rimantadine and Grippe studies

Rimantadine: An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.

Research Excerpts

Excerpt	Relevance	Reference
" Trifluridine, idoxuridine, and vidarabine are effective topically in herpes simplex virus keratoconjunctivitis infection."	6.15	Antiviral drugs 1983. ( Douglas, RG, 1983)
" However, intranasal zanamivir and oral oseltamivir significantly reduced MEP abnormalities during experimental influenza in adults, and oseltamivir treatment appears to reduce the likelihood of otitis media in children with acute influenza."	4.80	Influenza virus and rhinovirus-related otitis media: potential for antiviral intervention. ( Hayden, FG, 2000)
"To review the maternal and neonatal outcomes after antepartum exposure to M2 ion channel inhibitors or oseltamivir to provide some guidance on the risk, if any, of antiviral medication during pregnancy."	3.76	Maternal and neonatal outcomes after antepartum treatment of influenza with antiviral medications. ( Greer, LG; McIntire, DD; Roberts, SW; Rogers, VL; Sheffield, JS; Wendel, GD, 2010)
" This allowed a total dosage not much less than might have been given by other routes, but with the advantage that it was evenly deposited over the surface of the infected respiratory tract beginning within seconds of the start of treatment and reached higher concentration in nasal secretions than in serum."	3.76	Chemotherapy of respiratory viruses. ( Gilbert, BE; Knight, V, 1986)
"(table: see text) For influenza A virus infections, both oral amantadine and rimantadine are effective when used for seasonal prophylaxis and for prophylaxis in institutional populations."	3.75	Clinical applications of antiviral agents for chemophrophylaxis and therapy of respiratory viral infections. ( Hayden, FG, 1985)
"The importance and significance of amantadine- or rimantadine-resistant influenza viruses in immunocompromised patients was studied in a population of adult bone marrow transplant (BMT) recipients and patients with leukemia prospectively cultured for respiratory viruses."	3.70	Common emergence of amantadine- and rimantadine-resistant influenza A viruses in symptomatic immunocompromised adults. ( Atmar, RL; Champlin, RE; Cox, NJ; Englund, JA; Kantarjian, H; Klimov, AI; Regnery, H; Tarrand, J; Whimbey, E; Wyde, PR; Yousuf, H, 1998)
" Currently, acyclovir is the most effective agent for the treatment of herpes simplex and varicella-zoster virus infections."	3.67	Antiviral agents. ( Cockerill, FR; Hermans, PE, 1987)
"Influenza is an important cause of hospitalization due to lower respiratory tract involvement for which there is no specific antiviral treatment with proven efficacy."	2.71	Safety and efficacy of nebulized zanamivir in hospitalized patients with serious influenza. ( Elliott, M; Gnann, JW; Hayden, FG; Ison, MG; Nagy-Agren, S; Paya, C; Steigbigel, R; Treannor, J; Weiss, HL, 2003)
"Despite vaccination, influenza remains a common of morbidity in nursing homes."	2.69	Efficacy of zanamivir for chemoprophylaxis of nursing home influenza outbreaks. ( Ambrozaitis, A; Drinka, P; Gravenstein, M; Gravenstein, S; Jones, HH; Krause, P; Povinelli, L; Powers, D; Schilling, M; Shult, P, 1998)
" When data for the 100- and 200-mg/day dosage groups were combined and compared with data for the group receiving placebo, the efficacy of rimantadine in reducing the risk of clinical influenza-like illness was estimated to be 58 percent (P = 0."	2.68	Safety and efficacy of long-term use of rimantadine for prophylaxis of type A influenza in nursing homes. ( Hornbuckle, K; Monto, AS; Ohmit, SE; Pearce, CL, 1995)
" Subjects were monitored for adverse effects and evidence of influenza virus infection weekly for six weeks."	2.67	Safety and prophylactic efficacy of low-dose rimantadine in adults during an influenza A epidemic. ( Brady, MT; Clements, ML; DePamphilis, J; Oakes, M; Pacini, DL; Samorodin, R; Sears, SD; Soo, W, 1990)
"Overall, at least one contact developed influenza in 8 of the 56 RH group households and 19 of the 55 placebo group households (p = 0."	2.67	[Prevention of influenza A. Effectiveness and tolerance of rimantadine hydrochloride]. ( Boissel, JP; Bricaire, F; Hannoun, C, 1990)
"When influenza A occurred in a family, the members (including the index patient) were given either rimantadine (adult oral dose, 200 mg per day) or placebo for 10 days."	2.66	Emergence and apparent transmission of rimantadine-resistant influenza A virus in families. ( Belshe, RB; Clover, RD; Hay, AJ; Hayden, FG; Oakes, MG; Soo, W, 1989)
"Rimantadine was well tolerated by the children, with no significant difference in reported side effects between the placebo and rimantadine groups."	2.66	Effectiveness of rimantadine prophylaxis of children within families. ( Abell, TD; Clover, RD; Couch, RB; Crawford, SA; Glezen, WP; Ramsey, CN, 1986)
"Treatment with rimantadine of influenza in children and the potential development of resistance in clinical isolates associated with therapy have not been previously studied."	2.66	Children with influenza A infection: treatment with rimantadine. ( Disney, FA; Dolin, R; Francis, AB; Gala, CL; Green, JL; Hall, CB; Madore, PH; Markovitz, DM; Talpey, WB; Zhang, YQ, 1987)
"Rimantadine was well-tolerated by the children, with no significant difference in reported adverse effects between the placebo and rimantadine groups."	2.66	Rimantadine prophylaxis in children: a follow-up study. ( Abell, TD; Clover, RD; Couch, RB; Crawford, SA; Glezen, P; Ramsey, CN, 1988)
"The emergence of influenza A viruses which had acquired resistance to rimantadine during a clinical trial (C."	2.66	Genetic basis of resistance to rimantadine emerging during treatment of influenza virus infection. ( Belshe, RB; Betts, R; Hall, CB; Hay, AJ; Smith, MH, 1988)
" These questions concern appropriate routes of administration for antiviral compounds, optimal dosage regimens, risks of long-term prophylaxis, and the emergence of resistant organisms."	2.66	Antiviral chemotherapy and chemoprophylaxis. ( Dolin, R, 1985)
"Rimantadine was compared with acetaminophen in a double-blind randomly assigned therapeutic trial in 63 children presenting with influenzal symptoms."	2.66	A comparison of acetaminophen and rimantadine in the treatment of influenza A infection in children. ( Fleet, W; Lawrence, E; Morris, L; Pierce, E; Thompson, J; Wright, P, 1987)
"Hence, during an influenza outbreak, five days of empirical therapy with amantadine or rimantadine for persons with an influenza-like syndrome should ameliorate clinical symptoms and might decrease spread of virus."	2.65	Successful treatment of naturally occurring influenza A/USSR/77 H1N1. ( Betts, RF; Christmas, WA; Douglas, RG; Hayden, FG; Van Voris, LP, 1981)
"placebo)."	2.65	A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infection. ( Dolin, R; Linton, PN; Madore, HP; Maynard, R; Reichman, RC; Webber-Jones, J, 1982)
"In experimental influenza A virus infection, characterized by mild clinical illness and short duration of virus shedding, low doses of aerosolized rimantadine had a therapeutic effect comparable to that found with larger doses of oral rimantadine."	2.65	Comparative therapeutic effect of aerosolized and oral rimantadine HCl in experimental human influenza A virus infection. ( Hayden, FG; Iljenko, VI; Padolka, YV; Zylidnikov, DM, 1982)
"The assumed risk of influenza A in the control group was 10 per 100."	2.50	Amantadine and rimantadine for influenza A in children and the elderly. ( Alves da Cunha, AJ; Alves Galvão, MG; Rocha Crispino Santos, MA, 2014)
"The assumed risk of influenza in the control group was 10 per 100 and the corresponding risk in the RMT group was one per 100 (95% CI 0 to 3)."	2.48	Amantadine and rimantadine for influenza A in children and the elderly. ( Alves da Cunha, AJ; Alves Galvão, MG; Rocha Crispino Santos, MA, 2012)
"At present, four anti-influenza agents have been approved by the FDA for the treatment of influenza, including two M2 protein ion channel inhibitors-amantadine and rimantadine and two neuraminidase inhibitors-zanamivir and oseltamivir."	2.46	[Research progress of anti-influenza virus agents]. ( Li, JF; Shen, JS; Xiong, RS; Zhang, Q; Zhao, QJ, 2010)
"During the autumn-winter months (influenza seasons), influenza circulates more frequently, causing a greater proportion of influenza-like illness, and sometimes serious seasonal epidemics."	2.45	Influenza. ( Jefferson, T, 2009)
"Influenza vaccine is the mainstay of influenza prevention strategies."	2.44	Influenza guideline for South Africa--update 2008. ( Cameron, NA; Eggers, RR; Feldman, C; Green, RJ; Klugman, K; Lalloo, U; Madhi, SA; Phillips, D; Richards, GA; Schoub, B; Zar, HJ, 2008)
"Influenza is a highly contagious and debilitating disease that imposes an excess burden of complications and mortality."	2.44	Antivirals for the treatment and prevention of epidemic and pandemic influenza. ( Oxford, JS, 2007)
"In the United States, seasonal influenza epidemics account for > 200,000 hospitalizations and > 30,000 deaths annually."	2.44	Influenza: evolving strategies in treatment and prevention. ( Lynch, JP; Walsh, EE, 2007)
" Because no prospective data exist on the efficacy of these agents in humans for H5N1 strains, the dosage and duration of therapy in adults and children may differ from those documented to be effective for epidemic influenza strains."	2.44	Antiviral therapy and prophylaxis for influenza in children. ( , 2007)
"Typically, influenza B is associated with relatively mild, local outbreaks, whereas influenza A is the cause of world-wide pandemics."	2.44	Occasional review: influenza in COPD: pathogenesis, prevention, and treatment. ( Wesseling, G, 2007)
"Zanamivir prevented influenza A more effectively than RMT in the elderly."	2.44	Amantadine and rimantadine for influenza A in children and the elderly. ( Alves da Cunha, AJ; Alves Galvão, MG; Rocha Crispino Santos, MA, 2008)
"confirmed influenza A, and adverse effects were analysed."	2.42	Amantadine and rimantadine for preventing and treating influenza A in adults. ( Deeks, JJ; Demicheli, V; Jefferson, T; Rivetti, D; Rudin, M, 2004)
"A small armentarium of anti-influenza drugs now exists, and includes the M2 blockers (amantadine and rimantadine) and the neuraminidase inhibitors (Relenza and Tamiflu)."	2.42	Treatment of epidemic and pandemic influenza with neuraminidase and M2 proton channel inhibitors. ( Balasingam, S; Bossuyt, S; Lambkin, R; Mann, A; Novelli, P; Oxford, JS, 2003)
"Although the influenza vaccine can help prevent pneumonia and hospitalization, it is limited by less than ideal immunization rates and the possibility of viral antigenic shifts that render the vaccine ineffective."	2.41	Neuraminidase inhibitors in patients with underlying airways disease. ( Pegram, PS; Williamson, JC, 2002)
"Symptoms of influenza include fever, chills, headache, myalgia and respiratory symptoms."	2.41	Antivirals for influenza: what is their role in the older patient? ( Dumyati, G; Falsey, AR, 2002)
"Currently, annual influenza immunization is recommended for all children 6 months and older with high-risk conditions."	2.41	Reduction of the influenza burden in children. ( , 2002)
"Amantadine prevented 23% of clinical influenza cases (95% confidence interval 11% to 34%), and 63% of serologically confirmed clinical influenza A cases (95% confidence interval 42% to 76%)."	2.41	Amantadine and rimantadine for preventing and treating influenza A in adults. ( Deeks, JJ; Demicheli, V; Jefferson, TO; Rivetti, D, 2002)
"Every year, influenza viruses cause global epidemics that result in significant morbidity and mortality."	2.41	Antiviral therapy for influenza virus infections. ( Prober, CG, 2002)
"This is so even when the incidence of influenza is high and adverse effect quality of life preferences are rated low."	2.41	Prevention and early treatment of influenza in healthy adults. ( Deeks, J; Demicheli, V; Jefferson, T; Rivetti, D, 2000)
