riluzole has been researched along with Pancreatic Neoplasms in 3 studies
Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Riluzole (RIL) is mainly used to treat amyotrophic lateral sclerosis clinically, but many previous studies have shown that RIL could inhibit tumors." | 4.02 | The new role of riluzole in the treatment of pancreatic cancer through the apoptosis and autophagy pathways. ( He, X; Jiang, X; Sun, R; Tao, H, 2021) |
| "Riluzole was given at 100 mg PO BID in combination with sorafenib, beginning at 200 mg PO daily and escalating in 200 mg increments per level in 28-day cycles." | 3.30 | A phase I trial of riluzole and sorafenib in patients with advanced solid tumors: CTEP #8850. ( Aisner, J; Cerchio, R; Chan, N; Chen, S; Ganesan, S; Goodin, S; Gounder, M; Li, J; Lin, H; Malhotra, J; Marinaro, C; Mehnert, JM; Portal, DE; Shih, W; Silk, AW; Spencer, KR; Stein, MN, 2023) |
| "However, pancreatic cancer cells switch to glutamine metabolism to survive under hypoxic conditions." | 1.72 | Riluzole regulates pancreatic cancer cell metabolism by suppressing the Wnt-β-catenin pathway. ( Lam, BQ; Ma, Y; Roy, SK; Shankar, S; Shrivastava, A; Srivastav, S; Srivastava, RK, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Roy, SK | 1 |
| Ma, Y | 1 |
| Lam, BQ | 1 |
| Shrivastava, A | 1 |
| Srivastav, S | 1 |
| Shankar, S | 1 |
| Srivastava, RK | 1 |
| Spencer, KR | 1 |
| Portal, DE | 1 |
| Aisner, J | 1 |
| Stein, MN | 1 |
| Malhotra, J | 1 |
| Shih, W | 1 |
| Chan, N | 1 |
| Silk, AW | 1 |
| Ganesan, S | 1 |
| Goodin, S | 1 |
| Gounder, M | 1 |
| Lin, H | 1 |
| Li, J | 1 |
| Cerchio, R | 1 |
| Marinaro, C | 1 |
| Chen, S | 1 |
| Mehnert, JM | 1 |
| Sun, R | 1 |
| He, X | 1 |
| Jiang, X | 1 |
| Tao, H | 1 |
1 trial available for riluzole and Pancreatic Neoplasms
| Article | Year |
|---|---|
A phase I trial of riluzole and sorafenib in patients with advanced solid tumors: CTEP #8850.
Topics: Antineoplastic Combined Chemotherapy Protocols; Humans; Maximum Tolerated Dose; Neoplasms; Niacinami | 2023 |
2 other studies available for riluzole and Pancreatic Neoplasms
| Article | Year |
|---|---|
Riluzole regulates pancreatic cancer cell metabolism by suppressing the Wnt-β-catenin pathway.
Topics: Animals; beta Catenin; Cell Line, Tumor; Cell Proliferation; Glutamine; Mice; Pancreatic Neoplasms; | 2022 |
Riluzole regulates pancreatic cancer cell metabolism by suppressing the Wnt-β-catenin pathway.
Topics: Animals; beta Catenin; Cell Line, Tumor; Cell Proliferation; Glutamine; Mice; Pancreatic Neoplasms; | 2022 |
Riluzole regulates pancreatic cancer cell metabolism by suppressing the Wnt-β-catenin pathway.
Topics: Animals; beta Catenin; Cell Line, Tumor; Cell Proliferation; Glutamine; Mice; Pancreatic Neoplasms; | 2022 |
Riluzole regulates pancreatic cancer cell metabolism by suppressing the Wnt-β-catenin pathway.
Topics: Animals; beta Catenin; Cell Line, Tumor; Cell Proliferation; Glutamine; Mice; Pancreatic Neoplasms; | 2022 |
The new role of riluzole in the treatment of pancreatic cancer through the apoptosis and autophagy pathways.
Topics: Amyotrophic Lateral Sclerosis; Apoptosis; Autophagy; Cell Line, Tumor; Humans; Pancreatic Neoplasms; | 2021 |
The new role of riluzole in the treatment of pancreatic cancer through the apoptosis and autophagy pathways.
Topics: Amyotrophic Lateral Sclerosis; Apoptosis; Autophagy; Cell Line, Tumor; Humans; Pancreatic Neoplasms; | 2021 |
The new role of riluzole in the treatment of pancreatic cancer through the apoptosis and autophagy pathways.
Topics: Amyotrophic Lateral Sclerosis; Apoptosis; Autophagy; Cell Line, Tumor; Humans; Pancreatic Neoplasms; | 2021 |
The new role of riluzole in the treatment of pancreatic cancer through the apoptosis and autophagy pathways.
Topics: Amyotrophic Lateral Sclerosis; Apoptosis; Autophagy; Cell Line, Tumor; Humans; Pancreatic Neoplasms; | 2021 |