rimiterol and Urethral-Stricture

Currently, animal models of urethral stricture are not standardized. Transforming Growth Factor Beta 1 (TGF-β1) regulates extracellular matrix deposition in homeostatic and pathological responses.. The aim of this study was to present the potential model to be developed as a urethral stricture.. True experimental laboratory research was conducted by using Male New Zealand rabbits (. An increase in the dose of TGF-β1 decreased the mean rabbit's urethral lumen diameter (29.3% in the 2µg group and 34% in the 4µg group) compared to controls. Three rabbits decreased as much as ≤ 50% in urethral lumen diameter. Significant increases in total collagen density in the periluminal and peripheral urethral spongiosum were noted by increasing doses of TGF-β1. The percentage of urethral lumen diameter has a strong negative correlation with periluminal total collagen density (r = -0,798; p = 0,000) and very strong negative correlation with peripheral spongiosa total collagen density (r = -0,748, p = 0,000).. TGF-β1 plays a role in changing total collagen compositions of the rabbit's urethral wall, decreasing the urethral lumen diameter. Further research with increasing doses of TGF-β1 is needed to determine the effective dose of TGF-β1 in inducing urethral stricture.

Topics: Animals; Collagen; Male; Models, Animal; Rabbits; Transforming Growth Factor beta1; Urethra; Urethral Stricture