riluzole and Paraplegia
riluzole has been researched along with Paraplegia in 3 studies
Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.
Paraplegia: Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"Riluzole has a neuroprotective effect in a rat model of spinal cord injury/reperfusion when administered up to 4h post-injury, a clinically relevant therapeutic time window." | 5.40 | Riluzole improves outcome following ischemia-reperfusion injury to the spinal cord by preventing delayed paraplegia. ( Fehlings, MG; Satkunendrarajah, K; Wu, Y, 2014) |
" We investigated the effects of the anti-excitotoxic drugs magnesium sulfate (MgSO(4)) and riluzole in a rabbit model of spinal cord ischemia." | 3.70 | Prevention of ischemic spinal cord injury: comparative effects of magnesium sulfate and riluzole. ( Dupont, H; Heurteaux, C; Lang-Lazdunski, L; Lazdunski, M; Widmann, C, 2000) |
"Riluzole has a neuroprotective effect in a rat model of spinal cord injury/reperfusion when administered up to 4h post-injury, a clinically relevant therapeutic time window." | 1.40 | Riluzole improves outcome following ischemia-reperfusion injury to the spinal cord by preventing delayed paraplegia. ( Fehlings, MG; Satkunendrarajah, K; Wu, Y, 2014) |
"Temporary spinal cord ischemia was induced by 29 min of infrarenal balloon occlusion of the aorta in 60 anesthetized New Zealand white rabbits." | 1.31 | Neuroprotective effects of riluzole and ketamine during transient spinal cord ischemia in the rabbit. ( Bodewits, P; de Haan, P; Dzoljic, M; Jacobs, MJ; Kalkman, CJ; Lips, J; Vanicky, I, 2000) |
Research
Studies (3)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (66.67) | 29.6817 |
2010's | 1 (33.33) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Wu, Y | 1 |
Satkunendrarajah, K | 1 |
Fehlings, MG | 1 |
Lang-Lazdunski, L | 1 |
Heurteaux, C | 1 |
Dupont, H | 1 |
Widmann, C | 1 |
Lazdunski, M | 1 |
Lips, J | 1 |
de Haan, P | 1 |
Bodewits, P | 1 |
Vanicky, I | 1 |
Dzoljic, M | 1 |
Jacobs, MJ | 1 |
Kalkman, CJ | 1 |
Other Studies
3 other studies available for riluzole and Paraplegia
Article | Year |
---|---|
Riluzole improves outcome following ischemia-reperfusion injury to the spinal cord by preventing delayed paraplegia.
Topics: Animals; Female; Neuroprotective Agents; Paraplegia; Rats; Reperfusion Injury; Riluzole; Spinal Cord | 2014 |
Prevention of ischemic spinal cord injury: comparative effects of magnesium sulfate and riluzole.
Topics: Animals; Aorta; Aorta, Thoracic; Constriction; Female; Immunohistochemistry; Ischemia; Magnesium Sul | 2000 |
Neuroprotective effects of riluzole and ketamine during transient spinal cord ischemia in the rabbit.
Topics: Animals; Disease Models, Animal; Excitatory Amino Acid Antagonists; Infarction; Ketamine; Neuroprote | 2000 |