riluzole has been researched along with Seizures in 13 studies
Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute intoxication with tetramethylenedisulfotetramine (TETS) can trigger status epilepticus (SE) in humans." | 8.02 | Strain differences in the extent of brain injury in mice after tetramethylenedisulfotetramine-induced status epilepticus. ( Boosalis, CA; Bruun, DA; Calsbeek, JJ; Chaudhari, AJ; Garbow, JR; González, EA; Harvey, DJ; Lein, PJ; Rogawski, MA; Rowland, DJ; Saito, NH; Zolkowska, D, 2021) |
| "In this study we investigated the effectiveness of two antiepileptic drugs: riluzole and topiramate against pilocarpine-induced seizures, which are considered to be a model of intractable epilepsy commonly used to investigate the antiepileptic effect of drugs and mechanisms of epileptogenesis." | 7.76 | Evidences for pharmacokinetic interaction of riluzole and topiramate with pilocarpine in pilocarpine-induced seizures in rats. ( Brzana, W; Czuczwar, M; Kiś, J; Nieoczym, D; Turski, WA; Wlaź, P; Zgrajka, W, 2010) |
| "Infusion of the K(+) channel blocker 4-aminopyridine in the hippocampus induces the release of glutamate, as well as seizures and neurodegeneration." | 7.70 | Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels. ( Peña, F; Tapia, R, 2000) |
| "Acute intoxication with tetramethylenedisulfotetramine (TETS) can trigger status epilepticus (SE) in humans." | 4.02 | Strain differences in the extent of brain injury in mice after tetramethylenedisulfotetramine-induced status epilepticus. ( Boosalis, CA; Bruun, DA; Calsbeek, JJ; Chaudhari, AJ; Garbow, JR; González, EA; Harvey, DJ; Lein, PJ; Rogawski, MA; Rowland, DJ; Saito, NH; Zolkowska, D, 2021) |
| " Finally, we investigated its effects on pilocarpine-induced seizures in rats." | 3.78 | Characterizing the effects of Eugenol on neuronal ionic currents and hyperexcitability. ( Chow, JC; Huang, CW; Tsai, JJ; Wu, SN, 2012) |
| "In this study we investigated the effectiveness of two antiepileptic drugs: riluzole and topiramate against pilocarpine-induced seizures, which are considered to be a model of intractable epilepsy commonly used to investigate the antiepileptic effect of drugs and mechanisms of epileptogenesis." | 3.76 | Evidences for pharmacokinetic interaction of riluzole and topiramate with pilocarpine in pilocarpine-induced seizures in rats. ( Brzana, W; Czuczwar, M; Kiś, J; Nieoczym, D; Turski, WA; Wlaź, P; Zgrajka, W, 2010) |
| " In the present study, we compared the effects of riluzole and valproate (VPA) in the pilocarpine-induced limbic seizure model and in the gamma-hydroxybutyrate lactone (GBL)-induced absence seizure model." | 3.74 | Anti-glutamatergic effect of riluzole: comparison with valproic acid. ( Choi, HC; Choi, SY; Kang, TC; Kim, DS; Kim, JE; Kim, YI; Kwak, SE; Kwon, OS; Song, HK, 2007) |
| "It was demonstrated that inhibitory effects of riluzole on both kindled seizures and the development of behavioral seizures in kindling acquisition with relatively mild correlation to afterdischarge duration." | 3.71 | Effect of riluzole on the acquisition and expression of amygdala kindling. ( Noguchi, E; Ohkoshi, N; Tsuru, N; Yoshida, M, 2001) |
