Page last updated: 2024-11-03

risperidone and Acute Post-Traumatic Stress Disorder

risperidone has been researched along with Acute Post-Traumatic Stress Disorder in 32 studies

Risperidone: A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.
risperidone : A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.

Research Excerpts

ExcerptRelevanceReference
" This study tested the hypothesis that low-dose risperidone reduces aggression and other PTSD-related symptoms in combat veterans."9.10Low-dose risperidone as adjunctive therapy for irritable aggression in posttraumatic stress disorder. ( Ciraulo, DA; Keane, T; Knapp, C; Monnelly, EP, 2003)
" This study tested the hypothesis that low-dose risperidone reduces aggression and other PTSD-related symptoms in combat veterans."5.10Low-dose risperidone as adjunctive therapy for irritable aggression in posttraumatic stress disorder. ( Ciraulo, DA; Keane, T; Knapp, C; Monnelly, EP, 2003)
"DSM-IV PTSD diagnoses were made by using the Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Nonpatient Edition."2.82Sleep disturbance in chronic military-related PTSD: clinical impact and response to adjunctive risperidone in the Veterans Affairs cooperative study #504. ( Collins, J; Cramer, JA; Huang, GD; Jones, KM; Krystal, AD; Krystal, JH; Pietrzak, RH; Rosenheck, RA; Vertrees, JE; Vessicchio, J, 2016)
"T-tests showed that the PTSD sample had more severe symptoms on the Depressive factor, and the schizophrenia sample on the Positive, Negative, and Disorganized factors, with no significant difference on the Excited factor."2.79Symptom structure and severity: a comparison of responses to the positive and negative syndrome scale (PANSS) between patients with PTSD or schizophrenia. ( Krystal, JH; Rosenheck, RA; Stefanovics, EA, 2014)
"The Clinician-Administered PTSD Scale (CAPS) (range, 0-136)."2.76Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD: a randomized trial. ( Cramer, JA; Horney, RA; Huang, GD; Jones, KM; Krystal, JH; Rosenheck, RA; Stock, C; Vertrees, JE; Vessicchio, JC, 2011)
"Symptoms of PTSD and depression and psychotic symptoms were measured prospectively throughout the 16-week study."2.73Placebo-controlled trial of risperidone augmentation for selective serotonin reuptake inhibitor-resistant civilian posttraumatic stress disorder. ( Brady, KT; Connor, KM; Davidson, JR; Heekin, MH; Killeen, TK; Rothbaum, BO, 2008)
"Risperidone was well tolerated with minimal extrapyramidal symptoms."2.71Adjunctive risperidone treatment in post-traumatic stress disorder: a preliminary controlled trial of effects on comorbid psychotic symptoms. ( Arana, GW; Faldowski, RA; Frueh, BC; Hamner, MB; Huber, MG; Ulmer, HG, 2003)
"Risperidone-treated patients had a significantly greater reduction in total score on the CAPS-2 (z = -2."2.71A preliminary study of risperidone in the treatment of posttraumatic stress disorder related to childhood abuse in women. ( Hennen, J; Reich, DB; Stanculescu, C; Watts, T; Winternitz, S, 2004)
"Risperidone was added to a stable psychotropic medication regimen in 92% of subjects."2.71Adjunctive risperidone in the treatment of chronic combat-related posttraumatic stress disorder. ( Bartzokis, G; Lu, PH; Mintz, J; Saunders, CS; Turner, J, 2005)