"The prevention of influenza virus infections by the use of vaccines remains the most cost-effective and practical method of influenza virus control, but the use of antiviral prophylaxis and treatment in certain populations or high-risk individuals is also possible."	2.41	Antiviral therapy of influenza. ( Englund, JA, 2002)
"Annual influenza immunization should be offered to elderly patients, subjects with chronic disease, and those in long-term residential or nursing home care."	2.41	Nosocomial transmission of influenza. ( Carman, WF; Kerr, G; Stott, DJ, 2002)
"Amantadine prevented 23% of clinical influenza cases (95% confidence interval 11% to 34%), and 63% of serologically confirmed clinical influenza A cases (95% confidence interval 42% to 76%) Amantadine reduced duration of fever by one day (95% confidence interval 0."	2.41	Amantadine and rimantadine for preventing and treating influenza A in adults. ( Deeks, JJ; Demicheli, V; Jefferson, TO; Rivetti, D, 2000)
"Amantadine prevented 23% of clinical influenza cases (95% confidence interval 11% to 34%), and 63% of serologically confirmed clinical influenza A cases (95% confidence interval 42% to 76%)."	2.41	Amantadine and rimantadine for preventing and treating influenza A in adults. ( Deeks, JJ; Demicheli, V; Jefferson, TO; Rivetti, D, 2001)
"Annual influenza immunisation of high-risk persons and their contacts, including healthcare workers, is the primary means of preventing nosocomial influenza."	2.41	Influenza in the acute hospital setting. ( Farr, BM; Hall, KK; Hayden, FG; Salgado, CD, 2002)
" It is obvious that most important problem in clinical use of anti-FluV drugs should be its side effects, bioavailability and stability in human bodies."	2.40	[Current status of research and development for anti-influenza virus drugs--chemotherapy for influenza]. ( Shigeta, S, 1997)
"Zanamivir, a new agent for treating influenza, offers promise but needs further study and approval by the Food and Drug Administration before it can be recommended for routine use."	2.40	Underused options for preventing and treating influenza. ( Mossad, SB, 1999)
"The effectiveness of influenza vaccine in preventing or attenuating illness varies, depending primarily on (1) the degree of similarity between the virus strains included in the vaccine and those that circulate during the influenza season, and (2) the age and immunocompetence of the vaccine recipient."	2.40	Influenza, influenza vaccine, and amantadine/rimantadine. ( Ahwesh, ER; Ruben, FL; Zimmerman, RK, 1997)
"Live attenuated cold-adapted influenza vaccines are nearing availability."	2.40	Measures for control of influenza. ( Couch, RB, 1999)
" Adverse effects are more prominent in the elderly but can be minimized by dosage reductions."	2.39	Use of antivirals in influenza in the elderly: prophylaxis and therapy. ( Nicholson, KG, 1996)
"However, comparing rhinovirus and influenza, there is no doubt that influenza viruses produce more severe symptoms."	2.39	Viral respiratory infections in the community: epidemiology, agents, and interventions. ( Monto, AS, 1995)
"Risk of influenza mortality is high among older Americans and especially so among those residing in nursing homes."	2.39	Using antiviral agents to control outbreaks of influenza A infection. ( Monto, AS, 1994)
" Careful attention to published dosage adjustment guidelines for these compounds, avoidance of interacting drugs and avoiding these agents in patients with a history of seizures may be the best means to reduce the risk of toxicity in elderly patients."	2.39	Amantadine and rimantadine prophylaxis of influenza A in nursing homes. A tolerability perspective. ( Guay, DR, 1994)
"To provide a review of rimantadine, including its antiviral activity, pharmacokinetics, efficacy, adverse effects, drug interactions, and dosage and administration."	2.39	Rimantadine: a clinical perspective. ( Nahata, MC; Wintermeyer, SM, 1995)
"Amantadine has been available for many years for prophylaxis and therapy, but there have been concerns about side effects, particularly in the elderly."	2.38	Implications of viral resistance to amantadine in control of influenza A. ( Arden, NH; Monto, AS, 1992)
"Influenza is a leading cause of morbidity and mortality in the United States, particularly among persons with cardiac and/or pulmonary disease and those over age 65."	2.38	Amantadine and rimantadine for the prevention of influenza A. ( Betts, RF, 1989)
"Pandemic influenza A virus (IAV) remains a significant threat to global health."	1.56	Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza. ( Atkins, E; Bao, P; Barclay, WS; Bentham, M; Claridge, JK; Cook, GP; Elderfield, R; Evans, S; Foster, R; Foster, TL; Goldhill, DH; Griffin, S; Kankanala, J; Loundras, E; McKimmie, CS; Pingen, M; Schnell, JR; Scott, C; Simmons, K; Stilwell, PR; Targett-Adams, P; Tathineni, R; Thompson, J, 2020)
"The International Society for Influenza and other Respiratory Virus Diseases (isirv) held its 4th Antiviral Group Conference at the University of Texas on 2-4 June, 2015."	1.43	Meeting report: 4th ISIRV antiviral group conference: Novel antiviral therapies for influenza and other respiratory viruses. ( Fry, AM; McKimm-Breschkin, JL, 2016)
"By attaching multiple copies of the influenza M2 ion channel inhibitors amantadine (1) and rimantadine (2) to polymeric chains, we endeavored to recover their potency in inhibiting drug-resistant influenza viruses."	1.39	Conjugation to polymeric chains of influenza drugs targeting M2 ion channels partially restores inhibition of drug-resistant mutants. ( Chen, J; Klibanov, AM; Larson, AM, 2013)
"Pregnancy was a negative predictor of antiviral treatment before the pandemic (adjusted odds ratio [aOR], 0."	1.37	Description of antiviral treatment among adults hospitalized with influenza before and during the 2009 pandemic: United States, 2005-2009. ( Arnold, K; Baumbach, J; Bennett, NM; Doshi, S; Finelli, L; Fry, AM; Gershman, K; Hancock, EB; Kamimoto, L; Lynfield, R; Morin, C; Perez, A; Reingold, A; Ryan, P; Schaffner, W; Thomas, A; Yousey-Hindes, K; Zansky, S, 2011)
" The pharmacokinetic parameters of allindicated active components exhibited no detectable distinctions, except for the time to attaining maximum concentration ofparacetamol and the value of the maximum concentration of loratadine."	1.37	[Comparative pharmacokinetics of antigrippin-maximum administered in capsules and powder for preparing solutions]. ( Belolipetskaia, VG; Belolipetskiĭ, NA; Blagodatskikh, SV; Guranda, DF; Kibalchich, DA; Rudenko, LI; Zhabina, EA, 2011)
"In recent years in addition to seasonal influenza an outbreak of avian influenza occurred in 2005 and the new H1N1 pandemic occurred in 2009."	1.37	[Influenza : clinical symptoms, diagnostics and therapy]. ( Rohde, GG, 2011)
" To assess potential neurologic adverse effects of oseltamivir use in infants, a retrospective chart review was performed in infants less than 12 months of age who received oseltamivir, amantadine, or rimantadine."	1.36	Safety of oseltamivir compared with the adamantanes in children less than 12 months of age. ( Abughali, N; Abzug, MJ; Bradley, JS; Cloud, GA; Englund, J; Griffin, J; Guzman-Cottrill, J; Jacobs, RF; Jester, P; Kimberlin, DW; Lang, D; Leach, C; Ramilo, O; Robinson, J; Romero, JR; Shalabi, M; Shelton, M; Storch, G; Wade, KC; Whitley, RJ, 2010)
"Only 11% of respondents could test for influenza A subtype."	1.36	Influenza antiviral prescribing practices during the 2007-08 and 2008-09 influenza seasons in the setting of increased resistance to oseltamivir among circulating influenza viruses. ( Beekmann, SE; Dharan, NJ; Finelli, L; Fiore, A; Fry, AM; Polgreen, PM; Uyeki, TM, 2010)
" The use of every of the compounds in combination with rimantadine resulted in a 2-16 times decrease of their EC50 and correction of the concentration-effect relation of rimantadine."	1.35	[New betulin derivatives in combination with rimantadine for inhibition of influenza virus reproduction]. ( Boreko, EI; Pavlova, NI; Savinova, OV, 2009)
"Along with influenza vaccines, the world is currently almost completely dependent on two licensed drugs for the treatment or prevention of seasonal (influenza A and B viruses) and pandemic influenza (influenza A viruses)."	1.35	Oseltamivir resistance and the H274Y neuraminidase mutation in seasonal, pandemic and highly pathogenic influenza viruses. ( Barr, IG; Holien, JK; Hurt, AC; Parker, MW, 2009)
"The 2009 pandemic influenza A (H1N1) virus emerged in the United States in April 2009 and has since spread worldwide."	1.35	Update: influenza activity - United States, August 30-October 31, 2009. ( , 2009)
"Resistance of influenza viruses to antiviral drugs can emerge following medication or may result from natural variation."	1.35	Detection of molecular markers of antiviral resistance in influenza A (H5N1) viruses using a pyrosequencing method. ( Balish, A; Bright, RA; Deyde, VM; Gubareva, LV; Klimov, AI; Lindstrom, S; Nguyen, T; Shu, B, 2009)
"The NAIs prevent both types of seasonal influenza, shorten duration of illness, and reduce complications."	1.35	Antivirals and influenza: frequency of resistance. ( Monto, AS, 2008)
"The results of molecular analysis of 15 influenza A(H3N2) and 17-A(H1N1) epidemic strains isolated in the Russian Federation in 1995-2007 are described."	1.35	[Molecular and genetic analysis of influenza A viruses isolated in Russia, based on the neuraminidase and M2 protein gene sequence]. ( Burtseva, EI; Grebennikova, TV; Rotanov, M; Shevchenko, ES, 2008)
"In this study we analysed recent human influenza A strains isolated in Australia and regionally for evidence of resistance to adamantanes and found evidence of significant resistant emerging during 2005."	1.34	Increased adamantane resistance in influenza A(H3) viruses in Australia and neighbouring countries in 2005. ( Barr, IG; Deed, N; Hurt, AC; Iannello, P; Komadina, N; Tomasov, C, 2007)
"Rimantadine treatment is no longer recommended."	1.34	Emergence of rimantadine-resistant virus within 6 days of starting rimantadine prophylaxis with oseltamivir treatment of symptomatic cases. ( Drinka, PJ; Haupt, T, 2007)
"In this study we analysed 101 human influenza A viruses isolated in 2006 that were referred to the WHO Collaborating Centre for Reference and Research in Melbourne, from Australia and the surrounding regions, for evidence of resistance to adamantanes."	1.34	The emergence of adamantane resistance in influenza A(H1) viruses in Australia and regionally in 2006. ( Barr, IG; Deed, N; Hurt, AC; Iannello, P; Komadina, N; Tomasov, C, 2007)
"Oseltamivir has been shown to decrease antibiotic use, the number of hospitalizations, and, probably, the risk of death after influenza."	1.33	Antiviral management of seasonal and pandemic influenza. ( Hayden, FG; Pavia, AT, 2006)
"During 2 influenza seasons, we placed all our participants on ramantidine prophylaxis within a 2-week period."	1.33	A 5-year experience with influenza prevention and containment in a program of all-inclusive care for elderly adults. ( Desbiens, NA, 2005)
"In the case of influenza disease there is no possible to make unquestionable diagnosis only on the basis of clinical picture."	1.33	[Significance of virological diagnostics for the effective treatment of hospitalized patients infected with influenza virus]. ( Brydak, LB; Gawryluk, D; Machała, M; Wiatr, E, 2006)
"To determine the cost-effectiveness of influenza testing and treatment strategies for older adults."	1.32	Management of influenza in adults older than 65 years of age: cost-effectiveness of rapid testing and antiviral therapy. ( Bellantonio, S; Rose, DN; Rothberg, MB, 2003)
"The 1918 influenza pandemic caused more than 20 million deaths worldwide."	1.31	Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus. ( Basler, CF; García-Sastre, A; Mikulasova, A; Palese, P; Swayne, DE; Taubenberger, JK; Tumpey, TM, 2002)
