and disruptive behavior disorders in children with subaverage IQs. ( Aman, M; Binder, C; Carroll, A; Fisman, S; Snyder, R; Turgay, A, 2002)
"We randomly assigned 38 adolescents (33 boys; 10 subjects with slightly subaverage IQ, 14 with borderline IQ, and 14 with mild mental retardation), who were hospitalized for treatment of psychiatric disorders associated with severe aggression, to receive risperidone or placebo."5.09A randomized controlled trial of risperidone in the treatment of aggression in hospitalized adolescents with subaverage cognitive abilities. ( Buitelaar, JK; Cohen-Kettenis, P; Melman, CT; van der Gaag, RJ, 2001)
"There is some evidence that in the short term risperidone may reduce aggression and conduct problems in children and youths with disruptive behaviour disorders There is also evidence that this intervention is associated with significant weight gain."4.95Atypical antipsychotics for disruptive behaviour disorders in children and youths. ( Hetrick, SE; Loy, JH; Merry, SN; Stasiak, K, 2017)
"There is some limited evidence of efficacy of risperidone reducing aggression and conduct problems in children aged 5 to 18 with disruptive behaviour disorders in the short term."4.88Atypical antipsychotics for disruptive behaviour disorders in children and youths. ( Hetrick, SE; Loy, JH; Merry, SN; Stasiak, K, 2012)
"MEDLINE and EMBASE databases were used to identify controlled studies of risperidone in the treatment of disruptive behavior disorders and pervasive developmental disorders in pediatric patients, acute agitation or aggression in adults, and psychological and behavioral symptoms of dementia in the elderly."4.83Risperidone in the management of agitation and aggression associated with psychiatric disorders. ( Buitelaar, J; De Deyn, PP, 2006)
"The Panel considered recent studies of the efficacy and tolerability of risperidone and other atypical antipsychotics in adults and children with mental retardation and developmental disabilities."4.82Treatment of behavior disorders in mental retardation: report on transitioning to atypical antipsychotics, with an emphasis on risperidone. ( Aman, MG; Gharabawi, GM, 2004)
"Study 1: Between April 2004 and September 2007, participants were enrolled from outpatient settings in a prospective randomized clinical trial comparing the efficacy of risperidone monotherapy to the combination of risperidone and behavior therapy in targeting disruptive behavior in 4- to 13-year-old children with DSM-IV-TR-based autism spectrum disorder."3.81Iron homeostasis during risperidone treatment in children and adolescents. ( Aman, M; Arnold, LE; Calarge, CA; Del Castillo, N; McCracken, JT; McDougle, CJ; Scahill, L; Ziegler, EE, 2015)
"Children treated with risperidone or quetiapine are at a significant risk for developing obesity, elevated waist circumference, and dyslipidemia during 12 months of treatment."3.81Increased Risk of Obesity and Metabolic Dysregulation Following 12 Months of Second-Generation Antipsychotic Treatment in Children: A Prospective Cohort Study. ( Davidson, J; Nguyen, D; Panagiotopoulos, C; Ronsley, R, 2015)
" Prolactin levels, hyperprolactinemia, risperidone levels, and 9-hydroxyrisperidone levels were assessed and the participants were genotyped for common CYP2D6 polymorphisms and the Taq1A allele of the dopamine D2 receptor gene."3.79The effect of the Taq1A variant in the dopamine D₂ receptor gene and common CYP2D6 alleles on prolactin levels in risperidone-treated boys. ( Boot, AM; Buitelaar, JK; Franke, B; Galesloot, TE; Roke, Y; van Harten, PN, 2013)
"Hyperprolactinemia is a common side effect in young males treated over the long term with risperidone."3.78Risk of hyperprolactinemia and sexual side effects in males 10-20 years old diagnosed with autism spectrum disorders or disruptive behavior disorder and treated with risperidone. ( Boot, AM; Buitelaar, JK; Roke, Y; Tenback, D; van Harten, PN, 2012)
"Risperidone is a promising agent for the treatment of schizophrenia, Tourette's disorder, mood disorders, and disruptive behavior disorders in young populations."3.76Six months of treatment with risperidone may be associated with nonsignificant abnormalities of liver function tests in children and adolescents: a longitudinal, observational study from Turkey. ( Erdogan, A; Karaman, MG; Kurcer, MA; Ozdemir, E; Tufan, AE; Yurteri, N, 2010)
"Co-morbid diagnoses, such as disruptive behavior disorders (DBDs) and high levels of aggression, are extremely common among youth with pediatric bipolar disorder (PBD) and may interfere with treatment response; however, they have rarely been examined as predictors of response to pharmacotherapy."2.76Co-morbid disruptive behavior disorder and aggression predict functional outcomes and differential response to risperidone versus divalproex in pharmacotherapy for pediatric bipolar disorder. ( Celio, CI; Henry, D; Pavuluri, MN; Weinstein, SM; West, AE, 2011)