"Treatment with risperidone for either 3 or 6 weeks in an open trial significantly reduced total and subscales scores on the PANSS and on the PTSD-I and CGI-S when compared to baseline scores in patients with psychotic PTSD."2.71Risperidone in psychotic combat-related posttraumatic stress disorder: an open trial. ( Kozarić-Kovacić, D; Mück-Seler, D; Pivac, N; Rothbaum, BO, 2005)
"Posttraumatic stress disorder (PTSD) is an important mental health issue in terms of the number of people affected and the morbidity and functional impairment associated with the disorder."2.49Meta-analysis of the efficacy of treatments for posttraumatic stress disorder. ( Friedman, MJ; Mayo, L; Schnurr, PP; Watts, BV; Weeks, WB; Young-Xu, Y, 2013)
"Posttraumatic stress disorder (PTSD) can be a chronic and disabling illness with a limited response to antidepressant treatment, particularly in the case of combat-induced PTSD."2.47A review of atypical antipsychotic medications for posttraumatic stress disorder. ( Ahearn, EP; Becker, T; Cordes, T; Juergens, T; Krahn, D, 2011)
"Posttraumatic stress disorder (PTSD) is a prevalent and disabling mental illness."2.44The atypical antipsychotics olanzapine and risperidone in the treatment of posttraumatic stress disorder: a meta-analysis of randomized, double-blind, placebo-controlled clinical trials. ( Ajwani, N; Lee, C; Lim, HK; Pae, CU; Patkar, AA; Peindl, K; Serretti, A, 2008)
"Risperidone and piracetam were found to be effective alone, while their high dose combination, produced potentiating effect in reversing the extinction deficit, behavioral alterations, altered cortical and hippocampal BDNF, IL-6, TNF-α, caspase-3, oxidative stress markers, and neurotransmitter levels."1.51Co-treatment of piracetam with risperidone rescued extinction deficits in experimental paradigms of post-traumatic stress disorder by restoring the physiological alterations in cortex and hippocampus. ( Akhtar, A; Bansal, Y; Kuhad, A; Sah, SP; Singh, R; Uniyal, A, 2019)
"Posttraumatic stress disorder (PTSD) is a chronic and often difficult-to-treat condition that is prevalent among military veterans."1.46Correlates of Nonimprovement to Pharmacotherapy for Chronic, Antidepressant-Resistant, Military Service-Related Posttraumatic Stress Disorder: Insights From the Veterans Affairs Cooperative Study No. 504. ( Byrne, SP; Krystal, JH; Pietrzak, RH; Rosenheck, RA; Vessicchio, J, 2017)
"Risperidone ameliorated increase in the activity of mitochondrial respiratory complex (I, II, IV, and V), decreases in the levels of mitochondrial membrane potential, cytochrome-C and caspase-9 in the hippocampus, hypothalamus, pre-frontal cortex, and amygdala."1.42Risperidone Attenuates Modified Stress-Re-stress Paradigm-Induced Mitochondrial Dysfunction and Apoptosis in Rats Exhibiting Post-traumatic Stress Disorder-Like Symptoms. ( Ahmad, A; Garabadu, D; Krishnamurthy, S, 2015)
"The management for post-traumatic stress disorder (PTSD) involves chronic administration of drugs."1.39Risperidone ameliorates post-traumatic stress disorder-like symptoms in modified stress re-stress model. ( Garabadu, D; Joy, KP; Krishnamurthy, S, 2013)
"PTSD is a possible sequela of exposure to traumatic events."1.30Risperidone as an adjunct therapy for post-traumatic stress disorder. ( Krashin, D; Oates, EW, 1999)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (12.50)18.2507
2000's13 (40.63)29.6817
2010's13 (40.63)24.3611
2020's2 (6.25)2.80