"Strategies for control of influenza must combine preventive approaches, such as vaccination, educational approaches, and the introduction of policies that allow health care professionals anticipate, identify, and efficiently respond to influenza outbreaks."	1.31	Current strategies for management of influenza in the elderly population. ( Davidson, HE; Gravenstein, S, 2002)
"However, the optimal influenza prevention and treatment strategy is unknown."	1.31	Economic analysis of influenza vaccination and antiviral treatment for healthy working adults. ( Clements, DA; Hamilton, JD; Huber, J; Lee, PY; Matchar, DB; Peterson, ED, 2002)
"Traditional methods used to monitor influenza infection typically require 2-5 days to perform, prompting a need for more rapid and quantitative methods for monitoring viral infection in 96-well formats."	1.31	Development of a novel influenza A antiviral assay. ( Leong, MA; Simmen, KA; Wagaman, PC, 2002)
"Amantadine use was associated with a significantly higher incidence of central nervous system adverse events than rimantadine use in this elderly population receiving influenza prophylaxis."	1.31	Comparison of central nervous system adverse effects of amantadine and rimantadine used as sequential prophylaxis of influenza A in elderly nursing home patients. ( Bertino, JS; Karl, M; Keyser, LA; Nafziger, AN, 2000)
"We report an outbreak of influenza A from a four-building veterans' facility in King, Wisconsin."	1.31	Reintroduction of influenza A to a nursing building. ( Dissing, M; Drinka, PJ; Gravenstein, S; Krause, P; Nest, L; Shult, P, 2000)
"In 1997, an H5N1 avian influenza A/Hong Kong/156/97 virus transmitted directly to humans and killed six of the 18 people infected."	1.31	The neuraminidase inhibitor GS4104 (oseltamivir phosphate) is efficacious against A/Hong Kong/156/97 (H5N1) and A/Hong Kong/1074/99 (H9N2) influenza viruses. ( Goloubeva, OG; Govorkova, EA; Leneva, IA; Roberts, N; Webster, RG, 2000)
"Large outbreaks of influenza A and B may occur in nursing homes despite high resident vaccination rates, even when the vaccine strain is matched to the circulating strain."	1.30	Outbreaks of influenza A and B in a highly immunized nursing home population. ( Drinka, PJ; Gravenstein, S; Krause, P; Miller, BA; Schilling, M; Shult, P, 1997)
"This report and other information on influenza can be accessed at the website for the Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, CDC at	1.30	Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP). ( , 1999)
"The spread of drug-resistant influenza viruses type A to close contacts in families, schools, and nursing homes has been well documented."	1.30	Low incidence of rimantadine resistance in field isolates of influenza A viruses. ( Cox, NJ; Hampson, AW; Hemphill, ML; Klimov, AI; Perez-Oronoz, G; Regnery, HL; Ziegler, ML; Ziegler, T, 1999)
"In the event of influenza pandemic, clinicians have to be sure that vaccination has been correctly performed in all patients in whom it is usually recommended."	1.29	Therapeutic approaches of clinicians to influenza pandemic. ( Cordier, JF; Philit, F, 1994)
"Amantadine was used for case treatment and prophylaxis in all three nursing homes."	1.29	Amantadine-resistant influenza A in nursing homes. Identification of a resistant virus prior to drug use. ( Cox, N; Hemphill, M; Hirsh, D; Houck, P; LaCroix, S, 1995)
"Clinical isolates of influenza A viruses identified during outbreaks in two winters were tested for their rimantadine susceptibilities by an enzyme-linked immunosorbent assay modified from that described previously by Belshe et al."	1.29	Susceptibilities to rimantadine of influenza A/H1N1 and A/H3N2 viruses isolated during the epidemics of 1988 to 1989 and 1989 to 1990. ( Allard, JP; Aymard, M; Millet, V; Valette, M, 1993)
"This combination warrants testing in human influenza."	1.29	Combination antiviral therapy for respiratory virus infections. ( Hayden, FG, 1996)
"All clinical isolates of influenza A viruses from patients in Huntington, West Virginia, during the decade 1978-1988 were tested, and 65 of 65 H1N1 and 176 of 181 H3N2 viruses were susceptible to the antiviral action of amantadine and rimantadine."	1.28	Resistance of influenza A virus to amantadine and rimantadine: results of one decade of surveillance. ( Belshe, RB; Burk, B; Cerruti, RL; Newman, F; Sim, IS, 1989)
"Amantadine has been used in Norway to treat Parkinson's disease since 1972."	1.28	[Amantadine and rimantadine against influenza A]. ( Bruu, AL; Orstavik, I, 1992)
"The complex system of influenza control was introduced into practice at the public health institutions of Severodvinsk in 1976-1980."	1.27	[Organization and evaluation of the effectiveness of emergency prophylaxis and early treatment of influenza with remantadine in Serevodvinsk]. ( Araslanova, II; Gagarinova, VM; Kubar', OI; Kustikova, IuG; Shadrin, AS, 1983)
" A dosage of 200 mg of either drug for a 3-5-day period is effective but treatment has to commence on the first day of symptoms."	1.27	Current status of amantadine and rimantadine as anti-influenza-A agents: memorandum from a WHO meeting. ( , 1985)
"Current influenza vaccines are about 80 percent protective, but grossly underused."	1.27	Community-acquired lower respiratory tract infections. Prevention and cost-control strategies. ( La Force, FM, 1985)
"Contemporary strains of influenza A viruses (subtypes H1N1, H3N2, HSW1N1) required amantadine hydrochloride and rimantadine hydrochloride 50% inhibitory concentrations in the range of 0."	1.26	Plaque inhibition assay for drug susceptibility testing of influenza viruses. ( Cote, KM; Douglas, RG; Hayden, FG, 1980)

Timeframe	Studies, this research(%)	All Research%
pre-1990	53 (23.45)	18.7374
1990's	66 (29.20)	18.2507
2000's	83 (36.73)	29.6817
2010's	21 (9.29)	24.3611
2020's	3 (1.33)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Amantadine for COVID-19: A Randomized, Placebo Controlled, Double-blinded, Clinical Trial[NCT04894617]	Phase 3	226 participants (Anticipated)	Interventional	2021-06-01	Recruiting
Oseltamivir Treatment in Children Under One Year of Age With Moderate or Severe Influenza Lower Respiratory Tract Infection - a Clinical and Pharmacokinetic Study[NCT01037634]	Phase 2	0 participants (Actual)	Interventional	2010-03-31	Withdrawn
Application of LiveSpo Navax in Treatment of Acute Respiratory Disease in Children Infected With Influenza Virus[NCT05378022]		70 participants (Actual)	Interventional	2020-12-21	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Antivirals--current trends in fighting influenza. Acta biochimica Polonica, 2014, Volume: 61, Issue:3 Topics: Amantadine; Antiviral Agents; Disease Outbreaks; Drug Therapy, Combination; Enzyme Inhibitors; Human	2014
Amantadine and rimantadine for influenza A in children and the elderly. The Cochrane database of systematic reviews, 2014, Nov-21, Issue:11 Topics: Adolescent; Aged; Amantadine; Antiviral Agents; Child; Humans; Influenza A virus; Influenza A Virus,	2014
[Antiviral treatment of influenza in humans]. Therapeutische Umschau. Revue therapeutique, 2007, Volume: 64, Issue:11 Topics: Amantadine; Animals; Antiviral Agents; Clinical Trials as Topic; Disease Outbreaks; Drug Resistance,	2007
Influenza guideline for South Africa--update 2008. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2008, Volume: 98, Issue:3 Pt 2 Topics: Adolescent; Adult; Amantadine; Antiviral Agents; Child; Child, Preschool; Contraindications; Humans;	2008
Influenza. BMJ clinical evidence, 2009, Mar-12, Volume: 2009 Topics: Acute Disease; Administration, Inhalation; Humans; Incidence; Influenza Vaccines; Influenza, Human;	2009
Antivirals for the treatment and prevention of epidemic and pandemic influenza. Influenza and other respiratory viruses, 2007, Volume: 1, Issue:1 Topics: Amantadine; Antiviral Agents; Chemoprevention; Disease Outbreaks; Drug Resistance, Viral; Humans; In	2007
Resistance characteristics of influenza to amino-adamantyls. Biochimica et biophysica acta, 2011, Volume: 1808, Issue:2 Topics: Adamantane; Amantadine; Amino Acid Sequence; Drug Resistance, Viral; Genes, Viral; Hemagglutinin Gly	2011
[Research progress of anti-influenza virus agents]. Yao xue xue bao = Acta pharmaceutica Sinica, 2010, Volume: 45, Issue:3 Topics: Acids, Carbocyclic; Amantadine; Antiviral Agents; Cyclopentanes; Guanidines; Humans; Indoles; Influe	2010
Antiviral drugs for influenza. The Medical letter on drugs and therapeutics, 2012, Jan-09, Volume: 54, Issue:1381 Topics: Adult; Amantadine; Antiviral Agents; Child; Female; Humans; Influenza Vaccines; Influenza, Human; Ne	2012
Amantadine and rimantadine for influenza A in children and the elderly. The Cochrane database of systematic reviews, 2012, Jan-18, Volume: 1 Topics: Adolescent; Aged; Amantadine; Antiviral Agents; Child; Humans; Influenza A virus; Influenza A Virus,	2012
Antivirals for treatment of influenza: a systematic review and meta-analysis of observational studies. Annals of internal medicine, 2012, Apr-03, Volume: 156, Issue:7 Topics: Administration, Inhalation; Administration, Oral; Amantadine; Antiviral Agents; Confounding Factors,	2012
Antiviral therapy for influenza virus infections. Seminars in pediatric infectious diseases, 2002, Volume: 13, Issue:1 Topics: Acetamides; Age Factors; Amantadine; Antiviral Agents; Child; Clinical Trials as Topic; Global Healt	2002
Antiviral therapy of influenza. Seminars in pediatric infectious diseases, 2002, Volume: 13, Issue:2 Topics: Acetamides; Administration, Inhalation; Administration, Oral; Adult; Amantadine; Antiviral Agents; C	2002
Amantadine and rimantadine for preventing and treating influenza A in adults. The Cochrane database of systematic reviews, 2002, Issue:3 Topics: Adult; Aged; Amantadine; Antiviral Agents; Drug Administration Schedule; Humans; Influenza A virus;	2002
Nosocomial transmission of influenza. Occupational medicine (Oxford, England), 2002, Volume: 52, Issue:5 Topics: Aged; Amantadine; Antiviral Agents; Cross Infection; Health Personnel; Humans; Influenza Vaccines; I	2002
Influenza. Clinical evidence, 2002, Issue:7 Topics: Acetamides; Administration, Inhalation; Administration, Oral; Adult; Amantadine; Antiviral Agents; C	2002
Antivirals for influenza: what is their role in the older patient? Drugs & aging, 2002, Volume: 19, Issue:10 Topics: Acetamides; Aged; Amantadine; Antiviral Agents; Drug Resistance, Viral; Guanidines; Humans; Influenz	2002
Reduction of the influenza burden in children. Pediatrics, 2002, Volume: 110, Issue:6 Topics: Adolescent; Adult; Amantadine; Child; Comorbidity; Cost of Illness; Evidence-Based Medicine; Female;	2002
Influenza. Clinical evidence, 2002, Issue:8 Topics: Acetamides; Administration, Inhalation; Administration, Oral; Adult; Amantadine; Antiviral Agents; C	2002
Treatment of epidemic and pandemic influenza with neuraminidase and M2 proton channel inhibitors. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2003, Volume: 9, Issue:1 Topics: Acetamides; Amantadine; Antiviral Agents; Clinical Trials as Topic; Disease Outbreaks; Endemic Disea	2003
[Antiviral agents for influenza]. Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 2 Topics: Acetamides; Age Factors; Amantadine; Antiviral Agents; Drug Resistance, Viral; Guanidines; Humans; I	2003
Review of the use of neuraminidase inhibitors for prophylaxis of influenza. Communicable disease and public health, 2003, Volume: 6, Issue:2 Topics: Acetamides; Amantadine; Antiviral Agents; Enzyme Inhibitors; Guanidines; Health Planning; Humans; In	2003
A case for rimantadine to be marketed in Canada for prophylaxis of influenza A virus infection. Canadian respiratory journal, 2003, Volume: 10, Issue:7 Topics: Amantadine; Antiviral Agents; Canada; Data Interpretation, Statistical; Drug Administration Schedule	2003
Neuraminidase inhibitors in patients with underlying airways disease. American journal of respiratory medicine : drugs, devices, and other interventions, 2002, Volume: 1, Issue:2 Topics: Acetamides; Amantadine; Antiviral Agents; Asthma; Bronchial Spasm; Comorbidity; Guanidines; Humans;	2002