"Risperidone treatment resulted in no decline in cognitive function among children and adolescents."2.74Cognitive function with long-term risperidone in children and adolescents with disruptive behavior disorder. ( Cornblatt, B; Pandina, GJ; Zhu, Y, 2009)
"Risperidone was generally well tolerated."2.73Treating disruptive behavior disorders with risperidone: a 1-year, open-label safety study in children and adolescents. ( Haas, M; Karcher, K; Pandina, GJ, 2008)
"Risperidone dosage was based on weight (patients <50 kg: 0."2.72A randomized, double-blind, placebo-controlled study of risperidone maintenance treatment in children and adolescents with disruptive behavior disorders. ( Augustyns, I; Buitelaar, J; Eerdekens, M; Reyes, M; Toren, P, 2006)
" Safety was assessed using the Extrapyramidal Symptom Rating Scale (ESRS), clinical laboratory tests, electrocardiograms, and the recording of adverse events, vital signs, Tanner score, and changes in body mass index (BMI)."2.72Long-term safety and efficacy of risperidone in children with disruptive behaviour disorders. Results of a 2-year extension study. ( Augustyns, I; Csaba, K; Eerdekens, M; Olah, R; Reyes, M, 2006)
"Risperidone-treated patients had clinically and statistically significant reductions in both disruptive behavior and hyperactivity subscale scores, compared to placebo, regardless of concomitant stimulant use."2.71Risperidone effects in the presence/absence of psychostimulant medicine in children with ADHD, other disruptive behavior disorders, and subaverage IQ. ( Aman, MG; Binder, C; Turgay, A, 2004)
"Risperidone was well tolerated and effective in the long-term treatment of disruptive behavior disorders in children with subaverage intelligence."2.71Risperidone in children with disruptive behavior disorders and subaverage intelligence: a 1-year, open-label study of 504 patients. ( Croonenberghs, J; De Smedt, G; Fegert, JM; Findling, RL; Van Dongen, S, 2005)
" These results were achieved with a mean modal dosage of 1."2.71Short- and long-term efficacy and safety of risperidone in adults with disruptive behavior disorders. ( Eerdekens, M; Gagiano, C; Read, S; Thorpe, L; Van Hove, I, 2005)
"Risperidone was associated with rapid, significant improvement on the conduct problem subscale score of the Nisonger Child Behavior Rating Form in patients previously treated with placebo; improvement was maintained during long-term treatment and in patients previously given risperidone."2.71Long-term, open-label study of risperidone in children with severe disruptive behaviors and below-average IQ. ( Aman, MG; Derivan, A; Eerdekens, M; Findling, RL; Lyons, B, 2004)
"Risperidone was also associated with significantly greater improvement than placebo on all other Nisonger Child Behavior Rating Form subscales at endpoint, as well as on the Aberrant Behavior Checklist subscales for irritability, lethargy/social withdrawal, and hyperactivity; the Behavior Problems Inventory aggressive/destructive behavior subscale; a visual analogue scale of the most troublesome symptom; and the Clinical Global Impression change score."2.70Double-blind, placebo-controlled study of risperidone for the treatment of disruptive behaviors in children with subaverage intelligence. ( Aman, MG; De Smedt, G; Derivan, A; Findling, RL; Lyons, B, 2002)
"Youth aggression is associated with complex genetic, neurobiological, and environmental risks."2.61Understanding Chronic Aggression and Its Treatment in Children and Adolescents. ( Magalotti, SR; McVoy, MK; Neudecker, M; Zaraa, SG, 2019)
"Risperidone was found to be efficacious in reducing symptoms in children and adolescents with DBD."2.49Efficacy of risperidone in children with disruptive behavioural disorders. ( Duhig, MJ; Saha, S; Scott, JG, 2013)
"Risperidone-treated children had a mean increase in height 1."2.42Growth and sexual maturation during long-term treatment with risperidone. ( Daneman, D; Dunbar, F; Kusumakar, V; Schulz, M, 2004)
"Risperidone was prevalent in younger, male patients with disruptive behavioral disorders; aripiprazole, in patients with tic disorders."1.43Persistence in Therapy With Risperidone and Aripiprazole in Pediatric Outpatients: A 2-Year Naturalistic Comparison. ( Antoniazzi, S; Auricchio, F; Bernardini, R; Bertella, S; Bravaccio, C; Capuano, A; Carnovale, C; Cattaneo, D; Clementi, E; Ferrajolo, C; Gentili, M; Guastella, G; Mani, E; Molteni, M; Pascotto, A; Pisano, S; Pozzi, M; Radice, S; Rafaniello, C; Riccio, MP; Rizzo, R; Rossi, F; Scuderi, MG; Sperandeo, S; Sportiello, L; Villa, L, 2016)