Authors

AuthorsStudies
Rosenheck, R1
Kurtz, SG1
Anand, ST1
Hau, C1
Smedberg, D1
Sicilia, R1
Pontzer, JF1
Ferguson, RE1
Uniyal, A1
Singh, R1
Akhtar, A1
Bansal, Y1
Kuhad, A1
Sah, SP1
Jerrom, R1
Mortimer, H1
Martin, K1
Siddiquee, R1
Bagchi, D1
Goulding, JMR1
Byrne, SP1
Krystal, JH5
Rosenheck, RA5
Vessicchio, J2
Pietrzak, RH3
Watts, BV1
Schnurr, PP1
Mayo, L1
Young-Xu, Y1
Weeks, WB1
Friedman, MJ1
Krishnamurthy, S2
Garabadu, D2
Joy, KP1
Cukor, J1
Difede, J1
Stefanovics, EA1
Cramer, JA3
Vessichio, JC1
Tsai, J1
Southwick, SM1
Ahmad, A1
Jones, KM2
Huang, GD2
Vertrees, JE2
Collins, J1
Krystal, AD1
Keeshin, BR1
Strawn, JR1
Khachiyants, N2
Ali, R2
Kovesdy, CP1
Detweiler, JG2
Kim, KY2
Detweiler, MB2
Ahearn, EP1
Juergens, T1
Cordes, T1
Becker, T1
Krahn, D1
Vessicchio, JC1
Horney, RA1
Stock, C1
Hamner, MB1
Faldowski, RA1
Ulmer, HG1
Frueh, BC1
Huber, MG1
Arana, GW1
Monnelly, EP1
Ciraulo, DA1
Knapp, C1
Keane, T1
Reich, DB1
Winternitz, S1
Hennen, J1
Watts, T1
Stanculescu, C1
Bartzokis, G1
Lu, PH1
Turner, J1
Mintz, J1
Saunders, CS1
Kozarić-Kovacić, D1
Pivac, N1
Mück-Seler, D1
Rothbaum, BO2
Rasmussen, K1
Padala, PR1
Madison, J1
Monnahan, M1
Marcil, W1
Price, P1
Ramaswamy, S1
Din, AU1
Wilson, DR1
Petty, F1
Stevens, HE1
Pae, CU1
Lim, HK1
Peindl, K1
Ajwani, N1
Serretti, A1
Patkar, AA1
Lee, C1
Berger, W1
Portella, CM1
Fontenelle, LF1
Kinrys, G1
Mendlowicz, MV1
Killeen, TK1
Davidson, JR1
Brady, KT1
Connor, KM1
Heekin, MH1
Feeney, DJ1
Klykylo, W1
Leyba, CM1
Wampler, TP1
Roberts, MD1
Krashin, D1
Oates, EW1
Eidelman, I1
Seedat, S1
Stein, DJ1

Clinical Trials (10)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Stellate Ganglion Block to Augment Trauma-focused Therapy Among Veterans With PTSD[NCT05107752]Phase 280 participants (Anticipated)Interventional2022-01-03Recruiting
Co-occurring Eating Disorders and Posttraumatic Stress Disorder: Facilitating Full and Sustained Recovery Through Empirically-Based Concurrent Treatment[NCT03502564]43 participants (Actual)Interventional2015-10-22Completed
Wearable Emotion Prosthetics for Post Traumatic Stress Disorder[NCT03529981]16 participants (Actual)Interventional2018-04-09Completed
Acupuncture and Meditation for Wellness (AMWELL)[NCT04859686]77 participants (Actual)Interventional2008-09-01Completed
Effectiveness of Thought Field Therapy Provided by Newly Instructed Community Workers to a Traumatized Population in Uganda: A Randomised Trial[NCT01681628]256 participants (Actual)Interventional2012-06-30Completed
CSP #504 - Risperidone Treatment for Military Service Related Chronic Post-Traumatic Stress Disorder[NCT00099983]Phase 2296 participants (Actual)Interventional2006-10-31Completed
A Double-Blind, Placebo-Controlled Random Order Crossover Study of Iloperidone for Symptoms of Arousal in PTSD Including Insomnia and Irritability.[NCT01917318]Phase 21 participants (Actual)Interventional2013-07-31Terminated (stopped due to Enrollment challenges - Single participant discontinued after placebo, no relevant outcome measure data was recorded.)
Characterization of the Use of Antipsychotics in PTSD During the Past Seven Years[NCT00230893]99 participants Observational2005-07-31Completed
Characterization of the Use of Antipsychotics in Posttraumatic Stress Disorder During the Past Decade[NCT00233467]0 participants (Actual)Observational2005-09-01Withdrawn (stopped due to Funding expired; no subjects enrolled as this was a retrospective chart review)
Placebo-Controlled Trial of Risperidone Augmentation for SSRI-Resistant Civilian PTSD[NCT00133822]Phase 1/Phase 265 participants Interventional2004-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Post-traumatic Stress Disorder Check List for Civilians (PLC-C) Score.