Amantadine and rimantadine for preventing and treating influenza A in adults. The Cochrane database of systematic reviews, 2004, Issue:3 Topics: Adult; Aged; Amantadine; Antiviral Agents; Drug Administration Schedule; Humans; Influenza A virus;	2004
What is the best antiviral agent for influenza infection? American family physician, 2004, Oct-01, Volume: 70, Issue:7 Topics: Acetamides; Administration, Oral; Adult; Amantadine; Antiviral Agents; Child; Contraindications; Evi	2004
Influenza. Clinical evidence, 2003, Issue:10 Topics: Acetamides; Adult; Amantadine; Antiviral Agents; Guanidines; Humans; Influenza A virus; Influenza B	2003
Pandemic influenza: is an antiviral response realistic? The Pediatric infectious disease journal, 2004, Volume: 23, Issue:11 Suppl Topics: Amantadine; Antiviral Agents; Disaster Planning; Disease Outbreaks; Drug Resistance, Viral; Health S	2004
Influenza. Clinical evidence, 2004, Issue:12 Topics: Acetamides; Adult; Amantadine; Antiviral Agents; Guanidines; Humans; Influenza A virus; Influenza B	2004
Amantadine and rimantadine for influenza A in adults. The Cochrane database of systematic reviews, 2006, Apr-19, Issue:2 Topics: Adult; Aged; Amantadine; Antiviral Agents; Drug Administration Schedule; Emergencies; Humans; Influe	2006
Which agents should we use to treat and prevent influenza in 2006-2007? Cleveland Clinic journal of medicine, 2006, Volume: 73, Issue:11 Topics: Amantadine; Antiviral Agents; Drug Resistance, Viral; Humans; Influenza, Human; Neuraminidase; Oselt	2006
Antiviral therapy and prophylaxis for influenza in children. Pediatrics, 2007, Volume: 119, Issue:4 Topics: Adamantane; Amantadine; Antiviral Agents; Child; Child, Preschool; Dose-Response Relationship, Drug;	2007
Antiviral therapy and prophylaxis for influenza in children. Pediatrics, 2007, Volume: 119, Issue:4 Topics: Adamantane; Amantadine; Antiviral Agents; Child; Child, Preschool; Dose-Response Relationship, Drug;	2007
Antiviral therapy and prophylaxis for influenza in children. Pediatrics, 2007, Volume: 119, Issue:4 Topics: Adamantane; Amantadine; Antiviral Agents; Child; Child, Preschool; Dose-Response Relationship, Drug;	2007
Antiviral therapy and prophylaxis for influenza in children. Pediatrics, 2007, Volume: 119, Issue:4 Topics: Adamantane; Amantadine; Antiviral Agents; Child; Child, Preschool; Dose-Response Relationship, Drug;	2007
Influenza: evolving strategies in treatment and prevention. Seminars in respiratory and critical care medicine, 2007, Volume: 28, Issue:2 Topics: Aged; Amantadine; Antiviral Agents; Centers for Disease Control and Prevention, U.S.; Child, Prescho	2007
Occasional review: influenza in COPD: pathogenesis, prevention, and treatment. International journal of chronic obstructive pulmonary disease, 2007, Volume: 2, Issue:1 Topics: Amantadine; Antiviral Agents; Humans; Influenza Vaccines; Influenza, Human; Oseltamivir; Pulmonary D	2007
Amantadine and rimantadine for influenza A in children and the elderly. The Cochrane database of systematic reviews, 2008, Jan-23, Issue:1 Topics: Aged; Amantadine; Antiviral Agents; Child; Humans; Influenza A virus; Influenza, Human; Randomized C	2008
Antiviral therapy. Respiratory infections, genital herpes, and herpetic keratitis. Lancet (London, England), 1984, Sep-15, Volume: 2, Issue:8403 Topics: Acyclovir; Adult; Amantadine; Antiviral Agents; Child; Female; Herpes Genitalis; Humans; Idoxuridine	1984
An assessment of antiviral drugs for the management of infectious diseases in humans. Antiviral research, 1981, Volume: 1, Issue:2 Topics: Amantadine; Antiviral Agents; Ascorbic Acid; Dosage Forms; Drug Evaluation; Encephalitis; Hepatitis;	1981
Antiviral drugs 1983. The Medical clinics of North America, 1983, Volume: 67, Issue:5 Topics: Acyclovir; Amantadine; Antiviral Agents; Clinical Trials as Topic; Female; Herpes Genitalis; Herpes	1983
Antiviral drugs today. The New Zealand medical journal, 1984, Dec-12, Volume: 97, Issue:769 Topics: Acyclovir; Administration, Topical; Adolescent; Amantadine; Antiviral Agents; Chickenpox; Child; Cli	1984
Rimantadine: a clinical perspective. The Annals of pharmacotherapy, 1995, Volume: 29, Issue:3 Topics: Absorption; Amantadine; Controlled Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Comb	1995
Amantadine and rimantadine prophylaxis of influenza A in nursing homes. A tolerability perspective. Drugs & aging, 1994, Volume: 5, Issue:1 Topics: Aged; Amantadine; Homes for the Aged; Humans; Influenza A virus; Influenza, Human; Nursing Homes; Ri	1994
Using antiviral agents to control outbreaks of influenza A infection. Geriatrics, 1994, Volume: 49, Issue:12 Topics: Aged; Amantadine; Disease Outbreaks; Homes for the Aged; Humans; Influenza A virus; Influenza Vaccin	1994
Viral respiratory infections in the community: epidemiology, agents, and interventions. The American journal of medicine, 1995, Dec-29, Volume: 99, Issue:6B Topics: Adolescent; Adult; Age Factors; Aged; Amantadine; Antiviral Agents; Child; Child, Preschool; Humans;	1995
Use of antivirals in influenza in the elderly: prophylaxis and therapy. Gerontology, 1996, Volume: 42, Issue:5 Topics: Aged; Amantadine; Antiviral Agents; Disease Outbreaks; Humans; Influenza, Human; Orthomyxoviridae; R	1996
Antivirals for pandemic influenza. The Journal of infectious diseases, 1997, Volume: 176 Suppl 1 Topics: Amantadine; Antiviral Agents; Humans; Influenza, Human; Neuraminidase; Ribavirin; Rimantadine	1997
Influenza, influenza vaccine, and amantadine/rimantadine. The Journal of family practice, 1997, Volume: 45, Issue:2 Topics: Amantadine; Antiviral Agents; Contraindications; Humans; Influenza Vaccines; Influenza, Human; Riman	1997
[Current status of research and development for anti-influenza virus drugs--chemotherapy for influenza]. Nihon rinsho. Japanese journal of clinical medicine, 1997, Volume: 55, Issue:10 Topics: Amantadine; Antiviral Agents; Humans; Influenza, Human; Quinolizines; Rimantadine	1997
Update on emerging infections from the Centers for Disease Control and Prevention. Influenza: ED considerations for the 1997-98 season. Annals of emergency medicine, 1997, Volume: 30, Issue:5 Topics: Amantadine; Antiviral Agents; Emergency Medicine; Humans; Influenza Vaccines; Influenza, Human; Rima	1997
Strategies for prevention of community-acquired pneumonia. Seminars in respiratory infections, 1998, Volume: 13, Issue:1 Topics: Amantadine; Antiviral Agents; Community-Acquired Infections; Humans; Influenza Vaccines; Influenza,	1998
Underused options for preventing and treating influenza. Cleveland Clinic journal of medicine, 1999, Volume: 66, Issue:1 Topics: Adolescent; Adult; Aged; Amantadine; Antiviral Agents; Child; Child, Preschool; Drug Administration	1999
[Prophylaxis and treatment of respiratory infections caused by influenza virus types A and B]. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 1999, Volume: 12, Issue:1 Topics: Amantadine; Antiviral Agents; Drug Resistance, Microbial; Humans; Influenza, Human; Neuraminidase; O	1999
Prevention and early treatment of influenza in healthy adults. Vaccine, 2000, Jan-06, Volume: 18, Issue:11-12 Topics: Adolescent; Adult; Amantadine; Antiviral Agents; Cost-Benefit Analysis; Guanidines; Humans; Influenz	2000
Measures for control of influenza. PharmacoEconomics, 1999, Volume: 16 Suppl 1 Topics: Amantadine; Amines; Antiviral Agents; Enzyme Inhibitors; Guanidines; Humans; Influenza A virus; Infl	1999
Cochrane reviews and systematic reviews of economic evaluations. Amantadine and rimantadine in the prevention and treatment of influenza. PharmacoEconomics, 1999, Volume: 16 Suppl 1 Topics: Adult; Amantadine; Antiviral Agents; Cost of Illness; Humans; Influenza, Human; Rimantadine; United	1999
Antiviral agents for treating influenza. Cleveland Clinic journal of medicine, 2000, Volume: 67, Issue:2 Topics: Acetamides; Amantadine; Antiviral Agents; Drug Administration Schedule; Guanidines; Humans; Influenz	2000
Amantadine and rimantadine for preventing and treating influenza A in adults. The Cochrane database of systematic reviews, 2000, Issue:2 Topics: Adult; Aged; Amantadine; Antiviral Agents; Drug Administration Schedule; Humans; Influenza A virus;	2000
Prevention and treatment of influenza in immunocompromised patients. The American journal of medicine, 1997, Mar-17, Volume: 102, Issue:3A Topics: Aerosols; AIDS-Related Opportunistic Infections; Amantadine; Antiviral Agents; Bone Marrow Transplan	1997
Updated treatment for influenza A and B. American family physician, 2000, Dec-01, Volume: 62, Issue:11 Topics: Acetamides; Amantadine; Antiviral Agents; Clinical Trials as Topic; Enzyme Inhibitors; Guanidines; H	2000
Influenza virus and rhinovirus-related otitis media: potential for antiviral intervention. Vaccine, 2000, Dec-08, Volume: 19 Suppl 1 Topics: Acetamides; Adult; Anti-Bacterial Agents; Antiviral Agents; Child; Child, Preschool; Clinical Trials	2000
Managing influenza: amantadine, rimantadine and beyond. International journal of clinical practice, 2001, Volume: 55, Issue:3 Topics: Adolescent; Adult; Aged; Amantadine; Antiviral Agents; Child; Child, Preschool; Guanidines; Humans;	2001
Amantadine and rimantadine for preventing and treating influenza A in adults. The Cochrane database of systematic reviews, 2001, Issue:2 Topics: Adult; Aged; Amantadine; Antiviral Agents; Drug Administration Schedule; Humans; Influenza A virus;	2001
Adverse cutaneous reactions to influenza vaccinations and chemotherapy. International journal of dermatology, 2001, Volume: 40, Issue:7 Topics: Acetamides; Amantadine; Antiviral Agents; Drug Eruptions; Drug-Related Side Effects and Adverse Reac	2001
Perspectives on antiviral use during pandemic influenza. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2001, Dec-29, Volume: 356, Issue:1416 Topics: Acetamides; Amantadine; Antiviral Agents; Chemoprevention; Disease Outbreaks; Drug Resistance, Multi	2001
Anti-influenza therapies. Virus research, 2002, Jan-30, Volume: 82, Issue:1-2 Topics: Amantadine; Antiviral Agents; Humans; Influenza, Human; Neuraminidase; Rimantadine	2002
Influenza in the acute hospital setting. The Lancet. Infectious diseases, 2002, Volume: 2, Issue:3 Topics: Acetamides; Amantadine; Antiviral Agents; Cross Infection; Disease Outbreaks; Guanidines; Hospitals;	2002
Implications of viral resistance to amantadine in control of influenza A. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1992, Volume: 15, Issue:2 Topics: Amantadine; Drug Resistance, Microbial; Humans; Influenza, Human; Rimantadine	1992
Prevention and control of influenza A outbreaks in long-term care facilities. Infection control and hospital epidemiology, 1992, Volume: 13, Issue:1 Topics: Amantadine; Disease Outbreaks; Humans; Influenza A virus; Influenza Vaccines; Influenza, Human; Long	1992
Emergence and transmission of influenza A viruses resistant to amantadine and rimantadine. Current topics in microbiology and immunology, 1992, Volume: 176 Topics: Amantadine; Animals; Drug Resistance, Microbial; Humans; Influenza A virus; Influenza, Human; Rimant	1992
Prophylaxis and treatment of influenza. The New England journal of medicine, 1990, Feb-15, Volume: 322, Issue:7 Topics: Amantadine; Humans; Influenza Vaccines; Influenza, Human; Rimantadine	1990
Clinical applications of antiviral agents for chemophrophylaxis and therapy of respiratory viral infections. Antiviral research, 1985, Volume: Suppl 1 Topics: Adult; Amantadine; Antiviral Agents; Child; Child, Preschool; Clinical Trials as Topic; Humans; Infl	1985
Chemotherapy of respiratory viruses. Advances in internal medicine, 1986, Volume: 31 Topics: Acyclovir; Adult; Amantadine; Animals; Antiviral Agents; Benzimidazoles; Child; Clinical Trials as T	1986
Respiratory pharmacology. Antiviral agents. Clinics in chest medicine, 1986, Volume: 7, Issue:3 Topics: Acyclovir; Amantadine; Antiviral Agents; Ganciclovir; Herpesviridae Infections; Humans; Influenza, H	1986
Amantadine and rimantadine for the prevention of influenza A. Seminars in respiratory infections, 1989, Volume: 4, Issue:4 Topics: Adamantane; Adult; Age Factors; Aged; Amantadine; Child; Humans; Influenza A virus; Influenza, Human	1989