Research

Studies (72)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (1.39)18.2507
2000's32 (44.44)29.6817
2010's36 (50.00)24.3611
2020's3 (4.17)2.80

Authors

AuthorsStudies
Baweja, R1
Waxmonsky, JG1
Hodgins, GE1
Winsor, K1
Barnhill, J1
Naguy, A1
Hashem, MS1
AlKhadhar, S1
Magalotti, SR1
Neudecker, M1
Zaraa, SG1
McVoy, MK1
Cortese, S1
Novins, DK1
Loy, JH2
Merry, SN2
Hetrick, SE2
Stasiak, K2
Masi, G1
Manfredi, A1
Nieri, G1
Muratori, P1
Pfanner, C1
Milone, A1
Barterian, JA1
Arnold, LE7
Brown, NV4
Farmer, CA5
Williams, C1
Findling, RL13
Kolko, DJ3
Bukstein, OG3
Molina, BSG2
Townsend, L1
Aman, MG12
Fortea, A1
Ilzarbe, D1
Espinosa, L1
Solerdelcoll, M1
de Castro, C1
Oriolo, G1
Sugranyes, G1
Baeza, I1
Shafiq, S1
Pringsheim, T2
Joseph, HM1
Farmer, C1
Kipp, H2
Kolko, D1
Aman, M4
McGinley, J1
Gadow, KD5
Weiss, MD1
Margari, L1
Matera, E1
Craig, F1
Petruzzelli, MG1
Palmieri, VO1
Pastore, A1
Margari, F1
Roke, Y2
van Harten, PN2
Franke, B1
Galesloot, TE1
Boot, AM2
Buitelaar, JK3
Baribeau, DA1
Anagnostou, E1
Elbe, D1
Barr, AM1
Honer, WG1
Procyshyn, RM1
Kolko, DG1
Molina, BS3
Buchan-Page, KA3
Rice, RR3
Bangalore, SS1
Bukstein, O2
Rundberg-Rivera, EV3
McNamara, N1
Li, X1
Bangalore, S1
Buchan-Page, K1
Hurt, EA1
Rice, R1
McNamara, NK3
Townsend, LD1
Schneider, J2
Molina, BB1
Michel, C1
Austin, A1
Ince, E1
Algedik, P1
Demirdogen, ES1
Emul, M1
Demir, T1
Calarge, CA2
Burns, TL1
Schlechte, JA1
Zemel, BS1
Ziegler, EE1
Del Castillo, N1
McDougle, CJ1
Scahill, L1
McCracken, JT1
Ronsley, R1
Nguyen, D1
Davidson, J1
Panagiotopoulos, C1
Daneman, D2
Butter, E1
Pozzi, M1
Pisano, S1
Bertella, S1
Capuano, A1
Rizzo, R1
Antoniazzi, S1
Auricchio, F1
Carnovale, C1
Cattaneo, D1
Ferrajolo, C1
Gentili, M1
Guastella, G1
Mani, E1
Rafaniello, C1
Riccio, MP1
Scuderi, MG1
Sperandeo, S1
Sportiello, L1
Villa, L1
Radice, S1
Clementi, E1
Rossi, F1
Pascotto, A1
Bernardini, R1
Molteni, M1
Bravaccio, C1
Jahangard, L1
Akbarian, S1
Haghighi, M1
Ahmadpanah, M1
Keshavarzi, A1
Bajoghli, H1
Sadeghi Bahmani, D1
Holsboer-Trachsler, E1
Brand, S1
Chang, KD1
Haas, M1
Karcher, K1
Pandina, GJ4
Bandou, N1
Koike, K1
Matuura, H1
Zhu, Y1
Cornblatt, B1
Rothermel, B1
Poustka, L1
Banaschewski, T1
Becker, K1
Erdogan, A1
Karaman, MG1
Ozdemir, E1
Yurteri, N1
Tufan, AE1
Kurcer, MA1
McKinney, C1
Renk, K1
Martínez-Ortega, JM1
Diaz-Atienza, F1
Gutiérrez-Rojas, L1
Jurado, D1
Gurpegui, M1
Duhig, MJ1
Saha, S1
Scott, JG1
West, AE1
Weinstein, SM1
Celio, CI1
Henry, D1
Pavuluri, MN1
Stern, AP1
Trieu, ML1
Gorman, D1
Tenback, D1
Lohr, WD1
Honaker, J1
De Smedt, G2
Derivan, A2
Lyons, B2
Snyder, R1
Turgay, A2
Binder, C3
Fisman, S1
Carroll, A1
Martin, A1
L'Ecuyer, S1
Crosland, KA1
Zarcone, JR1
Lindauer, SE1
Valdovinos, MG1
Zarcone, TJ1
Hellings, JA1
Schroeder, SR1
Eerdekens, M4
Dunbar, F1
Kusumakar, V2
Schulz, M1
Gharabawi, GM1
Croonenberghs, J1
Fegert, JM1
Van Dongen, S1
Gagiano, C1
Read, S1
Thorpe, L1
Van Hove, I1
Buitelaar, J3
Smedt, GD1
Wapenaar, R1
Lauwers, K1
De Hert, M1
LeBlanc, JC1
Binder, CE1
Armenteros, JL1
Wang, JS1
Hew, H1
Keenan, K1
De Deyn, PP1
Reyes, M2
Toren, P1
Augustyns, I2
Olah, R1
Csaba, K1
Biederman, J1
Mick, E1
Faraone, SV1
Wozniak, J1
Spencer, T1
Pandina, G1
Shatkin, JP1
Ipser, J1
Stein, DJ1
Günther, T1
Herpertz-Dahlmann, B1
Jolles, J1
Konrad, K1
Bilder, R1
Harvey, PD1
Keefe, RS1
Gharabawi, G1
Sabuncuoglu, O1
Winsberg, B1
Usubiaga, H1
Cooper, T1
Capone, GT1
Goyal, P1
Grados, M1
Smith, B1
Kammann, H1
Roberts, MD1
van der Gaag, RJ1
Cohen-Kettenis, P1
Melman, CT1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Stimulant and Risperidone in Children With Severe Physical Aggression[NCT00796302]Phase 4168 participants (Actual)Interventional2008-08-31Completed
Risperidone and Behavioral Therapy in Treatment of Children and Adolescents With Autistic Disorder[NCT00080145]124 participants (Actual)Interventional2004-02-29Completed
Monitoring of Metabolic Adverse Events of Second Generation Antipsychotics in a Naive Pediatric Population Followed in Mental Health Outpatient and Inpatient Clinical Settings (MEMAS Prospective Study)[NCT04395326]120 participants (Anticipated)Observational2017-01-01Recruiting
The Investigation of the Impact of Atypical Antipsychotics on Brain Functioning in Youths With Conduct Disorder[NCT01867398]12 participants (Actual)Observational2013-04-29Terminated
The Safety And Efficacy Of Risperidone Versus Placebo In Conduct Disorder and Other Disruptive Behavior Disorders In Mild, Moderate And Borderline Mentally Retarded Children Aged 5 To 12 Years[NCT00266552]Phase 3118 participants (Actual)InterventionalCompleted
The Safety And Efficacy Of Risperidone Versus Placebo In Conduct Disorder In Mild, Moderate And Borderline Mentally Retarded Children Aged 5 To 12 Years[NCT00250354]Phase 3110 participants (Actual)Interventional1997-09-30Completed
1/2-MC4R Genotype and Pediatric Antipsychotic Drug- Induced Weight Gain[NCT01844700]Phase 414 participants (Actual)Interventional2013-07-31Terminated (stopped due to very slow recruitment, no sufficient results)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Antisocial Behavior Scale - Reactive Aggression Subscale