"PCL-C (post traumatic check list for civilians) is a measure of the severity of post traumatic stress disorder (PTSD), and can also be used for screening populations, It is a self-completed questionnaire with 17 questions scoring from 1 - 5. The scores of each question are added to create the total score for each participant. The highest possible score for any individual is 85, the lowest score being 17. A diagnostic score for PTSD is accepted as being more than 50. Participants completed the PCL-C just before treatment and one week later. The wait list group received no treatment at Time 1.~In the treatment arm, measure immediately pre-treatment (baseline) (time 1) and one week later (time 2).~In the wait-list no therapy arm, measure at baseline (time 1), and after one week (no treatment) (time 2). The wait-list group (Thought Field Therapy group) were then treated and reassessed after a further week (time 3)." (NCT01681628)
Timeframe: Baseline (Time 1), One week later (Time 2) and Two weeks later (Time 3 for Wait-list: Thought field Therapy Arm)

Interventionunits on a scale (Mean)
Thought Field Therapy32.4
Wait List: no Therapy12.4
Wait-list: Thought Field Therapy20.6

Assessment of Any Persisting Benefit of TFT (Thought Field Therapy) After 19 Months.

PCL-C (post traumatic check list for civilians) is a measure of the severity of post traumatic stress disorder (PTSD), and can also be used for screening populations, It is a self-completed questionnaire with 17 questions scoring from 1 - 5. The scores of each question are added to create the total score for each participant. The highest possible score for any individual is 85, the lowest score being 17. A diagnostic score for PTSD is accepted as being more than 50. Participants completed the PCL-C one week following treatment and nineteen months later. Comparison of PCL-C scores at nineteen months compared to one week following treatment. (NCT01681628)
Timeframe: 1 week post-treatment (Time 2, TFT; Time 3, WL) and 19 months later.

Interventionunits on a scale (PCL-C score) (Mean)
one week following treatment19 months later
Thought Field Therapy25.843.6

Assessment of Continuing Benefit of TFT After 19 Months, in Control Group, as Measured by a Diagnosis of PTSD According to a PCL-C Score of >50.

PCL-C (post traumatic check list for civilians) is a measure of the severity of post traumatic stress disorder (PTSD), and can also be used for screening populations, It is a self-completed questionnaire with 17 questions scoring from 1 - 5. The scores of each question are added to create the total score for each participant. The highest possible score for any individual is 85, the lowest score being 17. A diagnostic score for PTSD is accepted as being more than 50. Participants completed the PCL-C just before treatment and one week later. Only the wait-list control group was used as the treatment group did not not have a run-in score, and would have given inappropriately positive results. (NCT01681628)
Timeframe: Time 2 and 19 months later.

Interventionpercentage of PCL-C scores >50. (Number)
PCL-C score pre-treatment (time 2) >50% with PCL-C score >50 at 19 months
Wait List Group41.826.6

Percentage With Scores Diagnostic for Post Traumatic Stress Disorder (PCL-C > 50) Before and After Treatment in Treatment and Control Groups.

PCL-C (post traumatic check list for civilians) is a measure of the severity of post traumatic stress disorder (PTSD), and can also be used for screening populations, It is a self-completed questionnaire with 17 questions scoring from 1 - 5. The scores of each question are added to create the total score for each participant. The highest possible score for any individual is 85, the lowest score being 17. A diagnostic score for PTSD is accepted as being more than 50. Participants completed the PCL-C just before treatment and one week later. The wait list group received no treatment at Time 1. (NCT01681628)
Timeframe: Baseline (Time 1), One week later (Time 2) and Two weeks later (Time 3 for Wait-list: Thought field Therapy Arm)

,
Interventionpercentage with PCL-C score > 50 (Number)
Time 1Time 2
Thought Field Therapy67.51.8
Wait List no Treatment82.841.8

Percentage With Scores Diagnostic for Post Traumatic Stress Disorder (PCL-C > 50) Before and After Treatment in Treatment and Control Groups.