Rimantadine hydrochloride and amantadine hydrochloride use in influenza A virus infections. Infectious disease clinics of North America, 1987, Volume: 1, Issue:2 Topics: Adamantane; Adult; Aged; Amantadine; Humans; Influenza A virus; Influenza, Human; Rimantadine	1987
Influenza--recent developments in prophylaxis and treatment. British medical bulletin, 1985, Volume: 41, Issue:4 Topics: Acetylmuramyl-Alanyl-Isoglutamine; Administration, Oral; Aerosols; Amantadine; Humans; Influenza, Hu	1985

Article	Year
Safety and efficacy of nebulized zanamivir in hospitalized patients with serious influenza. Antiviral therapy, 2003, Volume: 8, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Antiviral Agents; Double-Blind Method; Drug Resistance, Viral; Drug	2003
Antiviral drugs 1983. The Medical clinics of North America, 1983, Volume: 67, Issue:5 Topics: Acyclovir; Amantadine; Antiviral Agents; Clinical Trials as Topic; Female; Herpes Genitalis; Herpes	1983
Antiviral drugs today. The New Zealand medical journal, 1984, Dec-12, Volume: 97, Issue:769 Topics: Acyclovir; Administration, Topical; Adolescent; Amantadine; Antiviral Agents; Chickenpox; Child; Cli	1984
[Evaluation of rimantadine effectiveness during influenza A2-Texas epidemic in 1979-1980]. Klinicheskaia meditsina, 1981, Volume: 59, Issue:2 Topics: Adamantane; Clinical Trials as Topic; Disease Outbreaks; Dose-Response Relationship, Drug; Drug Admi	1981
Safety of prolonged administration of rimantadine hydrochloride in the prophylaxis of influenza A virus infections in nursing homes. Antimicrobial agents and chemotherapy, 1984, Volume: 26, Issue:1 Topics: Adamantane; Cross Infection; Humans; Influenza A virus; Influenza, Human; Nursing Homes; Rimantadine	1984
Successful treatment of naturally occurring influenza A/USSR/77 H1N1. JAMA, 1981, Mar-20, Volume: 245, Issue:11 Topics: Adult; Amantadine; Central Nervous System; Clinical Trials as Topic; Double-Blind Method; Humans; In	1981
A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infection. The New England journal of medicine, 1982, Sep-02, Volume: 307, Issue:10 Topics: Adamantane; Adolescent; Adult; Amantadine; Clinical Trials as Topic; Humans; Infant, Newborn; Influe	1982
Comparative therapeutic effect of aerosolized and oral rimantadine HCl in experimental human influenza A virus infection. Antiviral research, 1982, Volume: 2, Issue:3 Topics: Adamantane; Administration, Oral; Aerosols; Female; Fever; Humans; Influenza, Human; Male; Rimantadi	1982
[Remantadine in the treatment of influenza in children]. Vestnik Rossiiskoi akademii meditsinskikh nauk, 1994, Issue:9 Topics: Adolescent; Child; Child, Preschool; Humans; Influenza A virus; Influenza B virus; Influenza, Human;	1994
Safety and efficacy of long-term use of rimantadine for prophylaxis of type A influenza in nursing homes. Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:10 Topics: Aged; Aged, 80 and over; Antiviral Agents; Female; Humans; Influenza A virus; Influenza, Human; Male	1995
Effect of rimantadine treatment on clinical manifestations and otologic complications in adults experimentally infected with influenza A (H1N1) virus. The Journal of infectious diseases, 1998, Volume: 177, Issue:5 Topics: Adolescent; Adult; Antiviral Agents; Double-Blind Method; Humans; Influenza A virus; Influenza A Vir	1998
Efficacy of zanamivir for chemoprophylaxis of nursing home influenza outbreaks. Vaccine, 1998, Volume: 16, Issue:18 Topics: Aged; Antiviral Agents; Disease Outbreaks; Female; Guanidines; Humans; Influenza A virus; Influenza	1998
[Chemotherapeutics for treatment of influenza and other viral respiratory tract infections in children]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 1998, Volume: 43, Issue:9 Topics: Adolescent; Antibodies, Viral; Antibody Formation; Antiviral Agents; Child; Child, Preschool; Female	1998
Evidence for cytokine mediation of disease expression in adults experimentally infected with influenza A virus. The Journal of infectious diseases, 1999, Volume: 180, Issue:1 Topics: Adolescent; Adult; Antiviral Agents; Female; Humans; Influenza A virus; Influenza, Human; Interleuki	1999
Effect of rimantadine on the immune response to influenza A infections. Journal of medical virology, 1991, Volume: 34, Issue:1 Topics: Antibody Formation; Disease Outbreaks; Humans; Immunity, Cellular; Immunoglobulin A; Immunoglobulin	1991
Recovery of drug-resistant influenza A virus during therapeutic use of rimantadine. Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:9 Topics: Adolescent; Adult; Child; Child, Preschool; Drug Evaluation; Drug Resistance, Microbial; Female; Hum	1991
Safety and pharmacokinetics of rimantadine small-particle aerosol. Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:11 Topics: Adult; Aerosols; Air Microbiology; Half-Life; Humans; Influenza, Human; Particle Size; Respiratory F	1990
[Prevention of influenza A. Effectiveness and tolerance of rimantadine hydrochloride]. Presse medicale (Paris, France : 1983), 1990, Jan-20, Volume: 19, Issue:2 Topics: Adamantane; Clinical Trials as Topic; Drug Evaluation; Female; France; Humans; Influenza A virus; In	1990
Safety and prophylactic efficacy of low-dose rimantadine in adults during an influenza A epidemic. Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:9 Topics: Adolescent; Adult; Disease Outbreaks; Dose-Response Relationship, Drug; Double-Blind Method; Female;	1990
Clinical applications of antiviral agents for chemophrophylaxis and therapy of respiratory viral infections. Antiviral research, 1985, Volume: Suppl 1 Topics: Adult; Amantadine; Antiviral Agents; Child; Child, Preschool; Clinical Trials as Topic; Humans; Infl	1985
Chemotherapy of respiratory viruses. Advances in internal medicine, 1986, Volume: 31 Topics: Acyclovir; Adult; Amantadine; Animals; Antiviral Agents; Benzimidazoles; Child; Clinical Trials as T	1986
Emergence and apparent transmission of rimantadine-resistant influenza A virus in families. The New England journal of medicine, 1989, Dec-21, Volume: 321, Issue:25 Topics: Adamantane; Administration, Oral; Adolescent; Adult; Aged; Child; Child, Preschool; Clinical Trials	1989
Antiviral chemotherapy and chemoprophylaxis. Science (New York, N.Y.), 1985, Mar-15, Volume: 227, Issue:4692 Topics: Acyclovir; Adult; Aged; Amantadine; Antiviral Agents; Chickenpox; Clinical Trials as Topic; Cytomega	1985
Genetic basis of resistance to rimantadine emerging during treatment of influenza virus infection. Journal of virology, 1988, Volume: 62, Issue:5 Topics: Adamantane; Amino Acid Sequence; Base Sequence; Clinical Trials as Topic; Drug Resistance, Microbial	1988
Rimantadine prophylaxis in children: a follow-up study. The Pediatric infectious disease journal, 1988, Volume: 7, Issue:6 Topics: Adamantane; Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Metho	1988
Children with influenza A infection: treatment with rimantadine. Pediatrics, 1987, Volume: 80, Issue:2 Topics: Acetaminophen; Adamantane; Adolescent; Child; Child, Preschool; Clinical Trials as Topic; Double-Bli	1987
Effectiveness of rimantadine prophylaxis of children within families. American journal of diseases of children (1960), 1986, Volume: 140, Issue:7 Topics: Adamantane; Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Metho	1986
Oral rimantadine hydrochloride therapy of influenza A virus H3N2 subtype infection in adults. Antimicrobial agents and chemotherapy, 1986, Volume: 29, Issue:2 Topics: Adamantane; Administration, Oral; Adult; Body Temperature; Clinical Trials as Topic; Double-Blind Me	1986
A comparison of acetaminophen and rimantadine in the treatment of influenza A infection in children. Journal of medical virology, 1987, Volume: 21, Issue:3 Topics: Acetaminophen; Adamantane; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Method; H	1987

Article	Year
Anti-influenza active and low toxic N-phenyl-substituted β-amidoamidines structurally related to natural antibiotic amidinomycin. Bioorganic & medicinal chemistry letters, 2013, Apr-15, Volume: 23, Issue:8 Topics: Amidines; Animals; Antiviral Agents; Cyclopentanes; Dogs; Humans; Influenza A Virus, H3N2 Subtype; I	2013
Synthesis and structure-activity relationships of novel camphecene analogues as anti-influenza agents. Bioorganic & medicinal chemistry letters, 2019, 12-01, Volume: 29, Issue:23 Topics: Camphor; Ethanolamines; Humans; Influenza, Human; Structure-Activity Relationship	2019
New type of anti-influenza agents based on benzo[d][1,3]dithiol core. Bioorganic & medicinal chemistry letters, 2020, 12-15, Volume: 30, Issue:24 Topics: Animals; Antiviral Agents; Dogs; Hemagglutinin Glycoproteins, Influenza Virus; Humans; Influenza A V	2020
Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza. PLoS pathogens, 2020, Volume: 16, Issue:8 Topics: Antiviral Agents; Drug Resistance, Viral; Drug Synergism; Drug Therapy, Combination; Humans; Influen	2020
Increased Dissociation of Adamantanamines in Influenza A M2 S31N with Partial Block by Rimantadine. Biophysical journal, 2020, 11-03, Volume: 119, Issue:9 Topics: Amantadine; Antiviral Agents; Dissociative Disorders; Humans; Influenza, Human; Rimantadine; Viral M	2020
Conjugation to polymeric chains of influenza drugs targeting M2 ion channels partially restores inhibition of drug-resistant mutants. Journal of pharmaceutical sciences, 2013, Volume: 102, Issue:8 Topics: Amantadine; Animals; Antiviral Agents; Cell Line; Dogs; Drug Carriers; Drug Resistance, Viral; Human	2013
The influenza viruses. The Ceylon medical journal, 2015, Volume: 60, Issue:1 Topics: Amantadine; Animals; Antiviral Agents; Humans; Influenza Vaccines; Influenza, Human; Orthomyxovirida	2015
Meeting report: 4th ISIRV antiviral group conference: Novel antiviral therapies for influenza and other respiratory viruses. Antiviral research, 2016, Volume: 129 Topics: Amantadine; Antibody-Dependent Enhancement; Antiviral Agents; Coronavirus Infections; Drug Resistanc	2016
Antivirals and influenza: frequency of resistance. The Pediatric infectious disease journal, 2008, Volume: 27, Issue:10 Suppl Topics: Amantadine; Antiviral Agents; Disease Outbreaks; Drug Resistance, Viral; Humans; Influenza A virus;	2008
Detection of molecular markers of antiviral resistance in influenza A (H5N1) viruses using a pyrosequencing method. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:3 Topics: Amantadine; Animals; Antiviral Agents; Birds; Drug Resistance, Viral; Genetic Markers; Humans; Influ	2009
[Do we really need antiflu virus medication?]. Medecine et maladies infectieuses, 2009, Volume: 39, Issue:9 Topics: Amantadine; Anti-Bacterial Agents; Antiviral Agents; Bacterial Infections; Enzyme Inhibitors; Humans	2009
Update: influenza activity - United States, August 30-October 31, 2009. MMWR. Morbidity and mortality weekly report, 2009, Nov-13, Volume: 58, Issue:44 Topics: Adolescent; Adult; Aged; Amantadine; Antiviral Agents; Child; Child, Preschool; Disease Outbreaks; D	2009
Oseltamivir resistance and the H274Y neuraminidase mutation in seasonal, pandemic and highly pathogenic influenza viruses. Drugs, 2009, Volume: 69, Issue:18 Topics: Cross Infection; Drug Resistance, Viral; Global Health; Humans; Influenza A virus; Influenza A Virus	2009
Safety of oseltamivir compared with the adamantanes in children less than 12 months of age. The Pediatric infectious disease journal, 2010, Volume: 29, Issue:3 Topics: Adamantane; Antiviral Agents; Central Nervous System; Female; Humans; Infant; Infant, Newborn; Influ	2010
[New betulin derivatives in combination with rimantadine for inhibition of influenza virus reproduction]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2009, Volume: 54, Issue:5-6 Topics: Animals; Antiviral Agents; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Drug The	2009
Maternal and neonatal outcomes after antepartum treatment of influenza with antiviral medications. Obstetrics and gynecology, 2010, Volume: 115, Issue:4 Topics: Amantadine; Antiviral Agents; Enterocolitis, Necrotizing; Female; Humans; Infant, Newborn; Influenza	2010
