riluzole has been researched along with Tauopathies in 2 studies
Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.
Tauopathies: Neurodegenerative disorders involving deposition of abnormal tau protein isoforms (TAU PROTEINS) in neurons and glial cells in the brain. Pathological aggregations of tau proteins are associated with mutation of the tau gene on chromosome 17 in patients with ALZHEIMER DISEASE; DEMENTIA; PARKINSONIAN DISORDERS; progressive supranuclear palsy (SUPRANUCLEAR PALSY, PROGRESSIVE); and corticobasal degeneration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Riluzole-treated TauP301L mice exhibited improved performance in the water radial arm maze and the Morris water maze, associated with a decrease in glutamate release and an increase in glutamate uptake in the dentate gyrus, cornu ammonis 3 (CA3), and cornu ammonis 1 (CA1) regions of the hippocampus." | 1.42 | Riluzole rescues glutamate alterations, cognitive deficits, and tau pathology associated with P301L tau expression. ( Gerhardt, GA; Hickman, JE; Hunsberger, HC; Libell, EM; Reed, MN; Rudy, CC; Speer, RR; Weitzner, DS, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hunsberger, HC | 1 |
| Weitzner, DS | 1 |
| Rudy, CC | 1 |
| Hickman, JE | 1 |
| Libell, EM | 1 |
| Speer, RR | 1 |
| Gerhardt, GA | 1 |
| Reed, MN | 1 |
| Whitcomb, DJ | 1 |
| Molnár, E | 1 |
2 other studies available for riluzole and Tauopathies
| Article | Year |
|---|---|
Riluzole rescues glutamate alterations, cognitive deficits, and tau pathology associated with P301L tau expression.
Topics: Alzheimer Disease; Animals; Brain Chemistry; Cognition Disorders; Excitatory Amino Acid Antagonists; | 2015 |
Is riluzole a new drug for Alzheimer's disease?
Topics: Animals; Cognition Disorders; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Neuroprotect | 2015 |