PCL-C (post traumatic check list for civilians) is a measure of the severity of post traumatic stress disorder (PTSD), and can also be used for screening populations, It is a self-completed questionnaire with 17 questions scoring from 1 - 5. The scores of each question are added to create the total score for each participant. The highest possible score for any individual is 85, the lowest score being 17. A diagnostic score for PTSD is accepted as being more than 50. Participants completed the PCL-C just before treatment and one week later. The wait list group received no treatment at Time 1. (NCT01681628)
Timeframe: Baseline (Time 1), One week later (Time 2) and Two weeks later (Time 3 for Wait-list: Thought field Therapy Arm)

Interventionpercentage with PCL-C score > 50 (Number)
Time 2Time 3
Wait List: Thought Field Therapy41.81.9

Change in CAPS Score From Baseline to Week 24

The primary outcome measure for this study was the total score on the 34-item Clinician-Administered PTSD Scale (CAPS). This study was the intent-to-treat analysis of the improvement in PTSD symptoms from baseline to week-24 follow-up as measured by the CAPS. Total score range for the CAPS is 0-136 with higher values representing a worse outcome. This study was powered initially to detect a 9-point difference between the treatment groups in the CAPS change score. (NCT00099983)
Timeframe: 24 Weeks

Interventionunits on a scale (Least Squares Mean)
Risperidone-16.3
Sugar Pill-12.5

Intensity of Suicidal Ideation

"Intensity of Suicidal Ideation was monitored over the course of the trial by the second section of the Columbia Suicide Severity Rating Scale (CSSRS). This section is only administered if the patient answers yes to the first section. The section consists of 5 questions that refer to the most severe level of ideation endorsed in the first section of the CSSRS. The total score ranges from 2 to 25, with a higher number indicating more intense ideation and greater risk.~Only lifetime intensity of suicidal ideation was explored as the patient had no suicidal ideation from the month prior to beginning the study to the completion of the study" (NCT01917318)
Timeframe: Baseline

Interventionscore on a scale (Number)
Placebo / Iloperidone16

Aggression

Aggression was measured by the Modified Overt Aggression Scale (MOAS).This assessment measures four types of aggressive behavior (verbal, aggression against property, autoaggression, and physical aggression) . Total scores on the MOAS range from 0-40, with a higher score indicating more aggressive behavior. (NCT01917318)
Timeframe: Randomization and 8 weeks of treatment, during both treatment periods

Interventionunits on a scale (Number)
MOAS at randomization 1MOAS after 8 weeks with placeboMOAS at randomization 2MOAS after 2 weeks with iloperidone treatment
Placebo / Iloperidone1000

Change in Clinician Administered PTSD Scale (CAPS) Part B and D

"The Clinician-Administered PTSD Scale (CAPS) is a structured interview used to diagnose and assess PTSD. Part B of CAPS evaluates symptoms of re-experiencing. Part D evaluates avoidance and numbing.~CAPS-B scores range from 0 to 40 where higher scores indicate more symptoms. A score 0 means no re-experiencing symptoms.~CAPS-D scores range form 0 to 56 and higher scores indicate more symptoms. A score 0 means no avoidance or numbing symptoms.~The primary endpoint was changes in CAPS part B and D after 8 weeks of treatment." (NCT01917318)
Timeframe: Randomization and at the end of each treatment period. Placebo treatment lasted 8 weeks. Iloperidone treatment lasted 2 weeks.

