Page last updated: 2024-11-03

riluzole and Neoplasms

riluzole has been researched along with Neoplasms in 6 studies

Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
"Riluzole was given at 100 mg PO BID in combination with sorafenib, beginning at 200 mg PO daily and escalating in 200 mg increments per level in 28-day cycles."3.30A phase I trial of riluzole and sorafenib in patients with advanced solid tumors: CTEP #8850. ( Aisner, J; Cerchio, R; Chan, N; Chen, S; Ganesan, S; Goodin, S; Gounder, M; Li, J; Lin, H; Malhotra, J; Marinaro, C; Mehnert, JM; Portal, DE; Shih, W; Silk, AW; Spencer, KR; Stein, MN, 2023)
"Riluzole has no negative effect on oxaliplatin antiproliferative capacity in human colorectal cancer cells and on its anticancer effect in a mouse model of colorectal cancer."1.48Targeting the TREK-1 potassium channel via riluzole to eliminate the neuropathic and depressive-like effects of oxaliplatin. ( Aissouni, Y; Authier, N; Balayssac, D; Barriere, DA; Busserolles, J; Eschalier, A; Giraudet, F; Kerckhove, N; Lamoine, S; Lazdunski, M; Lolignier, S; Meleine, M; Pereira, V; Poupon, L; Prival, L; Richard, D, 2018)
"Current cancer therapies are challenged by weakly soluble drugs and by drug combinations that exhibit non-uniform biodistribution and poor bioavailability."1.39Multifunctional albumin nanoparticles as combination drug carriers for intra-tumoral chemotherapy. ( Chen, S; Cui, M; Griffith, CK; Moghe, PV; Naczynski, DJ; Poventud-Fuentes, I; Roth, CM; Sheihet, L; Zevon, M, 2013)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's3 (50.00)24.3611
2020's2 (33.33)2.80

Authors

AuthorsStudies
Diamandis, P1
Wildenhain, J1
Clarke, ID1
Sacher, AG1
Graham, J1
Bellows, DS1
Ling, EK1
Ward, RJ1
Jamieson, LG1
Tyers, M1
Dirks, PB1
Lin, R1
Elf, S1
Shan, C1
Kang, HB1
Ji, Q1
Zhou, L1
Hitosugi, T1
Zhang, L1
Zhang, S1
Seo, JH1
Xie, J1
Tucker, M1
Gu, TL1
Sudderth, J1
Jiang, L1
Mitsche, M1
DeBerardinis, RJ1
Wu, S1
Li, Y1
Mao, H1
Chen, PR1
Wang, D1
Chen, GZ1
Hurwitz, SJ1
Lonial, S1
Arellano, ML1
Khoury, HJ1
Khuri, FR1
Lee, BH1
Lei, Q1
Brat, DJ1
Ye, K1
Boggon, TJ1
He, C1
Kang, S1
Fan, J1
Chen, J1
Blyufer, A1
Lhamo, S1
Tam, C1
Tariq, I1
Thavornwatanayong, T1
Mahajan, SS1
Spencer, KR1
Portal, DE1
Aisner, J1
Stein, MN1
Malhotra, J1
Shih, W1
Chan, N1
Silk, AW1
Ganesan, S1
Goodin, S1
Gounder, M1
Lin, H1
Li, J1
Cerchio, R1
Marinaro, C1
Chen, S2
Mehnert, JM1
Poupon, L1
Lamoine, S1
Pereira, V1
Barriere, DA1
Lolignier, S1
Giraudet, F1
Aissouni, Y1
Meleine, M1
Prival, L1
Richard, D1
Kerckhove, N1
Authier, N1
Balayssac, D1
Eschalier, A1
Lazdunski, M1
Busserolles, J1
Cui, M1
Naczynski, DJ1
Zevon, M1
Griffith, CK1
Sheihet, L1
Poventud-Fuentes, I1
Roth, CM1
Moghe, PV1

Reviews

2 reviews available for riluzole and Neoplasms

ArticleYear
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
    Nature cell biology, 2015, Volume: 17, Issue:11

    Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms;

2015
Riluzole: A neuroprotective drug with potential as a novel anti‑cancer agent (Review).
    International journal of oncology, 2021, Volume: 59, Issue:5

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Mice; Neopl

2021

Trials

1 trial available for riluzole and Neoplasms

ArticleYear
A phase I trial of riluzole and sorafenib in patients with advanced solid tumors: CTEP #8850.
    Oncotarget, 2023, 04-10, Volume: 14

    Topics: Antineoplastic Combined Chemotherapy Protocols; Humans; Maximum Tolerated Dose; Neoplasms; Niacinami

2023

Other Studies

3 other studies available for riluzole and Neoplasms

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic

2007
Targeting the TREK-1 potassium channel via riluzole to eliminate the neuropathic and depressive-like effects of oxaliplatin.
    Neuropharmacology, 2018, 09-15, Volume: 140

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Depression; Humans; Male; Mice; Mice,

2018
Multifunctional albumin nanoparticles as combination drug carriers for intra-tumoral chemotherapy.
    Advanced healthcare materials, 2013, Volume: 2, Issue:9

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Collagenases; Curcumin; Drug Carriers; Human

2013