Influenza antiviral prescribing practices during the 2007-08 and 2008-09 influenza seasons in the setting of increased resistance to oseltamivir among circulating influenza viruses. Antiviral research, 2010, Volume: 88, Issue:2 Topics: Adamantane; Antiviral Agents; Disease Outbreaks; Drug Resistance, Viral; Drug Utilization; Humans; I	2010
Amantadine resistance in relation to the evolution of influenza A(H3N2) viruses in Iran. Antiviral research, 2010, Volume: 88, Issue:2 Topics: Amantadine; Amino Acid Substitution; Antiviral Agents; Drug Resistance, Viral; Evolution, Molecular;	2010
[Influenza : clinical symptoms, diagnostics and therapy]. Der Internist, 2011, Volume: 52, Issue:9 Topics: Adamantane; Adult; Age Factors; Aged; AIDS-Related Opportunistic Infections; Antiviral Agents; Child	2011
[Comparative pharmacokinetics of antigrippin-maximum administered in capsules and powder for preparing solutions]. Eksperimental'naia i klinicheskaia farmakologiia, 2011, Volume: 74, Issue:7 Topics: Acetaminophen; Adult; Antiviral Agents; Area Under Curve; Biological Availability; Capsules; Chromat	2011
[Susceptibility of pandemic influenza virus A 2009 H1N1 and highly pathogenic avian influenza virus A H5N1 to antiinfluenza agents in cell culture]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2011, Volume: 56, Issue:3-4 Topics: Animals; Antiviral Agents; Birds; Cell Line; Drug Resistance, Viral; Humans; Indoles; Influenza A Vi	2011
Description of antiviral treatment among adults hospitalized with influenza before and during the 2009 pandemic: United States, 2005-2009. The Journal of infectious diseases, 2011, Dec-15, Volume: 204, Issue:12 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amantadine; Antiviral Agents; Drug Therapy, Combination;	2011
Magic-angle-spinning NMR of the drug resistant S31N M2 proton transporter from influenza A. Journal of the American Chemical Society, 2012, May-02, Volume: 134, Issue:17 Topics: Amino Acid Sequence; Antiviral Agents; Carrier Proteins; Drug Resistance, Viral; Humans; Influenza A	2012
Development of a novel influenza A antiviral assay. Journal of virological methods, 2002, Volume: 105, Issue:1 Topics: Animals; Antiviral Agents; Branched DNA Signal Amplification Assay; Cell Line; Dogs; Guanidines; Hum	2002
Economic analysis of influenza vaccination and antiviral treatment for healthy working adults. Annals of internal medicine, 2002, Aug-20, Volume: 137, Issue:4 Topics: Acetamides; Adolescent; Adult; Antiviral Agents; Computer Simulation; Cost of Illness; Cost-Benefit	2002
Summaries for patients. Influenza vaccination or antiviral treatment for healthy working adults: an economic analysis. Annals of internal medicine, 2002, Aug-20, Volume: 137, Issue:4 Topics: Acetamides; Adolescent; Adult; Antiviral Agents; Computer Simulation; Cost of Illness; Cost-Benefit	2002
Current strategies for management of influenza in the elderly population. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2002, Sep-15, Volume: 35, Issue:6 Topics: Acetamides; Aged; Aged, 80 and over; Chemoprevention; Complementary Therapies; Cost-Benefit Analysis	2002
Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus. Proceedings of the National Academy of Sciences of the United States of America, 2002, Oct-15, Volume: 99, Issue:21 Topics: Amantadine; Animals; Antiviral Agents; Disease Outbreaks; Enzyme Inhibitors; Genes, Viral; Hemagglut	2002
Management of influenza in adults older than 65 years of age: cost-effectiveness of rapid testing and antiviral therapy. Annals of internal medicine, 2003, Sep-02, Volume: 139, Issue:5 Pt 1 Topics: Acetamides; Aged; Amantadine; Antiviral Agents; Computer Simulation; Cost-Benefit Analysis; Decision	2003
Summaries for patients. Cost-effective management of flu in adults older than 65 years of age. Annals of internal medicine, 2003, Sep-02, Volume: 139, Issue:5 Pt 1 Topics: Acetamides; Aged; Amantadine; Antiviral Agents; Computer Simulation; Cost-Benefit Analysis; Decision	2003
[Treatment of influenza in children]. Zhonghua er ke za zhi = Chinese journal of pediatrics, 2003, Volume: 41, Issue:2 Topics: Adamantane; Amantadine; Antiviral Agents; Child; Guanidines; Humans; Influenza, Human; Pyrans; Riman	2003
Avian influenza should be ruffling our feathers. The Lancet. Infectious diseases, 2004, Volume: 4, Issue:10 Topics: Acetamides; Amantadine; Animals; Antiviral Agents; Asia, Eastern; Asia, Southeastern; Birds; Disease	2004
Antiviral drugs for prophylaxis and treatment of influenza. The Medical letter on drugs and therapeutics, 2004, Oct-25, Volume: 46, Issue:1194 Topics: Amantadine; Antiviral Agents; Enzyme Inhibitors; Humans; Influenza, Human; Neuraminidase; Rimantadin	2004
Antiviral drugs for prophylaxis and treatment of influenza. Obstetrics and gynecology, 2005, Volume: 105, Issue:2 Topics: Adolescent; Adult; Aged; Amantadine; Antiviral Agents; Child; Child, Preschool; Female; Humans; Infl	2005
I wish to comment on several points in the recent "Guidelines". Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2005, Volume: 33, Issue:1 Topics: Aged; Amantadine; Antiviral Agents; Drug Resistance, Viral; Humans; Influenza A virus; Influenza B v	2005
A 5-year experience with influenza prevention and containment in a program of all-inclusive care for elderly adults. American journal of infection control, 2005, Volume: 33, Issue:4 Topics: Aged; Antiviral Agents; Caregivers; Female; Frail Elderly; Health Personnel; Health Services for the	2005
Statement on travel, influenza, and prevention. Canada communicable disease report = Releve des maladies transmissibles au Canada, 2005, Mar-15, Volume: 31, Issue:ACS-2 Topics: Amantadine; Antiviral Agents; Humans; Influenza Vaccines; Influenza, Human; Rimantadine; Travel	2005
Antiviral drugs for prophylaxis and treatment of influenza. The Medical letter on drugs and therapeutics, 2005, Nov-21, Volume: 47, Issue:1222 Topics: Adolescent; Amantadine; Antiviral Agents; Child; Child, Preschool; Humans; Infant; Influenza Vaccine	2005
Antiviral resistance in influenza viruses--implications for management and pandemic response. The New England journal of medicine, 2006, Feb-23, Volume: 354, Issue:8 Topics: Amantadine; Antiviral Agents; Disease Outbreaks; Drug Resistance, Viral; Humans; Influenza A Virus,	2006
[Influenza virus of seasonal influenza , high increase of resistance to amantadine and rimantadine]. Revue medicale suisse, 2006, Jan-25, Volume: 2, Issue:50 Topics: Amantadine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Humans; Influenza A	2006
Distribution of amantadine-resistant H5N1 avian influenza variants in Asia. The Journal of infectious diseases, 2006, Jun-15, Volume: 193, Issue:12 Topics: Amantadine; Amino Acid Substitution; Animals; Antiviral Agents; Asia; Birds; Drug Resistance, Viral;	2006
Increased adamantane resistance in influenza A(H3) viruses in Australia and neighbouring countries in 2005. Antiviral research, 2007, Volume: 73, Issue:2 Topics: Adamantane; Antiviral Agents; Australia; Drug Resistance, Viral; Hemagglutinin Glycoproteins, Influe	2007
Recommended composition of influenza virus vaccines for use in the 2007 influenza season. Releve epidemiologique hebdomadaire, 2006, Oct-13, Volume: 81, Issue:41 Topics: Amantadine; Antiviral Agents; Drug Resistance, Viral; Humans; Influenza A Virus, H1N1 Subtype; Influ	2006
Amantadine may be lifesaving in severe influenza A. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2006, Nov-15, Volume: 43, Issue:10 Topics: Amantadine; Antiviral Agents; Dilatation; Disease Outbreaks; Humans; Influenza A virus; Influenza, H	2006
Antiviral management of seasonal and pandemic influenza. The Journal of infectious diseases, 2006, Nov-01, Volume: 194 Suppl 2 Topics: Amantadine; Animals; Antiviral Agents; Clinical Trials as Topic; Disease Outbreaks; Drug Resistance,	2006
[Significance of virological diagnostics for the effective treatment of hospitalized patients infected with influenza virus]. Pneumonologia i alergologia polska, 2006, Volume: 74, Issue:2 Topics: Adult; Amantadine; Antiviral Agents; Diagnosis, Differential; Fluorescent Antibody Technique; Hospit	2006
The emergence of adamantane resistance in influenza A(H1) viruses in Australia and regionally in 2006. Antiviral research, 2007, Volume: 75, Issue:2 Topics: Adamantane; Adolescent; Adult; Aged; Amino Acid Substitution; Antiviral Agents; Asia, Eastern; Asia,	2007
Emergence of rimantadine-resistant virus within 6 days of starting rimantadine prophylaxis with oseltamivir treatment of symptomatic cases. Journal of the American Geriatrics Society, 2007, Volume: 55, Issue:6 Topics: Antiviral Agents; Cohort Studies; Drug Administration Schedule; Drug Resistance, Viral; Humans; Infe	2007
Influenza. Canadian family physician Medecin de famille canadien, 2008, Volume: 54, Issue:3 Topics: Amantadine; Antiviral Agents; Humans; Influenza Vaccines; Influenza, Human; Mass Vaccination; Oselta	2008
[Molecular and genetic analysis of influenza A viruses isolated in Russia, based on the neuraminidase and M2 protein gene sequence]. Molekuliarnaia genetika, mikrobiologiia i virusologiia, 2008, Issue:2 Topics: Antiviral Agents; Disease Outbreaks; Drug Resistance, Viral; Genes, Viral; Humans; Influenza A Virus	2008
[Combined prevention of influenza using inactivated influenza vaccine and remantadine in organized collectives of adults]. Trudy Instituta imeni Pastera, 1982, Volume: 57 Topics: Adamantane; Adult; Disease Outbreaks; Drug Evaluation; Humans; Influenza Vaccines; Influenza, Human;	1982
[Organization and evaluation of the effectiveness of emergency prophylaxis and early treatment of influenza with remantadine in Serevodvinsk]. Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1983, Issue:3 Topics: Adamantane; Adult; Drug Evaluation; Emergencies; Epidemiologic Methods; Humans; Influenza, Human; Ri	1983
[Efficacy of remantadin in influenza B]. Terapevticheskii arkhiv, 1983, Volume: 55, Issue:9 Topics: Adamantane; Adult; Humans; Influenza, Human; Orthomyxoviridae; Rimantadine; Russia; Serotyping	1983
[Effectiveness of remantadine in outpatients during a period of epidemic outbreaks of influenza A and B]. Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1984, Issue:1 Topics: Absenteeism; Adamantane; Ambulatory Care; Disease Outbreaks; Drug Evaluation; Humans; Influenza, Hum	1984
[New organized approach to rendering medical services to patients during influenza outbreak]. Terapevticheskii arkhiv, 1984, Volume: 56, Issue:1 Topics: Adamantane; Antiviral Agents; Disease Outbreaks; Humans; Influenza A virus; Influenza, Human; Rimant	1984
Influenza: prevention and therapy. Henry Ford Hospital medical journal, 1984, Volume: 32, Issue:2 Topics: Amantadine; Humans; Influenza Vaccines; Influenza, Human; Rimantadine; Vaccination	1984
[Emergency prevention of influenza with remantadine]. Meditsinskaia sestra, 1984, Volume: 43, Issue:3 Topics: Adamantane; Adolescent; Adult; Disease Outbreaks; Humans; Influenza, Human; Rimantadine; USSR	1984
[The current system to control influenza]. Meditsinskaia sestra, 1984, Volume: 43, Issue:3 Topics: Adolescent; Child; Child, Preschool; Humans; Influenza Vaccines; Influenza, Human; Interferon Type I	1984
[Amantadine and riamantadine in the treatment of influenza]. Recenti progressi in medicina, 1983, Volume: 74, Issue:3 Topics: Adamantane; Amantadine; Humans; Influenza, Human; Rimantadine	1983
Perspectives of cooperation of CMEA countries in combatting influenza. Journal of hygiene, epidemiology, microbiology, and immunology, 1982, Volume: 26, Issue:3 Topics: Cuba; Czechoslovakia; Germany, East; Humans; Hungary; Influenza Vaccines; Influenza, Human; Poland;	1982
[Emergency prevention of influenza with remantadin]. Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1982, Issue:9 Topics: Adamantane; Adolescent; Adult; Disease Outbreaks; Drug Evaluation; Female; Humans; Influenza Vaccine	1982