The Antisocial Behavior Scale (ABS) is a 28-item scale that contains 10 Proactive Aggression items and six Reactive Aggression items. Each item is rated on a 3-point scale, ranging from 1 (Never) to 3 (Very often). Thus, scores on the Reactive Aggression subscale can range from 6 through 18; with higher scores indicating more reactive aggression. (NCT00796302)
Timeframe: Measured at baseline and Week 9

,
Interventionunits on a scale (Mean)
BaselineWeek 9
Augmented (Stimulant + PMT + Risperidone)15.511.0
Basic (Stimulant + PMT + Placebo)15.912.3

Clinical Global Impressions Scale for Improvement

"Using this clinician rating scale the patient's improvement is scored on a 7-point scale which ranges from very much improved (1), through no change (4), to very much worse (7). This scale was used at baseline and Weeks 1, 2, 3, 4, 5, 6, 7, 8, & 9. Only endpoint (week 9 or subject's last visit) Clinical Global Impressions Scale for Improvement scores are reported below." (NCT00796302)
Timeframe: Measured at endpoint visit

,
Interventionparticipants (Number)
Much or very much improved at endpointMinimally improved at endpointUnchanged or worse at endpoint
Augmented (Stimulant + PMT + Risperidone)63116
Basic (Stimulant + PMT + Placebo)58223

Clinical Global Impressions Scale for Severity of Illness

Using this clinician rating scale the severity of the illness is scored from 1= normal to 7= extremely ill. This scale was used at baseline and Weeks 1, 2, 3, 4, 5, 6, 7, 8, & 9. Only endpoint (week 9 or subject's last visit) Clinical Global Impressions Scale for Severity of Illness scores are reported below. (NCT00796302)
Timeframe: Measured at endpoint visit

,
Interventionparticipants (Number)
Normal/Borderline/Mildly ill at endpointModerately/Markedly/Severely ill at endpoint
Augmented (Stimulant + PMT + Risperidone)5622
Basic (Stimulant + PMT + Placebo)4934

NCBRF-TIQ D-Total Score

"Parent ratings of aggression and hostility on the Nisonger Child Behavior Rating Form-Typical IQ (NCBRF-TIQ) D-Total Score. The NCBRF provides 1 prosocial subscale (Positive/Social) and 6 problem behavior subscales (Conduct Problem, Oppositional Behavior, Hyperactive, Inattentive, Overly Sensitive, and Withdrawn/Dysphoric). The NCBRF has excellent internal consistency, distinguishes between controls and subjects with DBDs. Conduct Problem and Oppositional Behavior subscales map closely to DSM-IV-TR symptoms of CD and ODD; they were scored together to form a variable called the D-Total.~For the NCBRF D-Total, higher scores reflect worse behavior. Each subscale is scored by taking the rating (0 [did not occur or was not a problem] to 3 [occurred a lot or was a very severe problem]) for all component items. The D-Total score was computed by adding the 6 scores from the Oppositional subscale and the 10 items from the Conduct Problem subscale. Thus D-Total scores could range from 0-69." (NCT00796302)
Timeframe: Measured at baseline and Weeks 3, 4, 5, 6, 7, 8, 9

,
Interventionunits on a scale (Mean)
BaselineWeek 3Week 4Week 5Week 6Week 7Week 8Week 9
Augmented (Stimulant + PMT + Risperidone)42.125.917.112.113.813.011.710.7
Basic (Stimulant + PMT + Placebo)43.524.922.420.120.716.817.817.8

Percent Weight Change Compared to Baseline Weight

(NCT01844700)
Timeframe: baseline to week 12

Interventionpercentage of weight change (Mean)
Ziprasidone11.58
Aripiprazole, Quetiapine, Risperidone5.66