| "The anticonvulsant activity of riluzole against sound-induced seizures was studied in the DBA/2 mouse model." | 3.70 | NMDA and AMPA/kainate receptors are involved in the anticonvulsant activity of riluzole in DBA/2 mice. ( De Sarro, A; De Sarro, G; Ferreri, G; Gallelli, L; Siniscalchi, A, 2000) |
| "Infusion of the K(+) channel blocker 4-aminopyridine in the hippocampus induces the release of glutamate, as well as seizures and neurodegeneration." | 3.70 | Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels. ( Peña, F; Tapia, R, 2000) |
| "Using electroencephalographic (EEG) recordings in freely moving rats and extracellular neuronal firing-rate recordings in hippocampal slices, we examined the effects of riluzole (RP 54274), a compound with anti-glutamate properties, against the convulsive seizures and the cellular hyperexcitability produced by the mast-cell degranulating peptide (MCD), dendrotoxin I (DTXi) and 4-aminopyridine (4-AP)." | 3.68 | Riluzole prevents hyperexcitability produced by the mast cell degranulating peptide and dendrotoxin I in the rat. ( Blanchard, JC; Böhme, GA; Gandolfo, G; Gottesmann, C; Laduron, PM; Lafforgue, J; Lazdunski, M; Stutzmann, JM, 1991) |
| "2-Amino-6-trifluoromethoxy benzothiazole (PK 26124) prevented convulsions induced in rodents by maximal electroshock, inhibitors of the synthesis of gamma-aminobutyric acid (GABA) and ouabain, but was inactive against seizures provoked by GABA antagonists, unlike diazepam, chlordiazepoxide, phenobarbital and valproic acid." | 3.67 | 2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission--I. Anticonvulsant properties. ( Croucher, M; Gueremy, C; Le Fur, G; Legrand, JJ; Mazadier, M; Meldrum, B; Mizoule, J; Ollat, C; Uzan, A, 1985) |
| " SKA-19 is orally bioavailable and shows activity in a broad range of rodent seizure models." | 1.42 | The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant. ( Brown, BM; Cao, Z; Chen, YJ; Coleman, N; Goldin, AL; Jenkins, DP; Nguyen, HM; Pessah, IN; Rogawski, MA; Tanaka, BS; Wulff, H; Zolkowska, D, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Reddy, NL | 1 |
| Fan, W | 1 |
| Magar, SS | 1 |
| Perlman, ME | 1 |
| Yost, E | 1 |
| Zhang, L | 1 |
| Berlove, D | 1 |
| Fischer, JB | 1 |
| Burke-Howie, K | 1 |
| Wolcott, T | 1 |
| Durant, GJ | 1 |
| Jimonet, P | 1 |
| Audiau, F | 1 |
| Barreau, M | 1 |
| Blanchard, JC | 2 |
| Boireau, A | 1 |
| Bour, Y | 1 |
| Coléno, MA | 1 |
| Doble, A | 1 |
| Doerflinger, G | 1 |
| Huu, CD | 1 |
| Donat, MH | 1 |
| Duchesne, JM | 1 |
| Ganil, P | 1 |
| Guérémy, C | 2 |
| Honor, E | 1 |
| Just, B | 1 |
| Kerphirique, R | 1 |
| Gontier, S | 1 |
| Hubert, P | 1 |
| Laduron, PM | 2 |
| Le Blevec, J | 1 |
| Meunier, M | 1 |
| Miquet, JM | 1 |
| Nemecek, C | 1 |
| Mignani, S | 1 |
| Calsbeek, JJ | 1 |
| González, EA | 1 |
| Boosalis, CA | 1 |
| Zolkowska, D | 2 |
| Bruun, DA | 1 |
| Rowland, DJ | 1 |
| Saito, NH | 1 |
| Harvey, DJ | 1 |
| Chaudhari, AJ | 1 |
| Rogawski, MA | 2 |
| Garbow, JR | 1 |
| Lein, PJ | 1 |
| Coleman, N | 1 |
| Nguyen, HM | 1 |
| Cao, Z | 1 |
| Brown, BM | 1 |
| Jenkins, DP | 1 |
| Chen, YJ | 1 |
| Tanaka, BS | 1 |
| Goldin, AL | 1 |
| Pessah, IN | 1 |
| Wulff, H | 1 |
| Zgrajka, W | 1 |
| Nieoczym, D | 1 |
| Czuczwar, M | 1 |
| Kiś, J | 1 |
| Brzana, W | 1 |
| Wlaź, P | 1 |
| Turski, WA | 1 |
| Huang, CW | 1 |
| Chow, JC | 1 |
| Tsai, JJ | 1 |
| Wu, SN | 1 |
| Borowicz, KK | 1 |
| Rwiader, M | 1 |