[Therapeutic effectiveness of rimantadine and antigrippen against A1(H1N1) influenza in the 1977-1978 epidemic]. Vrachebnoe delo, 1981, Issue:6 Topics: Adamantane; Adult; Ascorbic Acid; Aspirin; Diphenhydramine; Drug Combinations; Evaluation Studies as	1981
Adamantine influenza and the adamantanes. Medical biology, 1981, Volume: 59, Issue:1 Topics: Amantadine; Humans; Influenza, Human; Orthomyxoviridae; Rimantadine	1981
[Experience with clinical trials of the new anti-influenza drug rimantadine]. Vrachebnoe delo, 1981, Issue:4 Topics: Adamantane; Antiviral Agents; Ascorbic Acid; Aspirin; Diphenhydramine; Drug Combinations; Humans; In	1981
[Clinical use of the anti-influenza preparation rimantadine]. Klinicheskaia meditsina, 1981, Volume: 59, Issue:2 Topics: Adamantane; Humans; Influenza A virus; Influenza, Human; Rimantadine	1981
Comparison of amantadine and rimantadine for prevention of type A (Russian) influenza. Antiviral research, 1981, Volume: 1, Issue:3 Topics: Adamantane; Adolescent; Adult; Age Factors; Amantadine; Antibodies, Viral; Double-Blind Method; Drug	1981
Plaque inhibition assay for drug susceptibility testing of influenza viruses. Antimicrobial agents and chemotherapy, 1980, Volume: 17, Issue:5 Topics: Amantadine; Antiviral Agents; Drug Resistance, Microbial; Humans; Influenza, Human; Microbial Sensit	1980
[Organization and the results of the early ambulatory treatment of influenza patients]. Sovetskaia meditsina, 1980, Issue:9 Topics: Adult; Ascorbic Acid; Child; Drug Evaluation; Drug Therapy, Combination; Early Ambulation; Humans; I	1980
Prolonged influenza A infection responsive to rimantadine therapy in a human immunodeficiency virus-infected child. The Pediatric infectious disease journal, 1995, Volume: 14, Issue:4 Topics: Child; Female; HIV Infections; Humans; Influenza A virus; Influenza Vaccines; Influenza, Human; Recu	1995
ACIP updates recommendations for the use of antiviral agents in influenza. Advisory Committee on Immunization Practices. American family physician, 1995, Volume: 52, Issue:2 Topics: Amantadine; Humans; Influenza, Human; Rimantadine	1995
Prevention and control of influenza recommendations of the Advisory Committee on Immunization Practices (ACIP). Centers for Disease Control and Prevention. MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports, 1995, Apr-21, Volume: 44, Issue:RR-3 Topics: Amantadine; Antiviral Agents; Humans; Immunization Schedule; Influenza A virus; Influenza B virus; I	1995
Influenza: prevention and control. Rhode Island medicine, 1994, Volume: 77, Issue:11 Topics: Adolescent; Adult; Aged; Amantadine; Child; Child, Preschool; Female; Humans; Infant; Influenza Vacc	1994
Rimantadine for influenza A prevention and treatment. The Nurse practitioner, 1994, Volume: 19, Issue:9 Topics: Adult; Aged; Child; Humans; Influenza A virus; Influenza, Human; Primary Prevention; Rimantadine	1994
Annualizing our approach to influenza. Hospital practice (Office ed.), 1995, Jan-15, Volume: 30, Issue:1 Topics: Adult; Aged; Amantadine; Child; Diagnosis, Differential; Humans; Influenza Vaccines; Influenza, Huma	1995
Therapeutic approaches of clinicians to influenza pandemic. European journal of epidemiology, 1994, Volume: 10, Issue:4 Topics: Adolescent; Adult; Aged; Amantadine; Child; Disease Outbreaks; Female; Humans; Influenza A virus; In	1994
Attitude of the French Armed Forces Health Service to the risk of influenza pandemic. European journal of epidemiology, 1994, Volume: 10, Issue:4 Topics: Attitude of Health Personnel; Disease Outbreaks; France; Humans; Influenza Vaccines; Influenza, Huma	1994
Amantadine-resistant influenza A in nursing homes. Identification of a resistant virus prior to drug use. Archives of internal medicine, 1995, Mar-13, Volume: 155, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Amantadine; Base Sequence; Disease Outbreaks; Drug Resistance, Micro	1995
Rimantadine approved for treatment, prophylaxis of influenza A. American journal of hospital pharmacy, 1994, Jan-01, Volume: 51, Issue:1 Topics: Adult; Child; Drug Approval; Humans; Influenza A virus; Influenza, Human; Rimantadine; United States	1994
Rimantadine for prevention and treatment of influenza. The Medical letter on drugs and therapeutics, 1993, Nov-26, Volume: 35, Issue:910 Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Disease Outbreaks; Humans; Infant; Influenza A vir	1993
Susceptibilities to rimantadine of influenza A/H1N1 and A/H3N2 viruses isolated during the epidemics of 1988 to 1989 and 1989 to 1990. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:10 Topics: Animals; Antigens, Viral; Disease Outbreaks; Enzyme-Linked Immunosorbent Assay; Humans; Influenza A	1993
[The efficacy of Polirem in the prevention of influenza in servicemen]. Voenno-meditsinskii zhurnal, 1995, Issue:2 Topics: Delayed-Action Preparations; Disease Outbreaks; Drug Evaluation; Humans; Influenza A virus; Influenz	1995
Prevention and control of influenza: Recommendations of the Advisory Committee on Immunization Practices (ACIP). Centers for Disease Control and Prevention. MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports, 1996, May-03, Volume: 45, Issue:RR-5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amantadine; Antiviral Agents; Child; Child, Preschool; C	1996
ACIP issues recommendations for the prevention and control of influenza in the 1996-97 season. American family physician, 1996, Volume: 54, Issue:2 Topics: Amantadine; Antiviral Agents; Contraindications; Humans; Immunization Programs; Influenza Vaccines;	1996
Combination antiviral therapy for respiratory virus infections. Antiviral research, 1996, Volume: 29, Issue:1 Topics: Amantadine; Animals; Antiviral Agents; Common Cold; Drug Therapy, Combination; Humans; Influenza, Hu	1996
Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports, 1997, Apr-25, Volume: 46, Issue:RR-9 Topics: Adolescent; Adult; Aged; Amantadine; Antiviral Agents; Breast Feeding; Child; Child, Preschool; Cont	1997
Advisory Committee on Immunization Practices issues recommendations for the 1997-98 influenza season. American family physician, 1997, Volume: 56, Issue:1 Topics: Amantadine; Antiviral Agents; Humans; Immunization Schedule; Influenza, Human; Rimantadine; United S	1997
A new antiviral agent for influenza--is there a clinical niche? The New England journal of medicine, 1997, Sep-25, Volume: 337, Issue:13 Topics: Amantadine; Antiviral Agents; Enzyme Inhibitors; Guanidines; Humans; Influenza A virus; Influenza B	1997
Influenza: immunization/prophylaxis for children, adults, and older adults. CDC Advisory Committee on Immunization Practices. The Nurse practitioner, 1997, Volume: 22, Issue:11 Topics: Adolescent; Adult; Aged; Amantadine; Antiviral Agents; Child; Child, Preschool; Female; Humans; Immu	1997
Outbreaks of influenza A and B in a highly immunized nursing home population. The Journal of family practice, 1997, Volume: 45, Issue:6 Topics: Aged; Aged, 80 and over; Amantadine; Antiviral Agents; Disease Outbreaks; Female; Humans; Influenza	1997
[Antiviral prophylaxis and treatment of influenza]. Ugeskrift for laeger, 1998, Mar-09, Volume: 160, Issue:11 Topics: Amantadine; Antiviral Agents; Haemophilus Vaccines; Humans; Influenza Vaccines; Influenza, Human; Ri	1998
Emergence of drug resistance during an influenza epidemic: insights from a mathematical model. The Journal of infectious diseases, 1998, Volume: 177, Issue:4 Topics: Amantadine; Antiviral Agents; Disease Outbreaks; Disease Transmission, Infectious; Drug Resistance,	1998
Influenza A outbreak on a cruise ship. Canada communicable disease report = Releve des maladies transmissibles au Canada, 1998, Jan-15, Volume: 24, Issue:2 Topics: Aged; Antiviral Agents; Canada; Disease Outbreaks; Humans; Influenza A virus; Influenza Vaccines; In	1998
Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP). Centers for Disease Control and Prevention. MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports, 1998, May-01, Volume: 47, Issue:RR-6 Topics: Adolescent; Adult; Aged; Amantadine; Antiviral Agents; Child; Child, Preschool; Contraindications; H	1998
Common emergence of amantadine- and rimantadine-resistant influenza A viruses in symptomatic immunocompromised adults. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1998, Volume: 26, Issue:6 Topics: Adult; Amantadine; Antiviral Agents; Bone Marrow Transplantation; Drug Resistance, Microbial; Humans	1998
Long-term stability of the anti-influenza A compounds--amantadine and rimantadine. Antiviral research, 1998, Volume: 38, Issue:3 Topics: Amantadine; Animals; Antiviral Agents; Cells, Cultured; Dogs; Drug Stability; Humans; Influenza A vi	1998
[Report on the therapeutic use of rimantadine and amantadine]. Revista cubana de medicina tropical, 1992, Volume: 44, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amantadine; Antiviral Agents; Homes for the Aged; Hospit	1992
Treating influenza with zanamivir. Management of Influenza in the Southern Hemisphere Trialists. Lancet (London, England), 1999, Feb-20, Volume: 353, Issue:9153 Topics: Administration, Inhalation; Amantadine; Antiviral Agents; Drug Resistance, Microbial; Guanidines; Hu	1999
Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports, 1999, Apr-30, Volume: 48, Issue:RR-4 Topics: Adolescent; Adult; Aged; Amantadine; Antiviral Agents; Child; Child, Preschool; Cost of Illness; Cro	1999
Low incidence of rimantadine resistance in field isolates of influenza A viruses. The Journal of infectious diseases, 1999, Volume: 180, Issue:4 Topics: Animals; Antiviral Agents; Biological Assay; Cell Line; Dogs; Drug Resistance, Microbial; Global Hea	1999
Comparison of central nervous system adverse effects of amantadine and rimantadine used as sequential prophylaxis of influenza A in elderly nursing home patients. Archives of internal medicine, 2000, May-22, Volume: 160, Issue:10 Topics: Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Amantadine; Antiviral Agents; Cent	2000
Reintroduction of influenza A to a nursing building. Infection control and hospital epidemiology, 2000, Volume: 21, Issue:11 Topics: Aged; Antiviral Agents; Female; Hospitals, Veterans; Humans; Influenza A virus; Influenza, Human; Ma	2000
The neuraminidase inhibitor GS4104 (oseltamivir phosphate) is efficacious against A/Hong Kong/156/97 (H5N1) and A/Hong Kong/1074/99 (H9N2) influenza viruses. Antiviral research, 2000, Volume: 48, Issue:2 Topics: Acetamides; Animals; Antiviral Agents; Brain; Cell Line; Dogs; Enzyme Inhibitors; Female; Humans; In	2000
Flu-fighting options: decisions, decisions.... Health news (Waltham, Mass.), 2000, Volume: 6, Issue:12 Topics: Acetamides; Amantadine; Antiviral Agents; Guanidines; Humans; Influenza, Human; Oseltamivir; Pneumon	2000
Infection of a child in Hong Kong by an influenza A H3N2 virus closely related to viruses circulating in European pigs. The Journal of general virology, 2001, Volume: 82, Issue:Pt 6 Topics: Amantadine; Animals; Antigens, Viral; Antiviral Agents; Birds; Drug Resistance, Microbial; Europe; G	2001
How to beat the flu: the latest options as a vaccine shortage looms. Consumer reports, 2000, Volume: 65, Issue:11 Topics: Acetamides; Amantadine; Antiviral Agents; Centers for Disease Control and Prevention, U.S.; Device A	2000
ACIP releases guidelines on the prevention and control of influenza. Advisory Committee on Immunization Practices. American family physician, 2001, Oct-01, Volume: 64, Issue:7 Topics: Acetamides; Age Factors; Amantadine; Antiviral Agents; Drug Administration Schedule; Guanidines; Hum	2001
Drugs for non-HIV viral infections. The Medical letter on drugs and therapeutics, 2002, Feb-04, Volume: 44, Issue:1123 Topics: 2-Aminopurine; Acyclovir; Administration, Oral; Administration, Topical; Amantadine; Animals; Antivi	2002
Influenza surveillance with rapid diagnostic tests. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2002, May-15, Volume: 34, Issue:10 Topics: Acetamides; Amantadine; Antiviral Agents; Centers for Disease Control and Prevention, U.S.; Humans;	2002
