Page last updated: 2024-11-03

riluzole and Paraplegia

riluzole has been researched along with Paraplegia in 3 studies

Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.

Paraplegia: Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.

Research Excerpts

ExcerptRelevanceReference
"Riluzole has a neuroprotective effect in a rat model of spinal cord injury/reperfusion when administered up to 4h post-injury, a clinically relevant therapeutic time window."5.40Riluzole improves outcome following ischemia-reperfusion injury to the spinal cord by preventing delayed paraplegia. ( Fehlings, MG; Satkunendrarajah, K; Wu, Y, 2014)
" We investigated the effects of the anti-excitotoxic drugs magnesium sulfate (MgSO(4)) and riluzole in a rabbit model of spinal cord ischemia."3.70Prevention of ischemic spinal cord injury: comparative effects of magnesium sulfate and riluzole. ( Dupont, H; Heurteaux, C; Lang-Lazdunski, L; Lazdunski, M; Widmann, C, 2000)
"Riluzole has a neuroprotective effect in a rat model of spinal cord injury/reperfusion when administered up to 4h post-injury, a clinically relevant therapeutic time window."1.40Riluzole improves outcome following ischemia-reperfusion injury to the spinal cord by preventing delayed paraplegia. ( Fehlings, MG; Satkunendrarajah, K; Wu, Y, 2014)
"Temporary spinal cord ischemia was induced by 29 min of infrarenal balloon occlusion of the aorta in 60 anesthetized New Zealand white rabbits."1.31Neuroprotective effects of riluzole and ketamine during transient spinal cord ischemia in the rabbit. ( Bodewits, P; de Haan, P; Dzoljic, M; Jacobs, MJ; Kalkman, CJ; Lips, J; Vanicky, I, 2000)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wu, Y1
Satkunendrarajah, K1
Fehlings, MG1
Lang-Lazdunski, L1
Heurteaux, C1
Dupont, H1
Widmann, C1
Lazdunski, M1
Lips, J1
de Haan, P1
Bodewits, P1
Vanicky, I1
Dzoljic, M1
Jacobs, MJ1
Kalkman, CJ1

Other Studies

3 other studies available for riluzole and Paraplegia

ArticleYear
Riluzole improves outcome following ischemia-reperfusion injury to the spinal cord by preventing delayed paraplegia.
    Neuroscience, 2014, Apr-18, Volume: 265

    Topics: Animals; Female; Neuroprotective Agents; Paraplegia; Rats; Reperfusion Injury; Riluzole; Spinal Cord

2014
Prevention of ischemic spinal cord injury: comparative effects of magnesium sulfate and riluzole.
    Journal of vascular surgery, 2000, Volume: 32, Issue:1

    Topics: Animals; Aorta; Aorta, Thoracic; Constriction; Female; Immunohistochemistry; Ischemia; Magnesium Sul

2000
Neuroprotective effects of riluzole and ketamine during transient spinal cord ischemia in the rabbit.
    Anesthesiology, 2000, Volume: 93, Issue:5

    Topics: Animals; Disease Models, Animal; Excitatory Amino Acid Antagonists; Infarction; Ketamine; Neuroprote

2000
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