Page last updated: 2024-11-03

riluzole and Nerve Degeneration

riluzole has been researched along with Nerve Degeneration in 15 studies

Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.

Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.

Research Excerpts

ExcerptRelevanceReference
"Infusion of the K(+) channel blocker 4-aminopyridine in the hippocampus induces the release of glutamate, as well as seizures and neurodegeneration."7.70Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels. ( Peña, F; Tapia, R, 2000)
"Riluzole is a neuroprotective drug used in the treatment of motor neurone disease."5.38Riluzole neuroprotection in a Parkinson's disease model involves suppression of reactive astrocytosis but not GLT-1 regulation. ( Carbone, M; Duty, S; Rattray, M, 2012)
"Riluzole was administered prior to and consecutively for ten days following double lesion placement in the left-sided medial forebrain bundle and ipsilateral striatum."5.33Riluzole improves motor deficits and attenuates loss of striatal neurons in a sequential double lesion rat model of striatonigral degeneration (parkinson variant of multiple system atrophy). ( Diguet, E; Poewe, W; Puschban, Z; Sather, T; Scherfler, C; Stefanova, N; Tison, F; Wenning, GK, 2005)
"Infusion of the K(+) channel blocker 4-aminopyridine in the hippocampus induces the release of glutamate, as well as seizures and neurodegeneration."3.70Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels. ( Peña, F; Tapia, R, 2000)
"Riluzole is a neuroprotective drug used in the treatment of motor neurone disease."1.38Riluzole neuroprotection in a Parkinson's disease model involves suppression of reactive astrocytosis but not GLT-1 regulation. ( Carbone, M; Duty, S; Rattray, M, 2012)
"Riluzole was administered prior to and consecutively for ten days following double lesion placement in the left-sided medial forebrain bundle and ipsilateral striatum."1.33Riluzole improves motor deficits and attenuates loss of striatal neurons in a sequential double lesion rat model of striatonigral degeneration (parkinson variant of multiple system atrophy). ( Diguet, E; Poewe, W; Puschban, Z; Sather, T; Scherfler, C; Stefanova, N; Tison, F; Wenning, GK, 2005)
"Neuronal death associated with cerebral ischemia and hypoglycemia is related to increased release of excitatory amino acids (EAA) and energy failure."1.33The anion channel blocker, 4,4'-dinitrostilbene-2,2'-disulfonic acid prevents neuronal death and excitatory amino acid release during glycolysis inhibition in the hippocampus in vivo. ( Camacho, A; Massieu, L; Montiel, T, 2006)
"Cotreatment with riluzole (4 mg/kg i."1.30Riluzole reduces incidence of abnormal movements but not striatal cell death in a primate model of progressive striatal degeneration. ( Brouillet, E; Guyot, MC; Hantraye, P; Mary, V; Palfi, S; Peschanski, M; Riche, D; Stutzmann, JM; Wahl, F, 1997)
"Riluzole treatment beyond 1 h (e."1.30Tirilazad widens the therapeutic window for riluzole-induced attenuation of progressive cortical degeneration in an infant rat model of the shaken baby syndrome. ( Hall, ED; Smith, SL, 1998)
"Riluzole treatment almost completely prevented the neuronal degeneration in these brain areas."1.30Effect of riluzole on the neurological and neuropathological changes in an animal model of cardiac arrest-induced movement disorder. ( Kanthasamy, AG; Nguyen, B; Truong, DD; Yun, RJ, 1999)
"Riluzole was injected or topically applied to the eye before or after ischemia and twice daily during the reperfusion period."1.30Riluzole improves functional recovery after ischemia in the rat retina. ( Ettaiche, M; Fillacier, K; Heurteaux, C; Lazdunski, M; Widmann, C, 1999)
" Moreover, human monocytoid cell lines infected by HIV release endogenous toxic factors with comparable cellular actions."1.29Prevention of HIV coat protein (gp120) toxicity in cortical cell cultures by riluzole. ( Bousseau, A; Couratier, P; Esclaire, F; Hugon, J; Sindou, P; Yardin, C, 1994)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (40.00)18.2507
2000's8 (53.33)29.6817
2010's1 (6.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brunet, N1
Tarabal, O1
Esquerda, JE1
Calderó, J1
Sanacora, G1
Carbone, M1
Duty, S1
Rattray, M1
Hersch, SM1
Rival, T1
Soustelle, L1
Strambi, C1
Besson, MT1
Iché, M1
Birman, S1
Scherfler, C1
Sather, T1
Diguet, E1
Stefanova, N1
Puschban, Z1
Tison, F1
Poewe, W1
Wenning, GK1
Camacho, A1
Montiel, T1
Massieu, L1
Amendola, J1
Gueritaud, JP1
Lamotte d'Incamps, B1
Bories, C1
Liabeuf, S1
Allene, C1
Pambo-Pambo, A1
Durand, J1
Sindou, P1
Couratier, P1
Esclaire, F1
Yardin, C1
Bousseau, A1
Hugon, J1
Dessi, F1
Ben-Ari, Y1
Charriaut-Marlangue, C1
Palfi, S1
Riche, D1
Brouillet, E1
Guyot, MC1
Mary, V1
Wahl, F1
Peschanski, M1
Stutzmann, JM1
Hantraye, P1
Smith, SL1
Hall, ED1
Kanthasamy, AG1
Yun, RJ1
Nguyen, B1
Truong, DD1
Ettaiche, M1
Fillacier, K1
Widmann, C1
Heurteaux, C1
Lazdunski, M1
Peña, F1
Tapia, R1