Prevention and control of influenza. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports, 2002, Apr-12, Volume: 51, Issue:RR-3 Topics: Acetamides; Adolescent; Adult; Aged; Amantadine; Antiviral Agents; Child; Child, Preschool; Cost-Ben	2002
[Prophylaxis of influenza. Vaccination and chemoprophylaxis]. La Revue du praticien, 1992, Oct-01, Volume: 42, Issue:15 Topics: Amantadine; Humans; Influenza Vaccines; Influenza, Human; Rimantadine	1992
[Amantadine and rimantadine against influenza A]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1992, Jun-20, Volume: 112, Issue:16 Topics: Amantadine; Clinical Trials as Topic; Humans; Influenza A virus; Influenza, Human; Norway; Rimantadi	1992
Antivirals for the chemoprophylaxis and treatment of influenza. Seminars in respiratory infections, 1992, Volume: 7, Issue:1 Topics: Administration, Intranasal; Administration, Oral; Amantadine; Drug Resistance; Humans; Influenza A v	1992
Prevention and control of influenza recommendations of the Immunization Practices Advisory Committee (ACIP). MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports, 1991, May-24, Volume: 40, Issue:RR-6 Topics: Adolescent; Adult; Aged; Amantadine; Child; Child, Preschool; Disease Outbreaks; Female; HIV Infecti	1991
[The use of influenza vaccines and remantadine for protection against influenza in industrial enterprises]. Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1990, Issue:10 Topics: Contraindications; Drug Evaluation; Humans; Immunization Schedule; Incidence; Influenza A virus; Inf	1990
Antiviral therapy. New drugs and their uses. Postgraduate medicine, 1986, Volume: 80, Issue:1 Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Amantadine; Antiviral Agents; Chickenpox; Common Cold	1986
Antiviral drugs for common respiratory diseases. What's here, what's to come. Postgraduate medicine, 1988, Feb-01, Volume: 83, Issue:2 Topics: Adult; Aged; Amantadine; Antiviral Agents; Child; Female; Humans; Infant; Infant, Newborn; Influenza	1988
[Treatment of influenza]. Klinicheskaia meditsina, 1989, Volume: 67, Issue:1 Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; gamma-Globulins; Humans; Influenza, Human; Interfero	1989
[Prevention of influenza]. Revue de l'infirmiere, 1989, Volume: 39, Issue:15 Topics: Amantadine; Humans; Influenza Vaccines; Influenza, Human; Rimantadine	1989
Rimantadine and seizures. Annals of internal medicine, 1989, Feb-15, Volume: 110, Issue:4 Topics: Adamantane; Adult; Aged; Aged, 80 and over; Anticonvulsants; Humans; Influenza, Human; Male; Rimanta	1989
Resistance of influenza A virus to amantadine and rimantadine: results of one decade of surveillance. The Journal of infectious diseases, 1989, Volume: 159, Issue:3 Topics: Adamantane; Amantadine; Animals; Antigens, Viral; Cell Line; Cytopathogenic Effect, Viral; Dogs; Dru	1989
[Principles of the use of anti-influenza drugs]. Terapevticheskii arkhiv, 1988, Volume: 60, Issue:8 Topics: Adamantane; Ambulatory Care; Disease Outbreaks; Drug Administration Schedule; Humans; Influenza, Hum	1988
[Influenza virus infection. Influenza preventive vaccination and chemoprevention]. Medizinische Monatsschrift fur Pharmazeuten, 1988, Volume: 11, Issue:10 Topics: Amantadine; Antiviral Agents; Humans; Influenza Vaccines; Influenza, Human; Rimantadine; Risk Factor	1988
[The epidemiologic effectiveness of the nonspecific prophylaxis of acute respiratory infections in organized collectives]. Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1988, Issue:11 Topics: Acute Disease; Adjuvants, Immunologic; Adolescent; Adult; Benzimidazoles; Drug Evaluation; Humans; I	1988
Antiviral agents. Mayo Clinic proceedings, 1987, Volume: 62, Issue:12 Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Amantadine; Antiviral Agents; Ganciclovir; Herpes Sim	1987
Current status of amantadine and rimantadine as anti-influenza-A agents: memorandum from a WHO meeting. Bulletin of the World Health Organization, 1985, Volume: 63, Issue:1 Topics: Adamantane; Amantadine; Humans; Influenza A virus; Influenza, Human; Rimantadine	1985
Community-acquired lower respiratory tract infections. Prevention and cost-control strategies. The American journal of medicine, 1985, Jun-28, Volume: 78, Issue:6B Topics: Amantadine; Cost Control; Cross Infection; Humans; Influenza Vaccines; Influenza, Human; Pneumonia;	1985

rimantadine and Grippe

Research Excerpts

Research

Studies (226)

Authors

Clinical Trials (3)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Korshin, EE	1
Zakharova, LG	1
Levin, YA	1
Shulaeva, MP	1
Pozdeev, OK	1
Yarovaya, OI	1
Sokolova, AS	1
Mainagashev, IY	1
Volobueva, AS	2
Lantseva, K	1
Borisevich, SS	2
Shtro, AA	1
Zarubaev, VV	2
Salakhutdinov, NF	2
Khomenko, TM	1
Kireeva, MV	1
Slita, AV	1
Korchagina, DV	1
Komarova, NI	1
Volcho, KP	1
Scott, C	1
Kankanala, J	1
Foster, TL	1
Goldhill, DH	1
Bao, P	1
Simmons, K	1
Pingen, M	1
Bentham, M	1
Atkins, E	1
Loundras, E	1
Elderfield, R	1
Claridge, JK	1
Thompson, J	2
Stilwell, PR	1
Tathineni, R	1
McKimmie, CS	1
Targett-Adams, P	1
Schnell, JR	1
Cook, GP	1
Evans, S	1
Barclay, WS	1
Foster, R	1
Griffin, S	1
McGuire, KL	1
Hill, JT	1
Busath, DD	1
Larson, AM	1
Chen, J	1
Klibanov, AM	1
Król, E	1
Rychłowska, M	1
Szewczyk, B	1
Alves Galvão, MG	3
Rocha Crispino Santos, MA	3
Alves da Cunha, AJ	3
Perera, HK	1
Peiris, JS	2
McKimm-Breschkin, JL	1
Fry, AM	3
Nüesch, R	1
Green, RJ	1
Feldman, C	1
Schoub, B	1
Richards, GA	1
Madhi, SA	1
Zar, HJ	1
Lalloo, U	1
Klugman, K	1
Phillips, D	1
Cameron, NA	1
Eggers, RR	1
Monto, AS	6
Deyde, VM	1
Nguyen, T	1
Bright, RA	1
Balish, A	1
Shu, B	1
Lindstrom, S	1
Klimov, AI	3
Gubareva, LV	1
Jefferson, T	5
Oxford, JS	2
Trémolières, F	1
Hurt, AC	3
Holien, JK	1
Parker, MW	1
Barr, IG	3
Kimberlin, DW	1
Shalabi, M	1
Abzug, MJ	1
Lang, D	1
Jacobs, RF	1
Storch, G	1
Bradley, JS	1
Wade, KC	1
Ramilo, O	1
Romero, JR	1
Shelton, M	1
Leach, C	1
Guzman-Cottrill, J	1
Robinson, J	1
Abughali, N	1
Englund, J	1
Griffin, J	1
Jester, P	1
Cloud, GA	1
Whitley, RJ	1
Savinova, OV	1
Pavlova, NI	1
Boreko, EI	1
Greer, LG	1
Sheffield, JS	1
Rogers, VL	1
Roberts, SW	1
McIntire, DD	1
Wendel, GD	1
Astrahan, P	1
Arkin, IT	1
Dharan, NJ	1
Beekmann, SE	1
Fiore, A	1
Finelli, L	2
Uyeki, TM	4
Polgreen, PM	1
Yavarian, J	1
Azad, TM	1
Zheng, X	1
Gregory, V	2
Lin, YP	2
Hay, A	2
Zhang, Q	1
Zhao, QJ	1
Xiong, RS	1
Li, JF	1
Shen, JS	1
Rohde, GG	1
Belolipetskaia, VG	1
Blagodatskikh, SV	1
Zhabina, EA	1
Kibalchich, DA	1
Guranda, DF	1
Belolipetskiĭ, NA	1
Rudenko, LI	1
Fediakina, IT	1
Shchelkanov, MIu	1
Deriabin, PG	1
Leneva, IA	2
Gudova, NV	1
Kondrat'eva, TV	1
L'vov, DK	1
Doshi, S	1
Kamimoto, L	1
Perez, A	1
Reingold, A	1
Gershman, K	1
Yousey-Hindes, K	1
Arnold, K	1
Ryan, P	1
Lynfield, R	1
Morin, C	1
Baumbach, J	1
Hancock, EB	1
Bennett, NM	1
Zansky, S	1
Thomas, A	1
Schaffner, W	1
Hsu, J	1
Santesso, N	1
Mustafa, R	1
Brozek, J	1
Chen, YL	1
Hopkins, JP	1
Cheung, A	1
Hovhannisyan, G	1
Ivanova, L	1
Flottorp, SA	1
Saeterdal, I	1
Wong, AD	1
Tian, J	1
Akl, EA	1
Alonso-Coello, P	1
Smaill, F	1
Schünemann, HJ	1
Andreas, LB	1
Eddy, MT	1
Chou, JJ	1
Griffin, RG	1
Prober, CG	1
Englund, JA	2
Jefferson, TO	3
Demicheli, V	7
Deeks, JJ	4
Rivetti, D	7
Wagaman, PC	1
Leong, MA	1
Simmen, KA	1
Stott, DJ	1
Kerr, G	1
Carman, WF	1
Lee, PY	1
Matchar, DB	1
Clements, DA	1
Huber, J	1
Hamilton, JD	1
Peterson, ED	1
Gravenstein, S	5
Davidson, HE	1
Uyeki, T	2
Winquist, A	2
Tumpey, TM	1
García-Sastre, A	1
Mikulasova, A	1
Taubenberger, JK	1
Swayne, DE	1
Palese, P	1
Basler, CF	1
Dumyati, G	1
Falsey, AR	1
Bossuyt, S	1
Balasingam, S	1
Mann, A	1
Novelli, P	1
Lambkin, R	1
Mitamura, K	1
Kirkbride, HA	1
Watson, J	1
Ison, MG	1
Gnann, JW	1
Nagy-Agren, S	1
Treannor, J	1
Paya, C	1
Steigbigel, R	1
Elliott, M	1
Weiss, HL	1
Hayden, FG	21
Rothberg, MB	1
Bellantonio, S	1
Rose, DN	1
Marra, F	1
Marra, CA	1
Stiver, HG	1
Williamson, JC	1
Pegram, PS	1
Lu, Q	1
Rudin, M	1
Fagan, HB	1
Moeller, AH	1
Hansen, L	2
Drew, WL	1
Desbiens, NA	1
Nau, JY	1
Di Pietrantonj, C	1
Cheung, CL	1
Rayner, JM	1
Smith, GJ	1
Wang, P	1
Naipospos, TS	1
Zhang, J	1
Yuen, KY	1
Webster, RG	3
Guan, Y	1
Chen, H	1
Iannello, P	2
Tomasov, C	2
Deed, N	2
Komadina, N	2
Cunha, BA	1
Mossad, SB	3
Pavia, AT	1
Machała, M	1
Wiatr, E	1
Gawryluk, D	1
Brydak, LB	1
Lynch, JP	1
Walsh, EE	1
Drinka, PJ	3
Haupt, T	1
Wesseling, G	1
Worrall, G	1
Rotanov, M	1
Grebennikova, TV	1
Burtseva, EI	1
Shevchenko, ES	1
Nicholson, KG	2
Galasso, GJ	1
Douglas, RG	4
Malysheva, AM	2
Ignat'eva, GS	1
Erofeeva, MK	3
Efremov, BV	1
Maksakova, VL	1
Gagarinova, VM	2
Shadrin, AS	6
Kubar', OI	5
Kustikova, IuG	1
Araslanova, II	2
Smagulov, KZ	1
Bigimbetova, ShSh	1
Smagulova, EG	1
Leonov, VM	1
Romanov, IuA	4
Gorenskaia, RL	1
Rumel', NB	2
Gorenskaia, RA	1
Reĭkh, LIa	1
Padalko, IuV	1
Goldwater, PN	1
Rumen', NB	1
Vasilevskaia, NM	2
Zherbina, LA	1
Patriarca, PA	1
Kater, NA	1
Kendal, AP	1
Bregman, DJ	1
Smith, JD	1
Sikes, RK	1
Valenti, WM	1
Sebastiani, A	1
Van Voris, LP	2
Betts, RF	3
Christmas, WA	1
Dolin, R	3
Reichman, RC	1
Madore, HP	1
Maynard, R	1
Linton, PN	1
Webber-Jones, J	1
Zylidnikov, DM	1
Iljenko, VI	1
Padolka, YV	1
Zykov, MP	1
Karpukhin, GI	1
Lugovskaia, VP	1
Oleĭnikova, EV	1
Zlydnikov, DM	4
Geĭker, VI	1
Hovi, T	1
Quarles, JM	2
Couch, RB	6
Cate, TR	1
Goswick, CB	1
Cote, KM	1
Dekterev, AN	1
Tamarkina, KN	1
Natsina, VK	2
Drinevskiĭ, VP	2
Milkint, KK	1
Evans, KD	1
Kline, MW	1
Wintermeyer, SM	1
Nahata, MC	1
Bandy, U	1
Kuritzky, L	1
Philit, F	1
Cordier, JF	1
Buisson, Y	1
Eono, P	1
Desfontaine, M	1
Laroche, R	1
Houck, P	1
Hemphill, M	1
LaCroix, S	1
Hirsh, D	1
Cox, N	2
Guay, DR	1
Valette, M	1
Allard, JP	1
Aymard, M	1
Millet, V	1
Efimov, EI	1
Razgulin, SA	1
Ohmit, SE	1
Hornbuckle, K	1
Pearce, CL	1
Zimmerman, RK	1
Ruben, FL	1
Ahwesh, ER	1
Shigeta, S	1
Merchant, GL	1
Mower, WR	1
Talan, DA	1
Krause, P	3
Schilling, M	2
Miller, BA	2
Shult, P	3
Pedersen, C	1
Gerstoft, J	1
Stilianakis, NI	1
Perelson, AS	1
Niederman, MS	1
Miller, J	1
Tam, T	1
Afif, C	1
Maloney, S	1
Cetron, M	1
Fukata, K	1
Klimov, A	2
Hall, H	2
Kertesz, D	1
Hockin, J	1
Doyle, WJ	2
Skoner, DP	2
Alper, CM	1
Allen, G	1
Moody, SA	1
Seroky, JT	1
Champlin, RE	1
Wyde, PR	1
Kantarjian, H	1
Atmar, RL	2
Tarrand, J	1
Yousuf, H	1
Regnery, H	1
Cox, NJ	4
Whimbey, E	1
Scholtissek, C	1
Pérez Rodríguez, AE	1
Expósito Rivas, L	1
Rodríguez Leyva, O	1
Goyenechea Hernández, A	1
Povinelli, L	1
Gravenstein, M	1
Ambrozaitis, A	1
Jones, HH	1
Drinka, P	2
Powers, D	1
Osidak, LV	1
Afanas'eva, OI	1
Mil'kint, KK	1
Danini, GV	1
Ispolatova, AV	1
Koreniako, IE	1
Karelina, NN	1
Marinich, IG	1
Boldasov, VK	1
Silagy, CA	1
Reina, J	1
Gentile, DA	1
Patel, A	1
Ziegler, T	1
Hemphill, ML	1
Ziegler, ML	1
Perez-Oronoz, G	1
Hampson, AW	1
Regnery, HL	1
Deeks, J	2
Long, JK	1
Goldman, MP	1
Keyser, LA	1
Karl, M	1
Nafziger, AN	1
Bertino, JS	1
Nest, L	1
Dissing, M	1
Roberts, N	1
Govorkova, EA	1
Goloubeva, OG	1
Montalto, NJ	1
Gum, KD	1
Ashley, JV	1
Rosen, DS	1
Fleming, DM	1
Lim, W	1
Cameron, K	1
Bennett, M	1
Marozin, S	1
Preboth, M	1
Holdiness, MR	1
Johnston, SL	1
Salgado, CD	1
Farr, BM	1
Hall, KK	1
Fukuda, K	2
Bridges, CB	1
Singleton, JA	1
Vildé, JL	1
Longuet, P	1
Arden, NH	1
Bruu, AL	1
Orstavik, I	1
Hay, AJ	4
Newell, PM	1
Clover, RD	5
Waner, JL	1
Becker, L	1
Davis, A	1
Sperber, SJ	1
Belshe, RB	4
Pyke, S	1
Greenberg, SB	1
Wilson, SZ	1
Tyler, B	1
Feldman, S	1
Mal'chikov, IA	1
Slobodeniuk, AV	1
Bricaire, F	2
Hannoun, C	1
Boissel, JP	1
Brady, MT	1
Sears, SD	1
Pacini, DL	1
Samorodin, R	1
DePamphilis, J	1
Oakes, M	1
Soo, W	2
Clements, ML	1
Knight, V	1
Gilbert, BE	1
Bean, B	1
Bryson, YJ	1
Johnson, DC	1
Bogomolov, BP	1
Oakes, MG	1
Bentley, DW	1
Karki, SD	1
Burk, B	1
Newman, F	1
Cerruti, RL	1
Sim, IS	1
Shvetsova, EG	1
Uhl, D	1
Semenenko, TA	1
Perepelkin, VS	1
Vasil'eva, VI	1
Grushko, TP	1
Katkov, AI	1
Smith, MH	1
Hall, CB	2
Betts, R	1
Crawford, SA	2
Abell, TD	2
Ramsey, CN	2
Glezen, P	1
Gala, CL	1
Markovitz, DM	1
Zhang, YQ	1
Madore, PH	1
Disney, FA	1
Talpey, WB	1
Green, JL	1
Francis, AB	1
Tominack, RL	1
Hermans, PE	1
Cockerill, FR	1
Glezen, WP	1
Fleet, W	1
Lawrence, E	1
Pierce, E	1
Morris, L	1
Wright, P	1
Galbraith, AW	1
La Force, FM	1