riluzole has been researched along with Peripheral Nerve Diseases in 7 studies
Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the efficacy, tolerability, and safety of riluzole in the treatment of peripheral neuropathic pain conditions." | 9.09 | Lack of efficacy of riluzole in the treatment of peripheral neuropathic pain conditions. ( Cluff, RS; Friedman, E; Galer, BS; Harle, J; Rowbotham, MC; Twilling, LL, 2000) |
| "The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain." | 7.74 | A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007) |
| "To assess the efficacy, tolerability, and safety of riluzole in the treatment of peripheral neuropathic pain conditions." | 5.09 | Lack of efficacy of riluzole in the treatment of peripheral neuropathic pain conditions. ( Cluff, RS; Friedman, E; Galer, BS; Harle, J; Rowbotham, MC; Twilling, LL, 2000) |
| "The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain." | 3.74 | A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007) |
| "Riluzole has no negative effect on oxaliplatin antiproliferative capacity in human colorectal cancer cells and on its anticancer effect in a mouse model of colorectal cancer." | 1.48 | Targeting the TREK-1 potassium channel via riluzole to eliminate the neuropathic and depressive-like effects of oxaliplatin. ( Aissouni, Y; Authier, N; Balayssac, D; Barriere, DA; Busserolles, J; Eschalier, A; Giraudet, F; Kerckhove, N; Lamoine, S; Lazdunski, M; Lolignier, S; Meleine, M; Pereira, V; Poupon, L; Prival, L; Richard, D, 2018) |
| "The treatment with riluzole stimulated ambulation in PTPN rats and improved their motor performance and coordination." | 1.32 | Riluzole restores motor activity in rats with post-traumatic peripheral neuropathy. ( Drago, F; Grech, M; Medico, M; Nicosia, A; Onesta, M; Rampello, L; Sessa, G, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Trinh, T | 1 |
| Park, SB | 1 |
| Murray, J | 1 |
| Pickering, H | 1 |
| Lin, CS | 1 |
| Martin, A | 1 |
| Friedlander, M | 1 |
| Kiernan, MC | 1 |
| Goldstein, D | 1 |
| Krishnan, AV | 1 |
| Poupon, L | 1 |
| Lamoine, S | 1 |
| Pereira, V | 1 |
| Barriere, DA | 1 |
| Lolignier, S | 1 |
| Giraudet, F | 1 |
| Aissouni, Y | 1 |
| Meleine, M | 1 |
| Prival, L | 1 |
| Richard, D | 1 |
| Kerckhove, N | 2 |
| Authier, N | 1 |
| Balayssac, D | 2 |
| Eschalier, A | 2 |
| Lazdunski, M | 1 |
| Busserolles, J | 2 |
| Stanbury, T | 1 |
| Pereira, B | 1 |
| Plence, V | 1 |
| Bonnetain, F | 1 |
| Krakowski, I | 1 |
| Pezet, D | 1 |
| Medico, M | 1 |
| Nicosia, A | 1 |
| Grech, M | 1 |
| Onesta, M | 1 |
| Sessa, G | 1 |
| Rampello, L | 1 |
| Drago, F | 1 |
| Shortland, PJ | 1 |
| Leinster, VH | 1 |
| White, W | 1 |
| Robson, LG | 1 |
| Coderre, TJ | 1 |
| Kumar, N | 1 |
| Lefebvre, CD | 1 |
| Yu, JS | 1 |
| Galer, BS | 1 |
| Twilling, LL | 1 |
| Harle, J | 1 |
| Cluff, RS | 1 |
| Friedman, E | 1 |
| Rowbotham, MC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effectiveness Assessment of Riluzole in the Prevention of Oxaliplatin-induced Peripheral Neuropathy: A Phase II Randomized Study by UNICANCER With the Cooperation of AFSOS[NCT03722680] | Phase 2 | 80 participants (Actual) | Interventional | 2020-10-28 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for riluzole and Peripheral Nerve Diseases
| Article | Year |
|---|---|
Neu-horizons: neuroprotection and therapeutic use of riluzole for the prevention of oxaliplatin-induced neuropathy-a randomised controlled trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Neuroprotection; Oxal | 2021 |
Effectiveness assessment of riluzole in the prevention of oxaliplatin-induced peripheral neuropathy: RILUZOX-01: protocol of a randomised, parallel, controlled, double-blind and multicentre study by the UNICANCER-AFSOS Supportive Care intergroup.
Topics: Antineoplastic Agents; Double-Blind Method; Humans; Multicenter Studies as Topic; Neuroprotective Ag | 2019 |
Lack of efficacy of riluzole in the treatment of peripheral neuropathic pain conditions.
Topics: Adult; Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Male; Middle Aged; Pain; Periph | 2000 |
4 other studies available for riluzole and Peripheral Nerve Diseases
| Article | Year |
|---|---|
Targeting the TREK-1 potassium channel via riluzole to eliminate the neuropathic and depressive-like effects of oxaliplatin.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Depression; Humans; Male; Mice; Mice, | 2018 |
Riluzole restores motor activity in rats with post-traumatic peripheral neuropathy.
Topics: Animals; Male; Motor Activity; Peripheral Nervous System Diseases; Rats; Rats, Wistar; Riluzole; Sci | 2004 |
Riluzole promotes cell survival and neurite outgrowth in rat sensory neurones in vitro.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cell Count; Cell Survival; Cells, Cultured; Disease | 2006 |
A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain.
Topics: Amines; Analgesics; Animals; Anticonvulsants; Cold Temperature; Cyclohexanecarboxylic Acids; Disease | 2007 |