Interventionunits on a scale (Number)
CAPS part B at randomization 1CAPS part B after 8 weeks with placeboCAPS part B at randomization 2CAPS part B after 2 weeks with iloperidoneCAPS part D at randomization 1CAPS part D after 8 weeks with placeboCAPS part D at randomization 2CAPS part D after 2 weeks with iloperidone
Placebo / Iloperidone204406270

Suicidal Behavior

The presence and severity os suicidal behavior was monitored over the course of the trial by the third section of the Columbia Suicide Severity Rating Scale (CSSRS). This sections consists of questions about 5 suicidal behaviors and non-suicidal self injurious behavior and it can be answered yes or no. The number of participants who experienced suicidal behavior is reported. (NCT01917318)
Timeframe: Total course of the study. CSSRS was administered during each study visit. Suicidal ideation during lifetime and during the month prior to screening were also explored

Interventionparticipants (Number)
Lifetime suicidal behavior1 month prior ro screeningDuring the course of the study
Placebo / Iloperidone000

Suicidal Ideation

The presence of suicidal ideation was monitored over the course of the trial by the first section of the Columbia Suicide Severity Rating Scale (CSSRS). This first section of the scale consists of 5 questions that can be answered yes or no. The number of participants who reported experiencing suicidal ideation is reported. (NCT01917318)
Timeframe: Total course of the study. CSSRS was administered during each study visit. Suicidal ideation during lifetime and during the month prior to screening were also explored

Interventionparticipants (Number)
Lifetime suicidal ideation1 month prior to screeningSuicidal ideation during the study
Placebo / Iloperidone100

Reviews

5 reviews available for risperidone and Acute Post-Traumatic Stress Disorder

ArticleYear
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Fructose; Humans; Male; Psycho

2013
A review of atypical antipsychotic medications for posttraumatic stress disorder.
    International clinical psychopharmacology, 2011, Volume: 26, Issue:4

    Topics: Antipsychotic Agents; Controlled Clinical Trials as Topic; Dibenzothiazepines; Humans; Quetiapine Fu

2011
Creating more effective antidepressants: clues from the clinic.
    Drug discovery today, 2006, Volume: 11, Issue:13-14

    Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Clinical Trials as Topic; Dep

2006
The atypical antipsychotics olanzapine and risperidone in the treatment of posttraumatic stress disorder: a meta-analysis of randomized, double-blind, placebo-controlled clinical trials.
    International clinical psychopharmacology, 2008, Volume: 23, Issue:1

    Topics: Antipsychotic Agents; Benzodiazepines; Data Interpretation, Statistical; Double-Blind Method; Humans

2008
[Antipsychotics, anticonvulsants, antiadrenergics and other drugs: what to do when posttraumatic stress disorder does not respond to selective serotonin reuptake inhibitors?].
    Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2007, Volume: 29 Suppl 2

    Topics: Adrenergic Antagonists; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Humans; Lamotrigine;

2007

Trials

11 trials available for risperidone and Acute Post-Traumatic Stress Disorder

ArticleYear
Impact of multi-site clinical trial results on clinical practice: Use of risperidone to treat PTSD nationally in the veterans health administration.
    Psychiatry research, 2023, Volume: 321

    Topics: Antipsychotic Agents; Humans; Risperidone; Stress Disorders, Post-Traumatic; United States; United S

2023
Symptom structure and severity: a comparison of responses to the positive and negative syndrome scale (PANSS) between patients with PTSD or schizophrenia.
    Comprehensive psychiatry, 2014, Volume: 55, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Chronic Disease; Combat Disorders; Diagnosis,

2014
Sleep disturbance in chronic military-related PTSD: clinical impact and response to adjunctive risperidone in the Veterans Affairs cooperative study #504.
    The Journal of clinical psychiatry, 2016, Volume: 77, Issue:4

    Topics: Adult; Aged; Combat Disorders; Double-Blind Method; Female; Humans; Interview, Psychological; Male;

2016
Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD: a randomized trial.
    JAMA, 2011, Aug-03, Volume: 306, Issue:5

    Topics: Adult; Afghan Campaign 2001-; Chronic Disease; Depression; Double-Blind Method; Drug Resistance; Fem

2011
Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD: a randomized trial.
    JAMA, 2011, Aug-03, Volume: 306, Issue:5

    Topics: Adult; Afghan Campaign 2001-; Chronic Disease; Depression; Double-Blind Method; Drug Resistance; Fem

2011
Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD: a randomized trial.
    JAMA, 2011, Aug-03, Volume: 306, Issue:5

