riluzole has been researched along with Glioma in 6 studies
Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Riluzole and memantine can be safely and effectively delivered intracranially via polymer in rat glioma models." | 7.80 | Efficacy of local polymer-based and systemic delivery of the anti-glutamatergic agents riluzole and memantine in rat glioma models. ( Blakeley, J; Brem, H; Gincel, D; Pardo, AC; Rothstein, JD; Tyler, B; Weaver, KD; Yohay, K, 2014) |
| " This study examined the effect of riluzole on [Ca2+]i in IMR32 neuroblastoma cells using fura-2 as a Ca2+ probe." | 7.71 | Effect of the neuroprotective agent riluzole on intracellular Ca2+ levels in IMR32 neuroblastoma cells. ( Chang, CH; Chen, WC; Chow, CK; Jan, CR; Law, YP; Lee, KC; Lu, T; Su, W; Tang, KY; Wang, JL, 2001) |
| "In the present study, we investigated the effects of mGluR1 inhibition in human glioma U87 cells using specific targeted small interfering RNA (siRNA) or selective antagonists Riluzole and BAY36-7620." | 3.81 | Anti-cancer effect of metabotropic glutamate receptor 1 inhibition in human glioma U87 cells: involvement of PI3K/Akt/mTOR pathway. ( Li, HY; Liao, YW; Liu, Q; Sang, SS; Su, J; Wang, XY; Yuan, XR; Zhang, C; Zhao, ZJ, 2015) |
| "Riluzole and memantine can be safely and effectively delivered intracranially via polymer in rat glioma models." | 3.80 | Efficacy of local polymer-based and systemic delivery of the anti-glutamatergic agents riluzole and memantine in rat glioma models. ( Blakeley, J; Brem, H; Gincel, D; Pardo, AC; Rothstein, JD; Tyler, B; Weaver, KD; Yohay, K, 2014) |
| " Finally, we investigated its effects on pilocarpine-induced seizures in rats." | 3.78 | Characterizing the effects of Eugenol on neuronal ionic currents and hyperexcitability. ( Chow, JC; Huang, CW; Tsai, JJ; Wu, SN, 2012) |
| " This study examined the effect of riluzole on [Ca2+]i in IMR32 neuroblastoma cells using fura-2 as a Ca2+ probe." | 3.71 | Effect of the neuroprotective agent riluzole on intracellular Ca2+ levels in IMR32 neuroblastoma cells. ( Chang, CH; Chen, WC; Chow, CK; Jan, CR; Law, YP; Lee, KC; Lu, T; Su, W; Tang, KY; Wang, JL, 2001) |
| "Riluzole is a drug approved for the treatment of amyotrophic lateral sclerosis (ALS) and may be effective for the treatment of other neurodegenerative and neuropsychiatric disorders." | 1.39 | Riluzole increases glutamate uptake by cultured C6 astroglial cells. ( Bobermin, LD; Dall'Igna, OP; Quincozes-Santos, A; Souza, DO, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dall'Igna, OP | 1 |
| Bobermin, LD | 1 |
| Souza, DO | 1 |
| Quincozes-Santos, A | 1 |
| Yohay, K | 1 |
| Tyler, B | 1 |
| Weaver, KD | 1 |
| Pardo, AC | 1 |
| Gincel, D | 1 |
| Blakeley, J | 1 |
| Brem, H | 1 |
| Rothstein, JD | 1 |
| Zhang, C | 1 |
| Yuan, XR | 1 |
| Li, HY | 1 |
| Zhao, ZJ | 1 |
| Liao, YW | 1 |
| Wang, XY | 1 |
| Su, J | 1 |
| Sang, SS | 1 |
| Liu, Q | 1 |
| Tsuchioka, M | 1 |
| Hisaoka, K | 1 |
| Yano, R | 1 |
| Shibasaki, C | 1 |
| Kajiatani, N | 1 |
| Takebayashi, M | 1 |
| Huang, CW | 1 |
| Chow, JC | 1 |
| Tsai, JJ | 1 |
| Wu, SN | 1 |
| Wang, JL | 1 |
| Lee, KC | 1 |
| Tang, KY | 1 |
| Lu, T | 1 |
| Chang, CH | 1 |
| Chow, CK | 1 |
| Chen, WC | 1 |
| Su, W | 1 |
| Law, YP | 1 |
| Jan, CR | 1 |
6 other studies available for riluzole and Glioma
| Article | Year |
|---|---|
Riluzole increases glutamate uptake by cultured C6 astroglial cells.
Topics: Analysis of Variance; Animals; Astrocytes; Cell Line, Tumor; Dose-Response Relationship, Drug; Excit | 2013 |
Efficacy of local polymer-based and systemic delivery of the anti-glutamatergic agents riluzole and memantine in rat glioma models.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Disease Models, Animal; Drug Delivery Systems; Excitator | 2014 |
Anti-cancer effect of metabotropic glutamate receptor 1 inhibition in human glioma U87 cells: involvement of PI3K/Akt/mTOR pathway.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Movement; Glioma | 2015 |
Riluzole-induced glial cell line-derived neurotrophic factor production is regulated through fibroblast growth factor receptor signaling in rat C6 glioma cells.
Topics: Animals; Cell Line, Tumor; CREB-Binding Protein; Dose-Response Relationship, Drug; Drug Interactions | 2011 |
Characterizing the effects of Eugenol on neuronal ionic currents and hyperexcitability.
Topics: Action Potentials; Animals; Calcium Channels, L-Type; Cell Line, Tumor; Delayed Rectifier Potassium | 2012 |
Effect of the neuroprotective agent riluzole on intracellular Ca2+ levels in IMR32 neuroblastoma cells.
Topics: Animals; Brefeldin A; Calcium; Calcium Channel Blockers; Carbonyl Cyanide m-Chlorophenyl Hydrazone; | 2001 |