BMI Percentile

(NCT01844700)
Timeframe: baseline to week 12

,
InterventionBMI percentile (Mean)
baselineweek 12 (n=1, n=2)
Aripiprazole, Quetiapine, Risperidone37.6762.5
Ziprasidone3259

BMI Z-scores

(NCT01844700)
Timeframe: baseline to week 12

,
InterventionBMI z-score (Mean)
baselineweek 12 (n=1, n=2)
Aripiprazole, Quetiapine, Risperidone-0.370.38
Ziprasidone-0.510.22

Weight Change

(NCT01844700)
Timeframe: baseline to week 12

,
Interventionlbs (Mean)
baselineweek 12 (n=1,2)
Aripiprazole, Quetiapine, Risperidone118.5141
Ziprasidone120.5151

Reviews

20 reviews available for risperidone and Attention Deficit and Disruptive Behavior Disorders

ArticleYear
Updates in Pharmacologic Strategies for Emotional Dysregulation in Attention Deficit Hyperactivity Disorder.
    Child and adolescent psychiatric clinics of North America, 2022, Volume: 31, Issue:3

    Topics: Adolescent; Aggression; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disor

2022
Pharmacotherapy of Disruptive Behaviors in Children with Intellectual Disabilities.
    Paediatric drugs, 2022, Volume: 24, Issue:5

    Topics: Aggression; Attention Deficit and Disruptive Behavior Disorders; Child; Conduct Disorder; Humans; In

2022
Understanding Chronic Aggression and Its Treatment in Children and Adolescents.
    Current psychiatry reports, 2019, 11-18, Volume: 21, Issue:12

    Topics: Adolescent; Aggression; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; A

2019
Atypical antipsychotics for disruptive behaviour disorders in children and youths.
    The Cochrane database of systematic reviews, 2017, 08-09, Volume: 8

    Topics: Adolescent; Aggression; Antipsychotic Agents; Anxiety Disorders; Attention Deficit and Disruptive Be

2017
Using antipsychotics for behavioral problems in children.
    Expert opinion on pharmacotherapy, 2018, Volume: 19, Issue:13

    Topics: Antipsychotic Agents; Aripiprazole; Attention Deficit and Disruptive Behavior Disorders; Autism Spec

2018
An update on medication management of behavioral disorders in autism.
    Current psychiatry reports, 2014, Volume: 16, Issue:3

    Topics: Adolescent; Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Aripiprazole; Atomoxetine

2014
The use of atypical antipsychotics in pediatric bipolar disorder.
    The Journal of clinical psychiatry, 2008, Volume: 69 Suppl 4

    Topics: Adolescent; Antipsychotic Agents; Aripiprazole; Attention Deficit and Disruptive Behavior Disorders;

2008
Atypical antipsychotic treatment of disruptive behavior disorders in children and adolescents.
    The Journal of clinical psychiatry, 2008, Volume: 69 Suppl 4

    Topics: Adolescent; Antipsychotic Agents; Aripiprazole; Attention Deficit and Disruptive Behavior Disorders;

2008
Atypical antipsychotic medications in the management of disruptive behaviors in children: safety guidelines and recommendations.
    Clinical psychology review, 2011, Volume: 31, Issue:3

    Topics: Adolescent; Antipsychotic Agents; Aripiprazole; Attention Deficit and Disruptive Behavior Disorders;

2011
Efficacy of risperidone in children with disruptive behavioural disorders.
    Journal of paediatrics and child health, 2013, Volume: 49, Issue:1

    Topics: Adolescent; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Child; Humans

2013
Atypical antipsychotics for disruptive behaviour disorders in children and youths.
    The Cochrane database of systematic reviews, 2012, Sep-12, Issue:9

    Topics: Adolescent; Aggression; Antipsychotic Agents; Anxiety Disorders; Attention Deficit and Disruptive Be

2012
Second-generation antipsychotics for the treatment of disruptive behaviour disorders in children: a systematic review.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2012, Volume: 57, Issue:12

    Topics: Adolescent; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Child; Child,

2012
Atypical antipsychotics for the treatment of disruptive behavior.
    Pediatric annals, 2013, Volume: 42, Issue:2

    Topics: Adolescent; Antipsychotic Agents; Aripiprazole; Attention Deficit and Disruptive Behavior Disorders;

2013
Atypical antipsychotics in the treatment of children and adolescents: clinical applications.
    The Journal of clinical psychiatry, 2004, Volume: 65 Suppl 6

    Topics: Adolescent; Age Factors; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders;

2004
Growth and sexual maturation during long-term treatment with risperidone.
    The American journal of psychiatry, 2004, Volume: 161, Issue:5

    Topics: Adolescent; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Child; Child,

2004
Treatment of behavior disorders in mental retardation: report on transitioning to atypical antipsychotics, with an emphasis on risperidone.
    The Journal of clinical psychiatry, 2004, Volume: 65, Issue:9

    Topics: Adult; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Basal Ganglia Dise

2004
Pharmacotherapy of disruptive behavior and item changes on a standardized rating scale: pooled analysis of risperidone effects in children with subaverage IQ.
    Journal of child and adolescent psychopharmacology, 2005, Volume: 15, Issue:2

    Topics: Analysis of Variance; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Chi