    Topics: Adult; Afghan Campaign 2001-; Chronic Disease; Depression; Double-Blind Method; Drug Resistance; Fem

2011
Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD: a randomized trial.
    JAMA, 2011, Aug-03, Volume: 306, Issue:5

    Topics: Adult; Afghan Campaign 2001-; Chronic Disease; Depression; Double-Blind Method; Drug Resistance; Fem

2011
Adjunctive risperidone treatment in post-traumatic stress disorder: a preliminary controlled trial of effects on comorbid psychotic symptoms.
    International clinical psychopharmacology, 2003, Volume: 18, Issue:1

    Topics: Adult; Antipsychotic Agents; Comorbidity; Double-Blind Method; Humans; Male; Middle Aged; Military P

2003
Low-dose risperidone as adjunctive therapy for irritable aggression in posttraumatic stress disorder.
    Journal of clinical psychopharmacology, 2003, Volume: 23, Issue:2

    Topics: Aggression; Antipsychotic Agents; Double-Blind Method; Humans; Irritable Mood; Middle Aged; Psychiat

2003
A preliminary study of risperidone in the treatment of posttraumatic stress disorder related to childhood abuse in women.
    The Journal of clinical psychiatry, 2004, Volume: 65, Issue:12

    Topics: Adolescent; Adult; Ambulatory Care; Antipsychotic Agents; Child; Child Abuse; Child Abuse, Sexual; D

2004
Adjunctive risperidone in the treatment of chronic combat-related posttraumatic stress disorder.
    Biological psychiatry, 2005, Mar-01, Volume: 57, Issue:5

    Topics: Adult; Antipsychotic Agents; Double-Blind Method; Drug Evaluation; Follow-Up Studies; Humans; Male;

2005
Risperidone in psychotic combat-related posttraumatic stress disorder: an open trial.
    The Journal of clinical psychiatry, 2005, Volume: 66, Issue:7

    Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Basal Ganglia Diseases; Combat Disorders; Croa

2005
Risperidone in psychotic combat-related posttraumatic stress disorder: an open trial.
    The Journal of clinical psychiatry, 2005, Volume: 66, Issue:7

    Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Basal Ganglia Diseases; Combat Disorders; Croa

2005
Risperidone in psychotic combat-related posttraumatic stress disorder: an open trial.
    The Journal of clinical psychiatry, 2005, Volume: 66, Issue:7

    Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Basal Ganglia Diseases; Combat Disorders; Croa

2005
Risperidone in psychotic combat-related posttraumatic stress disorder: an open trial.
    The Journal of clinical psychiatry, 2005, Volume: 66, Issue:7

    Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Basal Ganglia Diseases; Combat Disorders; Croa

2005
Risperidone monotherapy for post-traumatic stress disorder related to sexual assault and domestic abuse in women.
    International clinical psychopharmacology, 2006, Volume: 21, Issue:5

    Topics: Adult; Aged; Antipsychotic Agents; Domestic Violence; Double-Blind Method; Female; Humans; Middle Ag

2006
Placebo-controlled trial of risperidone augmentation for selective serotonin reuptake inhibitor-resistant civilian posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2008, Volume: 69, Issue:4

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Demography; Diagnostic and Statistical Manual of Ment

2008

Other Studies

16 other studies available for risperidone and Acute Post-Traumatic Stress Disorder

ArticleYear
Co-treatment of piracetam with risperidone rescued extinction deficits in experimental paradigms of post-traumatic stress disorder by restoring the physiological alterations in cortex and hippocampus.
    Pharmacology, biochemistry, and behavior, 2019, Volume: 185

    Topics: Animals; Antipsychotic Agents; Behavior, Animal; Corticosterone; Disease Models, Animal; Drug Synerg

2019
A case series of shared delusional infestation: folie à deux revisited.
    Clinical and experimental dermatology, 2020, Volume: 45, Issue:4

    Topics: Adult; Antipsychotic Agents; Delusional Parasitosis; Female; History, 19th Century; Humans; Male; Mi

