riluzole has been researched along with Epilepsy in 7 studies
Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Infusion of the K(+) channel blocker 4-aminopyridine in the hippocampus induces the release of glutamate, as well as seizures and neurodegeneration." | 7.70 | Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels. ( Peña, F; Tapia, R, 2000) |
| "Infusion of the K(+) channel blocker 4-aminopyridine in the hippocampus induces the release of glutamate, as well as seizures and neurodegeneration." | 3.70 | Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels. ( Peña, F; Tapia, R, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anger, T | 1 |
| Madge, DJ | 1 |
| Mulla, M | 1 |
| Riddall, D | 1 |
| Vivier, D | 1 |
| Bennis, K | 1 |
| Lesage, F | 1 |
| Ducki, S | 1 |
| Ittner, AA | 1 |
| Gladbach, A | 1 |
| Bertz, J | 1 |
| Suh, LS | 1 |
| Ittner, LM | 1 |
| Tryba, AK | 1 |
| Kaczorowski, CC | 1 |
| Ben-Mabrouk, F | 1 |
| Elsen, FP | 1 |
| Lew, SM | 1 |
| Marcuccilli, CJ | 1 |
| Spadoni, F | 1 |
| Hainsworth, AH | 1 |
| Mercuri, NB | 1 |
| Caputi, L | 1 |
| Martella, G | 1 |
| Lavaroni, F | 1 |
| Bernardi, G | 2 |
| Stefani, A | 1 |
| Peña, F | 1 |
| Tapia, R | 1 |
| Zona, C | 1 |
| Cavalcanti, S | 1 |
| De Sarro, G | 1 |
| Siniscalchi, A | 1 |
| Marchetti, C | 1 |
| Gaetti, C | 1 |
| Costa, N | 1 |
| Mercuri, N | 1 |
2 reviews available for riluzole and Epilepsy
| Article | Year |
|---|---|
Medicinal chemistry of neuronal voltage-gated sodium channel blockers.
Topics: Amyotrophic Lateral Sclerosis; Analgesics; Anticonvulsants; Epilepsy; Humans; Ion Channel Gating; Mo | 2001 |
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc | 2016 |
5 other studies available for riluzole and Epilepsy
| Article | Year |
|---|---|
p38 MAP kinase-mediated NMDA receptor-dependent suppression of hippocampal hypersynchronicity in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Dizocilpine Maleate; Electrodes, Implanted; Elec | 2014 |
Rhythmic intrinsic bursting neurons in human neocortex obtained from pediatric patients with epilepsy.
Topics: Action Potentials; Adolescent; Animals; Anticonvulsants; Calcium Channels; Child; Child, Preschool; | 2011 |
Lamotrigine derivatives and riluzole inhibit INa,P in cortical neurons.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Cerebral Cortex; Dose-Response Relatio | 2002 |
Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels.
Topics: 4-Aminopyridine; Animals; Epilepsy; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonis | 2000 |
Kainate-induced currents in rat cortical neurons in culture are modulated by riluzole.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cells, Cultured; Cerebral Cortex; Epilepsy; Excitatory Amino | 2002 |