Reviews

2 reviews available for riluzole and Nerve Degeneration

ArticleYear
Do glutamatergic agents represent a new class of antidepressant drugs? Part 1.
    The Journal of clinical psychiatry, 2009, Volume: 70, Issue:10

    Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Disease Models, Animal; Drug Design; Hum

2009
Huntington's disease: prospects for neuroprotective therapy 10 years after the discovery of the causative genetic mutation.
    Current opinion in neurology, 2003, Volume: 16, Issue:4

    Topics: Amantadine; Anti-Dyskinesia Agents; Antiparkinson Agents; Eicosapentaenoic Acid; Fatty Acids, Unsatu

2003

Other Studies

13 other studies available for riluzole and Nerve Degeneration

ArticleYear
Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord.
    The Journal of comparative neurology, 2009, Oct-01, Volume: 516, Issue:4

    Topics: Animals; Calcium Signaling; Chick Embryo; Disease Models, Animal; Dose-Response Relationship, Drug;

2009
Riluzole neuroprotection in a Parkinson's disease model involves suppression of reactive astrocytosis but not GLT-1 regulation.
    BMC neuroscience, 2012, Apr-05, Volume: 13

    Topics: Animals; Astrocytes; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Excitatory Amino

2012
Decreasing glutamate buffering capacity triggers oxidative stress and neuropil degeneration in the Drosophila brain.
    Current biology : CB, 2004, Apr-06, Volume: 14, Issue:7

    Topics: Animals; Brain; DNA Primers; Drosophila; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Tr

2004
Riluzole improves motor deficits and attenuates loss of striatal neurons in a sequential double lesion rat model of striatonigral degeneration (parkinson variant of multiple system atrophy).
    Journal of neural transmission (Vienna, Austria : 1996), 2005, Volume: 112, Issue:8

    Topics: Animals; Biomarkers; Corpus Striatum; Denervation; Disease Models, Animal; Dopamine and cAMP-Regulat

2005
The anion channel blocker, 4,4'-dinitrostilbene-2,2'-disulfonic acid prevents neuronal death and excitatory amino acid release during glycolysis inhibition in the hippocampus in vivo.
    Neuroscience, 2006, Nov-03, Volume: 142, Issue:4

    Topics: Animals; Aspartic Acid; Brain Ischemia; Cell Death; Energy Metabolism; Excitatory Amino Acids; Exocy

2006
Postnatal electrical and morphological abnormalities in lumbar motoneurons from transgenic mouse models of amyotrophic lateral sclerosis.
    Archives italiennes de biologie, 2007, Volume: 145, Issue:3-4

    Topics: Action Potentials; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Biotin; Cell Differenti

2007
Prevention of HIV coat protein (gp120) toxicity in cortical cell cultures by riluzole.
    Journal of the neurological sciences, 1994, Volume: 126, Issue:2

    Topics: Animals; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Antagonists; HIV Envelope Protein g

1994
Riluzole prevents anoxic injury in cultured cerebellar granule neurons.
    European journal of pharmacology, 1993, Dec-07, Volume: 250, Issue:2

    Topics: Animals; Cells, Cultured; Cerebellum; Hypoxia, Brain; Nerve Degeneration; Neurons; Rats; Riluzole; S

1993
Riluzole reduces incidence of abnormal movements but not striatal cell death in a primate model of progressive striatal degeneration.
    Experimental neurology, 1997, Volume: 146, Issue:1

    Topics: Acetylcholinesterase; Animals; Antiparkinson Agents; Apomorphine; Caudate Nucleus; Corpus Striatum;

1997
Tirilazad widens the therapeutic window for riluzole-induced attenuation of progressive cortical degeneration in an infant rat model of the shaken baby syndrome.
    Journal of neurotrauma, 1998, Volume: 15, Issue:9

    Topics: Age Factors; Animals; Battered Child Syndrome; Body Temperature; Disease Models, Animal; Dose-Respon

1998
Effect of riluzole on the neurological and neuropathological changes in an animal model of cardiac arrest-induced movement disorder.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:3

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Heart Arrest; Histocytochemistry; Male; Movement D

1999
Riluzole improves functional recovery after ischemia in the rat retina.
    Investigative ophthalmology & visual science, 1999, Volume: 40, Issue:3

    Topics: Administration, Topical; Animals; Apoptosis; Electroretinography; Glial Fibrillary Acidic Protein; I

1999
Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels.
    Neuroscience, 2000, Volume: 101, Issue:3

    Topics: 4-Aminopyridine; Animals; Epilepsy; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonis

2000