rimexolone has been researched along with Arthritis* in 2 studies
2 other study(ies) available for rimexolone and Arthritis
| Article | Year |
|---|---|
The persistence and effects of rimexolone in arthritic and normal rabbit knee joints.
The persistence and effects of 3H-labelled and intra-articularly administered 11 beta-hydroxy-16 alpha,17 alpha,21-trimethylpregna-1,4-diene-3,20-dione (rimexolone, [3H]-Org 6216 have been investigated in a model of fibrin-induced mono-articular arthritis in the rabbit. It appears that joint swelling is suppressed in a dose-dependent way when the drug is administered into the arthritic joint. With a dose of 15 mg the joint circumference was restored to the initial value recorded prior to antigen challenge within 14 days. Administration of rimexolone into the non-arthritic joint also suppressed contralateral arthritic joint swelling, but this effect was less pronounced and shorter lasting. Radioactivity from [3H]-rimexolone at doses of 5 or 15 mg disappears slowly from both non-arthritic and arthritic knee joints. Topics: Animals; Arthritis; Arthritis, Experimental; Body Weight; Glucocorticoids; Kinetics; Knee Joint; Male; Pregnadienes; Rabbits | 1980 |
The local anti-inflammatory activity of rimexolone (Org 6216) in fibrin-induced monoarticular arthritis and adjuvant-induced arthritis.
The effects of a number of steroids administered intra-articularly in a chronic model of fibrin-induced monoarticular arthritis in the rabbit have been investigated. Org 6216 hydrocortisone acetate, prednisolone tertiary butyl acetate and triamcinolone hexacetonide each suppressed the joint swelling produced 14 days after antigen challenge. These anti-inflammatory effects lasted for at least 7 days. Hydrocortisone semisuccinate was inactive in this model. In addition, the effects of the same compounds and several other anti-inflammatory steroids and indomethacin administered locally with adjuvant was assessed on the resultant paw oedema produced in the rat. The local anti-inflammatory activity, the duration of action and the systemic effects of these drugs varied considerably and only Org 6216, hydrocortisone acetate, prednisolone tertiary butyl acetate and indomethacin produced anti-inflammatory effects throughout the 4 days of the experiments and were devoid of significant adrenolytic and thymolytic activity. Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrin; Hydrocortisone; Indomethacin; Knee Joint; Male; Organ Size; Prednisolone; Pregnadienes; Rabbits; Rats; Time Factors; Triamcinolone | 1980 |