Page last updated: 2024-11-04

risedronic acid and Alveolar Bone Atrophy

risedronic acid has been researched along with Alveolar Bone Atrophy in 6 studies

Risedronic Acid: A pyridine and diphosphonic acid derivative that acts as a CALCIUM CHANNEL BLOCKER and inhibits BONE RESORPTION.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to develop a chitosan-based risedronate/zinc-hydroxyapatite intrapocket dental film (CRZHDF) for applications in the treatment of alveolar bone loss in an animal model of periodontitis."7.88Effect of locally administered novel biodegradable chitosan based risedronate/zinc-hydroxyapatite intra-pocket dental film on alveolar bone density in rat model of periodontitis. ( Khajuria, DK; Razdan, R; Zahra, SF, 2018)
"The aim of this study was to develop a chitosan-based risedronate/zinc-hydroxyapatite intrapocket dental film (CRZHDF) for applications in the treatment of alveolar bone loss in an animal model of periodontitis."3.88Effect of locally administered novel biodegradable chitosan based risedronate/zinc-hydroxyapatite intra-pocket dental film on alveolar bone density in rat model of periodontitis. ( Khajuria, DK; Razdan, R; Zahra, SF, 2018)
"The present study was designed to evaluate the effects of risedronate, one of the most potent bisphosphonates, on alveolar bone resorption and angiogenesis in rats with experimental periodontitis to identify dose-response curves and treatment durations that can be therapeutic for periodontal therapy versus those associated with osteonecrosis of the jaws."1.35Effects of risedronate on alveolar bone loss and angiogenesis: a stereologic study in rats. ( Ayas, B; Cetinkaya, BO; Gurgor, P; Keles, GC, 2008)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (33.33)18.2507
2000's2 (33.33)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ozaki, Y1
Koide, M1
Furuya, Y1
Ninomiya, T1
Yasuda, H1
Nakamura, M1
Kobayashi, Y1
Takahashi, N1
Yoshinari, N1
Udagawa, N1
Khajuria, DK1
Zahra, SF1
Razdan, R1
Cetinkaya, BO1
Keles, GC1
Ayas, B1
Gurgor, P1
Lane, N1
Armitage, GC1
Loomer, P1
Hsieh, S1
Majumdar, S1
Wang, HY1
Jeffcoat, M1
Munoz, T1
Shoji, K1
Horiuchi, H1
Shinoda, H2
Adachi, H1
Igarashi, K1
Mitani, H1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Investigation of the Effects of Bisphosphonate on the Gingival Crevicular Fluid Levels of Sclerostin and the DKK-1 in Individuals With Postmenopausal Osteoporosis With Periodontal Changes[NCT04149405]Phase 443 participants (Actual)Interventional2016-06-30Completed
Effect of Periodontal Therapy and Bisphosphonates on Gingival Crevicular Fluid Levels of Nuclear Factor- κb Ligand (RANKL) and Osteoprotegerin in Postmenopausal Osteoporosis: Results of a 12-Month Study[NCT02808988]Phase 447 participants (Actual)Interventional2013-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Dkk-1 Values for 12th Month

levels of dickkopf-related protein-1 in 12th month (NCT04149405)
Timeframe: 12 months

Interventionng/ml (Mean)
Group A3440.67
Group B3203.802
Group C2490.553
Group D4269.39

Dkk-1 Values for 6th Month

levels of dickkopf-related protein-1 in 6th month (NCT04149405)
Timeframe: 6 months

Interventionng/ml (Mean)
Group A3358.265
Group B1963.185
Group C3263.665
Group D4269.39

Sost Values for 12th Month

levels of sclerostin in 12th month (NCT04149405)
Timeframe: 12 month

Interventionng/ml (Mean)
Group A1702.265
Group B1347.330
Group C1114.988
Group D2131.87

Sost Values for 6th Month

levels of sclerostin in 6th month (NCT04149405)
Timeframe: 6 months

Interventionng/ml (Mean)
Group A1389.177
Group B1085.405
Group C1596.585
Group D2131.87

Trials

1 trial available for risedronic acid and Alveolar Bone Atrophy

ArticleYear
Bisphosphonate therapy improves the outcome of conventional periodontal treatment: results of a 12-month, randomized, placebo-controlled study.
    Journal of periodontology, 2005, Volume: 76, Issue:7

    Topics: Alendronate; Alveolar Bone Loss; Analysis of Variance; Chemotherapy, Adjuvant; Dental Scaling; Dipho

2005
Bisphosphonate therapy improves the outcome of conventional periodontal treatment: results of a 12-month, randomized, placebo-controlled study.
    Journal of periodontology, 2005, Volume: 76, Issue:7

    Topics: Alendronate; Alveolar Bone Loss; Analysis of Variance; Chemotherapy, Adjuvant; Dental Scaling; Dipho

2005
Bisphosphonate therapy improves the outcome of conventional periodontal treatment: results of a 12-month, randomized, placebo-controlled study.
    Journal of periodontology, 2005, Volume: 76, Issue:7

    Topics: Alendronate; Alveolar Bone Loss; Analysis of Variance; Chemotherapy, Adjuvant; Dental Scaling; Dipho

2005
Bisphosphonate therapy improves the outcome of conventional periodontal treatment: results of a 12-month, randomized, placebo-controlled study.
    Journal of periodontology, 2005, Volume: 76, Issue:7

    Topics: Alendronate; Alveolar Bone Loss; Analysis of Variance; Chemotherapy, Adjuvant; Dental Scaling; Dipho

2005

Other Studies

5 other studies available for risedronic acid and Alveolar Bone Atrophy

ArticleYear
Treatment of OPG-deficient mice with WP9QY, a RANKL-binding peptide, recovers alveolar bone loss by suppressing osteoclastogenesis and enhancing osteoblastogenesis.
    PloS one, 2017, Volume: 12, Issue:9

    Topics: Adaptor Proteins, Signal Transducing; Alveolar Bone Loss; Animals; Bone Density Conservation Agents;

2017
Effect of locally administered novel biodegradable chitosan based risedronate/zinc-hydroxyapatite intra-pocket dental film on alveolar bone density in rat model of periodontitis.
    Journal of biomaterials science. Polymer edition, 2018, Volume: 29, Issue:1

    Topics: Alveolar Bone Loss; Animals; Bone Density; Bone Density Conservation Agents; Chitosan; Drug Carriers

2018
Effects of risedronate on alveolar bone loss and angiogenesis: a stereologic study in rats.
    Journal of periodontology, 2008, Volume: 79, Issue:10

    Topics: Alveolar Bone Loss; Alveolar Process; Animals; Blood Vessels; Bone Density; Bone Density Conservatio

2008
Inhibitory effects of a bisphosphonate (risedronate) on experimental periodontitis in rats.
    Journal of periodontal research, 1995, Volume: 30, Issue:4

    Topics: Alveolar Bone Loss; Analysis of Variance; Animals; Bone Density; Calcium Channel Blockers; Cell Coun

1995
Effects of topical administration of a bisphosphonate (risedronate) on orthodontic tooth movements in rats.
    Journal of dental research, 1994, Volume: 73, Issue:8

    Topics: Administration, Topical; Alveolar Bone Loss; Alveolar Process; Analysis of Variance; Animals; Bone D

1994