2005
Risperidone in the management of agitation and aggression associated with psychiatric disorders.
    European psychiatry : the journal of the Association of European Psychiatrists, 2006, Volume: 21, Issue:1

    Topics: Aggression; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Humans; Menta

2006
Risperidone in the management of disruptive behavior disorders.
    Journal of child and adolescent psychopharmacology, 2006, Volume: 16, Issue:4

    Topics: Adolescent; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Child; Child,

2006
Systematic review of pharmacotherapy of disruptive behavior disorders in children and adolescents.
    Psychopharmacology, 2007, Volume: 191, Issue:1

    Topics: Adolescent; Attention Deficit and Disruptive Behavior Disorders; Child; Humans; Lithium Compounds; P

2007

Trials

25 trials available for risperidone and Attention Deficit and Disruptive Behavior Disorders

ArticleYear
A Naturalistic Comparison of Methylphenidate and Risperidone Monotherapy in Drug-Naive Youth With Attention-Deficit/Hyperactivity Disorder Comorbid With Oppositional Defiant Disorder and Aggression.
    Journal of clinical psychopharmacology, 2017, Volume: 37, Issue:5

    Topics: Aggression; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Attention Def

2017
Clinical Implications From the Treatment of Severe Childhood Aggression (TOSCA) Study: A Re-Analysis and Integration of Findings.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2017, Volume: 56, Issue:12

    Topics: Aggression; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Central Nervo

2017
Attendance and Engagement in Parent Training Predict Child Behavioral Outcomes in Children Pharmacologically Treated for Attention-Deficit/Hyperactivity Disorder and Severe Aggression.
    Journal of child and adolescent psychopharmacology, 2019, Volume: 29, Issue:2

    Topics: Aggression; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Attention Def

2019
Comorbid symptomatology moderates response to risperidone, stimulant, and parent training in children with severe aggression, disruptive behavior disorder, and attention-deficit/hyperactivity disorder.
    Journal of child and adolescent psychopharmacology, 2015, Volume: 25, Issue:3

    Topics: Aggression; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorder with Hyp

2015
Comorbid anxiety and social avoidance in treatment of severe childhood aggression: response to adding risperidone to stimulant and parent training; mediation of disruptive symptom response.
    Journal of child and adolescent psychopharmacology, 2015, Volume: 25, Issue:3

    Topics: Aggression; Antipsychotic Agents; Anxiety Disorders; Attention Deficit and Disruptive Behavior Disor

2015
Participant satisfaction in a study of stimulant, parent training, and risperidone in children with severe physical aggression.
    Journal of child and adolescent psychopharmacology, 2015, Volume: 25, Issue:3

    Topics: Aggression; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Attention Def

2015
Severely Aggressive Children Receiving Stimulant Medication Versus Stimulant and Risperidone: 12-Month Follow-Up of the TOSCA Trial.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2016, Volume: 55, Issue:6

    Topics: Aggression; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Central Nervo

2016
Children with ADHD and symptoms of oppositional defiant disorder improved in behavior when treated with methylphenidate and adjuvant risperidone, though weight gain was also observed - Results from a randomized, double-blind, placebo-controlled clinical t
    Psychiatry research, 2017, Volume: 251

    Topics: Adjuvants, Pharmaceutic; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Diso

2017
Treating disruptive behavior disorders with risperidone: a 1-year, open-label safety study in children and adolescents.
    Journal of child and adolescent psychopharmacology, 2008, Volume: 18, Issue:4

    Topics: Adolescent; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Basal Ganglia

2008
Cognitive function with long-term risperidone in children and adolescents with disruptive behavior disorder.
    Journal of child and adolescent psychopharmacology, 2009, Volume: 19, Issue:6

    Topics: Adolescent; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Child; Child,

2009
Co-morbid disruptive behavior disorder and aggression predict functional outcomes and differential response to risperidone versus divalproex in pharmacotherapy for pediatric bipolar disorder.
    Journal of child and adolescent psychopharmacology, 2011, Volume: 21, Issue:6

    Topics: Adolescent; Aggression; Antimanic Agents; Antipsychotic Agents; Attention Deficit and Disruptive Beh

2011
Double-blind, placebo-controlled study of risperidone for the treatment of disruptive behaviors in children with subaverage intelligence.
    The American journal of psychiatry, 2002, Volume: 159, Issue:8

    Topics: Aggression; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Child; Comorb

2002
Double-blind, placebo-controlled study of risperidone for the treatment of disruptive behaviors in children with subaverage intelligence.
    The American journal of psychiatry, 2002, Volume: 159, Issue:8

    Topics: Aggression; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Child; Comorb

2002
Double-blind, placebo-controlled study of risperidone for the treatment of disruptive behaviors in children with subaverage intelligence.
    The American journal of psychiatry, 2002, Volume: 159, Issue:8

    Topics: Aggression; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Child; Comorb

2002
Double-blind, placebo-controlled study of risperidone for the treatment of disruptive behaviors in children with subaverage intelligence.
    The American journal of psychiatry, 2002, Volume: 159, Issue:8

    Topics: Aggression; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Child; Comorb

2002
Effects of risperidone on conduct and disruptive behavior disorders in children with subaverage IQs.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2002, Volume: 41, Issue:9

    Topics: Analysis of Variance; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Chi