2020
Correlates of Nonimprovement to Pharmacotherapy for Chronic, Antidepressant-Resistant, Military Service-Related Posttraumatic Stress Disorder: Insights From the Veterans Affairs Cooperative Study No. 504.
    Journal of clinical psychopharmacology, 2017, Volume: 37, Issue:6

    Topics: Adult; Aged; Antidepressive Agents; Antipsychotic Agents; Drug Therapy, Combination; Female; Humans;

2017
Risperidone ameliorates post-traumatic stress disorder-like symptoms in modified stress re-stress model.
    Neuropharmacology, 2013, Volume: 75

    Topics: Animals; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Brain; Corticosterone; Dise

2013
Review: psychotherapy, somatic therapy and pharmacotherapy are all more effective than control for the treatment of PTSD.
    Evidence-based mental health, 2014, Volume: 17, Issue:1

    Topics: Antidepressive Agents; Female; Fructose; Humans; Male; Psychotherapy; Risperidone; Stress Disorders,

2014
Elucidating the transdiagnostic dimensional structure of trauma-related psychopathology: Findings from VA cooperative study 504 - risperidone treatment for military service related chronic post traumatic stress disorder.
    Journal of affective disorders, 2015, Feb-01, Volume: 172

    Topics: Adult; Aged; Antipsychotic Agents; Arousal; Comorbidity; Depressive Disorder, Major; Factor Analysis

2015
Risperidone Attenuates Modified Stress-Re-stress Paradigm-Induced Mitochondrial Dysfunction and Apoptosis in Rats Exhibiting Post-traumatic Stress Disorder-Like Symptoms.
    Journal of molecular neuroscience : MN, 2015, Volume: 56, Issue:2

    Topics: Animals; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Apoptosis; Brain; Corticost

2015
Risperidone treatment of an adolescent with severe posttraumatic stress disorder.
    The Annals of pharmacotherapy, 2009, Volume: 43, Issue:7

    Topics: Adolescent; Antipsychotic Agents; Child Abuse; Child Abuse, Sexual; Dose-Response Relationship, Drug

2009
Effectiveness of risperidone for the treatment of nightmares in veterans with posttraumatic stress disorder.
    Journal of clinical psychopharmacology, 2010, Volume: 30, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Combat Disorders; Dreams; Female; Humans; Male

2010
Risperidone for post-traumatic combat nightmares: a report of four cases.
    The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 2011, Volume: 26, Issue:12

    Topics: Adult; Aged; Antipsychotic Agents; Combat Disorders; Dreams; Humans; Male; Middle Aged; Risperidone;

2011
Oral candidiasis secondary to adverse anticholinergic effects of psychotropic medications.
    Journal of child and adolescent psychopharmacology, 2007, Volume: 17, Issue:1

    Topics: Antipsychotic Agents; Benztropine; Candidiasis, Oral; Child; Drug Therapy, Combination; Dyskinesia,

2007
Risperidone and tardive dyskinesia.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1996, Volume: 35, Issue:11

    Topics: Adolescent; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Depressive Disorder

1996
Risperidone in PTSD.
    Psychiatric services (Washington, D.C.), 1998, Volume: 49, Issue:2

    Topics: Adult; Antipsychotic Agents; Humans; Male; Middle Aged; Risperidone; Stress Disorders, Post-Traumati

1998
Risperdal and parkinsonian tremor.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1999, Volume: 38, Issue:3

    Topics: Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorde

1999
Risperidone as an adjunct therapy for post-traumatic stress disorder.
    Military medicine, 1999, Volume: 164, Issue:8

    Topics: Adult; Antipsychotic Agents; Arousal; Delusions; Female; Hallucinations; Humans; Military Personnel;

1999
Risperidone in the treatment of acute stress disorder in physically traumatized in-patients.
    Depression and anxiety, 2000, Volume: 11, Issue:4

    Topics: Acute Disease; Adult; Aged; Antipsychotic Agents; Arm Injuries; Female; Foot Injuries; Humans; Male;

2000