Page last updated: 2024-11-03

riluzole and Osteosarcoma

riluzole has been researched along with Osteosarcoma in 4 studies

Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.

Osteosarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)

Research Excerpts

ExcerptRelevanceReference
"Our lab has previously demonstrated Riluzole to be an effective drug in inhibiting proliferation and inducing apoptosis in both human and mouse osteosarcoma."8.02Riluzole-induced apoptosis in osteosarcoma is mediated through Yes-associated protein upon phosphorylation by c-Abl Kinase. ( Azeem, SM; Blyufer, A; Cecilio, L; ChandThakuri, S; Chowdhury, Y; Hasnat, R; Huang, YQ; Lhamo, S; Mahajan, SS; Raghubir, M; Rahman, CN; Tam, C; Tariq, I; Wong, L; Yan, S; Zhagui, R, 2021)
"In human osteosarcoma MG63 cells, the effect of the neuroprotective drug riluzole on the intracellular Ca(2+) concentration ([Ca(2+)](i)) was measured using fura-2."7.71Effect of riluzole on cytosolic Ca2+ increase in human osteosarcoma cells. ( Chang, HT; Huang, JK; Jan, CR; Jiann, BP; Lu, YC, 2002)
"Osteosarcomas are the most commonly occurring malignant bone cancer in young individuals."5.56Osteosarcoma growth suppression by riluzole delivery via iron oxide nanocage in nude mice. ( Fang, J; Mahajan, SS; Matsui, H; Raghubir, M; Rahman, CN, 2020)
"Thus Riluzole is an effective drug to inhibit proliferation and survival of osteosarcoma cells and has therapeutic potential for the treatment of osteosarcoma exhibiting autocrine glutamate signaling."5.46Osteosarcoma cell proliferation and survival requires mGluR5 receptor activity and is blocked by Riluzole. ( Ait Taouit, L; Basu-Roy, U; Gulzar, H; Houssou, M; Jaikaran, T; Kozlitina, K; Liao, S; Mahajan, SS; Mansukhani, A; Ruiz, Y; Schvarts, Y; Yelskaya, Z, 2017)
"Our lab has previously demonstrated Riluzole to be an effective drug in inhibiting proliferation and inducing apoptosis in both human and mouse osteosarcoma."4.02Riluzole-induced apoptosis in osteosarcoma is mediated through Yes-associated protein upon phosphorylation by c-Abl Kinase. ( Azeem, SM; Blyufer, A; Cecilio, L; ChandThakuri, S; Chowdhury, Y; Hasnat, R; Huang, YQ; Lhamo, S; Mahajan, SS; Raghubir, M; Rahman, CN; Tam, C; Tariq, I; Wong, L; Yan, S; Zhagui, R, 2021)
"In human osteosarcoma MG63 cells, the effect of the neuroprotective drug riluzole on the intracellular Ca(2+) concentration ([Ca(2+)](i)) was measured using fura-2."3.71Effect of riluzole on cytosolic Ca2+ increase in human osteosarcoma cells. ( Chang, HT; Huang, JK; Jan, CR; Jiann, BP; Lu, YC, 2002)
"Osteosarcomas are the most commonly occurring malignant bone cancer in young individuals."1.56Osteosarcoma growth suppression by riluzole delivery via iron oxide nanocage in nude mice. ( Fang, J; Mahajan, SS; Matsui, H; Raghubir, M; Rahman, CN, 2020)
"Thus Riluzole is an effective drug to inhibit proliferation and survival of osteosarcoma cells and has therapeutic potential for the treatment of osteosarcoma exhibiting autocrine glutamate signaling."1.46Osteosarcoma cell proliferation and survival requires mGluR5 receptor activity and is blocked by Riluzole. ( Ait Taouit, L; Basu-Roy, U; Gulzar, H; Houssou, M; Jaikaran, T; Kozlitina, K; Liao, S; Mahajan, SS; Mansukhani, A; Ruiz, Y; Schvarts, Y; Yelskaya, Z, 2017)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's1 (25.00)24.3611
2020's2 (50.00)2.80

Authors

AuthorsStudies
Raghubir, M2
Azeem, SM1
Hasnat, R1
Rahman, CN2
Wong, L1
Yan, S1
Huang, YQ1
Zhagui, R1
Blyufer, A1
Tariq, I1
Tam, C1
Lhamo, S1
Cecilio, L1
Chowdhury, Y1
ChandThakuri, S1
Mahajan, SS3
Fang, J1
Matsui, H1
Liao, S1
Ruiz, Y1
Gulzar, H1
Yelskaya, Z1
Ait Taouit, L1
Houssou, M1
Jaikaran, T1
Schvarts, Y1
Kozlitina, K1
Basu-Roy, U1
Mansukhani, A1
Jan, CR1
Lu, YC1
Jiann, BP1
Chang, HT1
Huang, JK1

Other Studies

4 other studies available for riluzole and Osteosarcoma

ArticleYear
Riluzole-induced apoptosis in osteosarcoma is mediated through Yes-associated protein upon phosphorylation by c-Abl Kinase.
    Scientific reports, 2021, 10-25, Volume: 11, Issue:1

    Topics: Apoptosis; bcl-2-Associated X Protein; Bone Neoplasms; Cell Line, Tumor; Cell Nucleus; Cell Survival

2021
Osteosarcoma growth suppression by riluzole delivery via iron oxide nanocage in nude mice.
    Oncology reports, 2020, Volume: 43, Issue:1

    Topics: Animals; Bone Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Compo

2020
Osteosarcoma cell proliferation and survival requires mGluR5 receptor activity and is blocked by Riluzole.
    PloS one, 2017, Volume: 12, Issue:2

    Topics: Animals; Antineoplastic Agents; Bone and Bones; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cel

2017
Effect of riluzole on cytosolic Ca2+ increase in human osteosarcoma cells.
    Pharmacology, 2002, Volume: 66, Issue:3

    Topics: Calcium; Cytosol; Dose-Response Relationship, Drug; Humans; Osteosarcoma; Riluzole; Tumor Cells, Cul

2002