2002
Use of functional analysis methodology in the evaluation of medication effects.
    Journal of autism and developmental disorders, 2003, Volume: 33, Issue:3

    Topics: Adult; Aggression; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Autist

2003
Long-term, open-label study of risperidone in children with severe disruptive behaviors and below-average IQ.
    The American journal of psychiatry, 2004, Volume: 161, Issue:4

    Topics: Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Child; Child, Preschool;

2004
Risperidone effects in the presence/absence of psychostimulant medicine in children with ADHD, other disruptive behavior disorders, and subaverage IQ.
    Journal of child and adolescent psychopharmacology, 2004,Summer, Volume: 14, Issue:2

    Topics: Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorde

2004
Risperidone in children with disruptive behavior disorders and subaverage intelligence: a 1-year, open-label study of 504 patients.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2005, Volume: 44, Issue:1

    Topics: Adolescent; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Child; Child,

2005
Short- and long-term efficacy and safety of risperidone in adults with disruptive behavior disorders.
    Psychopharmacology, 2005, Volume: 179, Issue:3

    Topics: Adolescent; Adult; Attention Deficit and Disruptive Behavior Disorders; Disorders of Excessive Somno

2005
Risperidone reduces aggression in boys with a disruptive behaviour disorder and below average intelligence quotient: analysis of two placebo-controlled randomized trials.
    International clinical psychopharmacology, 2005, Volume: 20, Issue:5

    Topics: Aggression; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Child; Child,

2005
A randomized, double-blind, placebo-controlled study of risperidone maintenance treatment in children and adolescents with disruptive behavior disorders.
    The American journal of psychiatry, 2006, Volume: 163, Issue:3

    Topics: Adolescent; Age Factors; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders;

2006
Long-term safety and efficacy of risperidone in children with disruptive behaviour disorders. Results of a 2-year extension study.
    European child & adolescent psychiatry, 2006, Volume: 15, Issue:2

    Topics: Adolescent; Attention Deficit and Disruptive Behavior Disorders; Body Mass Index; Child; Diagnostic

2006
Risperidone for the treatment of affective symptoms in children with disruptive behavior disorder: a post hoc analysis of data from a 6-week, multicenter, randomized, double-blind, parallel-arm study.
    Clinical therapeutics, 2006, Volume: 28, Issue:5

    Topics: Affective Symptoms; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Depre

2006
Ghrelin and leptin response to oral glucose challenge among antipsychotic drug-treated children.
    Journal of clinical psychopharmacology, 2007, Volume: 27, Issue:6

    Topics: Administration, Oral; Adolescent; Age Factors; Analysis of Variance; Antipsychotic Agents; Aripipraz

2007
Risperidone use in children with Down syndrome, severe intellectual disability, and comorbid autistic spectrum disorders: a naturalistic study.
    Journal of developmental and behavioral pediatrics : JDBP, 2008, Volume: 29, Issue:2

    Topics: Adolescent; Attention Deficit and Disruptive Behavior Disorders; Autistic Disorder; Central Nervous

2008
A randomized controlled trial of risperidone in the treatment of aggression in hospitalized adolescents with subaverage cognitive abilities.
    The Journal of clinical psychiatry, 2001, Volume: 62, Issue:4

    Topics: Adolescent; Aggression; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; B

2001

Other Studies

27 other studies available for risperidone and Attention Deficit and Disruptive Behavior Disorders

ArticleYear
Atypical antipsychotics for Attention-Deficit/Hyperactivity disorder- science, art, or fad?
    European psychiatry : the journal of the Association of European Psychiatrists, 2019, Volume: 62

    Topics: Adolescent; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Attention Def

2019
Editorial: Why JAACAP Published an "Inconclusive" Trial: Optimize, Optimize, Optimize Psychostimulant Treatment.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2021, Volume: 60, Issue:2

    Topics: Aggression; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorder with Hyp

2021
Long-Acting Injectable Atypical Antipsychotic Use in Adolescents: An Observational Study.
    Journal of child and adolescent psychopharmacology, 2018, Volume: 28, Issue:4

    Topics: Adolescent; Antipsychotic Agents; Aripiprazole; Attention Deficit and Disruptive Behavior Disorders;

2018
Review: Limited evidence that risperidone reduces aggression and conduct problems in the short term in children and adolescents with disruptive behaviour disorders.
    Evidence-based mental health, 2013, Volume: 16, Issue:3

    Topics: Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Dibenzothiazepines; Human

2013
Tolerability and safety profile of risperidone in a sample of children and adolescents.
    International clinical psychopharmacology, 2013, Volume: 28, Issue:4

    Topics: Adolescent; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Body Composit

2013
The effect of the Taq1A variant in the dopamine D₂ receptor gene and common CYP2D6 alleles on prolactin levels in risperidone-treated boys.
    Pharmacogenetics and genomics, 2013, Volume: 23, Issue:9

    Topics: Adolescent; Alleles; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Chil

2013
Managing ADHD and disruptive behaviour disorders with combination psychostimulant and antipsychotic treatment.
    Journal of psychiatry & neuroscience : JPN, 2014, Volume: 39, Issue:3

    Topics: Aggression; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Attention Def

2014
The Relationship between Acute Dyskinesia with a Single Dose of Methylphenidate and Recent Risperidone Discontinuation in a Child with Attention-Deficit/Hyperactivity Disorder.
    Journal of child and adolescent psychopharmacology, 2015, Volume: 25, Issue:4