| Drelewska, E | 1 |
| Czuczwar, SJ | 1 |
| Kim, JE | 1 |
| Kim, DS | 1 |
| Kwak, SE | 1 |
| Choi, HC | 1 |
| Song, HK | 1 |
| Choi, SY | 1 |
| Kwon, OS | 1 |
| Kim, YI | 1 |
| Kang, TC | 1 |
| De Sarro, G | 1 |
| Siniscalchi, A | 1 |
| Ferreri, G | 1 |
| Gallelli, L | 1 |
| De Sarro, A | 1 |
| Peña, F | 1 |
| Tapia, R | 1 |
| Yoshida, M | 1 |
| Noguchi, E | 1 |
| Tsuru, N | 1 |
| Ohkoshi, N | 1 |
| Stutzmann, JM | 1 |
| Böhme, GA | 1 |
| Gandolfo, G | 1 |
| Gottesmann, C | 1 |
| Lafforgue, J | 1 |
| Lazdunski, M | 1 |
| Mizoule, J | 1 |
| Meldrum, B | 1 |
| Mazadier, M | 1 |
| Croucher, M | 1 |
| Ollat, C | 1 |
| Uzan, A | 1 |
| Legrand, JJ | 1 |
| Le Fur, G | 1 |
13 other studies available for riluzole and Seizures
| Article | Year |
|---|---|
Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Cell Line; CHO Cells; Cricetinae; Drug Design; Guani | 1998 |
Riluzole series. Synthesis and in vivo "antiglutamate" activity of 6-substituted-2-benzothiazolamines and 3-substituted-2-imino-benzothiazolines.
Topics: Animals; Benzothiazoles; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoxia; Imines; Injectio | 1999 |
Strain differences in the extent of brain injury in mice after tetramethylenedisulfotetramine-induced status epilepticus.
Topics: Animals; Brain; Bridged-Ring Compounds; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; | 2021 |
The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Male; Mice; Pain Threshold; Rats; Rats, Sprague-Da | 2015 |
Evidences for pharmacokinetic interaction of riluzole and topiramate with pilocarpine in pilocarpine-induced seizures in rats.
Topics: Animals; Anticonvulsants; Brain; Chromatography, High Pressure Liquid; Convulsants; Drug Interaction | 2010 |
Characterizing the effects of Eugenol on neuronal ionic currents and hyperexcitability.
Topics: Action Potentials; Animals; Calcium Channels, L-Type; Cell Line, Tumor; Delayed Rectifier Potassium | 2012 |
Interactions between riluzole and conventional antiepileptic drugs -- a comparison of results obtained in the subthreshold method and isobolographic analysis.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Electroshock; Ma | 2004 |
Anti-glutamatergic effect of riluzole: comparison with valproic acid.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Disease Models, Animal; Epilepsy, Absence; Excitatory Posts | 2007 |
NMDA and AMPA/kainate receptors are involved in the anticonvulsant activity of riluzole in DBA/2 mice.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Female; Male; Mice | 2000 |
Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels.
Topics: 4-Aminopyridine; Animals; Epilepsy; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonis | 2000 |
Effect of riluzole on the acquisition and expression of amygdala kindling.
Topics: Amygdala; Animals; Anticonvulsants; Kindling, Neurologic; Male; Rats; Rats, Wistar; Riluzole; Seizur | 2001 |
Riluzole prevents hyperexcitability produced by the mast cell degranulating peptide and dendrotoxin I in the rat.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Elapid Venoms; Electroe | 1991 |
2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission--I. Anticonvulsant properties.
Topics: Amino Acids; Animals; Anticonvulsants; Bicuculline; Electroshock; Female; Glutamate Decarboxylase; H | 1985 |