    Topics: Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorde

2015
Longitudinal examination of the skeletal effects of selective serotonin reuptake inhibitors and risperidone in boys.
    The Journal of clinical psychiatry, 2015, Volume: 76, Issue:5

    Topics: Adolescent; Attention Deficit and Disruptive Behavior Disorders; Bone Density; Child; Humans; Longit

2015
Iron homeostasis during risperidone treatment in children and adolescents.
    The Journal of clinical psychiatry, 2015, Volume: 76, Issue:11

    Topics: Adolescent; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Autism Spectr

2015
Increased Risk of Obesity and Metabolic Dysregulation Following 12 Months of Second-Generation Antipsychotic Treatment in Children: A Prospective Cohort Study.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2015, Volume: 60, Issue:10

    Topics: Adolescent; Antipsychotic Agents; Anxiety Disorders; Attention Deficit and Disruptive Behavior Disor

2015
Prolactin Levels During Long-Term Risperidone Treatment in Children and Adolescents: a reanalysis of data.
    The Journal of clinical psychiatry, 2016, Volume: 77, Issue:2

    Topics: Adolescent; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Child; Data I

2016
Persistence in Therapy With Risperidone and Aripiprazole in Pediatric Outpatients: A 2-Year Naturalistic Comparison.
    The Journal of clinical psychiatry, 2016, Volume: 77, Issue:12

    Topics: Adolescent; Antipsychotic Agents; Aripiprazole; Attention Deficit and Disruptive Behavior Disorders;

2016
Predictive familial risk factors and pharmacological responses in ADHD with comorbid disruptive behavior disorders.
    Pediatrics international : official journal of the Japan Pediatric Society, 2010, Volume: 52, Issue:3

    Topics: Adolescent; Age Distribution; Analysis of Variance; Attention Deficit and Disruptive Behavior Disord

2010
[Bipolar disorders as co-morbidity in childhood and adolescence--underdiagnosed or overinterpreted? Therapy of a 14-year-old boy with hyperkinetic conduct disorder and hypomania].
    Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie, 2010, Volume: 38, Issue:2

    Topics: Adolescent; Aggression; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; A

2010
Six months of treatment with risperidone may be associated with nonsignificant abnormalities of liver function tests in children and adolescents: a longitudinal, observational study from Turkey.
    Journal of child and adolescent psychopharmacology, 2010, Volume: 20, Issue:5

    Topics: Adolescent; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Body Weight;

2010
Confounding by indication of a specific antipsychotic and the increase of body mass index among children and adolescents.
    European child & adolescent psychiatry, 2011, Volume: 20, Issue:11-12

    Topics: Adolescent; Analysis of Variance; Antipsychotic Agents; Aripiprazole; Attention Deficit and Disrupti

2011
A case of antipsychotic-induced hyperglycemia in a child with insulin dependent diabetes mellitus.
    Journal of child and adolescent psychopharmacology, 2012, Volume: 22, Issue:5

    Topics: Adolescent; Antipsychotic Agents; Aripiprazole; Attention Deficit and Disruptive Behavior Disorders;

2012
Risk of hyperprolactinemia and sexual side effects in males 10-20 years old diagnosed with autism spectrum disorders or disruptive behavior disorder and treated with risperidone.
    Journal of child and adolescent psychopharmacology, 2012, Volume: 22, Issue:6

    Topics: Adolescent; Adult; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Child;

2012
Triglyceride, cholesterol and weight changes among risperidone-treated youths. A retrospective study.
    European child & adolescent psychiatry, 2002, Volume: 11, Issue:3

    Topics: Adolescent; Affective Disorders, Psychotic; Antipsychotic Agents; Attention Deficit and Disruptive B

2002
Glucose abnormalities in a non-psychotic patient treated with risperidone.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2005, Volume: 44, Issue:7

    Topics: Adolescent; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Diabetes Mell

2005
Antipsychotics in disruptive behavior disorders and ADHD.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2005, Volume: 44, Issue:10

    Topics: Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorde

2005
Elucidating the role of risperidone in the treatment of disruptive behavior disorders.
    Journal of child and adolescent psychopharmacology, 2006, Volume: 16, Issue:4

    Topics: Adolescent; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Child; Humans

2006
The influence of risperidone on attentional functions in children and adolescents with attention-deficit/hyperactivity disorder and co-morbid disruptive behavior disorder.
    Journal of child and adolescent psychopharmacology, 2006, Volume: 16, Issue:6

    Topics: Adolescent; Aggression; Antipsychotic Agents; Attention; Attention Deficit and Disruptive Behavior D

2006
Risperidone and cognitive function in children with disruptive behavior disorders.
    Biological psychiatry, 2007, Aug-01, Volume: 62, Issue:3

    Topics: Adolescent; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Child; Child,

2007
Risperidone-to-methylphenidate switch reaction in children: three cases.
    Journal of psychopharmacology (Oxford, England), 2007, Volume: 21, Issue:2

    Topics: Adolescent; Akathisia, Drug-Induced; Antipsychotic Agents; Attention Deficit and Disruptive Behavior

2007
Risperdal and parkinsonian tremor.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1999, Volume: 38, Issue:3

    Topics: Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorde

1999